| Patent Number |
Title Of Patent |
Date Issued |
| 7407760 |
Compositions and methods for enhancing the identification of prion protein PRP.sup.Sc |
August 5, 2008 |
| The present invention provides compositions, methods and kits for enhancing the amplification of PrP.sup.Sc for use in increasing the sensitivity of identifying the presence of PrP.sup.Sc in a sample. |
| 7387271 |
Immunostimulatory combinations |
June 17, 2008 |
| The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also may include an antigen. |
| 7361482 |
Method for detecting intracellular cholesterol |
April 22, 2008 |
| The present invention relates to a method of detecting intracellular cholesterol. The method provides contacting a permeabilized cell with labeled c.theta. complex. Methods of using this detection method to identify agents which modulate cholesterol accumulation in a cell are also pr |
| 7339043 |
Compositions and methods for affecting virulence determinants in bacteria |
March 4, 2008 |
| A novel sarR gene and sarR gene product which down regulates the expression of sarA and the resulting virulence determinants in Staphylococcus aureus is provided. Methods for modulating the expression of sarA and virulence determinants are also provided. A preferred embodiment of the |
| 7306803 |
Methods for modulating angiogenesis |
December 11, 2007 |
| Recombinant plasminogen activator inhibitor-1 (PAI-1) isoforms which lack the reactive center loop and contain the complete heparin-binding domain or lack at least a portion of the heparin-binding domain are described. The rPAI-1 isoforms disclosed herein may be used to modulate angiogen |
| 7288568 |
Therapeutic compositions and methods of use |
October 30, 2007 |
| Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis. |
| 7285270 |
Method of reducing neuropathic pain |
October 23, 2007 |
| The present invention relates to methods of treating pain. Monocyte chemoattractant protein-1 (MCP-1) antibodies or binding fragments thereof are used to prevent or reduce behavioral hypersensitivity associated with pain. |
| 7270975 |
Methods for regulating bud-hypha transitions and cAMP levels in Candida albicans |
September 18, 2007 |
| The infection of a mammalian host by a microorganism can be prevented or treated through the alteration of the C. albicans homologue of the high affinity phosphodiesterase, PDE2, gene and/or the adenylate cyclase-associated protein gene. These methods may be used in the identificatio |
| 7258995 |
Compositions and methods for affecting virulence determinants in bacteria |
August 21, 2007 |
| A novel sarR gene and sarR gene product which down regulates the expression of sarA and the resulting virulence determinants in Staphylococcus aureus is provided. Methods for modulating the expression of sarA and virulence determinants are also provided. A preferred embodiment of the |
| 7258984 |
Compositions and methods for identifying agents which regulate autolytic processes in bacteria |
August 21, 2007 |
| A nucleic acid sequence which regulates the autolytic activity of bacteria is provided. Methods for identifying and using agents which interact with the gene to inhibit bacterial growth and infectivity also are provided. |
| 7241446 |
Methods for modulating angiogenesis via VEGF |
July 10, 2007 |
| Recombinant plasminogen activator inhibitor-1 (PAI-1) isoforms which lack the reactive center loop and contain the complete heparin-binding domain or lack at least a portion of the heparin-binding domain are described. The rPAI-1 isoforms disclosed herein may be used to modulate angiogen |
| 7238782 |
Compositions and methods for regulating RNA stability using polypyrimidine tract proteins |
July 3, 2007 |
| Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of polypyrimidine tract proteins with the 3'-untranslated region of CD154. |
| 7186519 |
Method for detecting intracellular cholesterol |
March 6, 2007 |
| The present invention relates to a method of detecting intracellular cholesterol. The method provides contacting a permeabilized cell with labeled C.theta. complex. Methods of using this detection method to identify agents which modulate cholesterol accumulation in a cell are also pr |
| 7166763 |
Mouse model of myxomatous valvular disease |
January 23, 2007 |
| An animal selected for lacking heparan sulfate 3-O-sulfotransferase-1 activity is provided. This animal exhibits characteristics associated with myxomatous valvular disease and is useful for identifying agents which prevent, delay or treat myxomatous valvular disease. Methods of diag |
| 7148328 |
Compositions and methods for regulating autolytic processes in bacteria |
December 12, 2006 |
| A nucleic acid sequence required for regulating the autolytic activity of bacteria is provided. Also provided are polypeptides encoded by the gene or mutant gene as well as vector and host cells for expressing these polypeptides. Methods for identifying and using agents which interact |
| 7148210 |
Method of treating bone metastasis |
December 12, 2006 |
| The invention provides a drug combination for the treatment of diseases associated with bone metastasis. The combination provides adenosine or a derivative thereof, a bisphosphonate, and a targeting agent(s) to decrease the signs or symptoms associated with such diseases. |
| 7144710 |
Method for detecting inflammation and inflammatory conditions |
December 5, 2006 |
| Methods for detecting the inflammatory biomarkers molecule CD 163 in biological samples are provided. Also provided are methods for monitoring the course of an inflammatory process or condition in a patient and compositions and methods for preventing and treating inflammation and inf |
| 7135182 |
Inhibition of transglutaminase-mediated microbial interaction with a mammalian host |
November 14, 2006 |
| The infection of a mammalian host by a microorganism can be prevented or treated through the administration of substrates for transglutaminases or antibodies against such substrates that inhibit the transglutaminase-mediated interaction of the microorganism with the mammalian host. T |
| 7129349 |
Methods of synthesizing 3-amino-1,2,4-benzotriazines |
October 31, 2006 |
| An improved method of producing 3-amino-1,2,4-benzotriazines using nitrobenzene or a derivative thereof, a guanidine salt and a base as reactants is provided. The method is carried out at a moderate reaction temperature without producing halide wastes derived from nucleophilic substi |
| 7109294 |
Bacterial glycosyltransferase polypeptides involved in antibiotic resistance |
September 19, 2006 |
| Disclosed are various genes encoding proteins that are shown to play a role, direct or indirect, in microbial resistance of an organism in a biofilm and homologs thereof. Also disclosed are methods of identifying a compound that modulates microbial resistance of an organism in a biofilm, |
| 7049086 |
High-throughput screening assay for cholesterol inhibitors and inhibitors identified thereby |
May 23, 2006 |
| The present invention provides a high-throughput screening assay to identify test agents as cholesterol inhibitors via mutant NCP1 mammalian cells. Also provided are cholesterol inhibiting agents identified in accordance with this assay and methods for using such agents to inhibit ch |
| 7049075 |
Deoxyribonuclease II.beta. proteins and cDNAs |
May 23, 2006 |
| The present invention provides cDNAs encoding deoxyribonuclease II.beta. and isolated, purified deoxyribonuclease II.beta. proteins. Antibodies against this protein and antisense agents targeted to a cDNA or corresponding mRNA encoding deoxyribonuclease II.beta. are provided. In addi |
| 7033756 |
Methods of diagnosing, prognosticating and treating matrix metalloproteinase-1 related diseases |
April 25, 2006 |
| Methods and kits for diagnosing and prognosticating matrix metalloproteinase-1 related disease by detecting a single nucleotide polymorphism in the promoter of the gene are provided. Also provided are methods of identifying agents which inhibit binding of transcriptions factors to th |
| 7022487 |
Compositions and methods for regulating RNA stability using polypyrimidine tract proteins |
April 4, 2006 |
| Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of polypyrimidine tract proteins with the 3'-untranslated region of CD154. |
| 7012148 |
Compositions and methods for thionation during chemical synthesis reactions |
March 14, 2006 |
| Compositions and methods for using these compositions to produce high yields of thionated compounds are provided. |
| 6996241 |
Tuned feedforward LMS filter with feedback control |
February 7, 2006 |
| A method to automatically and adaptively tune a leaky, normalized least-mean-square (LNLMS) algorithm so as to maximize the stability and noise reduction performance in feedforward adaptive noise cancellation systems. The automatic tuning method provides for time-varying tuning param |
| 6943014 |
Deoxyribonuclease II.beta. proteins and CDNAs |
September 13, 2005 |
| The present invention provides cDNAs encoding deoxyribonuclease II.beta. and isolated, purified deoxyribonuclease II.beta. proteins. Antibodies against this protein and antisense agents targeted to a cDNA or corresponding mRNA encoding deoxyribonuclease II.beta. are provided. In addi |
| 6929913 |
Compositions and methods for regulating autolytic processes in bacteria |
August 16, 2005 |
| A nucleic acid sequence required for regulating the autolytic activity of bacteria is provided. Also provided are polypeptides encoded by the gene or mutant gene as well as vector and host cells for expressing these polypeptides. Methods for identifying and using agents which interact wi |
| 6927059 |
Compositions and methods for identifying agents which regulate autolytic processes in bacteria |
August 9, 2005 |
| A nucleic acid sequence which regulates the autolytic activity of bacteria is provided. Methods for identifying and using agents which interact with the gene to inhibit bacterial growth and infectivity also are provided. |
| 6887677 |
Compounds and methods for identifying compounds which inhibit a new class of aspartyl proteases |
May 3, 2005 |
| Compounds and methods for designing and identifying compounds which inhibit TFPP-like aspartyl protease enzymes by targeting the aspartic acid residues of the active site or mimicking peptides corresponding to the region surrounding the substrate's cleavage site are provided. Agents |
| 6847024 |
Prevention of ice formation by applying electric power to a liquid water layer |
January 25, 2005 |
| A first electrode is separated from a second electrode by an interelectrode space. The interelectrode space does not exceed 3 mm, and preferably does not exceed 100 .mu.m. Liquid water fills the interelectrode space, thereby electrically connecting the first electrode and the second elec |
| 6807534 |
System and method for managing copyrighted electronic media |
October 19, 2004 |
| Copyrighted electronic media are packaged in a secure electronic format, and registered on associated registration server, which serves to provide on-line licensing and copyright management for that media. Users are connected to the server, e.g., through a computer network or the Interne |
| 6767997 |
Antibodies that bind deoxyribonuclease II.beta. enzyme proteins |
July 27, 2004 |
| The present invention provides cDNAs encoding deoxyribonuclease II.beta. and isolated, purified deoxyribonuclease II.beta. proteins. Antibodies against this protein and antisense agents targeted to a cDNA or corresponding mRNA encoding deoxyribonuclease II.beta. are provided. In addi |
| 6741707 |
Method for tuning an adaptive leaky LMS filter |
May 25, 2004 |
| A method to automatically and adaptively tune a leaky, normalized least-mean-square (LNLMS) algorithm so as to maximize the stability and noise reduction performance in feedforward adaptive noise cancellation systems. The automatic tuning method provides for time-varying tuning param |
| 6733996 |
Methods for regulating gene expression using light |
May 11, 2004 |
| The invention provides methods of regulating gene expression using a light-activated transcription factor. The White Collar Complex, comprised of WC-1 and WC-2 proteins, binds FAD and becomes activated in the presence of light to stimulate transcription of genes operatively-linked to |
| 6632286 |
Cross-flow process for the production of decomposable soluble products from a slurry of solids |
October 14, 2003 |
| A process is described for the production of decomposable soluble products from a slurry of solids in which the slurry is convey axially through the reactor and excess liquid is removed radially through the walls of the reactor. The primary example is the hydrolysis of lignocellulosic bi |
| 6602710 |
Screening method for SREBP pathway-specific inhibitors |
August 5, 2003 |
| This invention provides a screening method for sterol regulatory element binding protein (SREBP) pathway-specific inhibitors using a mutant cultured cell, as well as therapeutic agents for hyperlipemia, arterial sclerosis, obesity or cancer containing an SREBP pathway-specific inhibi |
| 6590140 |
Metal-regulated transporters and uses therefor |
July 8, 2003 |
| Isolated nucleic acid molecules encoding members of the MRT family of polypeptides which include, in a preferred embodiment, at least one transmembrane domain having at least about 30%, more preferably at least about 50%, 55%, 60%, 70%, 80% or 90% amino acid sequence identity with SEQ |
| 6563053 |
Systems and methods for modifying ice adhesion strength |
May 13, 2003 |
| The invention includes system for modifying ice adhesion strength of ice adhered to an object. The system includes an electrode that is electrically insulated from the object and a DC source, e.g., a battery, coupled to the object and the electrode. The source generates a DC bias to |
| 6552075 |
Therapeutic compounds and methods of use |
April 22, 2003 |
| Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis. |
| 6509165 |
Detection methods for type I diabetes |
January 21, 2003 |
| Proinsulin peptide compounds that modulate an immunological response by T cells of Type I diabetic subjects are disclosed. The proinsulin peptide compounds of the invention are preferably derived from a region of proinsulin that spans the junction between the B chain and C peptide of |
| 6498193 |
Treatment for complications of type 2 diabetes |
December 24, 2002 |
| A method is disclosed of lowering plasma levels of .alpha.-dicarbonyl precursors of advanced glycation end-products, such as methylglyoxal, in a patient having type 2 diabetes by administrating metformin in a dosage from twenty-five to fifty percent in excess of its antidiabetic ther |
| 6485486 |
System and methods for fallopian tube occlusion |
November 26, 2002 |
| The invention provides systems, methods for 14 treatment, and occlusion of the fallopian tube. An elongated catheter (22) is placed into the isthmic region (14) of the fallopian tube (16) in a trans-cervical trans-uterine fashion, and a mono-pole antenna (92) is disposed within a distal |
| 6427946 |
Systems and methods for modifying ice adhesion strength |
August 6, 2002 |
| The invention includes system for modifying ice adhesion strength of ice adhered to an object. The system includes an electrode that is electrically insulated from the object and a DC source, e.g., a battery, coupled to the object and the electrode. The source generates a DC bias to |
| 6413976 |
Compositions and method for decreasing neuropathic pain |
July 2, 2002 |
| Compositions containing propentofylline, and methods for treating neuropathic pain with such compositions, are disclosed. |
| 6399077 |
Method of augmenting T cell-mediated immunity against Toxoplasma gondii |
June 4, 2002 |
| A method of augmenting T cell-mediated immunity against Toxoplasma gondii is provided. Immunization with Toxoplasma gondii soluble parasite antigen and exogenous rIL-15 was found to protect against Toxoplasma gondii infection. |
| 6375950 |
Methods for inducing T cell unresponsiveness to donor tissue or organ in a recipient with gp39 a |
April 23, 2002 |
| Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a |
| 6358723 |
Deoxyribonuclease II.beta. proteins and cDNAs |
March 19, 2002 |
| The present invention provides cDNAs encoding deoxyribonuclease II.beta. and isolated, purified deoxyribonuclease II.beta. proteins. Antibodies against this protein and antisense agents targeted to a cDNA or corresponding mRNA encoding deoxyribonuclease II.beta. are provided. In addi |
| 6328964 |
Method to treat multiple sclerosis with GP39-specific antibodies |
December 11, 2001 |
| Method for the treatment of multiple sclerosis and other T cell mediated autoimmune disorders is described. The method involves administering to a subject a therapeutically effective amount of an antagonist of a receptor on a surface of a T cell which mediates contact dependent helper ef |
| 6326507 |
Therapeutic compounds and methods of use |
December 4, 2001 |
| Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis. |
