| Patent Number |
Title Of Patent |
Date Issued |
| 6326507 |
Therapeutic compounds and methods of use |
December 4, 2001 |
| Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis. |
| 6312692 |
Method of treating graft-versus-host disease with anti-GP39 antibodies and bone marrow cells |
November 6, 2001 |
| A method of treating graft-vs-host diseases by administration of bone marrow and an anti-gp39 antibody specific to human gp39 is provided. |
| 6187787 |
Bis(9-aminoacridine) DNA intercalating agents having antitumor activity |
February 13, 2001 |
| A series of bis-acridinyl DNA intercalating agents with anticancer cell activity represented by formula (I), where Z is a linear arrangement of multiple aromatic rings, containing at least three aromatic rings, or at least two alicyclic rings, said rings being linked in a 1,4 or 1,3 mann |
| 6184034 |
Deoxyribonuclease II proteins and cDNAS |
February 6, 2001 |
| The present invention provides cDNAs encoding deoxyribonuclease II and isolated, purified deoxyribonuclease II proteins. Antibodies against this protein and antisense agents targeted to a cDNA or corresponding mRNA encoding deoxyribonuclease II are provided. In addition, methods of i |
| 6162900 |
Metal-regulated transporters and uses therefor |
December 19, 2000 |
| Isolated nucleic acid molecules encoding novel members of the MRT family of polypeptides which include, in a preferred embodiment, at least one transmembrane domain having at least about 30%, more preferably at least about 50%, 55%, 60%, 70%, 80% or 90% amino acid sequence identity with |
| 6124125 |
AMP activated protein kinase |
September 26, 2000 |
| Polynucleotides of AMPK .alpha.1, AMPK .beta. and AMPK .gamma. and polypeptides and biologically active fragments encoded thereby are provided. Vectors and host cells containing these polynucleotides are also provided. In addition, methods of preparing polypeptides and antibodies tar |
| 6057427 |
Antibody to cytokine response gene 2(CR2) polypeptide |
May 2, 2000 |
| Disclosed are an isolated antibody or antibody fragment that selectively binds a polypeptide encoded by Cytokine Response gene 2 (CR2), and in particular, selectively binds to a first polypeptide having the sequence of residues 1-60 of SEQ. ID No: 4. Also disclosed is a composition c |
| 6051398 |
Nucleic acids encoding CR3 polypeptide, vector and transformed cell thereof, and expression ther |
April 18, 2000 |
| Early-induced genes by interleukin-2 (IL-2) have various DNA sequences. This patent describes a nucleotide segment encoding a polypeptide including amino acids 1-356 of SEQ. ID No: 6, antibody binding homologues thereof, antibody binding fragments, and fusion proteins thereof, alleles |
| 6027914 |
Nucleic acids encoding CR6 polypeptide vector and transformed cell thereof, and expression there |
February 22, 2000 |
| Early-induced genes by interleukin-2 (IL-2) have various DNA sequences. This patent describes a nucleotide segment, such as SEQ. ID No: 11, SEQ. ID No. 31, or encoding a polypeptide of amino acids 1-159 of SEQ. ID No: 12, antibody binding homologues thereof, antibody binding fragments, a |
| 6027075 |
Systems and methods for modifying ice adhesion strength |
February 22, 2000 |
| The invention includes system for modifying ice adhesion strength of ice adhered to an object. The system includes an electrode that is electrically insulated from the object and a DC source, e.g., a battery, coupled to the object and the electrode. The source generates a DC bias to |
| 6024966 |
Gene encoding protein antigens of plasmodium falciparum and uses therefor |
February 15, 2000 |
| A Plasmodium falciparum gene encoding immunogenic SERA protein has been isolated by a) systematically screening a lambda gt11 recombinant DNA expression library with a murine monoclonal antibody directed against protein antigens of this pathogen, and b) systematically screening a lam |
| 6020155 |
Nucleic acids encoding CR1 fusion protein, vector, transfected cell and expression |
February 1, 2000 |
| A method for producing a complementary DNA (cDNA) library enriched in ligand-inducible genes of a cell is described. The method includes activating a cellular ligand receptor for a predetermined period of time in the presence of labelled RNA precursors and a substance which enhances |
| 6020124 |
Detection of soluble gene sequences in biological fluids |
February 1, 2000 |
| Methods are provided for detecting and quantitating gene sequences, such as mutated genes and oncogenes, in biological fluids. The fluid sample (e.g., plasma, serum, urine, etc.) is obtained, deproteinized and the DNA present in the sample is extracted. The DNA is then amplified using an |
| 6018031 |
Binding agents specific for IgA receptor |
January 25, 2000 |
| Binding agents which bind specifically to a receptor for human IgA, including monoclonal antibodies which react specifically to Fc receptor for IgA of human effector cells are disclosed. The binding agents, e.g., antibodies are useful for targeting human effector cells (e.g. macropha |
| 5942229 |
Method for prolonged suppression of humoral immune response to a thymus-dependent antigen therap |
August 24, 1999 |
| Methods of suppressing a humoral immune response to a thymus-dependent (TD) antigen are disclosed. The methods involve administering to a subject a TD antigen with an antagonist of a molecule which mediates contact-dependent helper effector functions. In a preferred embodiment, the antag |
| 5935949 |
Use of androgen therapy in fibromyalgia and chronic fatigue syndrome |
August 10, 1999 |
| A method of using androgen therapy to alleviate symptoms associated with chronic fatigue syndrome and fibromyalgia syndrome is provided. |
| 5882894 |
Nucleic acids encoding CR8 polypeptides, vector and transformed cell thereof, and expression the |
March 16, 1999 |
| Early-induced genes by interleukin-2 (IL-2) have various DNA sequences. This patent describes a polyribonucleotide with a nucleotide segment encoding amino acids 1-412 of SEQ. ID No: 14, antibody binding homologues thereof, antibody binding fragments thereof at least 5 amino acids long, |
| 5876718 |
Methods of inducing T cell non-responsiveness to transplanted tissues and of treating graft-vers |
March 2, 1999 |
| Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred embodiment, an antibody of the invention binds an epitope recognized by a monoclonal antibody 2 |
| 5871961 |
Nucleic acids encoding CR2 polypeptides, vector and transformed cell thereof, and expression the |
February 16, 1999 |
| Early-induced genes by interleukin-2 (IL-2) have various DNA sequences. This patent describes a polyribonucleotide with a nucleotide segment encoding amino acids 1-60 of SEQ. ID No: 4, antibody binding homologues thereof, antibody binding fragments thereof at least 5 amino acids long, |
| 5871960 |
Nucleic acids encoding CR5 polypeptide, vector and transformed cell thereof, and expression ther |
February 16, 1999 |
| Early-induced genes by interleukin-2 (IL-2) have various DNA sequences. This patent describes a nucleotide segment encoding a polypeptide including amino acids 1-258 of SEQ. ID No: 10, antibody binding homologues thereof, antibody binding fragments, and fusion proteins thereof, alleles |
| 5869049 |
Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists |
February 9, 1999 |
| Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates contact-dependent helper |
| 5859196 |
P30 peptides of Toxoplasma gondii |
January 12, 1999 |
| Genetic material encoding p30 and B1 peptides of Toxoplasma gondii has been isolated and characterized. This genetic material allows the production of peptides for use in diagnosis or immunization or can itself be directly used in hybridization assays. |
| 5846821 |
Metal-regulated transporters and uses therefor |
December 8, 1998 |
| Isolated nucleic acid molecules encoding novel members of the MRT family of polypeptides which include, in a preferred embodiment, at least one transmembrane domain having at least about 30%, more preferably at least about 50%, 55%, 60%, 70%, 80% or 90% amino acid sequence identity with |
| 5834283 |
Acyl coenzyme A:cholesterol acyltransferase (ACAT) |
November 10, 1998 |
| This invention pertains to purified, biologically active acyl coenzyme A: cholesterol acyltransferase (ACAT) and to nucleic acid (DNA or RNA) encoding acyl coenzyme A:cholesterol acyltransferase. The nucleic acid, or a fragment thereof, may be ligated with an expression vector and tr |
| 5833987 |
Treatment of T cell mediated autoimmune disorders |
November 10, 1998 |
| Method for the treatment of multiple sclerosis and other T cell mediated autoimmune disorders is described. The method involves administering to a subject a therapeutically effective amount of an antagonist of a receptor on a surface of a T cell which mediates contact dependent helper ef |
| 5833601 |
Methodology for determining oxygen in biological systems |
November 10, 1998 |
| The invention provides apparatus and methods for measuring oxygen tensions in biological systems utilizing physiologically acceptable paramagnetic material, such as India ink or carbon black, and electron paramagnetic resonance (EPR) oximetry. India ink is introduced to the biological sy |
| 5795752 |
Method for creating superinduced cDNA library & isolating ligand-stimulated genes |
August 18, 1998 |
| Disclosed is a method of producing a complementary DNA (cDNA) library enriched in ligand-inducible genes of a cell. The method includes activating a cellular ligand receptor for a predetermined period of time in the presence of labelled RNA precursors and a substance which enhances t |
| 5765152 |
System and method for managing copyrighted electronic media |
June 9, 1998 |
| Copyrighted electronic media are packaged in a secure electronic format, and registered on associated registration server, which serves to provide on-line licensing and copyright management for that media. Users are connected to the server, e.g., through a computer network or the Interne |
| 5747037 |
Anti-GP39 antibodies |
May 5, 1998 |
| Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred embodiment, an antibody of the invention binds an epitope recognized by a monoclonal antibody 2 |
| 5706805 |
Apparatus and methodology for determining oxygen tension in biological systems |
January 13, 1998 |
| The invention provides apparatus and methods for measuring oxygen tensions in biological systems utilizing physiologically acceptable paramagnetic material, such as India ink or carbon black, and electron paramagnetic resonance (EPR) oximetry. India ink is introduced to the biological sy |
| 5683693 |
Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand ant |
November 4, 1997 |
| Methods for inducing T cell unresponsiveness to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts w |
| 5635600 |
Bifunctional and heteroantibodies specific for the high affinity Fc receptor for immunoglobulin |
June 3, 1997 |
| Monoclonal antibodies which react specifically to Fc receptor of human effector cells IgG are disclosed. Binding of the antibodies to the receptor is not blocked by human immunoglobulin G. The antibodies are useful for targeting human effector cells (e.g. macrophages) against a targe |
| 5494030 |
Apparatus and methodology for determining oxygen in biological systems |
February 27, 1996 |
| The invention provides apparatus and methods for measuring oxygen tensions in biological systems utilizing physiologically acceptable paramagnetic material, such as India ink or carbon black, and electron paramagnetic resonance (EPR) oximetry. India ink is introduced to the biological sy |
| 5492816 |
Composition and method for enhancing detection of superoxide anion |
February 20, 1996 |
| A composition and method for enhancing luminol chemiluminescence assays for superoxide anion comprising an orthovanadate salt, such as sodium orthovanadate. Orthovanadate enhances photon emission when luminol is cleaved by superoxide anion. The orthovanadate salt is non-cytotoxic and |
| 5484727 |
Cloned gene encoding acylcoenzyme A: cholesterol acyltransferase (ACAT) |
January 16, 1996 |
| This invention pertains to purified, biologically active acyl coenzyme A: cholesterol acyltransferase (ACAT) and to nucleic acid (DNA or RNA) encoding acyl coenzyme A: cholesterol acyltransferase. The nucleic acid, or a fragment thereof, may be ligated with an expression vector and t |
| 5438402 |
System and method for measuring the interface tensile strength of planar interfaces |
August 1, 1995 |
| A system for measuring the tensile strength of a planar interface between a substrate and a coating which includes an energy source that generates an electromagnetic beam along a first axis, and a sample assembly disposed along the first axis having a first face, and a second face, where |
| 5401640 |
Method for enhancing detection of superoxide anion |
March 28, 1995 |
| A method for enhancing luminol chemiluminescence assays for superoxide anion comprising an orthovanadate salt, such as sodium orthovanadate. Orthovanadate enhances photon emission when luminol is cleaved by superoxide anion. The orthovanadate salt is non-cytotoxic and non-denaturing |
| 5314992 |
Lipocortin-1 receptor protein and its uses |
May 24, 1994 |
| A new cellular protein produced by activated monocytes/neutrophils and mononuclear cells, and involved in the binding of lipocortin-1 has been discovered. Methods for isolating and purifying this substantially pure lipocortin-1 receptor protein are disclosed herein as well as techniques |
| 5301687 |
Microwave applicator for transurethral hyperthermia |
April 12, 1994 |
| A radiant heating apparatus for deployment within an animal body to radiate heat-producing electromagnetic energy into the body includes an antenna mounted on a catheter element and connected to an electrical transmission line having first and second conductors for feeding electrical cur |
| 5268693 |
Semiconductor film free electron laser |
December 7, 1993 |
| Semiconductor film FEL uses an electron beam and a semiconducting-film-loaded, open, quasi-optical resonator to produce coherent, electromagnetic radiation at submm and far-infrared wavelengths. |
| 5263043 |
Free electron laser utilizing grating coupling |
November 16, 1993 |
| Free electron laser apparatus, for producing coherent electromagnetic radiation within a spectral range extending from millimeter to visible wavelengths, includes elements for generating an electron beam and for directing the beam to move over the surface of a diffraction grating, th |
| 5261747 |
Switchable thermoelectric element and array |
November 16, 1993 |
| A thermoelectric array, such as a thermocouple array, includes a pair of dissimilar conductors disposed adjacent to each other at a plurality of locations. A switch is provided which selectively electrically couples and decouples the conductors at each such location, and an effective |
| 5258293 |
Continuous process for ethanol production from lignocellulosic materials without mechanical agit |
November 2, 1993 |
| An improved and highly productive method of continuously producing ethanol from lignocellulosic substrates is provided. The method involves providing a suitable microbial system within a reaction vessel and adding fermentable substrate to the reactor to form a reaction mixture. The f |
| 5124004 |
Distillation process for ethanol |
June 23, 1992 |
| A method of distillation employing a heat pump (which may be driven by a compressor) using a vapor stream from within the distillation system as a heat source and a liquid stream from within the distillation system as a heat sink. The selection of heat-source vapors and heat-sink liquid |
| 4961826 |
Distillation process for ethanol |
October 9, 1990 |
| A method of distillation employing a heat pump (which may be driven by a compressor) using a vapor stream from within the distillation system as a heat source and a liquid stream from within the distillation system as a heat sink. The selection of heat-source vapors and heat-sink liquid |
| 4954617 |
Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
September 4, 1990 |
| Monoclonal antibodies specific for the high affinity (72 K.D.) F.sub.c receptor on human monocytes are diclosed. The monoclonal antibodies do not block normal IgG binding to the receptor. |
| 4954436 |
Dihydropyridine-sensitive calcium channel as a tumor associated marker |
September 4, 1990 |
| A protein antigen related to the dihydro-pyridine-sensitive calcium channel is expressed at high levels by small cell carcinoma of the lung and neuroblastomas. The antigen serves as a marker which can be exploited for diagnosis and therapy of these tumors. Methods of diagnosis and therap |
| 4937580 |
Geophysical radar apparatus and method |
June 26, 1990 |
| A ground probing radar is described for detecting radar reflections from underground objects. The radar is of the pulse compression type. A transmitter generates a biphGovernment SupportThe U.S. Government has rights to this invention pursuant to Contract No. 536115 (DACA 89-81-K-0004) a |
| 4755494 |
Use of pectin or pectin-like material in water-based ceramics |
July 5, 1988 |
| The use of pectins (or pectin-like materials) as an additive to clay to provide clay compositions of enhanced plasticity and stability is disclosed. |
| 4722056 |
Reference display systems for superimposing a tomagraphic image onto the focal plane of an opera |
January 26, 1988 |
| A reference display system that receives information from an imaging system (e.g., a CT scanner or the like), that extracts or derives three-dimensional anatomical and/or pathological information about a part of a body (e.g., the brain or other organ) of a patient. The information is |
