Resources Contact Us Home
Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use

Image Number 12 for United States Patent #5609869.

Hybrid immunoglobulin-enzyme molecules are provided which are composed of antibodies, or derivatives or fragments thereof, which specifically bind an arterial or venous thrombus that are operably linked to the enzymatically active portions of thrombolytic enzymes such as plasminogen activators. In a preferred embodiment the hybrid molecules specifically bind to fibrin and have fibrinolytic activity. The hybrid molecules of the present invention may be produced by any means, including chemical conjugation, or by means of recombinant DNA, genetic engineering and/or hybridoma technology. Methods for making and using the molecules in diagnosis and therapy are also disclosed.

  Recently Added Patents
Semiconductor memory device
End-of-session authentication
Cooking oven with energy saving mode and method
Processing biomass
Turbulence sensor and blade condition sensor system
Method and system for network configuration for virtual machines
Author signatures for legal purposes
  Randomly Featured Patents
Genomic screen for epigenetically silenced tumor suppressor genes
Optical switch
Nasal cannula harness
Silent stud gun attachment device
Antenna with echo cancelling elements
Wood derived, thermoplastic ester mixtures as a substitute for petroleum-derived components in compounded rubber stocks
Hydro-extracting apparatus for cheeses of yarn
Process for the preparation of a flavoring concentrate
Processes for the separatin of lipids
Data encryption security module