Resources Contact Us Home
Vaccine compositions and method for induction of mucosal immune response via systemic vaccination

Image Number 19 for United States Patent #5518725.

The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include 1,25-dihydroxy Vitamin D.sub.3, biologically active Vitamin D.sub.3 derivatives which are capable of activating the intracellular Vitamin D.sub.3 receptor, all trans-retinoic acid, retinoic acid derivatives, retinol, retinol derivatives and glucocorticoid. The vaccine composition may further comprise an immune response augmenting agent which enhances T cell lymphokine production. Suitable immune response augmenting agents include dehydroepiandrosterone (DHEA) and DHEA-derivatives. Examples of DHEA derivatives include DHEA-sulfate (DHEA-S), 16-.alpha.-bromo-DHEA, 7-oxo-DHEA, 16-.alpha.-Br-DHEA-S and 7-oxo-DHEA-S. The invention also relates to a method for inducing an antigen-specific mucosal immune response in a vertebrate animal which comprises administering a vaccine which comprises an antigen and a lymphoid organ modifying agent with or without an immune response augmenting agent to a site which drains into a peripheral lymphoid compartment.

  Recently Added Patents
System for purifying air through germicidal irradiation and method of manufacture
Solid-state imaging device
Optical scanner and image-forming device
Vanadium, cobalt and strontium additives for use in aluminum back solar cell contacts
Power surface mount light emitting die package
Data consumption framework for semantic objects
Semiconductor device including insulating layer of cubic system or tetragonal system
  Randomly Featured Patents
Mining sequential patterns in weighted directed graphs
Gas turbine engine combustion liner float wall cooling arrangement
Method of disposing of earth contaminated by leaking underground storage tanks
Dissector for endoscopic and laparoscopic use
Elongated drive tool for prosthesis in body cavity
Neuron circuit
Center loaded citizens band antenna
Extended recombinant polypeptides and compositions comprising same
Protocol for network having plurality of intelligent cells
Keyboard structure