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Whitehead Institute for Biomedical Research Patents
Assignee:
Whitehead Institute for Biomedical Research
Address:
Cambridge, MA
No. of patents:
150
Patents:


1 2 3










Patent Number Title Of Patent Date Issued
8568998 Methods of diagnosing, preventing and treating cancer metastasis October 29, 2013
The invention relates to methods and compositions for inhibiting metastasis, such as by inhibiting FOXC2 expression or activity. The invention further relates to methods of prognosticating, diagnosing, and assisting in the diagnosis of metastasis in an individual, or of determining t
8273357 Antigen-carbohydrate conjugates September 25, 2012
The present invention generally relates to compositions comprising antigen-carbohydrate conjugates and methods of immune modulation featuring these reagents.
8258271 mTOR kinase-associated proteins September 4, 2012
The invention describes isolated mTOR-associated proteins ("mTOR-APs") as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods
8252591 Hormone responsive tissue culture system and uses thereof August 28, 2012
The invention provides tissue culture system for primary cells (e.g. normal mammalian primary epithelial progenitors). This system includes: a) a serum-free, chemically defined cell culture media; and, b) methods for isolation and in vitro long-term propagation of primary cells (e.g.
8192986 Compositions and methods for treatment of protein misfolding diseases June 5, 2012
Disclosed are methods for identifying compounds that modulate huntingtin mediated impairment of protein degradation pathways. Compounds identified by such screens can be used as candidate drugs for the treatment of prevention of polyglutamine diseases such as Huntington's Disease.
8143480 Compositions and methods for efficient gene silencing in plants March 27, 2012
This invention relates to methods for knock-down of a target gene in plants, particularly efficient and specific methods for knock-down of a target gene in plants. This invention also relates to methods for silencing endogenous plant genes or plant pathogen genes. It further relates
8133679 Methods of identifying agents that diminish cellular toxicity associated with an .alpha.-synucle March 13, 2012
Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a
8124365 Identification of genotype-selective anti-tumor agents February 28, 2012
The present invention relate to methods of identifying a genotype-selective agent. In certain embodiments, the invention relates to agents that are selectively toxic to engineered human tumorigenic cells.
8106180 Methods and products for expression of micro RNAs January 31, 2012
The invention relates to microRNAs, methods of producing microRNAs and methods for using microRNAs.
8071369 Compositions for reprogramming somatic cells December 6, 2011
The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying
8058515 Plant cells and plants overexpressing vacuolar proton pyrophosphatases November 15, 2011
The present invention relates to a transgenic plant, comprising one or more plant cells transformed with exogenous nucleic acid which increases expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and seeds of the transgeni
8058012 Five-helix protein November 15, 2011
Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which includes the three N-helices an
8003852 Transgenic plants overexpressing a plant vacuolar pyrophosphatase August 23, 2011
Transgenic plants are described which are engineered to overexpress vacuolar H.sup.+-PPase. Plants such as tobacco and petunia transformed with A. Thaliana AVP-1 are shown to have increased meristematic activity resulting in larger leaves, stem, flower, fruit, root structures, increa
7960504 Inhibitors of HIV membrane fusion June 14, 2011
Inhibitors of HIV membrane fusion and a method of identifying drugs or agents which inhibit binding of the N-helix coiled-coil and the C helix of HIV gp41 envelope protein.
7906308 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex March 15, 2011
In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity.
7811578 Soluble chimeric peptide inhibitors of HIV entry comprising an IZ trimeric coiled-coil peptide a October 12, 2010
Described herein are chimeric peptides comprising a soluble trimeric coiled-coil and all or a portion of the N-peptide region of HIV gp41. These molecules are stable, trimeric coiled-coils that inhibit HIV entry into cells, such as human cells. Such peptides can be further assessed to
7807464 Methods for expansion and analysis of cultured hematopoietic stem cells October 5, 2010
Methods and kits for propagating hematopoietic stem cells are provided. The methods comprise culturing cells in medium comprising one or more angiopoietin-like proteins, under conditions sufficient for expansion of HSCs. Angiopoietin-like proteins include angiopoietin-like protein 2,
7767453 Cultured hematopoietic stem cells and method for expansion and analysis thereof August 3, 2010
Hematopoietic stem cells and methods for ex vivo expansion of hematopoietic stem cells are provided. The methods comprise culturing the cells in a media containing an effective amount insulin-like growth factor (IGF), fibroblast growth factor (FGF), thrombopoietin (TPO), and stem cel
7682828 Methods for reprogramming somatic cells March 23, 2010
The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an
7615554 Erastin and erastin binding proteins, and uses thereof November 10, 2009
The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also provides reagents and methods for effective killing of cancer cells with erastin and related
7611838 Biologically-active DNA-binding sites and related methods November 3, 2009
The invention relates to the identification of biologically-active DNA-binding sites to which a protein of interest binds in a cell. The invention also relates to the identification of agents and conditions which alter the biologically-active DNA-binding sites to which a protein bind
7575869 Genome wide location and function of DNA binding proteins August 18, 2009
The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to
7572575 SIR2 activity August 11, 2009
This invention relates to methods of screening compounds that modulate cellular and organismal processes by modification of the activity of SIR2 and/or transcription factors, e.g., p53, particularly methods of screening for compounds that modify lifespan and/or metabolism of a cell o
7556921 Methods for mapping signal transduction pathways to gene expression programs July 7, 2009
The invention relates to improved methods of identifying the gene expression programs that are regulated by a signal transduction pathway. The invention also provides methods of identifying agents which modulate signal transduction pathway. The invention also provides improved methods
7534933 Transgenic plants overexpressing a plant vacuolar H + -ATPase May 19, 2009
Transgenic plants are described which are engineered to overexpress vacuolar H.sup.+-PPase. Plants such as tobacco and petunia transformed with A. Thaliana AVP-1 are shown to have increased meristematic activity resulting in larger leaves, stem, flower, fruit, root structures, increa
7504224 Five-Helix protein March 17, 2009
Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which includes the three N-helices an
7501248 Prostate cancer diagnosis and outcome prediction by expression analysis March 10, 2009
Methods identifying prostate cancer, methods for prognosing and diagnosing prostate cancer, methods for identifying a compound that modulates prostate cancer development, methods for determining the efficacy of a prostate cancer therapy, and oligonucleotide microarrays containing pro
7501234 Stress proteins and uses therefor March 10, 2009
The present invention relates to stress proteins and methods of modulating an individual's immune response. In particular, it relates to the use of such stress proteins in immune therapy and prophylaxis, which results in an induction or enhancement of an individual's immune response and
7501125 Vivo CTL elicitation by heat shock protein fusion proteins maps to a discrete domain and is CD4+ March 10, 2009
The present invention relates to a method of inducing a CD8.sup.+ CTL response to a molecule in an individual deficient in CD4.sup.+ T cells comprising administering to the individual an hsp or a portion of an ATP binding domain of an hsp joined to the molecule. In one embodiment, the
7491943 Method and apparatus for UV imaging February 17, 2009
A method and apparatus for illuminating a subject with deep UV light and detecting 2-dimensional image information, e.g., a transmission image, fluorescence image, reflected light image, etc. The subject may be illuminated with a light pulse having a duration of 2 seconds or less and
7491530 Fusion partner cells and uses thereof February 17, 2009
The present invention provides in one aspect novel fusion partner cells that ectopically express one or more genes that alter the phenotype of a hybrid cell made from a fusion of the fusion partner cell and a fusion cell, hybrid cell lines produced using the fusion partner cells. The
7470507 Genome-wide location and function of DNA binding proteins December 30, 2008
The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to
7452670 Methods of identifying agents that diminish cellular toxicity associated with an .alpha.-synucle November 18, 2008
Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a
7402659 Thymic stromal lymphopoietin receptor molecules and uses thereof July 22, 2008
The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TSLPR polypeptides. The invention further provi
7402396 Core structure of gp41 from the HIV envelope glycoprotein July 22, 2008
Described are the crystal structure of the .alpha.-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.
7358262 Identification of genotype-selective anti-tumor agents April 15, 2008
The present invention relate to methods of identifying a genotype-selective agent. In certain embodiments, the invention relates to agents that are selectively toxic to engineered human tumorigenic cells.
7335874 Method and apparatus for generating a circularly polarized illumination beam February 26, 2008
A method and apparatus for illuminating a subject with deep UV light and detecting 2-dimensional image information, e.g., a transmission image, fluorescence image, reflected light image, etc. The subject may be illuminated with a light pulse having a duration of 2 seconds or less and
7324926 Methods for predicting chemosensitivity or chemoresistance January 29, 2008
Methods and apparatus for classifying or predicting the classes for samples based on gene expression are described. Also described are methods and apparatus for ascertaining or discovering new, previously unknown classes based on gene expression. Methods, computer systems and apparat
7239986 Methods for classifying samples and ascertaining previously unknown classes July 3, 2007
Methods and apparatus for classifying or predicting the classes for samples based on gene expression are described. Also described are methods and apparatus for ascertaining or discovering new, previously unknown classes based on gene expression.
7226598 Peptide inhibitors of HIV entry June 5, 2007
Described herein are chimeric peptides comprising a soluble trimeric coiled-coil and all or a portion of the N-peptide region of HIV gp41. These molecules are stable, trimeric coiled-coils that inhibit HIV entry into cells, such as human cells. Such peptides can be further assessed to
7105293 Genetic markers for tumors September 12, 2006
Sets of genetic markers for specific tumor classes are described, as well as methods of identifying a biological sample based on these markers. Also described are diagnostic, prognostic, and therapeutic screening uses for these markers, as well as oligonucleotide arrays comprising these
7101879 Treatments for neurotoxicity in Alzheimer's Disease September 5, 2006
The invention involves identification of a mechanism of .beta.-amyloid peptide cytotoxicity, which enables treatment of conditions caused by .beta.-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includes the ide
7053179 Five-Helix protein May 30, 2006
Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which includes the three N-helices an
7052870 mTOR kinase-associated proteins May 30, 2006
The invention describes isolated mTOR-associated proteins ("mTOR-APs") as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods
7033772 Methods of identifying inhibitors of fatty acid transport proteins (FATP) April 25, 2006
A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, vectors comprising th
7011947 MLL translocations specify a distinct gene expression profile, distinguishing a unique leukemia March 14, 2006
The present invention relates to the diagnosis of mixed lineage leukemia (MLL), acute lymphoblastic leukemia (ALL), and acute myelogenous leukemia (AML) according to the gene expression profile of a sample from an individual, as well as to methods of therapy and screening that utilize
6991713 Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated de January 31, 2006
A technique processes a sample of biomolecular analyte. The technique uses an apparatus having a support assembly that receives and supports a test module, a load assembly that loads the sample of biomolecular analyte onto the test module, an electrophoresis assembly that applies a curre
6955895 Thymic stromal lymphopoietin receptor molecules and uses thereof October 18, 2005
The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TSLPR polypeptides. The invention further provides
6951757 Transfection method and uses related thereto October 4, 2005
The invention features a method of introducing nucleic acid molecules into eukaryotic cells by (a) depositing a nucleic acid molecule-containing mixture onto a surface, (b) affixing the nucleic acid molecule-containing mixture to the surface, and (c) plating eukaryotic cells onto the sur
6949342 Prostate cancer diagnosis and outcome prediction by expression analysis September 27, 2005
Methods identifying prostate cancer, methods for prognosing and diagnosing prostate cancer, methods for identifying a compound that modulates prostate cancer development, methods for determining the efficacy of a prostate cancer therapy, and oligonucleotide microarrays containing probes
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