| Patent Number |
Title Of Patent |
Date Issued |
| H2055 |
Expression of tissue-type plasminogen activator in bacteria |
December 3, 2002 |
| A method, and DNA constructs useful therein, is provided for producing plasminogen activator in bacteria. Particular constructs are provided comprising a coding sequence for tissue plasminogen activator and the leader peptide thereof, which is used to transform E. coli to produce pro |
| 7446172 |
Cytokine protein family |
November 4, 2008 |
| The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-.alpha. at the amino acid sequence level. The receptor for this protein family is a class II cytokine re |
| 7445919 |
Zsig33-like peptides and polynucleotides |
November 4, 2008 |
| The present invention relates to polynucleotide related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes |
| 7445913 |
Nucleic acid encoding a human allelic variant of interferon-like protein ZCYTO21 |
November 4, 2008 |
| The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-.alpha. at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and met |
| 7445773 |
Cytokine protein family |
November 4, 2008 |
| The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-.alpha. at the amino acid sequence level. The receptor for this protein family is a class II cytokine re |
| 7445772 |
Heterodimeric four helix bundle cytokines |
November 4, 2008 |
| Heterodimeric proteins comprising two helical bundle cytokines are disclosed. One of the polypeptides comprises zsig81 and a second polypeptide which comprises either p19 (aka IL-12A) or p35 (aka IL-12A). The proteins may be produced as fusion proteins or expressed as a single chain. |
| 7435550 |
Methods of using cytokine receptor zalpha11 to detect its ligands |
October 14, 2008 |
| Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopo |
| 7429566 |
Method for treating Hemophilia B |
September 30, 2008 |
| Use of factor XIII for treating hemophilia B. A patient having hemophilia B is treated by administering factor XIII, generally in conjunction with factor IX. |
| 7427494 |
Nucleic acid encoding cytokine receptor zcytor17 |
September 23, 2008 |
| Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopo |
| 7425325 |
Cytokine zcytor17 ligand polypeptides |
September 16, 2008 |
| The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cel |
| 7411056 |
Polynucleotides encoding cytokine receptor zalpha11 |
August 12, 2008 |
| Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopo |
| 7410780 |
IL-21 antagonists |
August 12, 2008 |
| The polypeptides, and the polynucleotides encoding for them, described herein are IL-21 antagonists that bind with specificity and exhibit an EC.sub.50 that is not detectable in receptor binding studies. These molecules have mutations in the D helix of the IL-21 molecule, and can be |
| 7393684 |
Immunoconjugates of anti-IL-20 antibodies and hybridoma cell lines expressing anti-IL-20 antibod |
July 1, 2008 |
| The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding pa |
| 7393674 |
Thrombin compositions |
July 1, 2008 |
| Compositions comprising thrombin and methods of preparing them are disclosed. The composition may be in the form of an aqueous solution at pH 5.7-7.4 consisting essentially of 0.1 mg/mL to 5.0 mg/mL thrombin, 2% to 4% (w/v) sucrose, 3.5% to 5% (w/v) mannitol, 50 mM to 300 mM NaCl, 0-5 |
| 7387885 |
Growth factor homolog zvegf3 polynucleotides |
June 17, 2008 |
| Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ |
| 7387780 |
Soluble interleukin-20 receptor |
June 17, 2008 |
| A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and |
| 7381794 |
Dimeric fusion proteins and materials and methods for producing them |
June 3, 2008 |
| Polypeptide fusions, dimeric fusion proteins, and materials and methods for making them are disclosed. One of the polypeptide fusions consists of a non-immunoglobulin polypeptide, a polypeptide linker, a dimerizing domain, and, optionally, a linking polypeptide. Another of the polype |
| 7375182 |
Growth factor homolog zvegf4 |
May 20, 2008 |
| Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ |
| 7364732 |
Method for treating inflammation |
April 29, 2008 |
| A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult |
| 7354739 |
TML polynucleotides |
April 8, 2008 |
| The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, |
| 7351689 |
Use of IL-28 and IL-29 to treat cancer and autoimmune disorders |
April 1, 2008 |
| Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 function |
| 7351555 |
Mouse cytokine receptor Zcytor16 |
April 1, 2008 |
| Cytokines and their receptors have proven usefulness in both basic research, animal models, and as therapeutics. The present invention provides a new cytokine receptor designated as "mouse Zcytor16," which can bind and antagonize the IL-TIF cytokine. |
| 7323446 |
Growth factor homolog ZVEGF4 |
January 29, 2008 |
| Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ |
| 7323164 |
Use of interleukin-24 to treat ovarian cancer |
January 29, 2008 |
| The present invention relates to the anti-cancer activity of IL-24 polypeptide molecules. IL-24 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-24 for decreasing proliferation of ovarian cancer cells, treating ovarian cance |
| 7294613 |
Beta-defensins |
November 13, 2007 |
| The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the .beta.-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. T |
| 7291589 |
Uses of human Zven proteins and polynucleotides |
November 6, 2007 |
| The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides. |
| 7276478 |
Methods of treating autoimmune diseases using IL-21 |
October 2, 2007 |
| Administration of IL-21 results in decreasing autoimmune responses and thereby provides a beneficial treatment for autoimmune diseases. Specific autoimmune diseases that may be treated include multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, ankylosing |
| 7271255 |
Pichia methanolica secretory signal |
September 18, 2007 |
| Novel Pichia methanolica secretory signal polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods of using are disclosed. Methods of producing large amounts of recombinant proteins by employing DNA constructs having a polypeptide of interest preceded |
| 7271246 |
Mammalian cytokine-like polypeptide-10 |
September 18, 2007 |
| A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the heali |
| 7265211 |
Anti-IL-TIF antibodies and methods of making |
September 4, 2007 |
| The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF us |
| 7265203 |
Human cytokine receptor |
September 4, 2007 |
| Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as "Zcytor16." |
| 7262025 |
Hybrid vector having a cytomegalovirus enhancer and myeloproliferative sarcoma virus promoter |
August 28, 2007 |
| An expression vector capable of expressing high levels of heterologous proteins having a cytomegalovirus (CMV) enhancer 5' upstream from a myeloproliferative sarcoma virus (MPSV) promoter. |
| 7253261 |
Interferon-like protein Zcyto21 |
August 7, 2007 |
| The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-.alpha. at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and met |
| 7252969 |
Interferon-like protein Zcyto21 |
August 7, 2007 |
| The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-.alpha. at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and met |
| 7250274 |
IL-21 production in prokaryotic hosts |
July 31, 2007 |
| The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. |
| 7247608 |
FGF homolog polypeptides |
July 24, 2007 |
| The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. |
| 7247444 |
Use of interleukin-19 to treat cervical cancer |
July 24, 2007 |
| The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-19 for decreasing proliferation of cervical cancer cells, treating cervical can |
| 7241870 |
Interferon-like protein Zcyto21 |
July 10, 2007 |
| The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-.alpha. at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and met |
| 7241593 |
Materials and methods for preparing dimeric growth factors |
July 10, 2007 |
| Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D g |
| 7235385 |
Methods for enhancing expression of recombinant proteins |
June 26, 2007 |
| The present invention provides two novel E. coli synthetic promoters, Syn 1 and Syn 2. Syn 1 and Syn 2 are two tight regulated synthetic promoters that control uninduced, leaky expression of proteins that are toxic and interfere with production of recombinant protein from an E. coli |
| 7223564 |
Four-helical bundle protein zsig81 |
May 29, 2007 |
| This present invention is directed to polypeptide and polynucleotide molecules that encode a four-helical bundle cytokine. The cytokine has been designated zsig81, and has restricted expression in primarily heart, lung and liver. zsig81 has been shown to stimulate proliferation of he |
| 7217790 |
UMLR polypeptides |
May 15, 2007 |
| Novel secreted and membrane bound tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides, |
| 7208578 |
Adipocyte complement related protein homolog zacrp2 |
April 24, 2007 |
| The present invention relates to polynucleotide and polypeptide molecules for zacrp2, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. The polypeptides and polynucleotides encoding them, are involved in dimerization or oligomerization and may |
| 7205110 |
Uses of human Zven antagonists |
April 17, 2007 |
| The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine. |
| 7202077 |
Methods for enhancing the translation and expression of recombinant proteins |
April 10, 2007 |
| The increased use of nucleotide sequence data mining techniques has amplified the demand for efficient methods of producing recombinant proteins in prokaryotic cells. A strategy is provided for enhancing the synthesis of recombinant amino acid sequences by improving translation from |
| 7196172 |
Heterodimeric four helix bundle cytokines |
March 27, 2007 |
| Heterodimeric proteins comprising two helical bundle cytokines are disclosed. One of the polypeptides comprises zsig81 and a second polypeptide which comprises either p19 (aka IL-12A) or p35 (aka L-12A). The proteins may be produced as fusion proteins or expressed as a single chain. |
| 7192592 |
Methods for promoting growth of bone, ligament, and cartilage using zvegf4 |
March 20, 2007 |
| Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also d |
| 7189839 |
Isolated polynucleotides encoding a human cytokine receptor human cytokine receptor |
March 13, 2007 |
| Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as "Zcytor16." |
| 7189835 |
Pichia methanolica secretory signal |
March 13, 2007 |
| Novel Pichia methanolica secretory signal polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods of using are disclosed. Methods of producing large amounts of recombinant proteins by employing DNA constructs having a polypeptide of interest preceded |
| 7189695 |
Soluble zalpha11 cytokine receptors |
March 13, 2007 |
| Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or |
