Resources Contact Us Home
Method for inducing death of neoplastic cells using piperazne derivatives

Image Number 12 for United States Patent #5733911.

A method for inducing cell death in neoplastic cells, includes the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof, as a primary chemotherapeutic agent or substantially contemporaneously with chemotherapy, to a patient having multidrug-resistant neoplastic cells, in an amount sufficient to induce cell death in the neoplastic cells: ##STR1## where R.sup.1 is hydroxyl, C1-4 alkoxyl, C1-4 alkylcarboxyloxymethoxyl, phenyl C1-2 alkylamino group, 2,5-pyrrolidinedione-1-alkoxyl (C1-4), or ##STR2## wherein X.sup.1 is a chemical bond or C1-2 alkylene, X.sup.2 is hydrogen or carboxyl forming a 5-membered ring with X.sup.1 when X.sup.2 is methylene, X.sup.3 is hydrogen or C1-2 alkyl, X.sup.4 is hydrogen or C1-2 alkyl, or X.sup.3 and X.sup.4 together form a 5-membered ring, in which at least one of X.sup.2, X.sup.3, and X.sup.4 is hydrogen,R.sup.2 is C3-4 alkyl, R.sup.3 is C1-4 alkyl, ##STR3## in which n is an integer of 0 to 3.

  Recently Added Patents
Facility to reuse paper
Laser processing method and apparatus
Phenethanolamine derivatives for treatment of respiratory diseases
Treatment of cancer using the sodium salt of a benzoic acid derivative
Configurable caged ball insert for a downhole tool
Fingerprinting apparatus, system, and method
Fluid discrimination device
  Randomly Featured Patents
Automated low-pressure casting mechanism and method
Low profile multi-tier, automated, poultry cage feeder system
Sheet package, package member and printer
Wireless communication apparatus
Fire extinguishing systems and methods
Case with an obstacle-free basic frame element, lateral elements and different types of additional elements
Optical fiber
Fabrication methods for metal matrix composites
Compact adaptive optic-optical coherence tomography system
Optical system and light emitting diode having a light dividing surface portion