Resources Contact Us Home
Method for inducing death of neoplastic cells using piperazne derivatives

Image Number 12 for United States Patent #5733911.

A method for inducing cell death in neoplastic cells, includes the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof, as a primary chemotherapeutic agent or substantially contemporaneously with chemotherapy, to a patient having multidrug-resistant neoplastic cells, in an amount sufficient to induce cell death in the neoplastic cells: ##STR1## where R.sup.1 is hydroxyl, C1-4 alkoxyl, C1-4 alkylcarboxyloxymethoxyl, phenyl C1-2 alkylamino group, 2,5-pyrrolidinedione-1-alkoxyl (C1-4), or ##STR2## wherein X.sup.1 is a chemical bond or C1-2 alkylene, X.sup.2 is hydrogen or carboxyl forming a 5-membered ring with X.sup.1 when X.sup.2 is methylene, X.sup.3 is hydrogen or C1-2 alkyl, X.sup.4 is hydrogen or C1-2 alkyl, or X.sup.3 and X.sup.4 together form a 5-membered ring, in which at least one of X.sup.2, X.sup.3, and X.sup.4 is hydrogen,R.sup.2 is C3-4 alkyl, R.sup.3 is C1-4 alkyl, ##STR3## in which n is an integer of 0 to 3.

  Recently Added Patents
Termite tubing preventative for non-wood materials
Stereoscopic display
Synchronous rectifier network unit circuit and method
Small molecule inhibitors of kynurenine-3-monooxygenase
5-HT.sub.3 receptor modulators, methods of making, and use thereof
Restarting event and alert analysis after a shutdown in a distributed processing system
Curved structural part made of composite material and a process for manufacturing such a part
  Randomly Featured Patents
Remote control for portable rehearsal studio
Method and apparatus for the interferometric wavelength measurement of frequency tunable C.W. lasers
Field effect transistor with short channel length and process of fabrication thereof
Plant cultivation method
Component carrier
Integrated recuperation loop in fuel cell stack
Locking assembly for dental handpiece
Pipe testing apparatus
Laser oscillation apparatus, exposure apparatus, semiconductor device manufacturing method, semiconductor manufacturing factory, and exposure apparatus maintenance method
Process of recovering useful material through cracking of plastic material