Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Method for inducing death of neoplastic cells using piperazne derivatives










Image Number 12 for United States Patent #5733911.

A method for inducing cell death in neoplastic cells, includes the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof, as a primary chemotherapeutic agent or substantially contemporaneously with chemotherapy, to a patient having multidrug-resistant neoplastic cells, in an amount sufficient to induce cell death in the neoplastic cells: ##STR1## where R.sup.1 is hydroxyl, C1-4 alkoxyl, C1-4 alkylcarboxyloxymethoxyl, phenyl C1-2 alkylamino group, 2,5-pyrrolidinedione-1-alkoxyl (C1-4), or ##STR2## wherein X.sup.1 is a chemical bond or C1-2 alkylene, X.sup.2 is hydrogen or carboxyl forming a 5-membered ring with X.sup.1 when X.sup.2 is methylene, X.sup.3 is hydrogen or C1-2 alkyl, X.sup.4 is hydrogen or C1-2 alkyl, or X.sup.3 and X.sup.4 together form a 5-membered ring, in which at least one of X.sup.2, X.sup.3, and X.sup.4 is hydrogen,R.sup.2 is C3-4 alkyl, R.sup.3 is C1-4 alkyl, ##STR3## in which n is an integer of 0 to 3.








 
 
  Recently Added Patents
Bioreactor device, and method and system for fabricating tissues in the bioreactor device
Method for manufacturing thin film transistor and method for manufacturing display device
Compositions for inhibiting NADPH oxidase activity
Feedback method and processing system for policy installation failures
Translation system adapted for query translation via a reranking framework
Magnetoresistive shield with coupled lateral magnet bias
System and methods for obstacle mapping and navigation
  Randomly Featured Patents
Notched top soap container with bottom lug
System and method for composite display
Method of operating a fluid bed reactor
Multilayered wiring board, method of producing multilayered wiring board, electronic device and electronic apparatus
Fluid dispensing bins and related methods
Post top
Apparatus and method of forming parts
Hydroliquefaction of coal
Preservation of ergothioneine
Method and apparatus for trimming onions or like produce