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University of Pittsburgh Patents
Assignee:
University of Pittsburgh
Address:
Pittsburgh, PA
No. of patents:
339
Patents:


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Patent Number Title Of Patent Date Issued
8241892 Method and apparatus for holding cells August 14, 2012
The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the
8214012 Magnetic resonance imaging having patient video, microphone and motion tracking July 3, 2012
Critical needs for MRI patient instruction, testing, comfort, motion control, and speech communication are provided for better imaging which leads to more effective medical care. An MRI Digital Video Projection System is disclosed which provides better quality display to the patient
8211423 Muscle derived cells for the treatment of cardiac pathologies and methods of making and using th July 3, 2012
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also pro
8158409 Nanoscale surface plasmonics sensor with nanofluidic control April 17, 2012
A microfluidically-controlled transmission mode nanoscal surface plasmonics sensor device comprises one or more arrays of aligned nanochannels in fluid communication with inflowing and outflowing fluid handling manifolds that control the flow of fluid through the array(s). Fluid comp
8110217 Sphingomyelin liposomes for the treatment of hyperactive bladder disorders February 7, 2012
The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle
8029774 Wound healing polymeric networks October 4, 2011
A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing molecule retains the ability to undergo free radical polymerization after attachment of the
7993672 Stable lipid-comprising drug delivery complexes and methods for their production August 9, 2011
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture
7981448 Methods of treating necrotizing enterocolitis July 19, 2011
The present invention relates to a method of treating necrotizing enterocolitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.
7882909 Personal vehicle February 8, 2011
A personal vehicle comprises a frame with a seat, two large, non-drive wheels connected by an axle at one end of the frame, an elongated swing arm attached to the axle, a pair of caster wheels connected to the frame opposite the large, non-drive wheels and a main drive wheel mounted to a
7867752 Method and apparatus for holding cells January 11, 2011
The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the
7854920 Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imagin December 21, 2010
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find
7838251 Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the live November 23, 2010
Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-gel electrophoresis
7806589 Bi-plane X-ray imaging system October 5, 2010
A high-speed biplane radiography system for in-vivo assessment of joint function is provided. The system can acquire stereo-pair radiographic images at rates from 30-4000 frames per second of nearly any motion or joint. The radiographic equipment can be mounted in a gantry system that
7655468 Stable lipid-comprising drug delivery complexes and methods for their production February 2, 2010
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture
7585640 Diagnosing and monitoring inflammatory diseases by measuring complement components on white bloo September 8, 2009
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
7560538 Porcine isogloboside 3 synthase protein, cDNA, genomic organization, and regulatory region July 14, 2009
The present invention provides porcine isogloboside 3 (iGb3) synthase protein, cDNA, and genomic DNA regulatory sequence. The present also invention includes porcine animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack ex
7531634 Bladder matrix protein peptides and methods of detection of bladder cancer May 12, 2009
Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are subs
7527634 Device and method of use for functional isolation of animal or human tissues May 5, 2009
A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and me
7521504 Irreversible immobilization of enzymes into polyurethane coatings April 21, 2009
A method of irreversibly immobilizing an enzyme in a polyurethane and an enzyme-containing polyurethane having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyurethanes in the presence of enzyme has enabled the irreversible attachment of th
7456383 Surface plasmon-enhanced nano-optic devices and methods of making same November 25, 2008
A nanostructured optical device includes a metal film or a plurality of metal islands having an array of a plurality of openings having a width that is less than at least one first predetermined wavelength of incident radiation to be provided onto the film or the islands. The metal film
7429481 Targeting viruses using a modified sindbis glycoprotein September 30, 2008
The present invention relates to viruses that are engineered to contain a surface ligand molecule which targets the virus to a cell of interest. In particular non-limiting embodiments, the cell of interest is desirably ablated and may be a cancer cell, an infected cell, a cell exhibiting
7426040 Chip-scale optical spectrum analyzers with enhanced resolution September 16, 2008
A Fabry-Perot cavity filter includes a first mirror and a second mirror. A gap between the first and the second mirror monotonically varies as a function of width of the filter. This filter may be used with photodetector and a channel selection filter in an optical device, such as a
7420156 Metal nanowire based bandpass filter arrays in the optical frequency range September 2, 2008
A metal nanowire array acts as a band pass filter in the visible to IR range. The filter may be used in a monochromator, spectrometer, color camera, analyte detector or other devices.
7368284 Porcine CMP-N-Acetylneuraminic acid hydroxylase gene May 6, 2008
The present invention provides porcine CMP-N-Acetylneuraminic-Acid Hydroxylase (CMP-Neu5Ac hydroxylase) protein, cDNA, and genomic DNA regulatory sequences. Furthermore, the present invention includes porcine animals, tissues, and organs, as well as cells and cell lines derived from
7361640 Stable lipid-comprising drug delivery complexes and methods for their production April 22, 2008
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture
7361517 Real time method of detecting acute inflammatory conditions April 22, 2008
This invention relates to the diagnosis and/or monitoring of patients with inflammatory diseases or conditions, including systemic lupus erythematosus, particularly for diagnosis of the acute stage of the disease, including methods and kits for carrying out this activity. This disclo
7358869 Power efficient, high bandwidth communication using multi-signal-differential channels April 15, 2008
A low-power, area and pin efficient signaling alternative to serial differential links used for chip-to-chip, backplane, optical and other signaling applications. The multi-bit differential signaling (MBDS) generally comprises a driver and link termination network design coupled with
7351401 Thioflavin derivatives for use in the antemortem diagnosis of Alzheimers disease and in vivo ima April 1, 2008
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find
7336357 Multi-channel dual phase lock-in optical spectrometer February 26, 2008
The development of a multiple-channel dual phase lock-in optical spectrometer (LIOS) is presented, which enables parallel phase-sensitive detection at the output of an optical spectrometer. The light intensity from a spectrally broad source is modulated at the reference frequency, an
7335679 Wortmannin analogs and methods of using same February 26, 2008
Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well as tumor formation in a subject are described herein.
7335509 Stable lipid-comprising drug delivery complexes and methods for their production February 26, 2008
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture
7335400 Irreversible immobilization of enzymes into polyurethane coatings February 26, 2008
A method of irreversibly immobilizing an enzyme in a polyurethane and an enzyme-containing polyurethane having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyurethanes in the presence of enzyme has enabled the irreversible attachment of th
7321830 Identifying drugs for and diagnosis of benign prostatic hyperplasia using gene expression profil January 22, 2008
The present invention relates to a computer system comprising a database for elucidating changes in gene expression in prostate tissue isolated from patients exhibiting different clinical states of prostate hyperplasia as compared to normal prostate tissue, as well as the identificat
7321046 Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof January 22, 2008
Dictyostatin and its analogs show great promise as new anticancer agents. The present invention provides dictyostatin analogs, synthetic intermediates for the synthesis of dictyostatin analogs, and synthetic methods for the synthesis of such analogs and intermediates. Dictyostatin an
7315426 Metallic nano-optic lenses and beam shaping devices January 1, 2008
A nano-optic device comprises a plurality of subwavelength apertures in a metal film or between metal islands. The device is adapted to shape a radiation beam transmitted there through. For example, beam shaping includes at least one of beam focusing, beam bending and beam collimatin
7296361 Measuring device and method of measuring November 20, 2007
a device for measuring dimensions in a hollow organ of the body, includes: a length of conduit; a measuring mechanism on one end of the conduit; and an indicator in connection with a second end of the conduit. The indicator is in operative connection with the measuring mechanism to p
7271159 Camptothecin analogs and methods of preparation thereof September 18, 2007
The present invention provides generally a compound having the following general formula (1): ##STR00001## wherein R.sup.1 and R.sup.2 are independently the same or different and are hydrogen, an alkyl group, an alkenyl group, a benzyl group, an alkynyl group, an alkoxyl group, an a
7270800 Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imagin September 18, 2007
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find
7264948 Polypeptides for increasing mutant CFTR channel activity September 4, 2007
The present invention provides methods and compositions for enhancing channel activity to the mutant cystic fibrosis trans-membrane conductance regulator protein (CFTR). The compositions of the invention comprise polypeptides containing CFTR sub-domains that are designed to mimic the
7264823 Medical adhesive and methods of tissue adhesion September 4, 2007
An adhesive including a mixture of isocyanate capped molecules formed by reacting multi-isocyanate functional molecules with multi-functional precursor molecules including terminal functional groups selected from the group consisting of a hydroxyl group, a primary amino group and a s
7258991 Antibody to bladder cancer nuclear matrix protein and its use August 21, 2007
Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are subs
7220860 Camptothecin analogs and methods of preparation thereof May 22, 2007
A compound has the formula ##STR00001## in racemic form, enantiomerically enriched form or enantiomerically pure form. R.sup.6 is preferably --Si(R.sup.8R.sup.9R.sup.10) or --(R.sup.7)Si(R.sup.8R.sup.9R.sup.10), wherein R.sup.7 is an alkylene group, an alkenylene group, or an alkyny
7206633 Device and method to discriminate between supraventricular tachycardias and ventricular arrhythm April 17, 2007
A method discriminates between ventricular arrhythmia and supraventricular tachycardia by detecting an earliest arriving electrical signal following anti-tachycardia pacing. An implantable cardiac defibrillator provides simultaneous atrioventricular anti-tachycardia pacing bursts and det
7192941 Estradiol metabolites for the treatment of pulmonary hypertension March 20, 2007
Methods are provided for the treatment of pulmonary hypertension and other conditions associated therewith. In particular, the methods include treatment of pulmonary hypertension with estradiol metabolite or estradiol metabolite associated with biodegradable microparticles or nanopar
7189823 Antibody against illfdyfnr March 13, 2007
Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-gel electrophoresis
7135598 N-vinylformamide derivatives, polymers formed therefrom and synthesis thereof November 14, 2006
A method of synthesizing a compound having the formula: ##STR00001## comprising the step of: reacting a N-vinylformamide salt having the formula ##STR00002## with a compound having the formula XR.sup.1R.sup.2; wherein X is Br, Cl or I, M is an alkali metal or an alkali earth
7122686 Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis th October 17, 2006
A compound of the following structure: ##STR00001## wherein R.sup.1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R.sup.2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, --SiR.sup.aR.sup.bR.sup.c, CH.sub.2OR.sup.d, or
7122151 Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via activ October 17, 2006
A combination mass transfer and pump apparatus, which in a single step actively mixes a first mass and a second mass and simultaneously pumps one of the first mass and the second mass through the apparatus. The combination mass transfer and pump apparatus substantially comprises a ho
7105352 Intelligent polymerized crystalline colloidal array carbohydrate sensors September 12, 2006
The present invention is related to glucose sensors that are capable of detecting the concentration or level of glucose in a solution or fluid having either low or high ionic strength. The glucose sensors of the present invention comprise a polymerized crystalline colloidal array (PC
7090745 Method for increasing the strength of a cellulosic product August 15, 2006
A composition includes at least one hydrophilic polymer containing primary (--NH.sub.2) and/or secondary (--NHR) amine groups and at least one saccharide containing a reducible function. A method of increasing the strength of paper includes the step of contacting the paper with a com
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