Resources Contact Us Home
Method for inducing death of neoplastic cells using piperazne derivatives

Image Number 12 for United States Patent #5733911.

A method for inducing cell death in neoplastic cells, includes the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof, as a primary chemotherapeutic agent or substantially contemporaneously with chemotherapy, to a patient having multidrug-resistant neoplastic cells, in an amount sufficient to induce cell death in the neoplastic cells: ##STR1## where R.sup.1 is hydroxyl, C1-4 alkoxyl, C1-4 alkylcarboxyloxymethoxyl, phenyl C1-2 alkylamino group, 2,5-pyrrolidinedione-1-alkoxyl (C1-4), or ##STR2## wherein X.sup.1 is a chemical bond or C1-2 alkylene, X.sup.2 is hydrogen or carboxyl forming a 5-membered ring with X.sup.1 when X.sup.2 is methylene, X.sup.3 is hydrogen or C1-2 alkyl, X.sup.4 is hydrogen or C1-2 alkyl, or X.sup.3 and X.sup.4 together form a 5-membered ring, in which at least one of X.sup.2, X.sup.3, and X.sup.4 is hydrogen,R.sup.2 is C3-4 alkyl, R.sup.3 is C1-4 alkyl, ##STR3## in which n is an integer of 0 to 3.

  Recently Added Patents
Plants and seeds of corn variety CV294874
Reframing circuitry with virtual container drop and insert functionality to support circuit emulation protocols
Dynamic data caches, decoders and decoding methods
Integrated circuit packaging system with heat slug and method of manufacture thereof
Piezoelectric ultrasonic transducer apparatus
Methods and apparatus for processing audio signals
  Randomly Featured Patents
Method and apparatus for monitoring plasma processing operations
High altitude platform air drop system
Manually operated pump inserter for test tubes
Method and system for generating addresses for a processor
Foot massager
Gas fumigation method and system
Multi-channel analogue to digital convertor
Magneto-electric device
Partial page output caching
Cruciform golf spike construction