| Patent Number |
Title Of Patent |
Date Issued |
| RE35213 |
Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration |
April 16, 1996 |
| Compositions containing PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient, are disclosed for treating or preventing gastric ulceration caused by ingestion of non-steroidal anti-inflammatories. Based on animal studies, the dosage is |
| RE35112 |
Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage |
December 5, 1995 |
| Compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, which are active during ischemia in preventing ATP depletion of the cells which predisposes them to subsequent injury during reperfusion, and which are active during reperfusion as oxygen |
| 7618815 |
Viral vectors useful in soybean and methods of use |
November 17, 2009 |
| The invention provides Bean pod mottle virus (BPMV) vectors useful for expression of heterologous proteins in plants such as soybean. The BPMV vectors are also useful for virus-induced gene silencing. The invention also provides methods for expressing a heterologous polypeptide in a |
| 7611628 |
Aligned nanotubule membranes |
November 3, 2009 |
| A method is provided for producing a permeable membrane, comprising the steps of aligning a plurality of hollow nanotubules to form a mat, coating the mat with a continuous polymer matrix to form a membrane. The membrane is etched (a) to open the plurality of hollow nanotubules and f |
| 7605300 |
Genetic insulator for preventing influence by another gene promoter |
October 20, 2009 |
| A 16 bp polynucleotide sequence of Arabidopsis thaliana is a genetic insulator that can effectively isolate a transgene from positional effects of neighboring gene activities in transgenic plant cells. |
| 7604930 |
Methods and devices for cryopreservation of biological cells and tissues |
October 20, 2009 |
| Novel methods, compositions, and devices for achieving optimal cooling of living cells during cryopreservation are disclosed. In one aspect, the method comprises gradually cooling the cell to a first predetermined temperature, followed by rapidly cooling the cell to a second predeter |
| 7595430 |
Methods and animal model for analyzing age-related macular degeneration |
September 29, 2009 |
| Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and treatments on development of age-related macular degeneration. Also provided is a Ccl2-d |
| 7595149 |
Methods for cancer detection |
September 29, 2009 |
| A method is provided for detecting an analyte indicative of a cancer or a metastatic disease condition, which utilizes the ability of the analyte to induce permeability in a barrier. The method includes providing a biosensor having a barrier which is substantially impermeable to an ion, |
| 7588764 |
Compositions comprising human immunodeficiency virus Tat adsorbed to the surface of anionic nano |
September 15, 2009 |
| Non-denatured, recombinant human immunodeficiency virus (HIV) Tat that is free of bacterial RNA and endotoxin is employed in an anti-HIV vaccine. A process of producing the recombinant Tat protein includes steps for removing bacterial RNA from the recombinant Tat and for removing end |
| 7559321 |
Programmable multi-dose intranasal drug delivery device |
July 14, 2009 |
| An apparatus and method for the self-administration of a plurality of doses of an intranasal liquid pharmaceutical composition, including opioid analgesics, that includes a drug delivery device containing a plurality of sealed vials, each vial containing a predetermined volume of the |
| 7557923 |
Method and system for in situ spectroscopic evaluation of an object |
July 7, 2009 |
| A method and system for spectroscopically determining surface and product characteristics is employed for rapid detection of product characteristics and/or the presence or absence of suspected analytes, and the concentration of the analyte. The method and system uses a signal wide ba |
| 7553496 |
VEGF-A as an inhibitor of angiogenesis and methods of using same |
June 30, 2009 |
| The invention relates to methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization associated with neovascular disease. Administration of vascular endothelial growth factor (VEGF)-A into the eye when macrophage infiltration is reduced inhibits |
| 7547520 |
Methods to identify plant metabolites |
June 16, 2009 |
| This invention provides materials and methods to manipulate the plant genome at the level of single plant cells in culture resulting in the ability to assign metabolic functionality to plant genes involved in the production of biologically active molecules and to create a means of pr |
| 7538194 |
Genes encoding several poly (ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragmen |
May 26, 2009 |
| The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's |
| 7524946 |
Nucleic acids encoding Sarcocystis neurona antigen and uses thereof |
April 28, 2009 |
| The present invention provides novel isolated nucleic acids encoding antigenic proteins derived from Sarcocystis neurona, or unique fragments thereof. In particular, the invention provides novel isolated nucleic acids encoding membrane-associated polypeptides SnSAG2, SnSAG3, and SnSAG |
| 7521198 |
Compositions and methods for detecting and treating atherosclerosis |
April 21, 2009 |
| Methods for detecting atherosclerotic plaque and quantifying the amount of Group V sPLA.sub.2 in plasma are disclosed. These methods can be used to assess the risk of cardiovascular pathology in a patient. |
| 7517967 |
Monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma |
April 14, 2009 |
| The present invention relates to monoclonal antibody 1A7. This is an anti-idiotype produced by immunizing with an antibody specific for ganglioside GD2, and identifying a hybridoma secreting antibody with immunogenic potential in a multi-step screening process. Also disclosed are pol |
| 7517679 |
Recombinant watermelon (Citrullus lanatus) hydroperoxide lyase and uses thereof |
April 14, 2009 |
| Recombinant watermelon (Citrullus lanatus)hydroperoxide lyase protein, DNA sequences encoding the protein, vectors containing the DNA sequences and hosts containing the vectors are provided, together with methods for recombinantly producing watermelon hydroperoxide lyase, DNA sequences, |
| 7504078 |
Continuous production of aligned carbon nanotubes |
March 17, 2009 |
| An apparatus for continuous production of aligned carbon nanotubes is disclosed. The apparatus includes a reactor, an injector for delivering a feed solution into the reactor, and a conveyor for passing through the reactor a substrate on which nanotubes may be formed and grown. The a |
| 7501557 |
Method utilizing the tobacco phylloplanin promoter for expression of nucleic acids as gene produ |
March 10, 2009 |
| A method and system is provided for generating excreted gene products in a plant which includes generating a nucleic acid fusion construct comprising a phylloplanin promoter and a selected non-phylloplanin nucleic acid sequence whose transcription product is to be expressed and deliv |
| 7445923 |
Crystallization and structure of a plant peptide deformylase |
November 4, 2008 |
| This invention relates to the crystal structure of a plant peptide deformylase polypeptide and methods of using the structure to design compounds that modulate the activity of the polypeptide. |
| 7440590 |
System and technique for retrieving depth information about a surface by projecting a composite |
October 21, 2008 |
| A technique, associated system and program code, for retrieving depth information about at least one surface of an object. Core features include: projecting a composite image comprising a plurality of modulated structured light patterns, at the object; capturing an image reflected fr |
| 7438904 |
High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating t |
October 21, 2008 |
| A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations |
| 7425319 |
Method for enhancing protective cellular responses to genotoxic stress in skin |
September 16, 2008 |
| The present invention is directed to methods of using pro-NAD agents capable of enhancing the dermal and epidermal skin cell NAD content. These pro-NAD agents may be administered topically, orally, or parenterally to enhance DNA repair and other protective responses to DNA damage. Th |
| 7423008 |
Derivatives of mithramycin and methods of making and uses thereof |
September 9, 2008 |
| The invention, in one aspect, generally relates to mithramycin derivatives from mutated Streptomyces argillaceus and their production. The invention also relates using the derivatives for the treatment of various diseases. Finally, the invention relates to a mutated Streptomyces argillac |
| 7419815 |
Inhibitors of plant peptide deformylase for use as broad-spectrum herbicides and methods for ide |
September 2, 2008 |
| The invention relates to a method of identifying herbicides and to the use of inhibitors of plant peptide deformylase as broad spectrum herbicides. |
| 7419604 |
Use of boron compounds to precipitate uranium from water |
September 2, 2008 |
| A method is provided for removing uranium from water. The method includes the mixing of a boron reagent with water contaminated with uranyl dication ions, leading to removal of the uranium from that water. |
| 7399849 |
Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof |
July 15, 2008 |
| The present invention provides a monoclonal anti-Idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by |
| 7385221 |
Silylethynylated heteroacenes and electronic devices made therewith |
June 10, 2008 |
| Novel silylethynylated heteroacenes and electronic devices made with those compounds are disclosed. |
| 7385027 |
Membrane-permeable peptide capable of calpain inhibition |
June 10, 2008 |
| 5-mer peptides that can inhibit calpain I and calpain II are disclosed. The peptide sequence is as follows: Leu or Ala)-(Xaa)-(Asp or Glu)-(Xaa)-(Leu or Met), where Xaa can be any amino acid. |
| 7368443 |
2,6-disubstituted piperidines and piperazine compounds |
May 6, 2008 |
| The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula: ##STR00001## which are used to treat diseases of the central nervous system, drug abuse, and withdrawal therefrom as well as treating eating disorders. |
| 7364901 |
Recombinant Stokesia epoxygenase gene |
April 29, 2008 |
| A chimeric gene comprising an isolated nucleic acid molecule encoding a delta 12-fatty acid epoxygenase enzyme and transgenic plants containing the chimeric gene are described. Expression of the chimeric delta 12-epoxygenase gene leads to altered levels of fatty acids in transformed |
| 7345160 |
Aequorin and obelin mutants with differing wavelengths and bioluminescence |
March 18, 2008 |
| The invention relates to aequorin and obelin mutants whose emission is shifted with respect to wild type. The shift in emission is accomplished using a combination of mutations of amino acids within aequorin or obelin that affect bioluminescence; use of different types of chromophores, |
| 7342100 |
Hpr6 mutants and uses thereof |
March 11, 2008 |
| Methods and agents that interfere with Hpr6 function in non-sarcoma tumor cells are disclosed. Anti-Hpr6 agents are used to enhance the killing effect of anti-cancer agents in non-sarcoma tumor cells and to teat non-sarcoma tumors. |
| 7335642 |
Method for treating a viral infection related or a chemical toxin related hepatic injury with de |
February 26, 2008 |
| A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of |
| 7332597 |
Primers and probe to identify mycobacterium tuberculosis complex |
February 19, 2008 |
| Methods and nucleic acids for rapid, reliable and sensitive detection of Mycobacterium tuberculosis (MTB) complex pathogen in a biological sample. Oligonucleotides are provided which amplify MTB DNA and which are useful in carrying out real time PCR of DNA obtained from formalin-fixed an |
| 7317729 |
System and process for providing auxiliary information for a packet-switched network of shared n |
January 8, 2008 |
| A system and process for providing auxiliary information about a distributed network of shared nodes, at least a plurality of the nodes being adapted for receiving at least one type of ESP-(associative ephemeral store processing) packet. Available for access at each of the plurality |
| 7300651 |
Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1 |
November 27, 2007 |
| The present invention provides methods of delaying development of CEA-associated tumors using the anti-idiotype antibody 3H1, particularly in high-risk individuals. |
| 7282072 |
Synthetic fuel and methods for producing synthetic fuel |
October 16, 2007 |
| The present invention provides synthetic fuels, additives for use in preparing synthetic fuels and methods for producing synthetic fuel. The synthetic fuels include low levels of a chemical change additive selected from the group consisting of alkaline earth oxides and hydroxides and |
| 7259254 |
Mutants and assay system to identify USP/RXR ligands |
August 21, 2007 |
| The invention relates to mutant nuclear hormone receptors that encode mutant nuclear hormone receptors, in which particular amino acid residues are substituted with respect to wild type, so as to be able to detect ligand binding to the mutant receptor by either a change in a physical |
| 7256282 |
Nucleic acids encoding Sarcocystis neurona antigen and uses thereof |
August 14, 2007 |
| The present invention provides novel isolated nucleic acids encoding antigenic proteins derived from Sarcocystis neurona, or unique fragments thereof. In particular, the invention provides novel isolated nucleic acids encoding membrane-associated polypeptides SnSAG2, SnSAG3, and SnSA |
| 7229556 |
Delivery system for a composition |
June 12, 2007 |
| Devices and methods for cutaneous delivery of a composition are provided, wherein the composition is passed through an ordered nanoporous membrane in fluid communication with a reservoir. The nanoporous membrane includes a plurality of aligned hollow nanotubules coated with a continuous |
| 7214710 |
Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic ac |
May 8, 2007 |
| The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof. |
| 7211661 |
Trans-excision-splicing ribozyme and methods of use |
May 1, 2007 |
| A group I intron-derived ribozyme which binds RNA in trans, excises an internal segment from within the RNA, and splices the remaining 5' and 3' ends of the RNA back together (the trans-excision-splicing reaction) is disclosed. The excised segment can be as long as 28 nucleotides, or mor |
| 7200757 |
Data shuffling procedure for masking data |
April 3, 2007 |
| A method for data shuffling to preserve data confidentiality is provided. The method comprises masking of particular attributes of a dataset which are to be preserved in confidentiality, followed by a shuffling step comprising sorting the transformed dataset and a transformed confidentia |
| 7200532 |
Subdivision surface-based geometric modeling system |
April 3, 2007 |
| A method for surface modeling of images to produce realistic images or to provide simulations with accurate surface information is provided. More particularly, the present invention relates to a new subdivision depth computation technique and to an improved label-driven adaptive subd |
| 7186891 |
Plant cells and plants expressing chimeric isoprenoid synthases |
March 6, 2007 |
| The invention features plant cells and plants that include a nucleic acid molecule encoding a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned homologous domain. The chimeric isoprenoid synthases of the invention catalyze the production of isoprenoid reacti |
| 7183098 |
Loline alkaloid gene clusters of the fungal endophyte neotyphodium uncinatum |
February 27, 2007 |
| Loline alkaloids (LA), which are 1-aminopyrrolizidines with an oxygen bridge, are produced by Epichloe (anamorph=Neotyphodium) species, endophytes of grasses. LA are insecticidal, thus helping protect host plants from insect herbivory. Suppression subtractive hybridization PCR was us |
| 7166591 |
Catalytic cleavage of phosphate ester bonds by boron chelates |
January 23, 2007 |
| Novel chemical compounds are disclosed having the general formula L{YX.sub.m}.sub.n, wherein X is selected from the Group 13 elements, Y is a halide, and L is a chelating ligand containing at least one binding atom contacting the Group 13 element, the atom being selected from the gro |
| 7160531 |
Process for the continuous production of aligned carbon nanotubes |
January 9, 2007 |
| Novel methods and apparati for continuous production of aligned carbon nanotubes are disclosed. In one aspect, the method comprises dispersion of a metal catalyst in a liquid hydrocarbon to form a feed solution, and volatilizing the feed solution in a reactor through which a substrate is |
