Resources Contact Us Home
Vaccine compositions and method for induction of mucosal immune response via systemic vaccination

Image Number 19 for United States Patent #5518725.

The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include 1,25-dihydroxy Vitamin D.sub.3, biologically active Vitamin D.sub.3 derivatives which are capable of activating the intracellular Vitamin D.sub.3 receptor, all trans-retinoic acid, retinoic acid derivatives, retinol, retinol derivatives and glucocorticoid. The vaccine composition may further comprise an immune response augmenting agent which enhances T cell lymphokine production. Suitable immune response augmenting agents include dehydroepiandrosterone (DHEA) and DHEA-derivatives. Examples of DHEA derivatives include DHEA-sulfate (DHEA-S), 16-.alpha.-bromo-DHEA, 7-oxo-DHEA, 16-.alpha.-Br-DHEA-S and 7-oxo-DHEA-S. The invention also relates to a method for inducing an antigen-specific mucosal immune response in a vertebrate animal which comprises administering a vaccine which comprises an antigen and a lymphoid organ modifying agent with or without an immune response augmenting agent to a site which drains into a peripheral lymphoid compartment.

  Recently Added Patents
Flame-protected impact-modified polycarbonate compositions
Method and system for providing magnetic junctions having improved characteristics
Powerline communication device with load characterization functionality
Unified feedback frame for supporting a plurality of feedback modes and a multiple-input multiple-output (MIMO) communication system using the unified feedback frame
Battery pouch sheet edge insulation
1,3-diiodohydantoin compound and production method thereof
Method for manufacturing semiconductor element and semiconductor device, and deposition apparatus
  Randomly Featured Patents
Process for preparing ergoline derivatives
Laminated electrochromic devices and processes for forming the same
Process for drying brown coal of high water content
Flexible tubing with improved signal transmission and method of making
CMOS diodes with dual gate conductors, and methods for forming the same
Harvesting, collection and transfer apparatus
Architecture for MANET over Bluetooth
Tubular seat
Writing instrument
Sample adequacy measurement system having a plurality of sample tubes and using turbidity light scattering techniques