Resources Contact Us Home
Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use

Image Number 12 for United States Patent #5609869.

Hybrid immunoglobulin-enzyme molecules are provided which are composed of antibodies, or derivatives or fragments thereof, which specifically bind an arterial or venous thrombus that are operably linked to the enzymatically active portions of thrombolytic enzymes such as plasminogen activators. In a preferred embodiment the hybrid molecules specifically bind to fibrin and have fibrinolytic activity. The hybrid molecules of the present invention may be produced by any means, including chemical conjugation, or by means of recombinant DNA, genetic engineering and/or hybridoma technology. Methods for making and using the molecules in diagnosis and therapy are also disclosed.

  Recently Added Patents
Trash receptacle
Laser marking of a card
Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
Encoding and/or decoding memory devices and methods thereof
Reception method and reception apparatus
Elementary network description for efficient link between neuronal models and neuromorphic systems
Systems and methods for velocity profile based approach to point control
  Randomly Featured Patents
Control system for compression-ignition engine
Waste receptacle with foot pedal
Method and apparatus for machining work pieces
Lighting unit for a vehicle, having improved ventilating means
Exempt source for an x-ray fluorescence device
Display screen with graphical user interface for medical scheduling
Engine feedback control embodying learning
System and method for promoting intrinsic conduction through atrial timing modification and calculation of timing parameters
Adhesive comprising post-chlorinated polyethylene and polyvinyl chloride
Directional filter for a display screen, the method for manufacturing same and a display system, a cathode-ray tube in particular, provided with such a filter