Resources Contact Us Home
Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use

Image Number 12 for United States Patent #5609869.

Hybrid immunoglobulin-enzyme molecules are provided which are composed of antibodies, or derivatives or fragments thereof, which specifically bind an arterial or venous thrombus that are operably linked to the enzymatically active portions of thrombolytic enzymes such as plasminogen activators. In a preferred embodiment the hybrid molecules specifically bind to fibrin and have fibrinolytic activity. The hybrid molecules of the present invention may be produced by any means, including chemical conjugation, or by means of recombinant DNA, genetic engineering and/or hybridoma technology. Methods for making and using the molecules in diagnosis and therapy are also disclosed.

  Recently Added Patents
Multi-dimensional credibility scoring
Identification of websites that break out of frames
Method of inspecting wafer
Process for improving the hydrolysis of cellulose in high consistency systems using one or more unmixed and mixed hydrolysis reactors
Method and system for dynamic storage tiering using allocate-on-write snapshots
Churn prediction and management system
Chemically resistant membranes, coatings and films and methods for their preparation
  Randomly Featured Patents
Thin and dry diaper
Wiper apparatus
Removable circuit board with ducted cooling
Tool for gathering materials including particles and hairs
Process for recovering heavy metal ions or heavy metal ions and halogen values from solutions comprising a lower aliphatic monocarboxylic acid
Performing scalable L2 wholesale services in computer networks
Card game
Golf ball mold, master model and method of making the mold and model
Solid dispersion pharamaceutical formulations
Apparatus for fabricating pre-press masking film