Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Vaccine compositions and method for induction of mucosal immune response via systemic vaccination










Image Number 19 for United States Patent #5518725.

The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include 1,25-dihydroxy Vitamin D.sub.3, biologically active Vitamin D.sub.3 derivatives which are capable of activating the intracellular Vitamin D.sub.3 receptor, all trans-retinoic acid, retinoic acid derivatives, retinol, retinol derivatives and glucocorticoid. The vaccine composition may further comprise an immune response augmenting agent which enhances T cell lymphokine production. Suitable immune response augmenting agents include dehydroepiandrosterone (DHEA) and DHEA-derivatives. Examples of DHEA derivatives include DHEA-sulfate (DHEA-S), 16-.alpha.-bromo-DHEA, 7-oxo-DHEA, 16-.alpha.-Br-DHEA-S and 7-oxo-DHEA-S. The invention also relates to a method for inducing an antigen-specific mucosal immune response in a vertebrate animal which comprises administering a vaccine which comprises an antigen and a lymphoid organ modifying agent with or without an immune response augmenting agent to a site which drains into a peripheral lymphoid compartment.








 
 
  Recently Added Patents
Location-based method to specify ratio frequency spectrum rights
Method for generating optical codes for a print-context
Media processing method and device
Image reading apparatus, image reading method and program
Apparatus for preventing overcharge of a battery
Quick mounting device
High-resolution, active reflector radio frequency ranging system
  Randomly Featured Patents
Method and device including transistor component having a field electrode
Pad for use with a continent ostomy port
Beverage dispenser with additive dispensing
Digital still camera and image data processor
Combination process for selected aromatic hydrocarbon production
Idling control device for internal combustion engine with turbocharger
Image enhancement method using histogram equalization
Method and a system for displacing objects
Water timer
Aromatic polymers having phenylene groups linked by oxygen atoms, keto groups and sulphone groups