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Wyeth LLC Patents
Assignee:
Wyeth LLC
Address:
Madison, NJ
No. of patents:
207
Patents:


1 2 3 4 5










Patent Number Title Of Patent Date Issued
RE42531 Removably replaceable, readherable label July 12, 2011
A container is made from an elongated sheet having a front surface, a rear surface, and a first end, a second end, a top edge and a bottom edge. The sheet includes a removable portion and a remainder portion. Both the removable portion and the remainder portion have identifying indic
D661588 Infant formula container June 12, 2012
8586049 Antibody-drug conjugates November 19, 2013
Disclosed are anti-5T4 antibody drug conjugates and methods for preparing and using the same.
8575159 Triazine compounds as PI3 kinase and mTOR inhibitors November 5, 2013
Compounds of formula I ##STR00001## wherein: R.sup.1 is ##STR00002## and R.sup.2, R.sup.4, and R.sup.6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 k
8574597 Immunogenic compositions for the prevention and treatment of meningococcal disease November 5, 2013
The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to t
8568735 Immunogenic compositions of Staphylococcus aureus antigens October 29, 2013
The present invention relates to immunogenic compositions, comprising polypeptides and polysaccharides from Staphylococcus aureus. The present invention also relates to immunogenic compositions, comprising Staphylococcus aureus capsule polysaccharides conjugated to a carrier protein.
8563048 Botanical butter stick lip balm October 22, 2013
A stick lip balm with efficacious amounts of natural moisturizer and organoleptic/sensory attributes of lip feel associated with moisturizers and emollients is provided. The lip balm of the invention comprises at least 90% botanically derived materials and can be formed into a stick
8562999 Formulations which stabilize and inhibit precipitation of immunogenic compositions October 22, 2013
The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic
8299116 CCI-779 concentrate formulations October 30, 2012
This invention provides CCI-779 cosolvent concentrates which are useful in preparing a parenteral formulation of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) following admixture with a diluent.
8298552 Attenuated Mycoplasma gallisepticum strains October 30, 2012
The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated bacteria may additionally exhibit reduced expression of one or more proteins selected from the
8287878 Synergistic attenuation of vesicular stomatitis virus, vectors thereof and immunogenic compositi October 16, 2012
The present invention broadly relates to the synergistic attenuation of vesicular stomatitis virus (VSV). More particularly, the invention relates to the identification of combined mutation classes which synergistically attenuate the pathogenicity of VSV vectors in mammals and immuno
8273862 Processes for the convergent synthesis of calicheamicin derivatives September 25, 2012
This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
8269040 Derivatives of venlafaxine and methods of preparing and using the same September 18, 2012
Methods of preparing, and compositions comprising, derivatives of venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention defi
8263647 Treatment of sleep disturbances September 11, 2012
The present invention provides a new composition for treating pain-associated sleep disturbances, especially shortened sleep duration, comprising ibuprofen and diphenhydramine. The composition is further prepared as a bilayer tablet or caplet, or alternatively as a soft gelatin capsu
8242098 Methods of treating hormone-related conditions using thio-oxindole derivatives August 14, 2012
The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I
8241669 Endoparasiticidal gel composition August 14, 2012
A homogenous, clear, veterinary gel composition which has a broad spectrum of efficacy against endoparasites over a prolonged period of time and which allows for higher concentrations of a mixture of parasiticidal agents in a single application. This composition is useful for treatin
8232075 Rationally designed media for cell culture July 31, 2012
This invention relates to methods for rationally designing cell culture media for use in cell cultures, e.g., cell cultures employed in polypeptide production; cell culture media designed with the disclosed methods; methods of producing a polypeptide of interest, e.g., an antibody, u
8227403 A-.beta. immunogenic peptide carrier conjugates and methods of producing same July 24, 2012
The present invention is directed to methods of producing conjugates of A.beta. peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid r
8222384 Modified and stabilized GDF propeptides and uses thereof July 17, 2012
Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in
8221752 Antibodies against human interleukin-13 and uses therefor July 17, 2012
This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in d
8217036 Triazine compounds as PI3 kinase and mTOR inhibitors July 10, 2012
Compounds of formula I ##STR00001## wherein: R.sup.1 is ##STR00002## and R.sup.2, R.sup.4, and R.sup.6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 k
8192951 Glycolysis-inhibiting substances in cell culture June 5, 2012
An improved system for large scale production of proteins and/or polypeptides in cell culture is provided. In accordance with the present invention, cells expressing the protein or polypeptide of interest are grown in media that comprise a glycolysis-inhibiting substance. Additionall
8187603 Antibodies to human IL-22 May 29, 2012
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in
8187588 Mycoplasma hyopneumoniae bacterin vaccine May 29, 2012
The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant mixture, which, in
8183367 Methods of preparing polymorphic form A of bazedoxifene acetate May 22, 2012
The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate and polymorphic Form A prepared by such methods.
8182817 Antibodies to human IL-22 May 22, 2012
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in
8178097 Methods of treatment utilizing binding proteins of the interleukin-21 receptor May 15, 2012
The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods of using them. The binding proteins can act as, e.g., antagonists of IL-21R activity, t
8173814 Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quin- o May 8, 2012
The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quin- olinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions cont
8173394 Systems and methods for protein production May 8, 2012
The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing capacities. In one aspect, the invention features genetically-engineered cells comprising
8163884 Interleukin-21 receptor binding proteins April 24, 2012
The present invention provides binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those
8143385 Nucleic acids coding for antibodies against human IL-21 receptor and uses therefor March 27, 2012
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The antibodies can act as antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated b
8129524 Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the March 6, 2012
Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided: ##STR00001## Z are the same or different and are H, optionally substituted C.sub.1 to C.sub.6 alkyl, or COR.sup.A; R.sup.A is H, optionally substituted C.sub.1
8129523 Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2 March 6, 2012
A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-c
8129371 Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase in March 6, 2012
The invention relates to thienopyrimidine and pyrazolopyrimidine compounds of the Formulas (Ia) and (IIa), ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein compositions comprising the compounds, and methods for maki
8129145 Production of glycoproteins March 6, 2012
An improved system for large scale production of glycoproteins in cell culture is provided. In accordance with the present invention, cells expressing a glycoprotein are grown in media that contain manganese at a concentration of between approximately 10 and 600 nM. The use of such a
8128928 Humanized antibodies that recognize beta amyloid peptide March 6, 2012
The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of A.beta. in the brain of a patient. Preferred agents include humanized antibodies.
8124750 Recombinant protective protein from Streptococcus pneumoniae February 28, 2012
The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight of about 20 kilo Daltons (kDa). The PPP exhibits the ability to reduce colonization of p
8124723 Circovirus sequences associated with piglet weight loss disease (PWD) February 28, 2012
The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the n
8114869 Polymorph form II of tanaproget February 14, 2012
Tanaproget polymorph Form II, processes for preparing tanaproget polymorph Form II, pharmaceutical compositions including tanaproget polymorph Form II, micronized tanaproget polymorph Form II, and processes for converting Form II to tanaproget Form I are provided. Also provided are m
8114417 Recombinant protective protein from Streptococcus pneumoniae February 14, 2012
The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight of about 20 kilo Daltons (kDa). The PPP exhibits the ability to reduce colonization of p
8110705 Processes for making hydrazides February 7, 2012
A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slur
8110198 Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and February 7, 2012
The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also
8101590 9-aminocarbonylsubstituted derivatives of glycylcyclines January 24, 2012
This invention provides compounds of Formula I having the structure ##STR00001## where R.sub.1, R.sub.2, R.sub.3 and A are defined in the specification or a pharmaceutically acceptable salt thereof useful as antibacterial agents. Compounds according to Formula (II): ##STR00002## wh
8101194 Immunogenic compositions for the prevention and treatment of meningococcal disease January 24, 2012
The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to t
8092798 Method of increasing trabecular bone density in a patient in need thereof by an antibody against January 10, 2012
The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle
8071112 Compositions and methods of use of ORF-1358 from beta-hemolytic streptococcal strains December 6, 2011
The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions comprising polypeptides encoded by those polynucleotides. In addition, the invention re
8067182 Method of weak partitioning chromatography November 29, 2011
This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid containing one or more impurities. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause
8067013 Multivalent avian influenza vaccines November 29, 2011
A vaccine composition and method which is effective in preventing or ameliorating Avian Influenza Virus infection is set forth herein. The vaccine contains at least two inactivated strains of avian influenza virus, wherein the combined haemoagglutinin (HA) total is at least about 200
8063053 1-(arylsulfonyl)-4-(piperazin-1-yl)-1H-benzimidazoles as 5-hydroxytryptamine-6 ligands November 22, 2011
The invention relates to 1-(arylsulfonyl)-4-(piperazin-1-yl)-1H-benzimidazole compounds of the Formula I: ##STR00001## or a tautomer, stereoisomer, or pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the comp
8063041 Polymorphic Form D of bazedoxifene acetate and methods of preparing same November 22, 2011
The present disclosure relates to polymorphic Form D of bazedoxifene acetate, pharmaceutical compositions and methods of treatment using the same, and methods of preparing the same.
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