Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Vaccine compositions and method for induction of mucosal immune response via systemic vaccination










Image Number 19 for United States Patent #5518725.

The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include 1,25-dihydroxy Vitamin D.sub.3, biologically active Vitamin D.sub.3 derivatives which are capable of activating the intracellular Vitamin D.sub.3 receptor, all trans-retinoic acid, retinoic acid derivatives, retinol, retinol derivatives and glucocorticoid. The vaccine composition may further comprise an immune response augmenting agent which enhances T cell lymphokine production. Suitable immune response augmenting agents include dehydroepiandrosterone (DHEA) and DHEA-derivatives. Examples of DHEA derivatives include DHEA-sulfate (DHEA-S), 16-.alpha.-bromo-DHEA, 7-oxo-DHEA, 16-.alpha.-Br-DHEA-S and 7-oxo-DHEA-S. The invention also relates to a method for inducing an antigen-specific mucosal immune response in a vertebrate animal which comprises administering a vaccine which comprises an antigen and a lymphoid organ modifying agent with or without an immune response augmenting agent to a site which drains into a peripheral lymphoid compartment.








 
 
  Recently Added Patents
Support member, rotation device comprising such a support and rolling bearing assembly including such a detection device
Maesa japonica extracts and methods of use
System and method for multi-threaded MIMO OFDM channel equalizer
Simultaneous wafer bonding and interconnect joining
Human activity monitoring device
Remote ignition system for a vehicle and method for securing a remote ignition function
Retrievable outgoing audio messaging
  Randomly Featured Patents
Fuel regenerated non-polluting internal combustion engine
Apparatus and method for cleansing fishing reels
Hydraulic lockout device for pressure controlled well tools
Rotary borescopic optical dimensional mapping tool
Recombinant human beta interferon with enhanced solubility
Dynamic configuration for networked imaging devices
Ink jet print heads
Antenna apparatus for linearly polarized diversity antenna in RFID reader and method of controlling the antenna apparatus
Method and apparatus for treating radioactive waste
System and method for calculating floating point exponential values in a geometry accelerator