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Wisconsin Alumni Research Foundation Patents
Wisconsin Alumni Research Foundation
Madison, WI
No. of patents:

Patent Number Title Of Patent Date Issued
RE41491 (20S)-1.alpha.-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses August 10, 2010
This invention discloses (20S)-1.alpha.-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evi
RE41474 (20S)-1.alpha.-Hydroxy-2-Methylene-19-Nor-Bishomopregnacalciferol and its uses August 3, 2010
This invention discloses (20S)-1.alpha.-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evi
RE37264 Pasta filata-simulative cheese product and method of making July 3, 2001
A method of manufacturing cheese which is simulative of pasta filata cheeses, but which does not require a mixing and/or molding step, and the cheese product produced by the method, are disclosed. The method includes the steps of pre-acidifying milk; ripening the milk with a mesophilic
RE32911 Adjustable waveform spark source April 25, 1989
A capacitor is charged to a high voltage, and then is discharged through a circuit comprising an analytical spark gap and first and second inductive elements, whereby the discharge current is oscillatory. The waveform of the discharge current is modified by a diode rectifier shunted acro
RE32701 NMR scanner with motion zeugmatography June 21, 1988
An NMR zeugmatographic scanner is modified to produce flow images. A motion sensitizing gradient field is applied to the gyromagnetic nuclei after transverse excitation and prior to emission measurement. The motion sensitized free induction signal which results is processed using an
RE30538 3-Deoxy-1.alpha.-hydroxycholecalciferol March 3, 1981
3-Deoxy-1.alpha.-hydroxycholecalciferol. The compound is characterized by vitamin D-like activity.
RE29990 Processes for stereospecifically preparing chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one May 8, 1979
A method for stereospecifically preparing chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one which comprises asymmetrically reducing 2-substituted cyclopentane-1,3,4-trione to the corresponding 2-substituted-4(R)-hydroxy-cyclopentane-1,3-dione, enolizing the said dione to obtain the
PP8684 Elm tree named New Horizon April 12, 1994
A new interspecific hybrid elm tree of U. japonica.times.U. pumila which expresses exceptional vigor when young, attractive crown shape, compact habit, dense foliage concentration, resistance to branch shearing forces of weather, and a high level of resistance to common elm diseases and
PP8683 Elm tree named "Cathedral" April 12, 1994
A new and distinct variety of elm tree which is characterized by its resistance to Dutch elm disease caused by Ophiostoma ulmi (Buisman) Nannf. Trees of this variety are also highly tolerant to Verticillium wilt disease, limited susceptibility to black leaf spot disease, and good res
PP5335 Elm tree called Regal November 13, 1984
An elm tree characterized by high resistance to the Dutch elm disease.
PP14225 Cranberry variety named `HyRed` October 14, 2003
A new and distinct variety of cranberry is described. The variety has been named `HyRed` and is derived from a cross of the `Stevens` variety and Ben Lear No. 8. The `HyRed` variety exhibits significantly higher red pigment, short seasonal maturity, excellent vigor, and a yield comparabl
D633506 Keyboard March 1, 2011
D613746 Keyboard April 13, 2010
D603865 Keyboard November 10, 2009
D582430 Player December 9, 2008
D579940 Cartridge November 4, 2008
D451482 Control panel for individual with disabilities December 4, 2001
8586362 Method for DNA double-strand break repair in vitro and applications thereof November 19, 2013
A system and a method for DNA double-strand break repair in vitro are disclosed. Applications of the disclosed method in multiple areas are also disclosed.
8586338 Ligand functionalized substrates November 19, 2013
Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
8586034 Cytomegalovirus disintegrin-like peptides November 19, 2013
The present invention relates to methods and compositions for inhibiting the entry of viruses, such as herpesviruses into a host cell. A conserved viral integrin-binding gB disintegrin-like domain has been identified that engages integrins and facilitates viral internalization into the
8581306 Coupled electron shuttle providing electrical rectification November 12, 2013
A nanoscale electron shuttle with two elastically mounted conductors positioned within a gap between conductors produces asymmetrical electron conduction between the conductors when the conductors receive an AC signal to provide for rectification, detection and/or power harvesting.
8580977 Tautomycetin and tautomycetin analog biosynthesis November 12, 2013
The present invention relates to the biosynthetic gene cluster for tautomycetin (TTN) produces tautomycetin. Also provided are engineered micro-organisms for the production of TTN and analogs thereof, as well as methods of screening for compounds for activity.
8575136 2-methylene-1.alpha.-hydroxy-18,19,21-trinorvitamin D.sub.3 analogs and uses thereof November 5, 2013
Compounds of formula I are provided where X.sub.1 and X.sub.2 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions. ##STR00001##
8574898 Translation-coupling systems November 5, 2013
Disclosed are systems and methods for coupling translation of a target gene to a detectable response gene. A version of the invention includes a translation-coupling cassette. The translation-coupling cassette includes a target gene, a response gene, a response-gene translation control
8574420 Ultrathin multilayered films for controlled release of anionic reagents November 5, 2013
Multilayered films, particularly ultrathin multilayered films comprising cationic polymers which are useful for controlled release of anionic species, particularly for controlled release of nucleic acids. The multilayer films herein are useful for temporal controlled released of anio
8569574 Methods and compositions for improved fertilization and embryonic survival October 29, 2013
Single nucleotide polymorphic sites at positions 3117, 12195, 13244, 13319, and 13516 of the bovine STAT5 gene are associated with improved fertilization rate and/or improved embryo survival rate. Also disclosed are nucleic acid molecules, kits, methods of genotyping and marker assis
8569465 Method for modifying lignin structure using monolignol ferulate conjugates October 29, 2013
Described is an isolated lignified plant cell wall including lignin, wherein the lignin includes a ferulate residue incorporated therein, such as from coniferyl ferulate and/or sinapyl ferulate. Also described is a method to make the isolated lignified plant cell wall, and the lignin
8569457 Cytotoxic ribonuclease variants October 29, 2013
Cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex are disclosed. Also disclosed is the 3-D
8569043 Detection of post-translationally modified peptides with liquid crystals October 29, 2013
A method for differentiating between a post-translationally modified peptide and a peptide contained in a sample, comprising: (a) contacting the sample with a peptide attachment surface to create a peptidized surface, wherein the sample includes at least one functional group; (b) con
8563777 Ionizable isotopic labeling reagents for relative quantification by mass spectrometry October 22, 2013
Relative quantification of metabolites by Electrospray Ionization Mass Spectrometry (ESI-MS) requiring a mechanism for simultaneous analysis of multiple analytes in two or more samples. Labeling reagents that are reactive to particular compound classes and differ only in their isotopic
8301257 Method for suppressing and reversing epileptogenesis October 30, 2012
A method for identifying, suppressing, and reversing epileptogenesis, which is considered to be a learned response due to brain plasticity. The method includes identifying three epileptogenic conditions, neuronal hyperexcitability, spatial overconnectivity, and temporal overconnectiv
8298805 Signal for packaging of influenza virus vectors October 30, 2012
The invention provides a packaging (incorporation) signal for influenza virus vectors, and methods of using the signal to transmit and maintain influenza viral and foreign nucleic acid in virus and cells.
8293872 Cytotoxic ribonuclease variants October 23, 2012
This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclose
8293495 Blood-brain barrier model October 23, 2012
A method of creating a multicellular blood-brain barrier model is disclosed. In one embodiment, the method comprises culturing primary brain microvascular endothelial cells or embryonic stem cell-derived endothelial cells upon a permeable support in the presence of neural progenitor
8287957 Methods and compositions for forming aperiodic patterned copolymer films October 16, 2012
The present invention provides improved and compositions methods for replicating substrate patterns including patterns containing irregular features. The methods of the invention involve depositing block copolymer materials on a patterned substrate and ordering components in the mate
8282553 Method and apparatus for acoustoelastic extraction of strain and material properties October 9, 2012
An ultrasound machine processes ultrasonic data according to acoustoelastic properties of the materials to obtain strain information without specific assumptions with respect to the material properties of the measured material or a variety of different material properties normally no
8281164 Method and apparatus for optimizing clock speed and power dissipation in multicore architectures October 2, 2012
A multicore processor provides for local power control at each of the cores which is used to lower the maximum operating frequency of cores by any amount above of the maximum operating frequency of the slowest core. This power savings is then used to increase the maximum operating fr
8278436 Glycosylated warfarin analogs and uses thereof October 2, 2012
The present invention discloses a set of glycosylated warfarin analogs which are useful as anti-tumor or anti-metastatic agents and as reagents for studying sugar uptake in cells.
8278406 Bioactive and biocompatible polyurethane-buthanediol-glycosaminoglycan salt copolymers October 2, 2012
A bioactive and biocompatible polyurethane-butanediol-glycosaminoglycan copolymer for use in medical implant devices. The biocompatible urethane component being the reaction product of 4,4'-methylene-di-(p-phenyl isocyanate) and poly(tetramethylene oxide)n and further reacted with 1,
8278115 Methods for processing tandem mass spectral data for protein sequence analysis October 2, 2012
Various mass spectroscopy-based methods are provided to improve protein sequencing by detecting z-type product ions generated from the protein. A polypeptide is introduced to a mass spectrometer, and in particular c- and z-type product ions that are generated by selectively fragmenting t
8278040 Optically responsive and mechanically tunable colloid-in-liquid crystal gels October 2, 2012
Colloidal liquid crystal gels (CLCGs), sensors incorporating the CLCGs, culture substrates made from the CLCGs, and patterned films and molded articles made from the CLCGs are provided. The CLCGs are composite liquid crystal materials comprising networks of particles having liquid crysta
8275594 Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint September 25, 2012
Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creatin
8274059 Molecule mass detection via field emission of electrons from membranes September 25, 2012
An active detector and methods for detecting molecules, including large molecules such as proteins and oligonucleotides, at or near room temperature based on the generation of electrons via field emission (FE) and/or secondary electron emission (SEE). The detector comprises a semicon
8273778 Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth September 25, 2012
Compounds which inhibit microbial growth or attenuate the virulence of pathogen microorganisms. Compounds of the invention inhibit UDP-galactopyranose mutase (UGM) and have activity as inhibitors of microbial growth of microorganisms which contain this enzyme and particularly those m
8273569 Preparation of human embryonic stem cells September 25, 2012
A purified preparation of primate embryonic stem cells is disclosed. This preparation is characterized by the following cell surface markers: SSEA-1 (-); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+); and alkaline phosphatase (+). In a particularly advantageous embodiment, the cells of the
8271427 Computer database system for single molecule data management and analysis September 18, 2012
A computer database system for storing, processing, displaying, and analyzing single molecule data is capable of managing and processing variously formatted, different kinds of single molecule data and displaying subsets thereof upon instructions by a user. A component-based architec
8271251 Automated imaging system for single molecules September 18, 2012
There is provided a high throughput automated single molecule image collection and processing system that requires minimal initial user input. The unique features embodied in the present disclosure allow automated collection and initial processing of optical images of single molecule
8269196 Heavy ion radiation therapy system with stair-step modulation September 18, 2012
A system for modulating a fan beam for radiation treatment employs shutters that may move rapidly into and out of different beamlets of a fan beam, the shutters having a systematic weighting so that a limited number of shutters may obtain a far greater number of regularly spaced ener
8269039 Amino acids and catalytic preparatory methods September 18, 2012
The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide .alpha.-substituted-.gamma.-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrroli
8269024 Compounds and methods for modulating communication and virulence in quorum sensing bacteria September 18, 2012
The present invention provides compositions and methods for modulating the communication and virulence of quorum sensing bacteria. In various exemplary embodiments, the invention provides a combinatorial library of quorum sensing compounds including synthetic analogs of naturally occ

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