Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Vaccine compositions and method for induction of mucosal immune response via systemic vaccination










Image Number 19 for United States Patent #5518725.

The invention relates to a vaccine which comprises an antigen and a lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include 1,25-dihydroxy Vitamin D.sub.3, biologically active Vitamin D.sub.3 derivatives which are capable of activating the intracellular Vitamin D.sub.3 receptor, all trans-retinoic acid, retinoic acid derivatives, retinol, retinol derivatives and glucocorticoid. The vaccine composition may further comprise an immune response augmenting agent which enhances T cell lymphokine production. Suitable immune response augmenting agents include dehydroepiandrosterone (DHEA) and DHEA-derivatives. Examples of DHEA derivatives include DHEA-sulfate (DHEA-S), 16-.alpha.-bromo-DHEA, 7-oxo-DHEA, 16-.alpha.-Br-DHEA-S and 7-oxo-DHEA-S. The invention also relates to a method for inducing an antigen-specific mucosal immune response in a vertebrate animal which comprises administering a vaccine which comprises an antigen and a lymphoid organ modifying agent with or without an immune response augmenting agent to a site which drains into a peripheral lymphoid compartment.








 
 
  Recently Added Patents
Fast port switching in an audiovisual receiver by use of port pre-authentication by a partial PHY decoder core
Acoustic echo cancellation
Methods and systems providing desktop search capability to software application
Semiconductor device and manufacturing method thereof
Method and apparatus for reducing cost of optical amplification in a network
Stable aqueous composite compositions
Memory interface circuit, memory interface method, and electronic device
  Randomly Featured Patents
Flush valve
Strain relief mechanism and method
High speed swelling, pressure exerting hemostatic device
Container
Chair
vehicle control apparatus
Rotary cutting device
Tobacco compositions flavored with 2-hydroxymethylenecyclohexanones
Pallet puller tool
Light emitting optical fiber assemblies including light controlling