| Patent Number |
Title Of Patent |
Date Issued |
| 7459161 |
Methods for eliciting an immune response using cytolysin and hemolysin fusion proteins |
December 2, 2008 |
| The disclosure below provides a protein export system for efficiently producing recombinant protein from a host cell. In a preferred embodiment, the protein export system utilizes protein export machinery endogenous to the host bacterium into which the protein export system vector is |
| 7400397 |
Optical structures for metal-enhanced sensing |
July 15, 2008 |
| The present invention is directed to optical structures and methods detecting the fluorescence of a molecule using metal-enhanced fluorescence. In particular, the invention describes the use of surface plasmon excitation for excitation of fluorophores near the metal surface and the e |
| 7399474 |
Isolation and characterization of the csa operon (ETEC-CS4 pili) and methods of using same |
July 15, 2008 |
| Compositions comprising products of the csa operon, an isolated nucleic acid encoding the csa operon or functional fragments thereof, purified polypeptide products of the csa operon or functional fragments thereof, methods of eliciting an immune response to these products, and methods of |
| 7393525 |
Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors |
July 1, 2008 |
| A method for introducing and expressing genes in animal cells is disclosed comprising infecting said the animal cells with live invasive bacteria, wherein bacteria contain a eukaryotic expression cassette encoding said gene. The gene may encode, e.g., a vaccine antigen, an therapeutic ag |
| 7387614 |
Drug delivery to the inner ear and methods of using same |
June 17, 2008 |
| The inventors have demonstrated that they can deliver therapeutic compositions to the inner ear of mammals via a variety of routes including the round window membrane, the semicircular canals, via cochleostomy and through the stapes footplate. Using pancaspase inhibitors, the invento |
| 7333591 |
Method for the planning and delivery of radiation therapy |
February 19, 2008 |
| A new optimization method for generating treatment plans for radiation oncology is described and claimed. This new method works for intensity modulated radiation therapy (IMRT), intensity modulated arc therapy (IMAT), and hybrid IMRT. |
| 7312197 |
Method of modifying glucose activity using polypeptides selectively expressed in fat tissue |
December 25, 2007 |
| Isolated omentin polypeptides that selectively express in omental fat tissue and methods for the use of the polypeptides. The polypeptides can be used in a method for modifying insulin action and/or glucose metabolism in an animal. The polypeptides can be used to promote glucose upta |
| 7294689 |
Agonist polypeptide of receptor for Zot and Zonulin |
November 13, 2007 |
| Agonist polypeptide of a receptor protein has been identified. The agonist can be used to facilitate drug and antigen absorption. Suitable routes of administration include oral, nasal, transdermal, and intravenous. Pharmaceutical formulations may comprise a therapeutic agent or an im |
| 7291334 |
Antibodies to novel proteins in enteroaggregative Escherichia coli (EAEC) useful for diagnosis a |
November 6, 2007 |
| Novel proteins and their corresponding nucleotide sequences in enteroaggregative Escherichia coli (EAEC) are provided. In particular, Aap and the five gene cluster (aat) of the AA probe region of the pAA plasmid of EAEC 042 have been identified, sequenced, and further characterized. |
| 7285574 |
Methods for treating neural cell swelling |
October 23, 2007 |
| A composition comprising a novel Ca.sup.2+-activated, [ATP].sub.i-sensitive nonspecific cation (NC.sub.Ca-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submic |
| 7276240 |
Antibodies to novel proteins in enteroaggregative Escherichia coli (EAEC) useful for diagnosis a |
October 2, 2007 |
| Novel proteins and their corresponding nucleotide sequences in enteroaggregative Escherichia coli (EAEC) are provided. In particular, Aap and the five gene cluster (aat) of the AA probe region of the pAA plasmid of EAEC 042 have been identified, sequenced, and further characterized. |
| 7273963 |
Malarial animal model having a chimeric human liver |
September 25, 2007 |
| The present invention features a non-human animal model of malaria, e.g., Plasmodium, particularly Plasmodium falciparum. The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a uroki |
| 7265143 |
C-4 substituted retinoids |
September 4, 2007 |
| C-4 substituted retinoic acid analogs, synthesis methods of C-4 substituted retinoic acid analogs and methods of using C-4 substituted retinoic acid analogs to treat various cancers and dermatological diseases and conditions. The C-4 substituted retinoic acid analogs include C-4 all- |
| 7211559 |
Factor VIII compositions and methods |
May 1, 2007 |
| The present invention provides methods of increasing the half-life and/or specific activity of factor VIII. More specifically, the invention provides methods of increasing the half-life and/or specific activity of factor VIII by substituting one or more amino acids in the A2 domain. It |
| 7192702 |
Modulators of the interaction between Arp2/3 and cortactin or HS-1 |
March 20, 2007 |
| The invention relates to methods for screening compounds for their ability to modulate actin polymerization. The invention is also related to compounds which modulate actin polymerization. More specifically, the invention is related to methods of screening compounds which modulate the |
| 7189696 |
Peptide antagonists of zonulin and methods for use of the same |
March 13, 2007 |
| Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions. |
| 7162008 |
Method for the planning and delivery of radiation therapy |
January 9, 2007 |
| A new optimization method for generating treatment plans for radiation oncology is described and claimed. This new method works for intensity modulated radiation therapy (IMRT), intensity modulated arc therapy (IMAT), and hybrid IMRT. |
| 7141662 |
Nucleic acids encoding novel proteins in enteroaggregative Escherichia coli (EAEC) |
November 28, 2006 |
| Novel proteins and their corresponding nucleotide sequences in enteroaggregative Escherichia coli (EAEC) are provided. In particular, Aap and the five gene cluster (aat) of the AA probe region of the pAA plasmid of EAEC 042 have been identified, sequenced, and further characterized. |
| 7141408 |
Plasmid maintenance system for antigen delivery |
November 28, 2006 |
| The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression plasmids at two indep |
| 7138112 |
Plasmid maintenance system for antigen delivery |
November 21, 2006 |
| The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression plasmids at two indep |
| 7125720 |
Plasmid maintenance system for antigen delivery |
October 24, 2006 |
| The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression plasmids at two indep |
| 7121981 |
Bilateral arm trainer and method of use |
October 17, 2006 |
| A device and method for bilateral upper extremity training for patients with a paretic upper extremity, the device facilitating cortical remodeling, sustained relearning and improvement in functional outcomes in paretic and possibly non-paretic upper extremities. In one variation, th |
| 7087741 |
Nucleic acids encoding novel proteins in enteroaggregative escherichia coli (EAEC) |
August 8, 2006 |
| Novel proteins and their corresponding nucleotide sequences in enteroaggregative Escherichia coli (EAEC) are provided. In particular, Aap and the five gene cluster (aat) of the AA probe region of the pAA plasmid of EAEC 042 have been identified, sequenced, and further characterized. |
| 7060429 |
Treatment of neurodegenerative diseases by altering levels of TrkB isoforms and/or TrkC isoforms |
June 13, 2006 |
| This invention relates to a method of treating or preventing neuro-degenerative disorders and neuro-developmental disorders by altering the ratio of the amount of full-length TrkB polypeptide to the amount of truncated TrkB polypeptides in a neuron or by altering the ratio of the amo |
| 6969513 |
Plasmid maintenance system for antigen delivery |
November 29, 2005 |
| The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression plasmids at two dependent |
| 6936689 |
Peptide antagonists of zonulin and methods for use of the same |
August 30, 2005 |
| Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions. |
| 6902736 |
Isolation and characterization of the csa operon (ETEC-CS4 pili) and methods of using same |
June 7, 2005 |
| Compositions comprising products of the csa operon, an isolated nucleic acid encoding the csa operon or functional fragments thereof, purified polypeptide products of the csa operon or functional fragments thereof, methods of eliciting an immune response to these products, and methods of |
| 6840246 |
Apparatuses and methods for performing minimally invasive diagnostic and surgical procedures ins |
January 11, 2005 |
| Diagnostic and surgical procedures may be performed on a beating heart using an assembly which includes a port and a fluid transport device. The port has a housing for insertion through a wall of the heart chamber and may include one valve disposed in the housing and an inlet connected t |
| 6806089 |
Low frequency modulation sensors using nanosecond fluorophores |
October 19, 2004 |
| Described is a new approach to fluorescence sensing based on a mixture of fluorophores, one of which is sensitive to the desired analyte. If a long lifetime analyte-insensitive fluorophore is mixed with a short lifetime analyte-sensitive fluorophore, the modulation of the emission at |
| 6733762 |
Method of using Zot to inhibit lymphocyte proliferation in an antigen-specific manner |
May 11, 2004 |
| Methods of using Zot or zonulin as an antigen specific inhibitor of APC activity and lymphocyte proliferation, being primarily useful in the field of immunoregulation and immunotherapy as described. Specifically, Zot and zonulin inhibit antigen presenting cell-mediated antigen-specific |
| 6703233 |
Plasmid maintenance system for antigen delivery |
March 9, 2004 |
| The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid Maintenance System. The invention optimizes the maintenance of expression plasmids at two independe |
| 6682729 |
Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors |
January 27, 2004 |
| A method for introducing and expressing genes in animal cells is disclosed comprising infecting the animal cells with live invasive bacteria, wherein the bacteria contain a eukaryotic expression cassette encoding the gene. The gene may encode, e.g., a vaccine antigen, a therapeutic agent |
| 6670448 |
Peptide antagonists of zonulin and methods for use of the same |
December 30, 2003 |
| Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions. |
| 6660379 |
Luminescence spectral properties of CdS nanoparticles |
December 9, 2003 |
| The steady state and time resolved luminescence spectral properties of two types of novel CdS nanoparticles and nanoparticles are described. CdS nanoparticles formed in the presence of an amine-terminated dendrimer show blue emission. The emission wavelength of these nanoparticles depend |
| 6635259 |
Escherichia coli secreted protein B |
October 21, 2003 |
| Several EHEC proteins which are secreted into the culture supernatant have been discovered. These proteins are not produced by non-pathogenic E. coli, and produce a strong serum antibody response in patients with HUS and bloody diarrhea. |
| 6548287 |
Non-pyrogenic bacterial strains and use of the same |
April 15, 2003 |
| The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said strains for the preparation of non-pyrogenic DNA and use of the same for introducing endogen |
| 6472221 |
Lifetime-based sensing of sodium and potassium |
October 29, 2002 |
| A system and method of optically measuring Na.sup.+ and K.sup.+ in a sample such as blood which contains high concentrations Na.sup.+ (up to 160 mM) and K.sup.+ (up to 6.5 mM) using a photoluminescent probe having intrinsic analyte-induced lifetime changes. Specifically, the use of lifet |
| 6458925 |
Peptide antagonists of zonulin and methods for use of the same |
October 1, 2002 |
| Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions. |
| 6455249 |
Method of amplifying DNA and RNA mismatch cleavage products |
September 24, 2002 |
| Detection of probe fragment products of basepair mismatch cleavage indicate the presence and sequence of target DNA. Detection of the target is enhanced by amplification through recycling targets by maintaining an assay temperature between the melting point of the target/probe DNA duplex |
| 6376197 |
Diagnosis of interstitial cystitis |
April 23, 2002 |
| Interstitial cystitis (IC) is a chronic bladder disease for which the exact etiology is unknown and for which there is no reliably effective treatment. However, it is known that the bladder epithelium is often abnormal in IC. We discovered that normal, adult, human bladder epithelial |
| 6338751 |
Compositions containing bioactive glass and their use in treating tooth hypersensitivity |
January 15, 2002 |
| A novel silica based bioactive glass composition that can be used in conjunction with a delivery agent such as a toothpaste, gel saliva, etc. having a particle size range <90 .mu.m which will form a rapid and continuous reaction with body fluids due to the immediate and long term |
| 6313277 |
Breast cancer resistance protein (BCRP) and the DNA which encodes it |
November 6, 2001 |
| The Breast Cancer Resistance Protein is described, as well as the cDNA encoding said protein. This protein has been found to confer resistance to cancer chemotherapeutic drugs. |
| 6232289 |
Method of treating interstitial cytitis with recombinant heparin-binding epidermal growth factor |
May 15, 2001 |
| Interstitial cystitis (IC) is a chronic bladder disease for which the exact etiology is unknown and for which there is no reliably effective treatment. However, it is known that the bladder epithelium is often abnormal in IC. We discovered that human bladder epithelial cells from bot |
| 6225127 |
Enzyme-based fluorescence biosensor for chemical analysis |
May 1, 2001 |
| This invention generally relates to the detection, determination, and quantitation of certain ions and small molecules involving the quenching of a fluorescent label attached to a macromolecule, often due to fluorescence energy transfer to a colored inhibitor or certain metal ions bo |
| 6204004 |
Immunodiagnostic test for enterohemorrhagic Escherichia coli infection |
March 20, 2001 |
| Several EHEC proteins which are secreted into the culture supernatant have been discovered. These proteins are not produced by non-pathogenic E. coli, and produce a strong serum antibody response in patients with HUS and bloody diarrhea. |
| 6197258 |
Photoluminescent sensors of chemical analytes |
March 6, 2001 |
| The invention described in detail herein relates to the detection, determination, and quantitation of certain ions and small molecules in solution. The invention specifically relates to improvements in the area of photoluminescent sensors for use in a detection scheme involving the a |
| 6190669 |
Attenuated mutants of salmonella which constitutively express the Vi antigen |
February 20, 2001 |
| Attenuated Salmonella mutants which constitutively express the Vi antigen are disclosed, as well as vaccines against typhoid fever containing the same, live vector vaccines containing the same, and DNA-mediated vaccines containing the same. |
| 6180355 |
Method for diagnosing and treating chronic pelvic pain syndrome |
January 30, 2001 |
| The present invention provides a superior method of diagnosing Chronic Pelvic Pain Syndrome in men comprising measuring levels of cytokines in semen or components or fractions of semen. The invention also provides a method of treating a condition associated with elevated levels of a |
| 6156522 |
Heparin binding--epidermal growth factor-like growth factor in the diagnosis of Interstitial Cys |
December 5, 2000 |
| Interstitial cystitis (IC) is a chronic bladder disease for which the exact etiology is unknown and for which there is no reliably effective treatment. However, it is known that the bladder epithelium is often abnormal in IC. We discovered that normal, adult, human bladder epithelial |
| 6142779 |
Breakaway devices for stabilizing dental casts and method of use |
November 7, 2000 |
| A device for efficiently, accurately and consistently securing dental casts while an articulator is attached thereto includes a spine connecting a first stabilizing pad at one end to a second stabilizing pad at an opposite end. The device includes a breakaway feature which allows a c |
