| Patent Number |
Title Of Patent |
Date Issued |
| 7585640 |
Diagnosing and monitoring inflammatory diseases by measuring complement components on white bloo |
September 8, 2009 |
| The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells. |
| 7560538 |
Porcine isogloboside 3 synthase protein, cDNA, genomic organization, and regulatory region |
July 14, 2009 |
| The present invention provides porcine isogloboside 3 (iGb3) synthase protein, cDNA, and genomic DNA regulatory sequence. The present also invention includes porcine animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack ex |
| 7531634 |
Bladder matrix protein peptides and methods of detection of bladder cancer |
May 12, 2009 |
| Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are subs |
| 7527634 |
Device and method of use for functional isolation of animal or human tissues |
May 5, 2009 |
| A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and me |
| 7521504 |
Irreversible immobilization of enzymes into polyurethane coatings |
April 21, 2009 |
| A method of irreversibly immobilizing an enzyme in a polyurethane and an enzyme-containing polyurethane having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyurethanes in the presence of enzyme has enabled the irreversible attachment of th |
| 7456383 |
Surface plasmon-enhanced nano-optic devices and methods of making same |
November 25, 2008 |
| A nanostructured optical device includes a metal film or a plurality of metal islands having an array of a plurality of openings having a width that is less than at least one first predetermined wavelength of incident radiation to be provided onto the film or the islands. The metal film |
| 7429481 |
Targeting viruses using a modified sindbis glycoprotein |
September 30, 2008 |
| The present invention relates to viruses that are engineered to contain a surface ligand molecule which targets the virus to a cell of interest. In particular non-limiting embodiments, the cell of interest is desirably ablated and may be a cancer cell, an infected cell, a cell exhibiting |
| 7426040 |
Chip-scale optical spectrum analyzers with enhanced resolution |
September 16, 2008 |
| A Fabry-Perot cavity filter includes a first mirror and a second mirror. A gap between the first and the second mirror monotonically varies as a function of width of the filter. This filter may be used with photodetector and a channel selection filter in an optical device, such as a |
| 7420156 |
Metal nanowire based bandpass filter arrays in the optical frequency range |
September 2, 2008 |
| A metal nanowire array acts as a band pass filter in the visible to IR range. The filter may be used in a monochromator, spectrometer, color camera, analyte detector or other devices. |
| 7368284 |
Porcine CMP-N-Acetylneuraminic acid hydroxylase gene |
May 6, 2008 |
| The present invention provides porcine CMP-N-Acetylneuraminic-Acid Hydroxylase (CMP-Neu5Ac hydroxylase) protein, cDNA, and genomic DNA regulatory sequences. Furthermore, the present invention includes porcine animals, tissues, and organs, as well as cells and cell lines derived from |
| 7361640 |
Stable lipid-comprising drug delivery complexes and methods for their production |
April 22, 2008 |
| Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture |
| 7361517 |
Real time method of detecting acute inflammatory conditions |
April 22, 2008 |
| This invention relates to the diagnosis and/or monitoring of patients with inflammatory diseases or conditions, including systemic lupus erythematosus, particularly for diagnosis of the acute stage of the disease, including methods and kits for carrying out this activity. This disclo |
| 7358869 |
Power efficient, high bandwidth communication using multi-signal-differential channels |
April 15, 2008 |
| A low-power, area and pin efficient signaling alternative to serial differential links used for chip-to-chip, backplane, optical and other signaling applications. The multi-bit differential signaling (MBDS) generally comprises a driver and link termination network design coupled with |
| 7351401 |
Thioflavin derivatives for use in the antemortem diagnosis of Alzheimers disease and in vivo ima |
April 1, 2008 |
| This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find |
| 7336357 |
Multi-channel dual phase lock-in optical spectrometer |
February 26, 2008 |
| The development of a multiple-channel dual phase lock-in optical spectrometer (LIOS) is presented, which enables parallel phase-sensitive detection at the output of an optical spectrometer. The light intensity from a spectrally broad source is modulated at the reference frequency, an |
| 7335679 |
Wortmannin analogs and methods of using same |
February 26, 2008 |
| Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well as tumor formation in a subject are described herein. |
| 7335509 |
Stable lipid-comprising drug delivery complexes and methods for their production |
February 26, 2008 |
| Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture |
| 7335400 |
Irreversible immobilization of enzymes into polyurethane coatings |
February 26, 2008 |
| A method of irreversibly immobilizing an enzyme in a polyurethane and an enzyme-containing polyurethane having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyurethanes in the presence of enzyme has enabled the irreversible attachment of th |
| 7321830 |
Identifying drugs for and diagnosis of benign prostatic hyperplasia using gene expression profil |
January 22, 2008 |
| The present invention relates to a computer system comprising a database for elucidating changes in gene expression in prostate tissue isolated from patients exhibiting different clinical states of prostate hyperplasia as compared to normal prostate tissue, as well as the identificat |
| 7321046 |
Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof |
January 22, 2008 |
| Dictyostatin and its analogs show great promise as new anticancer agents. The present invention provides dictyostatin analogs, synthetic intermediates for the synthesis of dictyostatin analogs, and synthetic methods for the synthesis of such analogs and intermediates. Dictyostatin an |
| 7315426 |
Metallic nano-optic lenses and beam shaping devices |
January 1, 2008 |
| A nano-optic device comprises a plurality of subwavelength apertures in a metal film or between metal islands. The device is adapted to shape a radiation beam transmitted there through. For example, beam shaping includes at least one of beam focusing, beam bending and beam collimatin |
| 7296361 |
Measuring device and method of measuring |
November 20, 2007 |
| a device for measuring dimensions in a hollow organ of the body, includes: a length of conduit; a measuring mechanism on one end of the conduit; and an indicator in connection with a second end of the conduit. The indicator is in operative connection with the measuring mechanism to p |
| 7271159 |
Camptothecin analogs and methods of preparation thereof |
September 18, 2007 |
| The present invention provides generally a compound having the following general formula (1): ##STR00001## wherein R.sup.1 and R.sup.2 are independently the same or different and are hydrogen, an alkyl group, an alkenyl group, a benzyl group, an alkynyl group, an alkoxyl group, an a |
| 7270800 |
Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imagin |
September 18, 2007 |
| This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find |
| 7264948 |
Polypeptides for increasing mutant CFTR channel activity |
September 4, 2007 |
| The present invention provides methods and compositions for enhancing channel activity to the mutant cystic fibrosis trans-membrane conductance regulator protein (CFTR). The compositions of the invention comprise polypeptides containing CFTR sub-domains that are designed to mimic the |
| 7264823 |
Medical adhesive and methods of tissue adhesion |
September 4, 2007 |
| An adhesive including a mixture of isocyanate capped molecules formed by reacting multi-isocyanate functional molecules with multi-functional precursor molecules including terminal functional groups selected from the group consisting of a hydroxyl group, a primary amino group and a s |
| 7258991 |
Antibody to bladder cancer nuclear matrix protein and its use |
August 21, 2007 |
| Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are subs |
| 7220860 |
Camptothecin analogs and methods of preparation thereof |
May 22, 2007 |
| A compound has the formula ##STR00001## in racemic form, enantiomerically enriched form or enantiomerically pure form. R.sup.6 is preferably --Si(R.sup.8R.sup.9R.sup.10) or --(R.sup.7)Si(R.sup.8R.sup.9R.sup.10), wherein R.sup.7 is an alkylene group, an alkenylene group, or an alkyny |
| 7206633 |
Device and method to discriminate between supraventricular tachycardias and ventricular arrhythm |
April 17, 2007 |
| A method discriminates between ventricular arrhythmia and supraventricular tachycardia by detecting an earliest arriving electrical signal following anti-tachycardia pacing. An implantable cardiac defibrillator provides simultaneous atrioventricular anti-tachycardia pacing bursts and det |
| 7192941 |
Estradiol metabolites for the treatment of pulmonary hypertension |
March 20, 2007 |
| Methods are provided for the treatment of pulmonary hypertension and other conditions associated therewith. In particular, the methods include treatment of pulmonary hypertension with estradiol metabolite or estradiol metabolite associated with biodegradable microparticles or nanopar |
| 7189823 |
Antibody against illfdyfnr |
March 13, 2007 |
| Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-gel electrophoresis |
| 7135598 |
N-vinylformamide derivatives, polymers formed therefrom and synthesis thereof |
November 14, 2006 |
| A method of synthesizing a compound having the formula: ##STR00001## comprising the step of: reacting a N-vinylformamide salt having the formula ##STR00002## with a compound having the formula XR.sup.1R.sup.2; wherein X is Br, Cl or I, M is an alkali metal or an alkali earth |
| 7122686 |
Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis th |
October 17, 2006 |
| A compound of the following structure: ##STR00001## wherein R.sup.1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R.sup.2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, --SiR.sup.aR.sup.bR.sup.c, CH.sub.2OR.sup.d, or |
| 7122151 |
Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via activ |
October 17, 2006 |
| A combination mass transfer and pump apparatus, which in a single step actively mixes a first mass and a second mass and simultaneously pumps one of the first mass and the second mass through the apparatus. The combination mass transfer and pump apparatus substantially comprises a ho |
| 7105352 |
Intelligent polymerized crystalline colloidal array carbohydrate sensors |
September 12, 2006 |
| The present invention is related to glucose sensors that are capable of detecting the concentration or level of glucose in a solution or fluid having either low or high ionic strength. The glucose sensors of the present invention comprise a polymerized crystalline colloidal array (PC |
| 7090745 |
Method for increasing the strength of a cellulosic product |
August 15, 2006 |
| A composition includes at least one hydrophilic polymer containing primary (--NH.sub.2) and/or secondary (--NHR) amine groups and at least one saccharide containing a reducible function. A method of increasing the strength of paper includes the step of contacting the paper with a com |
| 7084605 |
Energy harvesting circuit |
August 1, 2006 |
| A station having a means for receipt of ambient energy from the environment and energizing power storage devices of objects of interest comprising one or more antennae and circuitry for converting said ambient energy into DC power for energizing said power storage devices. The circui |
| 7081475 |
Wortmannin analogs and methods of using same |
July 25, 2006 |
| Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well as tumor formation in a subject are described herein. |
| 7064202 |
Camptothecin intermediates and prodrugs and methods of preparation thereof |
June 20, 2006 |
| The present invention relates to novel intermediates and prodrugs of camptothecin and related analogs. |
| 7063860 |
Application of lipid vehicles and use for drug delivery |
June 20, 2006 |
| The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for pr |
| 7026511 |
Synthesis of N-vinylformamide |
April 11, 2006 |
| A process to produce N-vinylformamide includes the steps of: reacting hydroxyethyl formamide with a reactant comprising at least one cyclic anhydride group to form an ester, and dissociating the ester via heat in a thin film evaporation to synthesize N-vinylformamide and a compound c |
| 7022520 |
Cell culture media for mammalian cells |
April 4, 2006 |
| A chemically defined mammalian cell culture medium is provided that supports maintenance and long term clonal growth of mammalian hepatocytes and other cells. |
| 6995148 |
Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy |
February 7, 2006 |
| The present invention relates to novel compounds that are novel adenosine receptor analogues. Specifically, the compounds of the present invention preferably function as both adenosine receptor agonists and ganglionic blocking agents. To achieve this functionality, the compounds of the |
| 6982333 |
Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof |
January 3, 2006 |
| The present invention provides a short, convergent total synthesis of camptothecin and related compounds which consists of a novel 4+1 radical annulation. The present invention also provides novel chemical intermediates for such 4+1 radical annulations. |
| 6965052 |
Synthesis of N-vinyl formamide |
November 15, 2005 |
| A process to produce N-vinylformamide includes the steps of: reacting hydroxyethyl formamide with a reactant including at least one cyclic anhydride group to form an ester, and dissociating (or cracking) the ester to synthesize N-vinylformamide and a compound including at least one d |
| 6951926 |
Antibody to bladder cancer nuclear matrix protein and its use |
October 4, 2005 |
| Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are subs |
| 6943484 |
Tunable piezoelectric micro-mechanical resonator |
September 13, 2005 |
| One aspect of the invention relates to a composite member for a resonator having an active piezoelectric element and a passive piezoelectric element. The active piezoelectric element causes the resonator to vibrate and detects the frequency of the vibration. The passive piezoelectric |
| 6936468 |
Use of tolerogenic dendritic cells for enhancing tolerogenicity in a host and methods for making |
August 30, 2005 |
| The present invention relates to tolerogenic mammalian dendritic cells (DCs) and methods for the production of the tolerogenic DCs. In addition, the present invention provides a method for enhancing tolerogenicity in a host comprising administering the tolerogenic mammalian DCs of the pr |
| 6927213 |
Cationic cholesteryl derivatives containing cyclic polar groups |
August 9, 2005 |
| The present invention discloses compounds which are cationic cholesteryl derivatives having a nitrogen-containing ring structure as their polar head group. These compounds are useful for delivering biologically active substances to cells and for transfecting nucleic acids into cells. |
| 6905733 |
Irreversible immobilization of enzymes into polyurethane coatings |
June 14, 2005 |
| This invention provides a method of irreversibly immobilizing an enzyme into polyurethane coatings. This invention also provides for an enzyme-containing coating having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyurethane coatings i |
