| Patent Number |
Title Of Patent |
Date Issued |
| RE40418 |
Treatment of neoplasms with CCI-779/EKB-569 combination |
July 1, 2008 |
| This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms. |
| D530961 |
Power wing support merchandiser |
October 31, 2006 |
|
| D521871 |
Container with a scalloped cap |
May 30, 2006 |
|
| D519843 |
Container with a scalloped cap |
May 2, 2006 |
|
| D515422 |
Scalloped cap |
February 21, 2006 |
|
| D513977 |
Tablet dispenser |
January 31, 2006 |
|
| D513587 |
Scalloped cap with tabs |
January 17, 2006 |
|
| D511456 |
Container cap with tabs |
November 15, 2005 |
|
| D502391 |
Tablet dispenser |
March 1, 2005 |
|
| D497807 |
Tablet dispenser |
November 2, 2004 |
|
| D497806 |
Tablet dispenser |
November 2, 2004 |
|
| D497803 |
Tablet dispenser |
November 2, 2004 |
|
| 7432377 |
Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof |
October 7, 2008 |
| This invention is directed to methods of preparing 4-substituted quinoline compounds as intermediates in the manufacture of receptor tyrosine kinase inhibitors and intermediate compounds used in the methods thereof, wherein the 4-substituted quinoline compound has the following general |
| 7432279 |
4,6-diamino-[1,7]naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making an |
October 7, 2008 |
| The present invention provides compounds of formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5r.sup.6, m and n are defined as described herein. The invention also provides methods of making the compounds of fo |
| 7429582 |
Dihydro[1,4]oxazino[2,3,4-hi]indazole derivatives as 5-hydroxytryptamine-6 ligands and use there |
September 30, 2008 |
| The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor ##STR00001## |
| 7429491 |
Restricted glucose feed for animal cell culture |
September 30, 2008 |
| Methods of improving protein production in animal cell cultures are provided. Cell culture methods are presented wherein glucose is fed in a restricted manner to cell culture; this restricted feeding of glucose to the cell culture results in lactate production being controlled to a low |
| 7427507 |
Determination of antibiotic concentration in bone |
September 23, 2008 |
| A method of determining the concentration of antibiotic in bone comprising crushing the bone, adding a stabilizing agent to the bone, homogenizing the bone in an extraction solvent to obtain a homogenous suspension, and analyzing the suspension supernatant to determine the concentration |
| 7425580 |
(Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands |
September 16, 2008 |
| The present invention concerns compounds of formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the specification. |
| 7425558 |
Serotonergic agents for treating sexual dysfunction |
September 16, 2008 |
| Methods and compositions are provided for treating sexual dysfunction, e.g., sexual dysfunction associated with drug treatment, using 5-HT.sub.1A receptor antagonists. |
| 7423158 |
Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of .beta.-s |
September 9, 2008 |
| The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I ##STR00001## The present invention also provides methods for the use thereof to inhibit .beta.-secretase (BACE) and treat .beta.-amyloid deposits and neurofibrillary tangl |
| 7423059 |
Pharmaceutically active compounds and methods of use |
September 9, 2008 |
| The present invention relates to certain imine-substituted heterocyclic compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neur |
| 7423044 |
Pyrimidine derivatives useful in the treatment of insulin resistance and hyperglycemia |
September 9, 2008 |
| This invention provides compounds of Formula I having the structure: ##STR00001## wherein: B is alkyl of 1-4 carbons or alkoxy of 1-4 carbons; R.sub.1 is aryl or Het optionally substituted with R.sub.6; R.sub.2 and R.sub.3 are each independently, alkyl of 1-4 carbons, CF.sub.3, aryl |
| 7420083 |
Substituted aryloximes |
September 2, 2008 |
| The present invention relates to substituted aryl oximes and methods of using them. |
| 7420001 |
Biaryl sulfonamides and methods for using same |
September 2, 2008 |
| The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors. |
| 7419986 |
Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans |
September 2, 2008 |
| Compounds of the Formula: ##STR00001## are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre |
| 7419980 |
Fused-aryl and heteroaryl derivatives and methods of their use |
September 2, 2008 |
| The present invention is directed to fused-aryl and heteroaryl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dys |
| 7419678 |
Coated medical devices for the prevention and treatment of vascular disease |
September 2, 2008 |
| A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutane |
| 7419664 |
Method of treatment using antibody to CLCA-1 |
September 2, 2008 |
| The invention relates to methods of treating a disease or condition, wherein expression or activity of soluble CLCA1 is up-regulated, by administering inhibitors of soluble CLCA1. The invention also relates to methods of isolating soluble CLCA1 from a bodily fluid. |
| 7417148 |
4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (CML) |
August 26, 2008 |
| Compounds of the formula: ##STR00001## wherein: n is an integer from 1-3; X is N, CH, provided that when X is N, n is 2 or 3; R is alkyl of 1 to 3 carbon atoms; R.sup.1 is 2,4-diCl, 5-OMe; 2,4-diCl; 3,4,5-tri-OMe; 2-Cl, 5-OMe; 2-Me, 5-OMe; 2,4-di-Me; 2,4-diMe-5-OMe, 2,4-diCl, 5-OEt; R.s |
| 7417047 |
Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for .beta.-secretase mo |
August 26, 2008 |
| The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I ##STR00001## The present invention also provides methods for the use thereof to inhibit .beta.-secretase (BACE) and treat .beta.-amyloid deposits and neurofibrillary tangles. |
| 7416862 |
Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and |
August 26, 2008 |
| The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also |
| 7416849 |
HBM variants that modulate bone mass and lipid levels |
August 26, 2008 |
| The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides |
| 7414142 |
5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators |
August 19, 2008 |
| Compounds of formula I, wherein R.sub.1-R.sub.9 and n are defined herein, and pharmaceutical compositions and kits containing these compounds are provided. ##STR00001## Also provided are methods of inducing contraception, providing hormone replacement therapy, treating cycle-related |
| 7414052 |
Phenylaminopropanol derivatives and methods of their use |
August 19, 2008 |
| The present invention is directed to phenylaminopropanol derivatives of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine |
| 7414051 |
Substituted-dihydro[1,4]oxazino[2,3,4-hi]indazole derivatives as 5-hydroxytryptamine-6 ligands |
August 19, 2008 |
| The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ##STR00001## |
| 7413753 |
Calcium phosphate delivery vehicles for osteoinductive proteins |
August 19, 2008 |
| A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic composi |
| 7411083 |
Substituted acetic acid derivatives |
August 12, 2008 |
| The present invention relates generally to substituted acetic acid derivatives and methods of using them. |
| 7411064 |
1-Heterocyclylalkyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 lig |
August 12, 2008 |
| The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor ##STR00001## |
| 7408078 |
Anthranilic acid derivatives useful in treating infection with hepatitis C virus |
August 5, 2008 |
| The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering to a mammal the pharmaceutical compositions of the present invention. |
| 7407792 |
Compositions, organisms and methodologies employing a novel human kinase |
August 5, 2008 |
| This invention provides compositions, organisms and methodologies employing a novel human protein kinase, HPK3P23. The novel human kinase has sequence homology to the catalytic domains of several protein kinases. The gene encoding this novel protein kinase is localized in or near the |
| 7407781 |
Oocyte recording chamber |
August 5, 2008 |
| An oocyte recording chamber for electrophysiological measurements. The recording chamber includes a base and a cover attached to the base. The cover and the base define a chamber having a size sufficient to accommodate an oocyte. The recording chamber includes a first electrode and a |
| 7405215 |
Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof |
July 29, 2008 |
| The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D.sub.2 and its metabolites or certain thromboxane metabolites to the CRTH2 receptor |
| 7402703 |
Stereoselective synthesis of (E)-vinylboronic esters via a Zr mediated hydroboration of alkynes |
July 22, 2008 |
| There is herein provided a process for Zr-mediated hydroboration of alkynes which offers (E)-vinylboronic esters in high yield with stereoselectivity and regioselectivity. |
| 7402698 |
Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use |
July 22, 2008 |
| The present invention is directed to secondary amino- and cycloamino-cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptom |
| 7402687 |
Dihydrobenzofuran derivatives and uses thereof |
July 22, 2008 |
| Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. ##STR00001## or pharmaceutically acceptable salts thereof, wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.x, R.sup.y, and n are as defined herein |
| 7402414 |
Enzymatic process for deacetylation of a phenoxy-alkynyl acetate to the corresponding alcohol |
July 22, 2008 |
| A process for preparing the compound of formula II by reacting the compound of formula I with an enzyme that can hydrolyze the ester bond: ##STR00001## where * indicates a chiral center, R.sub.1 and R.sub.2 each independently represent H, C.sub.1-C.sub.6alkyl, --CN or --CCH, and R |
| 7402388 |
Expression analysis of FKBP54 in assessing prostate cancer therapy |
July 22, 2008 |
| The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating prostate cancer. FKBP markers are provided, wherein changes in the levels of expression of one or more of the FKBP markers is correlated with the presence of prostate cancer. |
| 7399870 |
Synthesis of pyrrole-2-carbonitriles |
July 15, 2008 |
| The instant invention concerns processes for the production of pyrrole-2-carbonitriles such as 1-methylpyrrole-2-carbonitrile. Such processes preferably comprise the steps of reacting a pyrrole with chlorosulfonyl isocyanate in the presence of a solvent and contacting the resulting p |
| 7399865 |
Protein tyrosine kinase enzyme inhibitors |
July 15, 2008 |
| This invention provides compounds of formula 1, having the structure ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are described within the specification. |
| 7399778 |
Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
July 15, 2008 |
| Compounds useful for lowering beta amyloid levels are provided. The compounds have the structure of formula Ia: ##STR00001## wherein, R.sub.1 is lower alkyl, substituted lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, benzyloxy, substituted benzyloxy, or SO.su |
