| Patent Number |
Title Of Patent |
Date Issued |
| 7353830 |
TRAP-coated bone grafts and prostheses |
April 8, 2008 |
| A composition or device suitable for orthopedic or dental implantation to bone, characterized by tartrate-resistant acid phosphatase (TRAP) adsorbed to a porous hydroxyapatite substratum. |
| 6916903 |
Collagen type III synthetic peptides for collagen resorption assays |
July 12, 2005 |
| Peptides synthesized to match C-telopeptide components of type III collagen degradation products in body fluids, selected from among EKAGGF (SEQ ID NO:39), IGGEKAGG (SEQ ID NO:40), IGGEKAGGF (SEQ ID NO:41), IAGIGGEKAGG (SEQ ID NO:42), IAGIGGEKAGGF (SEQ ID NO:43), and EKAGG (SEQ ID NO:44) |
| 6916604 |
Uses of synthetic peptides corresponding to telopeptide sequences of cross-linked type I collage |
July 12, 2005 |
| Peptides synthesized to match the human .alpha.1 (I) and .alpha.2 (I) amino-telopeptide sequences of type I collagen degradation products in body fluids, preferably either Asp-GIu-Lys-Ser-Thr-Gly-Gly (SEQ ID NO:5) or Gln-Tyr-Asp-Gly-Lys-Gly-Val-Gly (SEQ ID NO:6). used as calibrators and |
| 6887659 |
Urinary assay for measuring bone resorption |
May 3, 2005 |
| A method for assaying bone resorption rates which consists of quantitating the concentration of peptide fragments derived from bone collagen, found in a body fluid is disclosed. The method includes immunometric assay, fluorometric assay and electrochemical titration. The structure of |
| 6602980 |
Collagen type III synthetic peptides for collagen resorption assays |
August 5, 2003 |
| Peptides synthesized to match N-telopeptide components of type III collagen degradation products in body fluids, selected from among DVKSGVAVGG (SEQ ID NO 33), YDVKSGVAVGG (SEQ ID NO 34), SYDVKSGVAVGG (SEQ ID NO 35), DSYDVKSGVAVGG (SEQ ID NO 36), JYDSYDVKSGVAVGG (SEQ ID NO 37), and KSGVA |
| 6566492 |
Synthetic peptides of type II collagen for cartilage resorption assays |
May 20, 2003 |
| The claimed invention is peptides synthesized to match telopeptide components of type II collagen degradation products in synovial fluid and blood, selected from among LGPREKGPDP (SEQ ID NO 11), LGPREKGPDPLQ (SEQ ID NO 12), LGPREKGPDPLQY (SEQ ID NO 13), FAGLGPREKGPDP (SEQ ID NO 14), |
| 6509450 |
Immunoassay for quantification of C-terminal telopeptides of type I collagen in human serum |
January 21, 2003 |
| An immunoassay kit for the quantification of degradation products of carboxy-terminal telopeptides of type I collagen in a human serum sample, including an antibody that is characterized by binding to at least one peptide derived from the carboxy-terminal telopeptide domain of type I |
| 6508838 |
Compositions for medical implantation |
January 21, 2003 |
| A composition or device suitable for orthopedic or dental implantation to bone, characterized by tartrate-resistant acid phosphatase (TRAP) adsorbed to a porous hydroxyapatite substratum. |
| 6348320 |
Cartilage resorption assays measuring type II collagen fragments |
February 19, 2002 |
| Immunoassays for measuring type II collagen (cartilage) resorption in vivo employ either one or two antibodies. A first antibody binds to DEKAGGA (SEQ ID NO:21) but not to GGFDEKAGGAQLG (SEQ ID NO:27), where the K symbols refer to lysine or preferably to cross-linking 3-hydroxypyridinium |
| 6255056 |
Cartilage resorption assays |
July 3, 2001 |
| Immunoassays for measuring type II collagen (cartilage) resorption in vivo employ either one or two antibodies. A first antibody binds to EKGPDP (SEQ ID NO:2) but not to EKGPDPLQ (SEQ ID NO:10), where the K symbols refer to lysine or preferably to cross-linking 3-hydroxypyridinium residu |
| 6204367 |
Elisa kit for quantification of C-terminal telopeptides of type I collagen in human serum |
March 20, 2001 |
| An enzyme linked immunosorbent assay (ELISA) kit for the quantification of degradation products of carboxy-terminal telopeptides of type I collagen in a human serum sample, including an antibody that is characterized by binding to at least one peptide derived from the carboxy-terminal |
| 6190412 |
Trap-coated bone grafts and prostheses |
February 20, 2001 |
| A composition or device suitable for orthopedic or dental implantation to bone, characterized by tartrate-resistant acid phosphatase (TRAP) adsorbed to a porous hydroxyapatite substratum. |
| 6153732 |
Kit for detecting analyte indicative of type II collagen resorption in vivo |
November 28, 2000 |
| Immunoassay test kit for detecting analyte indicative of type II collagen resorption in vivo. including an immunological binding partner which binds to an amino-terminal or carboxy-terminal 3-hydroxypyridinium cross-linked telopeptide of type II collagen isolatable from a urine sample of |
| 6143511 |
Sandwich immunoassays for collagen type II degradation products |
November 7, 2000 |
| Sandwich immunoassays for detecting analyte indicative of type II collagen resorption in vivo, by contacting a body fluid sample with a first antibody and a second antibody such that analyte present in the sample forms a first antibody-analyte-second antibody complex, and detecting the |
| 6143027 |
Polymeric intraocular lens material having improved surface properties and intraocular lens cons |
November 7, 2000 |
| An intraocular lens is described that includes an optic portion formed of an optically suitable polymer or glass material that has been coated by a fluorocarbon polymer. A haptic portion of the IOL is attached to the optic. The resulting low-energy IOL surface induces significantly reduc |
| 6100379 |
Synthetic peptides corresponding to telopeptide sequences of cross-linked type II collagen metab |
August 8, 2000 |
| Peptides synthesized to match the human .alpha.1(II) carboxy-telopeptide sequences of type II collagen degradation products in body fluids, preferably Glu-Lys-Gly-Pro-Asp-Pro (SEQ ID NO:6). Useful as calibrators and antigens in immunoassays for detecting type II collagen degradation |
| 6048705 |
Sandwich immunoassays for collagen type I degradation products |
April 11, 2000 |
| Sandwich immunoassays for detecting analyte indicative of type 1 collagen resorption in vivo, by contacting a body fluid sample with a first antibody and a second antibody such that analyte present in the sample forms a first antibody-analyte-second antibody complex, and detecting the |
| 6035229 |
Method and apparatus for detecting Barrett's metaplasia of the esophagus |
March 7, 2000 |
| A system for detecting Barrett's metaplasia utilizes an illumination and imaging probe at the end of a catheter. The probe illuminates the wall of the esophagus and returns reflected light to be processed to provide a visual indication of the color of the esophageal wall. The position of |
| 6030799 |
Immunoassays for detecting chlamydial antigens or antibodies thereto using recombinant or synthe |
February 29, 2000 |
| Methods and compositions are provided for the production of a polypeptide which is immunologically cross-reactive with a naturally-occurring major outer membrane protein (MOMP) of Chlamydia trachomatis. A DNA construct including a replication system recognized by E. coli, and an MOMP gen |
| 6027903 |
Kit for detecting analyte indicative of type I collagen resorption in vivo |
February 22, 2000 |
| Immunoassay test kit for detecting analyte indicative of type I collagen resorption in vivo, comprising an immunological binding partner which binds to an amino-terminal or carboxy-terminal 3-hydroxypyridinium cross-linked telopeptide of type I collagen isolatable from a urine sample |
| 6025161 |
DNA sequences expressing mammalian .alpha..sub.1 -antitrypsin |
February 15, 2000 |
| DNA sequences to mammalian .alpha..sub.1 -antitrypsin are provided which can be used for expression of mammalian .alpha..sub.1 -antitrypsin.This work was supported in part by grants HL16919 and HL27509 from the National Institutes of Health. |
| 6025144 |
Immunoassay test kit for measuring bone resorption |
February 15, 2000 |
| An immunoassay test kit including an immunological binding partner that binds to lysyl pyridinoline, for analyzing a body fluid sample for bone resorption in vivo. |
| 6010862 |
Methods of detecting collagen type III degradation in vivo |
January 4, 2000 |
| In a method of analyzing a body fluid sample for the presence of analyte indicative of a physiological condition, comprising the steps of contacting the body fluid sample with an immunological binding partner which binds to the analyte, detecting binding of the immunological binding |
| 5962639 |
Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabo |
October 5, 1999 |
| Peptides synthesized to match the human .alpha.1(I) and .alpha.2(I) telopeptide sequences of the type I collagen metabolites, preferably selected from among Asp-Glu-Lys-Ser-Thr-Gly-Gly (SEQ ID NO:5), Gln-Tyr-Asp-Gly-Lys-Gly-Val-Gly (SEQ ID NO:6), and Glu-Lys-Ala-His-Asp-Gly-Gly-Arg ( |
| 5962236 |
Urinary assay for measuring bone resorption |
October 5, 1999 |
| Urinary assay for measuring bone resorption, by contacting an unhydrolyzed urine sample with an antibody that binds to free lysyl pyridinoline cross-links, detecting any binding of the antibody in the body fluid sample, and correlating the detected binding to bone resorption in vivo. |
| 5945274 |
Urinary assay for measuring bone resorption |
August 31, 1999 |
| A method for assaying bone resorption rates which consists of quantitating the concentration of free lysyl pyridinoline derived from bone collagen, found in a body fluid is disclosed. The method includes immunometric assay, fluorometric assay and electrochemical titration. The structure |
| 5939274 |
Methods of monitoring patient responses to anti-resorptive therapies |
August 17, 1999 |
| Method of monitoring a patient's response to an anti-resorptive therapy such as estrogen, by contacting a body fluid sample of the patient with an immunological binding partner specific for a cross-linked telopeptide having a sequence identical to that of a cross-linked amino-terminal or |
| 5919651 |
Expression of polypeptides in yeast |
July 6, 1999 |
| DNA expression vectors capable, in a transformant strain of yeast, of expressing a polypeptide under the control of a genetically distinct yeast promoter, processes of forming transformant strains of yeast and transformed yeast strains are disclosed. |
| 5919634 |
Methods of detecting collagen type II degradation in vivo |
July 6, 1999 |
| In a method of analyzing a body fluid sample for the presence of an analyte indicative of a physiological condition, comprising the steps of contacting the body fluid sample with an immunological binding partner which binds to the analyte, detecting binding of the immunological binding |
| 5912131 |
Detection of type 1 collagen degradation in vivo |
June 15, 1999 |
| Compositions useful in quantitating collagen peptides to determine the rate of bone resorption are prepared by treating bone with a protease, such as collagenase, and purifying the compositions so as to enrich them with peptides that contain 3-hydroxypyridinium cross-links. |
| 5856123 |
Expression of polypeptides in yeast |
January 5, 1999 |
| DNA expression vectors capable, in a transformant strain of yeast, of expressing a polypeptide under the control of a genetically distinct yeast promoter, processes of forming transformant strains of yeast and transformed yeast strains are disclosed. |
| 5854018 |
Expression of polypeptides in yeast |
December 29, 1998 |
| DNA expression vectors capable, in a transformant strain of yeast, of expressing a polypeptide under the control of a genetically distinct yeast promoter, processes of forming transformant strains of yeast and transformed yeast strains are disclosed. |
| 5834221 |
Assay for type I collagen carboxy-terminal telopeptide analytes |
November 10, 1998 |
| A method of determining collagen degradation in vivo, comprising quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a |
| 5821055 |
Chlamydia major outer membrane protein |
October 13, 1998 |
| Methods and compositions are provided for the production of a polypeptide which is immunologically cross-reactive with a naturally-occurring major outer membrane protein (MOMP) of Chlamydia trachomatis. A DNA construct including a replication system recognized by E. coli, and an MOMP gen |
| 5817755 |
Synthetic peptide analogs of cross-linked N-telopeptides of type I collagen |
October 6, 1998 |
| Synthetic linear peptides embodied by Xaa-Tyr-Xaa-Gly-Xaa-Gly-Val-Gly which mimic the epitope recognized by mAb 1H11 (ATCC No. HB 10611) in cross-linked N-telopeptides of type I collagen (NTx). |
| 5773230 |
Immune reactivity to expressed activated oncogenes for diagnosis and treatment of malignancy |
June 30, 1998 |
| Methods for the detection, monitoring and treatment of malignancies are disclosed. Detection of the proliferation of T cells in response to in vitro exposure to a protein expression product of an activated oncogene or cancer-related gene associated with a malignancy, or detection of |
| 5770714 |
Chlamydia major outer membrane protein |
June 23, 1998 |
| Methods and compositions are provided for the production of a polypeptide which is immunologically cross-reactive with a naturally-occurring major outer membrane protein (MOMP) of Chlamydia trachomatis. A DNA construct including a replication system recognized by E. coli, and an MOMP gen |
| 5750647 |
Synthetic peptide analogs of NTx |
May 12, 1998 |
| Synthetic linear peptides embodied by Y-Tyr-Asp-Gly-X-Gly-Val-Gly (SEQ ID NO:1) which mimic the epitope recognized by mAb 1H11 (ATCC No. HB 10611) in cross-linked N-telopeptides of type I collagen (NTx). |
| 5736379 |
DNA sequences expressing mammalian .alpha..sub.1 antitrypsin |
April 7, 1998 |
| DNA sequences to mammalian .alpha..sub.1 -antitrypsin are provided which can be used for expression of mammalian .alpha..sub.1 -antitrypsin.This work was supported in part by grants HL16919 and HL27509 from the National Institutes of Health. |
| 5702909 |
Methods of detecting collagen type II degradation in vivo |
December 30, 1997 |
| In a method of analyzing a body fluid sample for the presence of an analyte indicative of a physiological condition, comprising the steps of contacting the body fluid sample with an immunological binding partner which binds to the analyte, detecting binding of the immunological binding |
| 5695491 |
Endoscopic accessory and containment system |
December 9, 1997 |
| A therapeutic or diagnostic accessory and containment system for use with a flexible or rigid endoscope during an endoscopic procedure. The system includes an accessory and a containment enclosure, wherein the accessory has an elongated, flexible, and axially-rigid shaft shaped to fit in |
| 5688652 |
Detection of collagen degradation in vivo |
November 18, 1997 |
| Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide having the following structure: ##STR1## is hydroxylysyl pyridinoline or lysyl pyridinoline, and J is pyroglutamic acid or glutamine and (Leu) are opti |
| 5677198 |
Assay for peptide metabolites from the amino-terminal telopeptide domain of type I collagen |
October 14, 1997 |
| Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl |
| 5656439 |
Antibody to type-I collagen carboxy-terminal telopeptide |
August 12, 1997 |
| Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl |
| 5652112 |
Assay for type I collagen carboxy-terminal telopeptide analytes |
July 29, 1997 |
| A method of determining collagen degradation in vivo, comprising quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a |
| 5641837 |
Method of detecting collagen degradation in vivo |
June 24, 1997 |
| A method of determining collagen degradation in vivo, comprising quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a |
| 5641687 |
Methods of detecting collagen degradation in vivo |
June 24, 1997 |
| A method of determining collagen degradation in vivo, comprising quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a |
| 5618676 |
Expression of polypeptides in yeast |
April 8, 1997 |
| A DNA expression vector capable, in a transformant strain of yeast, of expressing a biologically competent polypeptide ordinarily exogenous to yeast under the control of a genetically distinct yeast promoter, the polypeptide not being required for the growth of the transformant; the |
| 5607862 |
Assay for N-terminal type I collagen telopeptide that survives bone resorption in vivo |
March 4, 1997 |
| A method for assaying bone resorption rates which consists of quantitating the concentration of peptide fragments derived from bone collagen, found in a body fluid is disclosed. The method includes immunometric assay, fluorometric assay and electrochemical titration. The structure of |
| 5601989 |
Immune reactivity to expressed activated oncogenes for diagnosis and treatment of malignancy |
February 11, 1997 |
| Methods for the detection, monitoring and treatment of malignancies are disclosed. Detection of the proliferation of T cells in response to in vitro exposure to a protein expression product of an activated oncogene or cancer-related gene associated with a malignancy, or detection of |
