| Patent Number |
Title Of Patent |
Date Issued |
| RE34153 |
Molecular gas analysis by Raman scattering in intracavity laser configuration |
December 29, 1992 |
| The concentration of multiple polyatomic gases are determined almost simultaneously by Raman scattering. The gas sample is placed in a sampling cell located in the resonance cavity of a laser and a polarized laser beam having sufficient intensity to produce detectable signals of Raman |
| RE32779 |
Radiographic systems employing multi-linear arrays of electronic radiation detectors |
November 8, 1988 |
| A scanning radiographic system employing a multi-linear array. The system includes a source of electronic radiation, which is focused upon the multi-linear array. The multi-linear array includes radiation sensors each of which is adapted to generate an intensity signal as a function of t |
| 7387997 |
.alpha.-conotoxin MII analogues |
June 17, 2008 |
| The invention relates to novel conopeptides and/or novel Luses of conopeptides. The conopeptides of the invention are analogs of .alpha.-Conotoxin MII that are selective for .alpha.6-containing nAChRs as described herein. |
| 7324899 |
Geophysical technique for mineral exploration and discrimination based on electromagnetic method |
January 29, 2008 |
| Mineral exploration needs a reliable method to distinguish between uneconomic mineral deposits and economic mineralization. A method and system includes a geophysical technique for subsurface material characterization, mineral exploration and mineral discrimination. The technique int |
| 7314713 |
Obesity gene and use thereof |
January 1, 2008 |
| The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human obesity and diabetes predisposing gene, specifically the TBC1D1 gene, some mutant alleles of which cause sus |
| 7196244 |
Method of transposon-mediated mutagenesis in the nematode caenorhabditis elegans |
March 27, 2007 |
| The present invention provides methods for generating and identifying mutations in Caenorhabditis elegans. Disclosed herein are methods for introducing DNA into the C. elegans germline, methods for expressing DNA in the C. elegans germline, and methods for generating C. elegans mutants |
| 7158903 |
Methods for quantitative analysis by tandem mass spectrometry |
January 2, 2007 |
| The present invention provides methods for high throughput analysis of analytes in complex mixtures for unresolved chromatographic peaks including specific embodiment for summing intensities for each mass transition of interest over a selected chromatographic peak (50) to generate a |
| 6943359 |
Structured organic materials and devices using low-energy particle beams |
September 13, 2005 |
| Organic materials exposed to an electron beam for patterning a substrate (1) to make an optoelectronic organic device which includes a source, a drain, gate dielectric layer (4), and a substrate for emitting light. |
| 6804967 |
High frequency thermoacoustic refrigerator |
October 19, 2004 |
| A thermoacoustic refrigerator having a relatively small size which utilizes one or more piezoelectric drivers to generate high frequency sound within a resonator at a frequency of between about 4000 Hz and ultrasonic frequencies. The interaction of the high frequency sound with one or mo |
| 6586180 |
Directed antisense libraries |
July 1, 2003 |
| A method for making a directed antisense library against a target transcript is described. A cDNA of the target transcript is cloned in an appropriate cloning vector. Next, a plurality of deletion derivatives of the cloned cDNA is prepared such that the deletions serially extend into |
| 6574968 |
High frequency thermoacoustic refrigerator |
June 10, 2003 |
| A thermoacoustic refrigerator having a relatively small size which utilizes one or more piezoelectric drivers to generate high frequency sound within a resonator at a frequency of between about 4000 Hz and ultrasonic frequencies. The interaction of the high frequency sound with one or mo |
| 6571524 |
Interconnection of building panels using fiber reinforced plastic composite-material connector p |
June 3, 2003 |
| Cementitious building panels are connected together using a connector plate made of a composite material of carbon fibers embedded in an organic matrix. The interconnection is made by removing cementitious material to form recesses in the building panels, applying an adhesive material in |
| 6537285 |
Spiral cervical retractor apparatus |
March 25, 2003 |
| A spiral cervical retraction apparatus is provided to straighten out the canal to the uterus during a medical procedure which allows for placement of instruments into the cavity of the uterus such as artificial insemination devices, curettes, biopsy instruments, and radiologic devices |
| 6432319 |
Method for improving the efficiency of absorption heat pumps using a crystallization-inhibiting |
August 13, 2002 |
| An absorption heat pump achieves improved efficiency by lowering the low cycle temperature of the circulation fluid. This is accomplished by adding a crystallization-inhibiting compound to the circulation fluid which substantially depresses the temperature at which the absorbent salt in |
| 6413727 |
Diagnosis for mutant APC by immunoassay |
July 2, 2002 |
| A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most no |
| 6340746 |
Prodrugs and conjugates of thiol- and selenol- containing compounds and methods of use thereof |
January 22, 2002 |
| Disclosed are prodrugs as follows:(I) a prodrug of the formula ##STR1##where A is a sulfur or a selenium, and R is a mono- di- or oligo-saccharide;(II) a prodrug of the formula ##STR2##where A is sulfur or selenium, R' is a sugar, or .dbd.O, and the R" groups are hydrogen, alkyl, alk |
| 6316258 |
Methods for preventing and treating fibrotic diseases resulting from accumulation of excess extr |
November 13, 2001 |
| The present invention is methods for inhibiting the renin-induced production of TGF.beta. using a renin inhibitory agent to reduce excess accumulation of extracellular matrix in tissue in a subject, and to the use of renin inhibitory agents and additional TGF.beta. inhibitory agents |
| 6219187 |
Laser beam coupler shaper and collimator |
April 17, 2001 |
| An apparatus for providing improved high power laser beams. An elongated reflector with a highly-reflective inner surface is utilized with a laser beam emitter, such as a broad area diode laser, a diode laser bar, or a diode laser array. The laser beams disperse and reflect off of the |
| 6205354 |
Method and apparatus for noninvasive measurement of carotenoids and related chemical substances |
March 20, 2001 |
| A method and apparatus are provided for the determination of levels of carotenoids and similar chemical compounds in biological tissue such as living skin. The method and apparatus provide a noninvasive, rapid, accurate, and safe determination of carotenoid levels which in turn can p |
| 6177025 |
Absorption heat pumps having improved efficiency using a crystallization-inhibiting additive |
January 23, 2001 |
| An absorption heat pump achieves improved efficiency by lowering the low cycle temperature of the circulation fluid. This is accomplished by adding a crystallization-inhibiting compound to the circulation fluid which substantially depresses the temperature at which the absorbent salt in |
| 6106725 |
Point-of-use removal of lead and copper in drinking water using hydroxylapatite and carbonate mi |
August 22, 2000 |
| A process for removing lead and copper from drinking water discharged from a drinking water outlet while suppressing the concentration of phosphate ions comprising directing the water through a matrix comprising phosphate mineral with a very low phosphate solubility, and a solid carbonat |
| 6087452 |
Metal-chelating surfacant |
July 11, 2000 |
| A modified surfactant of the PLURONIC.TM.-type compound and method for manufacture is disclosed. The surfactant compound has at least one PEO block attached at a first end to at least one PPO block, with at least one of the PEO block having an organic metal-chelating end group (R) attach |
| 6086242 |
Dual drive planetary mill |
July 11, 2000 |
| A mill for grinding and/or mixing a material. In one presently preferred embodiment of the present invention, the mill includes a first container rotatably mounted at a first end of a gyration arm. The container rotates about a first axis, and the gyration arm rotates about a second axis |
| 5988174 |
Method for coloring the skin |
November 23, 1999 |
| An apparatus and method are disclosed for marking the proper location of incisions to be made during a surgical procedure and for coloring the skin. The apparatus includes a pinwheel with a plurality of marking points extending therefrom for penetrating the outermost layer of the epiderm |
| 5976875 |
Diacylglycerol kinase isoforms epsilon and zeta and methods of use thereof |
November 2, 1999 |
| Two novel diacylglycerol kinase (DGK) isoforms are disclosed. The cDNA of one DGK isoform, designated DGK.epsilon., is about 2.6 kb in length. The DGK.epsilon. cDNA has an open reading frame encoding 567 amino acids and has a predicted molecular mass of 63 kDA. DAG kinase .epsilon. is hi |
| 5885780 |
Method of obtaining small conformationally rigid conopeptides |
March 23, 1999 |
| A method for separating, identifying and purifying small, conotoxin-like rigidly conformed peptides ("conopeptides") containing multiple Cys residues comprises forming a conoeffector library, each member of which has a nucleic acid encoding a potential conopeptide sequence. The conoe |
| 5761060 |
System and method for evaluating sign legibility |
June 2, 1998 |
| A method and apparatus are disclosed for using information about colors, fonts, and viewing distances to predict the legibility of a sign. The invention takes into account the colors used in the sign, in order to allow the use of many different color combinations while still avoiding |
| 5713890 |
Marking pen for coloring the skin |
February 3, 1998 |
| An apparatus and method are disclosed for marking the proper location of incisions to be made during a surgical procedure and for coloring the skin. The apparatus includes a pinwheel with a plurality of marking points extending therefrom for penetrating the outermost layer of the epiderm |
| 5693536 |
Gene therapy with MCC |
December 2, 1997 |
| A new human gene termed MCC is disclosed. Methods and kits are provided for assessing mutations of the MCC gene in human tissues and body samples. Gross rearrangement and point mutations in MCC are observed in human tumor cells. MCC is expressed in most normal tissues. These results sugg |
| 5691454 |
APC antibodies |
November 25, 1997 |
| A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most no |
| 5665240 |
Point-of-use removal of lead in drinking water using phosphate and carbonate minerals |
September 9, 1997 |
| A process for removing lead from drinking water discharged from a drinking water outlet comprising:(a) directing the water through a first matrix comprising a calcium mineral of between 10 and 100 weight percent of a solid calcium phosphate mineral which is slightly soluble in water, the |
| 5648212 |
Detection of inherited and somatic mutations of APC gene in colorectal cancer of humans |
July 15, 1997 |
| Methods are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. APC is a tumor suppressor. |
| 5645993 |
Deletion in chromosome 17p11.2-12 which causes the disorder hereditary neuropathy with liability |
July 8, 1997 |
| A method is disclosed for diagnosing Hereditary Neuropathy with Liability to Pressure Palsies (HNPP). A submicroscopic deletion of about 1.5 million basepairs on chromosome 17p11.2 is associated with the disorder in three unrelated pedigrees. The deletion includes all the markers known t |
| 5641462 |
Continuous solvent extraction with bottom gas injection |
June 24, 1997 |
| A method and apparatus for solvent extraction where the heavy and light phases are directed counter-currently into vertical mixing zones created by high-strength gas jets injecting gas up through the liquids to create an emulsion plume between the two liquids. The gas jets are at certain |
| 5639869 |
Mycoplasma arthritidis T-cell mitogen |
June 17, 1997 |
| A method of purifying Mycoplasma arthritidis mitogen (MAM) to electrophoretic and sequence homogeneity is disclosed. A preparation of MAM purified according to this method was used to determine the sequence of the N-terminal 54 amino acids of MAM. A synthetic peptide consisting of am |
| 5631153 |
Cells and non-human organisms containing predetermined genomic modifications and positive-negati |
May 20, 1997 |
| Positive-negative selector (PNS) vectors are provided for modifying a target DNA sequence contained in the genome of a target cell capable of homologous recombination. The vector comprises a first DNA sequence which contains at least one sequence portion which is substantially homologous |
| 5627059 |
Cells and non-human organisms containing predetermined genomic modifications and positive-negati |
May 6, 1997 |
| Positive-negative selector (PNS) vectors are provided for modifying a target DNA sequence contained in the genome of a target cell capable of homologous recombination. The vector comprises a first DNA sequence which contains at least one sequence portion which is substantially homologous |
| 5576422 |
MCC protein and antibody |
November 19, 1996 |
| A new human gene termed MCC is disclosed. Methods and kits are provided for assessing mutations of the MCC gene in human tissues and body samples. Gross rearrangement and point mutations in MCC are observed in human tumor cells. MCC is expressed in most normal tissues. These results sugg |
| 5571905 |
Gene mutated in colorectal cancer of humans |
November 5, 1996 |
| A new human gene termed MCC is disclosed. Methods, primers, probes and kits are provided for assessing mutations of the MCC gene in human tissues and body samples. Gross rearrangement and point mutations in MCC are observed in human tumor cells. MCC is expressed in most normal tissues. T |
| 5534260 |
Percutaneous drug delivery system |
July 9, 1996 |
| A percutaneous drug delivery method and enhancement composition are disclosed. The method comprises applying an enzyme preparation containing suitable amounts of non-enzyme permeation enhancers, such as lactam compounds (e.g. 1-substituted-azacycloheptan-2-one), and propylene glycol |
| 5529900 |
Direct genetic test for glucocorticoid-remediable aldosteronism |
June 25, 1996 |
| A method of screening for glucocorticoid remediable aldosteronism (GRA) in a mammal by detecting the presence or absence of a chimaeric gene duplication resulting from unequal crossing over of the 11, .beta.-hydroxylase and aldosterone synthase genes, or the product encoded by the ch |
| 5514182 |
Prosthetic joint with semipermeable capsule with reinforcing ribs |
May 7, 1996 |
| A prosthetic joint such as a hip prosthesis includes a semipermeable membrane to encapsulate articulating surfaces of the joint. The semipermeable membrane permits circulation of natural body fluid to the articulating surfaces of the joint for lubrication purposes, while preventing s |
| 5513867 |
Seat-lift wheelchair |
May 7, 1996 |
| A wheelchair includes a seat that pivots forward to assist the user in exiting and entering the chair. The seat is biased toward its forward or up-right position by mechanical springs having force adjustments for user adjustment of the seat-lift force. One embodiment includes a cam mecha |
| 5470710 |
Automated hybridization/imaging device for fluorescent multiplex DNA sequencing |
November 28, 1995 |
| A method is disclosed for automated multiplex sequencing of DNA with an integrated automated imaging hybridization chamber system. This system comprises an hybridization chamber device for mounting a membrane containing size-fractionated multiplex sequencing reaction products, appara |
| 5464535 |
Filter for on-line plasma sampling |
November 7, 1995 |
| A filter for use in the extracorporeal sampling of blood plasma is disclosed. The filter comprises a housing, an inlet, an outlet, and a sampling port and contains at least a hollow semi-permeable filter fiber through which blood plasma, but not whole blood, may pass. The filter may |
| 5389101 |
Apparatus and method for photogrammetric surgical localization |
February 14, 1995 |
| A method and apparatus for defining the location of a medical instrument relative to features of a medical workspace including a patient's body region are described. Pairs of two-dimensional images are obtained, preferably by means of two video cameras making images of the workspace |
| 5330892 |
MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans |
July 19, 1994 |
| A new human gene termed MCC is disclosed. Methods and kits are provided for assessing mutations of the MCC gene in human tissues and body samples. Gross rearrangement and point mutations in MCC are observed in human tumor cells. MCC is expressed in most normal tissues. These results sugg |
| 5308477 |
Method for coal liquefaction |
May 3, 1994 |
| A process is disclosed for coal liquefaction in which minute particles of coal in intimate contact with a hydrogenation catalyst and hydrogen arc reacted for a very short time at a temperature in excess of 400.degree. C. at a pressure of at least 1500 psi to yield over 50% liquids with a |
| 5296222 |
Percutaneous drug delivery system |
March 22, 1994 |
| A percutaneous drug delivery method and enhancement composition are disclosed. The method comprises applying an enzyme preparation containing suitable amounts of non-enzyme permeation enhancers, such as lactam compounds (e.g. 1-substituted-azacycloheptan-2-one), and propylene glycol |
| 5258453 |
Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light |
November 2, 1993 |
| Compositions for the treatment of cancerous tissues in warm-blooded animals containing both an anticancer drug and a photoactivatable drug attached to copolymeric carriers are made up of a member selected from the group consisting of (a) a copolymeric carrier having attached thereto both |
