Resources Contact Us Home
Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use

Image Number 12 for United States Patent #5609869.

Hybrid immunoglobulin-enzyme molecules are provided which are composed of antibodies, or derivatives or fragments thereof, which specifically bind an arterial or venous thrombus that are operably linked to the enzymatically active portions of thrombolytic enzymes such as plasminogen activators. In a preferred embodiment the hybrid molecules specifically bind to fibrin and have fibrinolytic activity. The hybrid molecules of the present invention may be produced by any means, including chemical conjugation, or by means of recombinant DNA, genetic engineering and/or hybridoma technology. Methods for making and using the molecules in diagnosis and therapy are also disclosed.

  Recently Added Patents
LED illumination systems
Packet communication system and packet communication method, and node and user device
Method for transitioning between Ziegler-Natta and metallocene catalysts in a bulk loop reactor for the production of polypropylene
Managing distributed applications using structural diagrams
Generating a network map
Method and apparatus for soft information transfer between constituent processor circuits in a soft-value processing apparatus
Methods of measuring cell viability in tissue engineered products
  Randomly Featured Patents
Heated glass sheet positioning on roll conveyor
Cargo stretch tarpaulin cover
Light-emitting diode device with a double-layer contact structure and a fabrication method thereof
Dialkylated glycol compositions and medicament preparations containing same
Method and apparatus for providing a current-in-plane (CIP) GMR sensor with an improved in-stack bias layer with a thinner sensor stack
Electronic intercommunications unit
Hand-held turbine power tool
Method and apparatus for particle removal
Interface accessory for use with an aerosol inhalation system
Medicaments for asthma treatment