| Patent Number |
Title Of Patent |
Date Issued |
| 6030785 |
Screening methods to identify agents that selectively inhibit hepatitis C virus replication |
February 29, 2000 |
| The present invention relates to novel methods for identifying antiviral agents which selectively interfere with viral proteins that override the interferon(IFN)-induced cellular defense mechanisms against viral infection. In particular, the present invention relates to screening ass |
| 6028189 |
Solvent for oligonucleotide synthesis and methods of use |
February 22, 2000 |
| The invention provides methods for assembling arrays of oligonucleotides on a solid support, wherein the arrays can optionally be removed from the support after assembly. The invention also provides a solvent suitable for automated assembly of arrays of oligonucleotides. |
| 6023742 |
Reconfigurable computing architecture for providing pipelined data paths |
February 8, 2000 |
| A configurable computing architecture (10) has its functionality controlled by a combination of static and dynamic control, wherein the configuration is referred to as static control and instructions are referred to as dynamic control. A reconfigurable data path (12) has a plurality of |
| 6022542 |
Glycoprotein B of the RFHV/KSHV subfamily of herpes viruses |
February 8, 2000 |
| This invention relates to polynucleotides encoding Glycoprotein B from the RFHV/KSHV subfamily of gamma herpes viruses, three members of which are characterized in detail. DNA extracts were obtained from Macaque nemestrina and Macaque mulatta monkeys affected with retroperitoneal fib |
| 6017693 |
Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry |
January 25, 2000 |
| A method for correlating a peptide fragment mass spectrum with amino acid sequences derived from a database is provided. A peptide is analyzed by a tandem mass spectrometer to yield a peptide fragment mass spectrum. A protein sequence database or a nucleotide sequence database is used to |
| 6014513 |
Discovering code and data in a binary executable program |
January 11, 2000 |
| A computer software tool used for automatically identifying code portions and data portions of a binary executable software program in which the code portions include machine instructions that are of arbitrary length. Software products are typically distributed as binary, executable file |
| 6007775 |
Multiple analyte diffusion based chemical sensor |
December 28, 1999 |
| The present invention provides a microfabricated sensor and a method capable of rapid simultaneous measurement of multiple analytes in a fluid sample. The sensor is inexpensive, disposable and portable, and requires only microliters of sample, a particular advantage with precious fluids |
| 6007499 |
Method and apparatus for medical procedures using high-intensity focused ultrasound |
December 28, 1999 |
| Methods and apparatus for enabling substantially bloodless surgery and for stemming hemorrhaging. High intensity focused ultrasound ("HIFU") is used to form cauterized tissue regions prior to surgical incision, for example, forming a cauterized tissue shell around a tumor to be removed. |
| 6003678 |
Particle separating apparatus and method |
December 21, 1999 |
| A disposable first tube (68) extends axially through, and is detachably connected to, an annular main body (10'). An input piezo electric element (38) is attached to a first end of the tubular main body (10'). A second, sensor piezo electric element (40) is attached to the opposite end o |
| 6003624 |
Stabilizing wheeled passenger carrier capable of traversing stairs |
December 21, 1999 |
| A double-inverted wheeled passenger carrier (WPC) that is actively stabilizing on two or more axially-spaced wheels through a controller that senses and adjusts three degrees of freedom that allows the WPC to actively stabilize itself to keep a passenger essentially upright during mo |
| 5998588 |
Interactive molecular conjugates |
December 7, 1999 |
| The combination of the capabilities of stimuli-responsive components such as polymers and interactive molecules to form site-specific conjugates which are useful in a variety of assays, separations, processing, and other uses is disclosed. The polymer chain conformation and volume can be |
| 5995264 |
Counter balanced optical scanner |
November 30, 1999 |
| The scanner includes a first spring plate and a second spring plate of common size and shape symmetrically aligned and spaced. A first reflective surface is located at an end of first spring plate. A counter balance mass is located at a corresponding end of the second spring plate. The f |
| 5991048 |
Surface plasmon resonance light pipe sensor |
November 23, 1999 |
| The present invention provides SPR sensors in which the sensing element is a planar lightpipe. The sensors of this invention include configurations which employ multiwavelength light incident on the SPR sensing area at a single angle or at a range of angles. Sensors of this invention als |
| 5989537 |
Methods for stimulating granulocyte/macrophage lineage using thrombopoietin |
November 23, 1999 |
| Methods for stimulating granulocyte/macrophage lineage cells using thrombopoiet in are provided. The methods provided may be used to stimulate granulocyte/macrophage progenitors and neutrophils in bone marrow and peripheral blood cells and in vitro and in vivo. In addition, methods f |
| 5982924 |
Method and system for reproducing color images as duotones |
November 9, 1999 |
| A full color process image that can be printed with cyan, magenta, yellow, and black inks is produced as a duotone image using only two colors of ink. Color data defining the colors used in the full color image serve as input to a process that maps the colors into a duotone gamut defined |
| 5982555 |
Virtual retinal display with eye tracking |
November 9, 1999 |
| Light emitted from a virtual retinal display light source passes through a beamsplitter to a scanning subsystem and on to an eyepiece and the viewer's eye. Some of the light is reflected from the viewer's eye passing back along the same path. Such light however is deflected at the be |
| 5982528 |
Optical scanner having piezoelectric drive |
November 9, 1999 |
| A piezoelectric circuit drives mirror movement along a scan path. The scanner includes a support, a reflective surface and a piezoelectric circuit. The support alternately rotates about an axis of rotation in a first direction and a second direction. The reflective surface moves with |
| 5980886 |
Recombinant vectors for reconstitution of liver |
November 9, 1999 |
| A combination of retroviral and adenoviral vectors are used for high efficiency gene transfer into hepatocytes, resulting in long term gene expression. Hepatocytes are transduced in vivo with a recombinant adenovirus vector that expresses a molecule capable of inducing hepatocyte reg |
| 5974867 |
Method for determining concentration of a laminar sample stream |
November 2, 1999 |
| Methods and apparatuses including programmed computers are provided for determining the initial concentration of diffusible particles in a sample stream introduced into a system wherein the sample stream which contains the diffusible particles flows in adjacent laminar flow with an indic |
| 5972710 |
Microfabricated diffusion-based chemical sensor |
October 26, 1999 |
| A channel-cell system is provided for detecting the presence and/or measuring the presence of analyte particles in a sample stream comprising: a) a laminar flow channel; b) two inlets in fluid connection with the laminar flow channel for respectively conducting into the laminar flow |
| 5971158 |
Absorption-enhanced differential extraction device |
October 26, 1999 |
| This invention provides an extraction device and a method for extracting desired particles from a sample stream containing the desired particles. The device has a sample stream inlet, an extraction stream inlet, and an extraction channel in fluid communication with the sample stream inle |
| 5969871 |
Virtual retinal display with lens array for expanding exit pupil |
October 19, 1999 |
| A display device is achieved using a simplified optical system which generates an expanded exit pupil without compromising magnification or resolution. Modulated light from a source is converged toward a focal point by an optics subsystem. A scanning subsystem deflects the converging |
| 5965642 |
Acrylic and fluoroacrylic polymers for oxygen pressure sensing and pressure-sensitive paints uti |
October 12, 1999 |
| The preparation and use of acrylic and fluoroacrylic polymers suitable for luminescence oxygen sensing applications are described. These materials can be used in luminophor coatings for optical fiber sensors or as coatings on aerodynamic surfaces for wind tunnel study. Compositions c |
| 5953534 |
Environment manipulation for executing modified executable and dynamically-loaded library files |
September 14, 1999 |
| A method and procedure for modifying modules comprising a binary executable software program in such a way that, despite the transformations performed and the creation of new versions of the modules, the transformed program appears (to that program, including all of its components) as if |
| 5948684 |
Simultaneous analyte determination and reference balancing in reference T-sensor devices |
September 7, 1999 |
| A reference T-sensor system is provided for detecting the presence and/or measuring the concentration of analyte particles in a sample stream. The system includes: a) a laminar flow channel; b) three or more inlet means in fluid connection with the laminar flow channel for respectively |
| 5937341 |
Simplified high frequency tuner and tuning method |
August 10, 1999 |
| An RF tuner and tuning method employs analog quadrature mixing with a coarse-stepwise tunable local oscillator to a near-baseband passband region, followed by A/D conversion of the I and Q signals, correction of phase, group delay, and amplitude errors, image rejection, and translation |
| 5932100 |
Microfabricated differential extraction device and method |
August 3, 1999 |
| This invention provides a microfabricated extraction system and methods for extracting desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effec |
| 5928239 |
Percutaneous surgical cavitation device and method |
July 27, 1999 |
| A device and method for percutaneous surgical cavitation. The device includes an elongated shaft and cutting tip interconnected by a freely-rotating hinge. Upon rotation of the shaft to a sufficient velocity, the cutting tip will be deflected toward a position that is angularly offse |
| 5925733 |
DNA polymerase of gamma herpes viruses associated with Kaposi's sarcoma and retroperitoneal fibr |
July 20, 1999 |
| This invention provides isolated polynucleotides encoding DNA polymerases of three members of a subfamily of gamma herpes viruses. Two were obtained from macaque monkeys affected with retroperitoneal fibromatosis, the other from human AIDS patients affected with Kaposi's sarcoma. A 454-b |
| 5922210 |
Tangential flow planar microfabricated fluid filter and method of using thereof |
July 13, 1999 |
| A microfilter utilizing the principles of tangential flow to prevent clogging, and sloped channel sides to overcome surface tension effects is provided which has feed inlet and exit connected by a feed flow channel, a barrier channel parallel to the feed flow channel, and a filtrate |
| 5913591 |
Augmented imaging using a silhouette to improve contrast |
June 22, 1999 |
| An augmented display includes an image display source and a silhouette display source. The image display source generates a virtual image to be perceived by a viewer. The silhouette display source occurs in the path of the background light. The silhouette display source generates a mask |
| 5911882 |
Removing contaminants from water using iron oxide coated mineral having olivine structure |
June 15, 1999 |
| Adsorbent media are prepared by contacting support material with iron containing solutions, followed by drying to coat the support material with iron. Support material such as sand and olivine are described. The adsorbent material can be used to remove metal contaminants and natural |
| 5903397 |
Display with multi-surface eyepiece |
May 11, 1999 |
| An augmented retinal scanning display device includes a multi-functional eyepiece. One function is to direct an image beam onto a viewer's eye. Another function is to correct the vision of the viewer's eye. The display is worn by a viewing person. The eyepiece includes a reflective surfa |
| 5902238 |
Medical tube and apparatus for locating the same in the body of a patient |
May 11, 1999 |
| A medical tube, apparatus and method for locating the medical tube within the body of a patient. The medical tube has a permanent magnet associated therewith and is capable of being located by a detection apparatus which senses the static magnetic field strength gradient generated by the |
| 5892437 |
On-board brake warning device for air brake equipped vehicles |
April 6, 1999 |
| A brake warning system for vehicles with pneumatic air brakes monitors various factors to provide an indication of a pending or actual brake failure condition. According to one embodiment, vehicle brakes are tested by determining a delay time between pressure changes in a control brake |
| 5891857 |
Characterized BRCA1 and BRCA2 proteins and screening and therapeutic methods based on characteri |
April 6, 1999 |
| Genetic analysis of familial breast and ovarian cancer indicates that BRCA1 is a tumor suppressor gene. The BRCA1 gene encodes a 190 kDa protein with sequence homology and biochemical analogy to the granin family of proteins. Granins are secreted from endocrine cells via the regulated |
| 5890802 |
Piezo-ceramic actuator-driven mixing device |
April 6, 1999 |
| A device and method for mixing an aspirated fluid slug (40), such as a DNA sample and reagent, within a capillary tube (28) through the electrical deflection of a diaphragm, such as a piezo-ceramic disk (12). The device (10) includes first and second mounting plates (16, 18). The piezo-c |
| 5889524 |
Reconstruction of three-dimensional objects using labeled piecewise smooth subdivision surfaces |
March 30, 1999 |
| A method is disclosed for reconstructing a surface of an object using three-dimensional imaging data. While the method can be applied to reconstruct the surface of almost any object represented by three-dimensional data obtained by some imaging modality, an example of the technique i |
| 5877010 |
Thymidine kinase mutants |
March 2, 1999 |
| The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encoding an amino acid substitution upstream from a DRH nucleoside binding site which increases a biological act |
| 5876712 |
Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the |
March 2, 1999 |
| Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or det |
| 5876187 |
Micropumps with fixed valves |
March 2, 1999 |
| Micropumps fabricated by micromachining techniques and employing fixed or no-moving-parts valves. As one aspect of the invention, a laser-assisted chemical etching technique is employed for providing smooth-walled, curved configuration necessary to obtain the desired flow characteristics |
| 5874291 |
Degradation of environmental toxins by a filamentous bacterium |
February 23, 1999 |
| This invention pertains to substantially purified cultures of a gram-negative, aerobic, filamentous bacterium with cells ranging in length from 20-200 .mu.m, that accumulates intracellular poly-.beta.-hydroxybutyrate in intracellular granules, and that degrades chlorinated aliphatic |
| 5869832 |
Device and method for forming ions |
February 9, 1999 |
| A device and method for forming ions by inductive ionization is disclosed. The device is an ion source that includes a capacitor having a pair of electrodes separated by a dielectric material. The method of the invention uses the capacitor-based ion source to form positive and negative i |
| 5869465 |
Methods of receptor modulation and uses therefor |
February 9, 1999 |
| Receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are utilized for the treatment and diagnosis of a variety of disorders in warm-blooded animals, including neoplastic disorders. The receptor modulating agent |
| 5869445 |
Methods for eliciting or enhancing reactivity to HER-2/neu protein |
February 9, 1999 |
| Compounds and compositions for eliciting or enhancing immune reactivity to HER-2/neu protein are disclosed. The compounds include polypeptides and nucleic acid molecules encoding such peptides. The compounds may be used for the prevention or treatment of malignancies in which the HER-2/n |
| 5866338 |
Cell cycle checkpoint genes |
February 2, 1999 |
| Human checkpoint huCDC34, huRAD9.sub.compA, and huRAD9.sub.compB cDNAs shown in FIGS. 1, 2, and 3. A method for isolating a human checkpoint cDNA that is capable of restoring growth at a restrictive temperature in a yeast test cell, wherein the yeast test cell comprises a genome having a |
| 5858967 |
Appetite supression factor and related methods |
January 12, 1999 |
| Methods for identifying factors that regulate appetite are disclosed. Preferably, the methods feature determinination of decreased food consumption in selected recipient mammals following administration of a test sample. A product having appetite suppressing activity is also describe |
| 5858799 |
Surface plasmon resonance chemical electrode |
January 12, 1999 |
| This disclosure describes new methods and devices for sensing redox-active analytes in solution. The invention combines a surface plasmon resonance (SPR) sensor and a chemical electrode sensor. A conducting layer which supports SPR is attached to a voltage source. The voltage source is a |
| 5851536 |
Therapeutic delivery using compounds self-assembled into high axial ratio microstructures |
December 22, 1998 |
| Therapeutic agents comprising plural therapeutic compounds self assembled into high axial ratio microstructures are described. The threapeutic compounds satisfy the formula HARFM-Th, wherein HARFM is a high axial ratio forming material and Th is a therapeutic associated with the HARFM. |
| 5847712 |
Method and system for generating graphic illustrations according to a stroke texture and a tone |
December 8, 1998 |
| A method and apparatus for generating an illustration having the steps of inputting a plurality of strokes in an area having a designated dimension, assigning a texture and tone to the area, where the tone determines the nature and quantity of the plurality of strokes, generating the tex |
