| Patent Number |
Title Of Patent |
Date Issued |
| 6174160 |
Staged prevaporizer-premixer |
January 16, 2001 |
| Method and apparatus to prevaporize and premix liquid and/or gaseous fuels with air in two stages at two different temperatures prior to combustion. The invention is directed to the entry of a finely atomized liquid fuel, such as No. 2 diesel, into an inlet end of an annular chamber. Air |
| 6171865 |
Simultaneous analyte determination and reference balancing in reference T-sensor devices |
January 9, 2001 |
| A reference sensor system is provided for detecting the presence and/or measuring the concentration of analyte particles in a sample stream. The system includes: a) a laminar flow channel; b) three or more inlet means in fluid connection with the laminar flow channel for respectively |
| 6171577 |
Radiolabeled annexins |
January 9, 2001 |
| Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeleci annexin conjugates are also provided. |
| 6167490 |
Using global memory information to manage memory in a computer network |
December 26, 2000 |
| A system and method for managing memory in a network. In a computer network in which multiple computers (nodes) are interconnected by a network, the primary memory on one node may be used to store memory data (pages)from other nodes. The transfer of a data page over the network from the |
| 6166841 |
Counter balanced optical scanner |
December 26, 2000 |
| The scanner includes a first spring plate and a second spring plate of common size and shape symmetrically aligned and spaced. A first reflective surface is located at an end of first spring plate. A counter balance mass is located at a corresponding end of the second spring plate. The f |
| 6165750 |
Modified-affinity streptavidin |
December 26, 2000 |
| Streptavidin tetramers have at least one monomer containing an amino acid modification that produces a reduced binding affinity for biotin, a modified off-rate, a modified on-rate, or an altered binding enthalpy. Polynucleotides encoding the modified monomers are also provided. The m |
| 6165509 |
Pegylated drug complexed with bioadhesive polymer suitable for drug delivery and methods relatin |
December 26, 2000 |
| PEGylated drugs complexed with bioadhesive polymers, wherein the PEGylated drugs comprise a polyethylene glycol covalently bonded to the drugs are disclosed. The PEGylated drug/bioadhesive polyner complex and compositions thereof may be topically administered to body fluids or mucosal ti |
| 6160095 |
Proteins capable of regulating NF-.kappa.B, JNK and apoptosis pathways and methods of using the |
December 12, 2000 |
| Testing methods are provided for determining whether given candidate compounds are effective for regulating NF-.kappa.B, JNK and apoptosis cell activities. The methods involve forming a mixture including a compound such as a proteinaceous specie containing two death effector domains |
| 6159739 |
Device and method for 3-dimensional alignment of particles in microfabricated flow channels |
December 12, 2000 |
| The present invention provides a sheath flow module made from a first plate of material having formed therein a laminar fluid flow channel; at least two inlets, each inlet joining the laminar flow channel at a junction, the first inlet junction being wider than the second inlet junction, |
| 6157352 |
Virtual retinal display with expanded exit pupil |
December 5, 2000 |
| A display device is achieved using a simplified optical system which generates an expanded exit pupil without compromising magnification or resolution. Modulated light from a source is converged toward a focal point by an optics subsystem. A scanning subsystem deflects the converging |
| 6156493 |
Modified-affinity streptavidin |
December 5, 2000 |
| Streptavidin tetramers have at least one monomer containing an amino acid modification that produces a reduced binding affinity for biotin, a modified off-rate, a modified on-rate, or an altered binding enthalpy. Polynucleotides encoding the modified monomers are also provided. The m |
| 6156303 |
Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom |
December 5, 2000 |
| The present invention provides isolated adenovirus-associated viruses ("AAV"), including AAV isolates designated AAV3B and AAV6. The invention also provides nucleic acid molecules of AAV3B (SEQ ID NO: 1) or AAV6 (SEQ ID NO: 2), including DNA or RNA, and provides substantially purified |
| 6154321 |
Virtual retinal display with eye tracking |
November 28, 2000 |
| Light emitted from a virtual retinal display light source passes through a beamsplitter to a scanning subsystem and on to an eyepiece and the viewer's eye. Some of the light is reflected from the viewer's eye passing back along the same path. Such light however is deflected at the be |
| 6150568 |
Valiolone, a method of preparing it, and its use to prepare acarbose and voglibose |
November 21, 2000 |
| Disclosed is the compound valiolone, which has the formula (I): ##STR1## a method of preparing valiolone, and a method of using valiolone to prepare acarbose and voglibose. |
| 6149903 |
Characterized BRCA1 and BRCA2 proteins and screening and therapeutic methods based on characteri |
November 21, 2000 |
| Genetic analysis of familial breast and ovarian cancer indicates that BRCA1 is a tumor suppressor gene. The BRCA1 gene encodes a 190 kDa protein with sequence homology and biochemical analogy to the granin family of proteins. Granins are secreted from endocrine cells via the regulated |
| 6145121 |
Trace based method for the analysis, benchmarking and tuning of object oriented databases and ap |
November 7, 2000 |
| A system and a method is disclosed for analyzing, benchmarking and tuning an object oriented database (OODB) and applications with a trace based technique. Code associated with the application is augmented with a plurality of instructions that define the production of an application |
| 6136952 |
Human jagged polypeptide, encoding nucleic acids and methods of use |
October 24, 2000 |
| The present invention provides an isolated polypeptide exhibiting substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the polypeptide does not have the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. The invention further provides an |
| 6136272 |
Device for rapidly joining and splitting fluid layers |
October 24, 2000 |
| A device and method for introducing a second laminar fluid layer to, or removing a second laminar fluid layer from, a first laminar fluid layer are provided. Each laminar fluid layer can contain two or more side by side laminar streams. The device includes a main flow channel, and at |
| 6134950 |
Method for determining concentration of a laminar sample stream |
October 24, 2000 |
| A method and apparatus including programmed computers are provided for determining the viscosity of a first stream in a laminar flow and a second stream in a laminar flow, the flow rates, the centerline of the flow channel, and the position of the interface between the streams with r |
| 6133921 |
Constructing shape skeletons of 3D objects using generalized Voronoi diagrams |
October 17, 2000 |
| Starting with a solid model of a 3D object, an accurate skeleton is produced by minimizing internal and edge errors of an initial approximate skeleton. To produce the initial approximate skeleton, the boundary of the solid is densely sampled to obtain a set of surface data points. Delaun |
| 6133044 |
High speed flow cytometer droplet formation system and method |
October 17, 2000 |
| A droplet forming flow cytometer system allows high speed processing without the need for high oscillator drive powers through the inclusion of an oscillator or piezoelectric crystal such as within the nozzle volume or otherwise unidirectionally coupled to the sheath fluid. The nozzle |
| 6132989 |
Methods and compositions for enhanced stability of non-adenoviral DNA |
October 17, 2000 |
| The invention provides compositions of a non-adenoviral vector containing a polynucleotide sequence encoding adenoviral pTP operationally linked domain. The invention also provides compositions of an adenoviral pTP binding domain. The invention also provides methods for increasing the |
| 6132776 |
Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase a |
October 17, 2000 |
| Methods and compositions related to HIV are disclosed. Using the methods of the present invention, nucleoside analogs may be screened for the ability to be incorporated by reverse transcriptase of human immunodeficiency virus ("HIV RT") and cause incorrect base pairing. Progressive mutat |
| 6132728 |
Hedgehog-derived polypeptides |
October 17, 2000 |
| The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G.sup..dwnarw. CF site recognized by the autoproteolytic domain in the nat |
| 6130036 |
Methods and compositions for screening for anti-AIDS drugs |
October 10, 2000 |
| Methods and compositions related to AIDS are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to inhibit reverse transcriptase of human immunodeficiency virus ("HIV RT"). Active HIV RT mutants may be detected by the disclosed |
| 6113792 |
Method for removing contaminants from water using membrane filtration in combination with partic |
September 5, 2000 |
| Heated iron oxide particles are combined with membrane filtration to remove contaminants from water. The use of the heated particles reduces fouling of the membrane typically encountered when membranes alone are used to remove contaminants from water. The heated particles of iron oxide a |
| 6110354 |
Microband electrode arrays |
August 29, 2000 |
| The present invention provides microband electrode array sensors for detecting the presence and measuring the concentration of analytes in a sample. The microband electrodes of the invention have both a width and a thickness of microscopic dimensions. Preferably the width and thickness o |
| 6107028 |
Ribozymes for treating hepatitis C |
August 22, 2000 |
| A method of inhibiting hepatitis C virus RNA replication or expression is provided. The method consists of introducing two or more ribozymes specific for hepatitis C virus RNA into a cell infected with hepatitis C virus. The ribozymes specific for hepatitis C virus RNA can specifically |
| 6107027 |
Ribozymes for treating hepatitis C |
August 22, 2000 |
| Adenoviral vectors are used for high efficiency transduction of ribozymes specific for hepatitis C virus RNA. Hepatocytes are transduced with a recombinant adenovirus vector that expresses a ribozyme capable of specifically cleaving HCV RNA. The compositions and methods thus provide |
| 6106466 |
Automated delineation of heart contours from images using reconstruction-based modeling |
August 22, 2000 |
| A method for defining a three-dimensional surface of at least a portion of a patient's heart, based on data obtained by ultrasound imaging of the heart. The imaging is carried out over at least one cardiac cycle and provides a plurality of images in different image planes made with an |
| 6102249 |
Jam resistant dispenser for capillary tubes and the like |
August 15, 2000 |
| A jam resistant dispenser (10) including a storage housing (14) of a size and shape to store and dispense a plurality of substantially identical cylindrical members (12), preferably, capillary tubes for gene sequencing reactions and other chemical/biological processes. Housing (14) inclu |
| 6099830 |
Methods for stimulating erythropoiesis using hematopoietic proteins |
August 8, 2000 |
| Methods for stimulating erythropoiesis using the hematopoietic protein thrombopoietin, optionally in combination with erythropoietin, are provided. The methods provided may be used to stimulate erythropoiesis in bone marrow and peripheral blood cells and in vitro and in vivo. In addi |
| 6097353 |
Augmented retinal display with view tracking and data positioning |
August 1, 2000 |
| A scanned beam tracking system is included in a virtual retinal display. An infrared light source generates light for scanning the viewer's environment in the direction the viewer is looking. A visible light source generates visible light which is scanned on a viewer's retina to generate |
| 6094199 |
3D objects morphing employing skeletons indicating symmetric differences to define intermediate |
July 25, 2000 |
| The present invention provides a unified, automated approach to 3D object interpolation and 3D morphing based on a geometric descriptor known as the skeleton. The skeleton of an object consists of the closure of the set of points minimally equidistant from two points on the object's boun |
| 6092175 |
Shared register storage mechanisms for multithreaded computer systems with out-of-order executio |
July 18, 2000 |
| A method and organization for implementing the registers required in a computer system supporting multithreading and dynamic out-of-order execution. Multithreaded computer systems are those in which the processor supports multiple contexts (threads), and either rapid context switching |
| 6090631 |
Methods and compositions for screening for presynaptic calcium channel blockers |
July 18, 2000 |
| Methods and compositions related to the identification of compounds that block neurotransmitter release are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to bind to presynaptic calcium channels such that the docking of presynap |
| 6090620 |
Genes and gene products related to Werner's syndrome |
July 18, 2000 |
| The present invention discloses nucleic acid molecules encoding WRN gene products, expresion vectors, viral vectors, and host cells suitable for expressing such products. |
| 6075122 |
Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the |
June 13, 2000 |
| Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or det |
| 6069725 |
Position detection of mechanical resonant scanner mirror |
May 30, 2000 |
| Two piezoelectric sensors are mounted on the back of a spring-plate of a mechanical resonance scanner on respective sides of a center line coinciding with an axis of rotation. As the scanner mirror rotates back and forth the two sensors are accelerated and decelerated at a 180.degree. |
| 6067157 |
Dual large angle light scattering detection |
May 23, 2000 |
| An optical analyzer with a configuration particularly suitable for use with planar liquid sample flow cells is provided comprising a polarized light source and at least two large angle scattered light photodetectors positioned respectively at acute, and right or oblique angles to the |
| 6063628 |
Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
May 16, 2000 |
| The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including HIV and HCV, or a virus which otherwise replicates through an RNA intermediate. The increase in the mutation rate of the virus results in reduce |
| 6061163 |
Position detection of mechanical resonant scanner mirror |
May 9, 2000 |
| Two piezoelectric sensors are mounted on the back of a spring-plate of a mechanical resonance scanner on respective sides of a center line coinciding with an axis of rotation. As the scanner mirror rotates back and forth the two sensors are accelerated and decelerated at a 180.degree. |
| 6049407 |
Piezoelectric scanner |
April 11, 2000 |
| A first piezoelectric actuator is located on a first support of a mirror. The first support is elongated having a first portion to one edge of the mirror and a second portion to an opposite edge of the mirror. The actuator drives mirror movement about a first axis of rotation which is |
| 6047980 |
Two-speed manual wheelchair |
April 11, 2000 |
| A manual two-speed wheelchair having a chair, frame, fixed wheel axles, and wheel assemblies. The wheelchair is capable of driving in a direct (1:1) power mode and a lower gear mode without shifting. A separate secondary input assembly provides for reduced gearing, one secondary input ri |
| 6046720 |
Point source scanning apparatus and method |
April 4, 2000 |
| A scanning display device directly scans a light source along at least one scanning path, rather than scanning a light beam emitted from such source along such scanning path. By scanning the light source a smaller, lighter weight scanner without a mirror can be used to achieve light sour |
| 6043799 |
Virtual retinal display with scanner array for generating multiple exit pupils |
March 28, 2000 |
| A scanned retinal display includes an optical scanning array to generate multiple exit pupils in conjunction with an eyepiece. The multiple exit pupils expand the effective exit pupil. As a user moves their eye the eye moves from one exit pupil to another. A scanning array creates the |
| 6042556 |
Method for determining phase advancement of transducer elements in high intensity focused ultras |
March 28, 2000 |
| Phase of each transducer element of a high intensity focused (HIFU) transducer array is controlled to compensate for phase change introduced by varying velocity through differing tissue along a path towards a treatment volume. The echo of a specific harmonic of ultrasound pulses of m |
| 6040421 |
Escherichia coli O157:H7 epithelial adhesion and vaccine |
March 21, 2000 |
| Polypeptides encoded by a continuous segment of chromosomal DNA from E. coli O157:H7, isolated on plasmid pSC(overlap) (ATCC No. 69648), that encodes an adhesin (SEQ ID NO:5) that mediates bacterial colonization of bovine intestines, vaccines derived therefrom, and antibodies directed |
| 6039897 |
Multiple patterned structures on a single substrate fabricated by elastomeric micro-molding tech |
March 21, 2000 |
| A method for patterning a material onto a substrate including the steps of: providing a micro-mold having a plurality of non-communicating independent channels and having a plurality of reservoirs for receiving a micro-molding fluid each of which reservoirs communicates with a channel, |
| 6037327 |
Specific saccharide compositions and methods for treating Alzheimer's disease and other amyloido |
March 14, 2000 |
| A pharmaceutical agent for treating an amyloid disease in a patient, wherein the pharmaceutical agent comprises a saccharide containing at least one substituted anionic group, or a pharmaceutically acceptable salt of the saccharide containing at least one substituted anionic group, and |
