Resources Contact Us Home
Rearranged taxol compounds and method of using in testing of in vivo activity

Image Number 2 for United States Patent #5194635.

In a preferred embodiment, taxol is treated with mesyl chloride to prepare a taxol derivative with a contracted A-ring, which has comparable activity to taxol in a tubulin depolymerization assay, and which shows cytotoxicity against KB cells in a cell culture assay. In an alternate preferred embodiment, taxol is treated with triethyloxonium tetrafluoroborate (Meerwein's reagent) to produce a taxol derivative with an opened oxetane ring. In another alternate preferred embodiment, reaction of taxol with acetyl chloride yields a taxol derivative in which the oxetane ring is opened and the A-ring is contracted. All of the aforementioned products show in vivo activity in KB cell culture assays. Further, the preferred compounds have different in vivo activities, which makes them ideal to form a range of standards for use in biological testing of other compounds.

  Recently Added Patents
Display device and method of manufacturing the same
Formulations, their use as or for producing dishwashing detergents and their production
Storage apparatus and method including page discard processing for primary and secondary volumes configured as a copy pair
Filtering method for improving the data quality of geometric tire measurements
Semiconductor unit having a power semiconductor and semiconductor apparatus using the same
Image processing device, printing apparatus, image processing method, and method of producing printing apparatus
Transmission apparatus and network protection method
  Randomly Featured Patents
Method and system for providing price protection for commodity purchasing through price protection contracts
System and Method for conveying cargo containers through environmentally controlled enclosures
Electric coffee maker
Video image monitoring system
Bonding pad structure and method thereof
Image processor and image processing method processing an image that includes a semi-transparent object or an image with periodically varying density
Gate controlled switch
Liquid crystal dropping apparatus for liquid crystal display device
Prayer token
Signal processing device capable of enhancing correctness of feedback signals