Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Vaccine compositions and method for induction of mucosal immune response via systemic vaccination










Image Number 19 for United States Patent #5518725.

The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include 1,25-dihydroxy Vitamin D.sub.3, biologically active Vitamin D.sub.3 derivatives which are capable of activating the intracellular Vitamin D.sub.3 receptor, all trans-retinoic acid, retinoic acid derivatives, retinol, retinol derivatives and glucocorticoid. The vaccine composition may further comprise an immune response augmenting agent which enhances T cell lymphokine production. Suitable immune response augmenting agents include dehydroepiandrosterone (DHEA) and DHEA-derivatives. Examples of DHEA derivatives include DHEA-sulfate (DHEA-S), 16-.alpha.-bromo-DHEA, 7-oxo-DHEA, 16-.alpha.-Br-DHEA-S and 7-oxo-DHEA-S. The invention also relates to a method for inducing an antigen-specific mucosal immune response in a vertebrate animal which comprises administering a vaccine which comprises an antigen and a lymphoid organ modifying agent with or without an immune response augmenting agent to a site which drains into a peripheral lymphoid compartment.








 
 
  Recently Added Patents
Biodegradable aliphatic-aromatic copolyester for use in nonwoven webs
Drinking glass with ball embedded in base
Method for forming a film
Catalyst composition comprising shuttling agent for ethylene multi-block copolymer formation
Call admission control method and system
Methods of forming semiconductor devices having diffusion regions of reduced width
Rechargeable battery
  Randomly Featured Patents
Album with replaceable front cover
Expert knowledge combination process based medical risk stratifying method and system
mTOR inhibtors and mTOR signaling pathway inhibitors induce differentiation of human embryonic stem cells into the osteoblastic lineage
Polycrystalline CDTE thin film semiconductor photovoltaic cell structures for use in solar electricity generation
Handheld screw driving gun
Toy animal for use with child transportation
Focusing an optical beam to two foci
Rod holder
Solar power plant
Method for manufacturing an electronic device