| Patent Number |
Title Of Patent |
Date Issued |
| 7105852 |
High speed electron tunneling devices |
September 12, 2006 |
| A detector includes a voltage source for providing a bias voltage and first and second non-insulating layers, which are spaced apart such that the bias voltage can be applied therebetween and form an antenna for receiving electromagnetic radiation and directing it to a specific locat |
| 6927285 |
Genes for human telomerase reverse transcriptase and telomerase variants |
August 9, 2005 |
| The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subu |
| 6677309 |
Anti-cancer drug aldehyde conjugate drugs with enhanced cytotoxicity compounds, compositions and |
January 13, 2004 |
| Monomeric and dimeric anti-cancer drug aldehyde conjugate compounds and pharmaceutically acceptable salts thereof. Specifically, monomeric and dimeric aldehyde conjugates of 1-2, dihetero-substituted anti-cancer drugs, including monomeric and dimeric aldehyde conjugates of anthracycl |
| 6627619 |
Antisense compositions for detecting and inhibiting telomerase reverse transcriptase |
September 30, 2003 |
| The present invention provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cancer. |
| 6617110 |
Cells immortalized with telomerase reverse transcriptase for use in drug screening |
September 9, 2003 |
| The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for |
| 6565820 |
Low temperature oxidation using support molten salt catalysts |
May 20, 2003 |
| Molten salt reactions are performed by supporting the molten salt on a particulate support and forming a fluidized bed of the supported salt particles. The method is particularly suitable for combusting hydrocarbon fuels at reduced temperatures, so that the formation NO.sub.x species is |
| 6501848 |
Method and apparatus for three-dimensional reconstruction of coronary vessels from angiographic |
December 31, 2002 |
| A method for in-room computer reconstruction of a three-dimensional (3-D) coronary vascular tree from routine biplane angiograms acquired at arbitrary angles and without using calibration objects. The method includes seven major steps: (1) acquisition of two standard angiogram sequen |
| 6497877 |
Plasminogen activator as an anti-inflammatory agent |
December 24, 2002 |
| Plasminogen activator acts as an anti-inflammatory agent by inhibiting generation of superoxide anion by a mechanism that is not related to L-arginine, is not dependent on thrombolytic activity, and is not a function of oxygen free radical scavenging. Moreover, in in vivo models of i |
| 6489450 |
High pressure refolding of protein aggregates and inclusion bodies |
December 3, 2002 |
| The present disclosure provides an effective method for the refolding of denatured proteins in solution so that properly folded, biologically active protein in solution is recovered in high yield. The refolding takes place at pressures between about 0.25 kbar to about 3.5 kbar, advan |
| 6482435 |
Temperature sensitive gel for sustained delivery of protein drugs |
November 19, 2002 |
| Pharmaceutical compositions for the delivery of pharmacologically active proteins are provided by the present invention. The compositions of the present invention comprise a polymeric matrix having thermal gelation properties in which is incorporated a discrete suspension of at least one |
| 6480299 |
Color printer characterization using optimization theory and neural networks |
November 12, 2002 |
| A color management method/apparatus generates image color matching and International Color Consortium (ICC) color printer profiles using a reduced number of color patch measurements. Color printer characterization, and the generation of ICC profiles usually require a large number of |
| 6479007 |
Apparatus and method for controlling pore size in polymeric membranes and thin films |
November 12, 2002 |
| An apparatus and method for controlling the pore structure of thin polymeric sheets, such as porous membranes and thin films, during solvent casting or interfacial polymerization. The invention may be used to reduce or eliminate macrovoid pore defects from solvent-cast or interfacially |
| 6475789 |
Human telomerase catalytic subunit: diagnostic and therapeutic methods |
November 5, 2002 |
| The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis, and treatment of human diseases, for |
| 6444650 |
Antisense compositions for detecting and inhibiting telomerase reverse transcriptase |
September 3, 2002 |
| The present invention provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cancer. |
| 6436636 |
Methods for identifying pharmacologicals for the treatment of heart failure |
August 20, 2002 |
| Methods are disclosed for treating heart failure. Methods are disclosed for screening pharmacologicals that inhibit the down-regulatory activity of AUF1 or AUF1-related polypeptide for .beta.-adrenergic activity. Methods are disclosed for treating a patient with a high level of the AUF1 |
| 6417950 |
Three-color imaging on each pixel for increased resolution |
July 9, 2002 |
| Apparatus for increasing color resolution and quality in digital imaging systems temporally modulates red, green and blue light, detects all three colors at each pixel, and band pass filters the detected light to extract values for red, green and blue at each pixel. A detector which pres |
| 6403672 |
Preparation and use of photopolymerized microparticles |
June 11, 2002 |
| Methods of forming polymer particles in situ from polymer precursors such as monomers or oligomers, comprising exposing a composition comprising at least one polymer precursor, a solvent or solvent mixture, and an antisolvent or antisolvent mixture to photoradiation under conditions |
| 6377341 |
Refractive index based detector system for liquid chromatography |
April 23, 2002 |
| An apparatus and method for on-column analysis in flash chromatography. The detection scheme utilizes refractive index changes as analytes move through an illuminated region of a chromatography column. The column packing material is a diffuse scattering medium when the refractive index |
| 6377202 |
Icing hazard avoidance system and method using dual-polarization airborne radar |
April 23, 2002 |
| An icing hazard avoidance system and method utilizes a forward-looking, single frequency, dual-polarization pulse radar system as well as temperature sensing means to determine if supercooled liquid water (SLW) drops are present in an aircraft's flight path. A processor determines the |
| 6365164 |
Use of neurotoxin therapy for treatment of urologic and related disorders |
April 2, 2002 |
| The present invention relates to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin. |
| 6356864 |
Methods for analysis and evaluation of the semantic content of a writing based on vector length |
March 12, 2002 |
| The present invention is a methodology for analyzing and evaluating a sample text, such as essay(s), or document(s). This methodology compares sample text to a reference essay(s), document(s), or text segment(s) within a reference essay or document. The methodology analyzes the amount |
| 6353151 |
Transgenic model for heart failure |
March 5, 2002 |
| The present invention discloses a transgenic mouse that is a model for congestive heart failure. The disclosed mouse is a subset of a transgenic mouse line that is a model for hypertrophic cardiomyopathy. Also disclosed are a recombinant nucleic acid molecule encoding a transgene, and me |
| 6325999 |
Use of Fas ligand to suppress T-lymphocyte-mediated immune responses |
December 4, 2001 |
| A method for inhibiting T-lymphocyte-mediated immune responses, including those directed against autologous and/or heterologous tissues, e.g., by a recipient mammal of a transplanted tissue, said method comprising providing the recipient mammal with Fas ligand. The Fas ligand may be |
| 6319521 |
Microparticles of lactide-co-glycolide copolymers and methods of making and using the same |
November 20, 2001 |
| The present invention relates to the formation of microparticles from copolymers during a process involving precipitation with compressed antisolvents. The family of suitable copolymers have a semi-crystalline structure that above their glass transition temperature retain sufficient |
| 6310673 |
Transmissive optical polarizing filters designed to maximize a desired portion of a spectral out |
October 30, 2001 |
| This invention provides a complementary color polarizer using a single polarizing film followed by a stack of two or more retarders. In a preferred embodiment, the color polarizers of this invention produce orthogonally polarized complementary primary colors (red/cyan, green/magenta, |
| 6309867 |
Telomerase |
October 30, 2001 |
| The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subu |
| 6268176 |
TRC8, a gene related to the hedgehog receptor, patched |
July 31, 2001 |
| The present invention provides the sequence for a novel gene called TRC8 which is located on chromosome 8. Various types of alterations in the gene have been shown to be associated with renal and thyroid tumors. One such alteration involves a 3;8 translocation which interrupts TRC8 and r |
| 6261836 |
Telomerase |
July 17, 2001 |
| The present invention is directed to telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits o |
| 6254865 |
Method of treating huntington's disease using HNT neurons |
July 3, 2001 |
| The present invention relates to methods and compositions for transplantation of neurons. The methods and compositions of the present invention provide a renewable supply of safe and effective therapeutic transplantable tissue. In particular, the present invention provides methods an |
| 6245966 |
Adenoviral mediated gene transfer into lymphocytes |
June 12, 2001 |
| The present application shows that the expression of Coxsackievirus and/or Adenovirus (CAR) in various lymphocyte cell lines is sufficient to facilitate the efficient transduction of these cells by adenoviruses. This property of CAR does not require its cytoplasmic domain. Use of a t |
| 6232119 |
Immortalized human fetal neuronal cell line |
May 15, 2001 |
| An immortalized line of human fetal brain cells capable of synthesizing dopamine has been developed. No tumor formation or rejection at 30 days post-transplantation has been detected. The cells are useful for transplantation therapy of a neurological deficit characterized by dopamine |
| 6228843 |
Method of using PKC inhibiting compounds to treat vascular disease |
May 8, 2001 |
| A method for treating pulmonary and systemic vascular diseases associated with cardiac hypotrophy, dysfunction or failure that involves the administration of an effective amount of a PKC antagonist to a patient suffering from one of such diseases is disclosed. PKC antagonists are sel |
| 6225063 |
RNA channels in biological membranes |
May 1, 2001 |
| The present invention provides nucleic acid molecules capable of binding phospholipid membranes, and more particularly RNA molecules capable of binding and forming channels in biological membranes. In this regard the present invention provides methods for screening nucleic acid molecules |
| 6224893 |
Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineer |
May 1, 2001 |
| Compositions for tissue engineering and drug delivery have been developed based on solutions of two or more polymers which form semi-interpenetrating or interpenetrating polymer networks upon exposure to active species following injection at a site in a patient in need thereof. The p |
| 6219341 |
Method for bandwidth efficient multiple access wireless communication |
April 17, 2001 |
| A method for wireless communication utilizes available channel bandwidth when multiplexing a plurality of user signals over a communication channel. The method utilizes signal power characteristics as a signature to multiplex and de-multiplex the plurality of signals applied to the c |
| 6218597 |
Transgenic model and treatment for heart disease |
April 17, 2001 |
| The invention provides a transgenic mouse that is a model for heart muscle disease and heart failure. Also provided are methods of using the transgenic mouse model to study heart muscle disease and heart failure and conditions and treatments related thereto. |
| 6203776 |
Method for identifying adrenergic receptor antagonists having good tolerability |
March 20, 2001 |
| Disclosed are methods to identify adrenergic receptor antagonists having good tolerability. These methods include measuring the inverse agonist activity and/or the intrinsic sympathomimetic activity of an adrenergic receptor antagonist. Also disclosed are a method to treat heart failure |
| 6201638 |
Comb generating optical cavity that includes an optical amplifier and an optical modulator |
March 13, 2001 |
| A low-loss comb-generating optical cavity including an optical amplifier and a microwave-driven electro-optic modulator crystal, produces a comb of optical frequency sidebands having spectral lines equally spaced around the frequency of an input laser beam incident on the comb-generating |
| 6166178 |
Telomerase catalytic subunit |
December 26, 2000 |
| The invention provides compositions and methods related to telomerase reverse transcriptase, the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the |
| 6161435 |
Method and apparatus for determining the state of fouling/cleaning of membrane modules |
December 19, 2000 |
| The fouling state of a polymeric membrane within the high pressure housing of a spiral wound or a hollow fiber membrane module is determined. An ultra sonic transducer positioned with its emitting face in physical engagement with the outer surface of the housing is pulse energized by a |
| 6141069 |
Liquid crystal phase modulator using a ferroelectric liquid crystal with a rotatable axis and ch |
October 31, 2000 |
| This invention provides a phase modulator comprising an electro-optically rotatable smectic liquid crystal half-wave retarder in combination with a cholesteric liquid crystal circular polarizer. Rotation of the half-wave retarder varies the phase delay of the modulator. A polarizing |
| 6093809 |
Telomerase |
July 25, 2000 |
| The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subu |
| 6090442 |
Method of growing films on substrates at room temperatures using catalyzed binary reaction seque |
July 18, 2000 |
| The present invention provides a method for growing atomic layer thin films on functionalized substrates at room temperature using catalyzed binary reaction sequence chemistry. Specifically, the atomic layer films are grown using two half-reactions. Catalysts are used to activate surface |
| 6090295 |
Method and apparatus for acoustically demixing aqueous solutions |
July 18, 2000 |
| A method and apparatus for demixing an aqueous solution is provided. The aqueous solution has at least two aqueous phases. The method comprises applying acoustic energy to the aqueous solution. The apparatus comprises a mechanism for applying acoustic energy to the aqueous solution until |
| 6080703 |
Method of making TIBiBaCaCuO based superconductors |
June 27, 2000 |
| A method for producing a high temperature superconductor system having the composition TlBiBaCaCuO. The system exhibits a T.sub.c of at least 116 K. The method includes the steps of mixing compounds including Tl, Bi, Ba, Ca, Cu, and O to create a mixture. The mixture is heated. The mixtu |
| 6069738 |
Apparatus and methods for extending depth of field in image projection systems |
May 30, 2000 |
| An optical system for providing an in-focus, extended depth of field image on a projection surface includes an encoded mask or light encoder for preceding the light to include object information (or, equivalently, information about the desired image), and an extended depth of field (EDF) |
| 6069167 |
Use of antioxidant agents to treat cholestatic liver disease |
May 30, 2000 |
| The present invention relates to formulations and methods for preventing and treating liver injury and fibrosis in cholestasis. This is accomplished by the administration of a composition which includes selected antioxidants. |
| 6049608 |
Variable length nonlinear feedback shift registers with dynamically allocated taps |
April 11, 2000 |
| A new class of variable length, nonlinear feedback shift registers (NLFSR's) is disclosed that uses data-dependent dynamically allocated taps to filter digital information reversibly, flexibly, and rapidly. This class of NLFSR's has been succinctly realized in terms of a multi-parame |
| 6046786 |
Switchable achromatic compound retarder |
April 4, 2000 |
| This invention provides achromatic liquid crystal compound retarders, achromatic polarization switches, and achromatic shutters using the liquid crystal compound retarders. It further provides achromatic variable retardance smectic liquid crystal retarders. The compound retarder of this |
| 6043177 |
Modification of zeolite or molecular sieve membranes using atomic layer controlled chemical vapo |
March 28, 2000 |
| A process for modifying surfaces of zeolites and molecular sieve membranes to decrease effective pore size for separation of materials includes atomic layer controlled vapor or liquid deposition. The atomic layer controlled deposition process steps include (i) exposing the surface to a |
