| Patent Number |
Title Of Patent |
Date Issued |
| D469181 |
Low intensity light imaging apparatus |
January 21, 2003 |
|
| 7629573 |
Tissue phantom calibration device for low level light imaging systems |
December 8, 2009 |
| The present invention relates to a phantom device that simplifies usage and testing of a low intensity light imaging system. The phantom device includes a body and a light source internal to the body. The body comprises an optically selective material designed to at least partially r |
| 7616985 |
Method and apparatus for 3-D imaging of internal light sources |
November 10, 2009 |
| The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through |
| 7603167 |
Method and apparatus for 3-D imaging of internal light sources |
October 13, 2009 |
| The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through |
| 7599731 |
Fluorescent light tomography |
October 6, 2009 |
| Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation of the mammal, and c) |
| 7595838 |
Multi-view imaging apparatus |
September 29, 2009 |
| Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera and sent to a pro |
| 7589786 |
Multi-view imaging of a sample in a box |
September 15, 2009 |
| Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera and sent to a pro |
| 7581191 |
Graphical user interface for 3-D in-vivo imaging |
August 25, 2009 |
| The present invention provides a computer system and user interface that allows a user to readily view and analyze two-dimensional and three-dimensional in vivo images and imaging data. The user interface is well-suited for one or more of the following actions pertinent to in vivo li |
| 7555334 |
Small animal light intensity monitor |
June 30, 2009 |
| Disclosed are methods and apparatus for collecting light emitted from an animal, where a luminescent reporter has been injected into the animal is disclosed. The apparatus includes a chamber for receiving the animal, wherein the chamber is light tight preventing a substantial portion of |
| 7555332 |
Fluorescent light tomography |
June 30, 2009 |
| Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation of the mammal, and c) |
| 7503323 |
Multiple output anesthesia system |
March 17, 2009 |
| The present invention provides improved anesthesia delivery systems that consistently and reliably deliver anesthesia gas to multiple gas outlets. The systems are particularly useful for anesthetizing multiple mammals and living specimens to be imaged by a low-light level imaging system. |
| 7474399 |
Dual illumination system for an imaging apparatus and method |
January 6, 2009 |
| A dual illumination system is disclosed for use with an imaging apparatus. The imaging apparatus defines a light-tight imaging compartment with an interior wall having a view port extending into the imaging compartment. This view port enables data acquisition of a biological specimen |
| 7474398 |
Illumination system for an imaging apparatus with low profile output device |
January 6, 2009 |
| A fluorescence illumination system is provided for use with an imaging apparatus that defines a light-tight imaging compartment. The fluorescence illumination system includes a trans-illumination component configured to direct excitation light into a first surface of the specimen whe |
| 7466418 |
Fluorescence illumination assembly for an imaging apparatus and method |
December 16, 2008 |
| A macroscopic fluorescence illumination assembly is provided for use with an imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a view port extending into the imaging compartment to enable viewing of a specimen contained |
| 7464707 |
Anesthesia delivery device for use in a light imaging system |
December 16, 2008 |
| The present invention provides improved anesthesia delivery systems that consistently and reliably deliver anesthesia gas to multiple gas outlets. The systems are particularly useful for anesthetizing multiple mammals and living specimens to be imaged by a low-light level imaging system. |
| 7461652 |
Imaging system with anesthesia system |
December 9, 2008 |
| The present invention provides improved anesthesia delivery systems that consistently and reliably deliver anesthesia gas to multiple gas outlets. The systems are particularly useful for anesthetizing multiple mammals and living specimens to be imaged by a low-light level imaging system. |
| 7449615 |
Non-invasive evaluation of physiological response in a transgenic mouse |
November 11, 2008 |
| The present invention relates to panels of reporter expression cassettes and the generation of transgenic non-human animals, wherein said reporter expression cassettes have selected control elements operable linked to reporter genes. The invention includes methods of use thereof for the |
| 7449567 |
Isolation and identification of mouse and human transcription control elements associated with c |
November 11, 2008 |
| The present invention relates to transcription control elements derived from mouse and human genes associated with cytochrome expression, e.g., Cyp3A11 and CYP3A4, respectively. Isolated polynucleotides, expression cassettes, vectors, recombinant cells, and transgenic animals, may co |
| 7403812 |
Method and apparatus for determining target depth, brightness and size within a body region |
July 22, 2008 |
| A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitt |
| 7383078 |
Imaging apparatus with heating element |
June 3, 2008 |
| An improved imaging apparatus is disclosed that allows a user to perform numerous imaging operations. The imaging apparatus may include one or more improvements to imaging box design to improve illumination control within the imaging box, such as improved door seal arrangements, improved |
| 7331341 |
Living specimen induction chamber |
February 19, 2008 |
| The invention described herein provides an induction chamber used to sedate one or more living specimens. The induction chamber comprises at least one gas inlet through which anesthesia gas and oxygen are supplied. To minimize escape of anesthetizing gas is into the ambient room or s |
| 7299420 |
Graphical user interface for in-vivo imaging |
November 20, 2007 |
| A graphical user interface is provided which allows the user to perform numerous operations suitable for analysis of in-vivo images within a single display screen or a single window. Using the the-vivo GUI, the user may create and manipulate analysis tools such as rectangle and ellip |
| 7298415 |
Structured light imaging apparatus |
November 20, 2007 |
| The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or p |
| 7196190 |
Methods and compositions for screening for angiogenesis modulating compounds |
March 27, 2007 |
| The present invention relates to novel transcription control elements, including promoters, derived from angiogenesis-related genes, particularly the mouse VEGF gene, the mouse VEGFR-2 receptor gene, and the mouse Tie2 gene. Also disclosed are isolated polynucleotides comprising such |
| 7190991 |
Multi-mode internal imaging |
March 13, 2007 |
| The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light em |
| 7177024 |
Bottom fluorescence illumination assembly for an imaging apparatus |
February 13, 2007 |
| A macroscopic fluorescence illumination assembly is provided for use with an a imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a view port extending into the imaging compartment to enable viewing of a specimen contain |
| 7116354 |
Absolute intensity determination for a light source in low level light imaging systems |
October 3, 2006 |
| The invention describes systems and methods to obtain and present imaging data in absolute units. The systems and methods convert relative image data produced by a camera to absolute light intensity data using a compensation factor. The compensation factor accommodates for hardware a |
| 7115793 |
Isolation and identification of transcription control elements associated with mouse eosinophil |
October 3, 2006 |
| The present invention relates to novel transcription control elements derived from a mouse eosinophil peroxidase gene. Such transcription control elements may comprise isolated polynucleotides, expression cassettes, vectors, recombinant cells, and transgenic animals, as described her |
| 7113217 |
Multi-view imaging apparatus |
September 26, 2006 |
| Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera and sent to a pro |
| 7090994 |
Methods of screening for introduction of DNA into a target cell |
August 15, 2006 |
| The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important advantage of the methods described herein is that drug resistant target cells or target |
| 7056728 |
Compositions and methods for use thereof in modifying the genomes of microorganisms |
June 6, 2006 |
| The present invention relates to bacterial luciferase transposon cassettes suitable for conferring bioluminescence properties on a Gram-positive bacteria, Gram-negative bacteria, and other organisms of interest. The invention further includes cells transformed with vectors carrying the |
| 6964856 |
Animal models and methods for sepsis |
November 15, 2005 |
| Methods for selecting a candidate drug for treating sepsis are disclosed. The methods involve labeling a sepsis-causing pathogen with a reporter and monitoring the progress of infection by detecting levels of the reporter in animals treated with test compounds or drugs. The comparisons m |
| 6922246 |
Bottom fluorescence illumination assembly for an imaging apparatus |
July 26, 2005 |
| A macroscopic fluorescence illumination assembly is provided for use with an imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a view port extending into the imaging compartment to enable viewing of a specimen contained the |
| 6919919 |
Light calibration device for use in low level light imaging systems |
July 19, 2005 |
| The invention describes systems and methods for calibrating a low-level light imaging system. Techniques described herein employ a light calibration device that is placed within a low level light imaging box to calibrate the system and its constituent components such as the camera and |
| 6901279 |
Imaging apparatus |
May 31, 2005 |
| An improved imaging apparatus is disclosed that allows a user to perform numerous imaging operations. The imaging apparatus may include one or more improvements to imaging box design to improve illumination control within the imaging box, such as improved door seal arrangements, improved |
| 6894289 |
Fluorescence illumination assembly for an imaging apparatus |
May 17, 2005 |
| A fluorescence imaging assembly including an imaging apparatus having an enclosure wall defining a view port into a light-tight imaging compartment thereof. A specimen platform is positioned in the imaging compartment having a support surface facing toward the view port. An illumination |
| 6867348 |
Methods and compositions for screening for angiogenesis modulating compounds |
March 15, 2005 |
| The present invention relates to novel promoters, including transcription regulator regions, for the mouse VEGFR-2 receptor, isolated polynucleotides comprising such promoters, nucleic acid constructs comprising such promoters operatively linked to genes encoding a gene product, such |
| 6858773 |
Transgenic mice comprising transcription control elements associated with mouse eosinophil perox |
February 22, 2005 |
| The present invention relates to novel transcription control elements derived from a mouse eosinophil peroxidase gene. The novel transcription control elements described in the disclosure may comprise isolated polynucleotides, expression cassettes, vectors, recombinant cells, and tra |
| 6775567 |
Imaging apparatus |
August 10, 2004 |
| An improved imaging apparatus is disclosed that allows a user to perform numerous imaging operations. The imaging apparatus may include one or more improvements to imaging box design to improve illumination control within the imaging box, such as improved door seal arrangements, improved |
| 6754008 |
Imaging lens arrangement designed for low light conditions |
June 22, 2004 |
| Disclosed is an improved lens system for low light applications. This improved low light lens system is designed for any suitable low light application, such as the above described biological imaging application. In one embodiment, a finite conjugate lens system is disclosed. The lens |
| 6737245 |
Luciferase expression cassettes and methods of use |
May 18, 2004 |
| The present invention relates to bacterial luciferase expression cassettes suitable for conferring bioluminescence properties on Gram-positive bacteria, cells transformed with such cassettes, and methods of making and using such cassettes. |
| 6638752 |
Biodetectors targeted to specific ligands |
October 28, 2003 |
| The present invention relates to biodetectors for detecting and quantifying molecules in liquid, gas, or matrices. More specifically, the present invention relates to biodetectors comprising a molecular switching mechanism to express a reporter gene upon interaction with target subst |
| 6614452 |
Graphical user interface for in-vivo imaging |
September 2, 2003 |
| A graphical user interface is provided which allows the user to perform numerous operations suitable for analysis of in-vivo images within a single display screen or a single window. Using the the-vivo GUI, the user may create and manipulate analysis tools such as rectangle and ellipse |
| 6610503 |
Animal models for predicting sepsis mortality |
August 26, 2003 |
| Methods for selecting a candidate drug for treating sepsis are disclosed. The methods involve labeling a sepsis-causing pathogen with a reporter and monitoring the progress of infection by detecting levels of the reporter in animals treated with test compounds or drugs. The comparisons m |
