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Trustees of Columbia University in the City of New York Patents
Assignee:
Trustees of Columbia University in the City of New York
Address:
New York, NY
No. of patents:
27
Patents:




Patent Number Title Of Patent Date Issued
7435429 Zinc salt compositions for the prevention of dermal and mucosal irritation October 14, 2008
The present invention provides for compositions and methods that may offer protection from irritants, as well as antimicrobial protection. Preferred embodiments of the invention include topical antimicrobial compositions comprising two or more water-soluble zinc salts in low concentratio
7393686 Genetic demonstration of requirement for NKX6.1 and NKX2.2 in ventral neuron generation July 1, 2008
This invention provides a method of converting a stem cell into a ventral neuron which comprises introducing into the stem cell a nucleic acid which expresses homeodomain transcription factor Nkx6.1 protein in the stem cell so as to thereby convert the stem cell into the ventral neuron.
7125976 Method of screening for agents inhibiting chloride intracellular channels October 24, 2006
The present invention isolates and characterizes the exc-4 gene of C. elegans, and identifies exc-4 as an orthologue of the human CLIC family of chloride intracellular channels. Accordingly, a nucleic acid having the sequence of SEQ ID NO.: 1 is disclosed, as well as recombinant vect
6958627 Asynchronous pipeline with latch controllers October 25, 2005
An asynchronous pipeline for high-speed applications uses simple transparent latches in its datapath and small latch controllers for each pipeline stage. The stages communicate with each other using request signals and acknowledgment signals. Each transition on the request signal ind
6951923 Genes displaying enhanced expression during cellular senescence and terminal cell differentiatio October 4, 2005
This invention provides for antibodies directed to OLD-35 protein, the product of the OLD-35 gene, which displays enhanced expression during cellular senescence and terminal cell differentiation.
6905857 RAD51 polypeptides June 14, 2005
Nucleic acid sequences encoding two RAD51 recombinases active in maize plants are provided. cDNA sequences including the ZmRAD51 coding sequences and unique 3'-untranslated regions which are useful as RFLP probes, are also provided. The production of plasmids containing a nucleic acid
6865668 Variable-length, high-speed asynchronous decoder circuit March 8, 2005
There is disclosed a decoder circuit (20) for decoding input data coded using a variable length coding technique, such as Huffman coding. The decoder circuit (20) comprises an input buffer (100), a logic circuit (150) coupled to the input buffer (100), and an output buffer (700) coup
6777180 Method for full-length cDNA cloning using degenerate stem-loop annealing primers August 17, 2004
The present invention provides a method for isolating a double-stranded cDNA having a nucleotide sequence of a complete open reading frame which comprises: (A) admixing (i) an isolated single-stranded cDNA, (ii) a first primer capable of forming a stem-loop structure, comprising (a) at t
6730487 Surface plasmon resonance biosensor for measurement of anti-glycolipid antibody levels in neurop May 4, 2004
The present invention provides a method of detecting human antibodies in a sera solution. The invention also provides a method of quantitating anti-glycolipid antibody levels in solutions. The invention provides a method of diagnosing disease states, including neurological diseases, by
6555449 Methods for producing uniform large-grained and grain boundary location manipulated polycrystall April 29, 2003
Methods for processing an amorphous silicon thin film sample into a polycrystalline silicon thin film are disclosed. In one preferred arrangement, a method includes the steps of generating a sequence of excimer laser pulses, controllably modulating each excimer laser pulse in the seq
6548650 Nucleic acid encoding melanoma differentiation associated gene-9 April 15, 2003
This invention provides a method for producing a temporally paced subtracted cDNA library comprising: a) isolating temporally spaced RNAs from cells; b) generating cDNA inserts from the RNAs isolated from step (a); c) producing a temporally spaced cDNA library having clones containin
6541684 Nucleotide sequences encoding maize RAD51 April 1, 2003
Nucleic acid sequences encoding two RAD51 recombinases active in maize plants are provided. cDNA sequences including the ZmRAD51 coding sequences and unique 3'-untranslated regions which are useful as RFLP probes, are also provided. The production of plasmids containing a nucleic acid
6540827 Slicing of single-crystal films using ion implantation April 1, 2003
A method is provided for detaching a single-crystal film from an epilayer/substrate or bulk crystal structure. The method includes the steps of implanting ions into the crystal structure to form a damage layer within the crystal structure at an implantation depth below a top surface
5968736 Methods for recording the reaction history of a solid support October 19, 1999
Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers
5721099 Complex combinatorial chemical libraries encoded with tags February 24, 1998
Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers
5616338 Infection-resistant compositions, medical devices and surfaces and methods for preparing and usi April 1, 1997
A method of preparing an infection-resistant medical device comprising one or more matrix-forming polymers selected from the group consisting of biomedical polyurethane, biomedical silicones and biodegradable polymers, and antimicrobial agents, especially a synergistic combination of a s
5555191 Automated statistical tracker September 10, 1996
A method for automatically monitoring a system to detect malfunctions, wherein said system generates messages based upon selected data, comprising the steps of receiving messages generated by said system, counting said messages over statistically significant time periods to form mess
5553074 Transmission format in packet based communications September 3, 1996
In packet based communications, e.g., in cellular or mobile communications, information is formatted as transmission frames. The transmission frames have equal length or duration, and they have a common format. Each transmission frame includes a frame marker field, a signaling field and
5487896 Antimicrobial glove comprising a rapid release matrix system for antiinfective agent delivery January 30, 1996
The present invention relates to an antimicrobial glove which exhibits rapid release of the antiinfective agent chlorhexidine. It is based, at least in part, on the discovery that when a slurry having a high ratio of chlorhexidine to starch lubricant, where the percentage of starch l
5149636 Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing protein September 22, 1992
Multiple copies of a foreign DNA I coding for the production of a protein may be introduced into eucaryotic cells by cotransforming suitable cells with foreign DNA I and with foreign DNA II which includes a functionally deficient, amplifiable gene coding for a selectable or identifiable
5019096 Infection-resistant compositions, medical devices and surfaces and methods for preparing and usi May 28, 1991
A method of preparing an infection-resistant medical device comprising one or more matrix-forming polymers selected from the group consisting of biomedical polyurethane, biomedical silicones and biodegradable polymers, and antimicrobial agents, especially a synergistic combination of a s
4952411 Method of inhibiting the transmission of AIDS virus August 28, 1990
An inexpensive, easily available and convenient method of inhibiting the transmission of the AIDS virus in humans as a result of sexual intercourse is provided. The method relies upon a dual mode of action of antiviral compositions comprising silver salts, such as silver sulfadiazine, al
4926180 Analog to digital conversion using correlated quantization and collective optimization May 15, 1990
A 1-bit nonstandard A/D converter for converting a block u of N samples of a continuous time analog signal u(t) into N corresponding 1-bit binary values x, such that a distortion measure of the form d(u,x)=(Au-Bx).sup.T (Au-Bx) is minimized, is implemented with an N-input parallel sa
4865577 Noncircular drive September 12, 1989
Noncircular drives, including chain drives with noncircular sprockets, achieve a desired functional relationship and minimize slack variation in the elongate flexible member thereof. Noncircular gears having the desired functional relationship are first designed. Noncircular members havi
4792696 Method and an apparatus for determining surface shape utilizing object self-shadowing December 20, 1988
A method and apparatus are provided wherein a moving light source is passed over a surface whose shape is to be determined, in two orthogonal paths and is fixed at a plurality of positions along each path such that the light source illuminates the surface at a different slope for each
4791407 Alternate mark/space inversion line code December 13, 1988
A communication system and method for transmitting information in the form of binary digital data to be transmitted is encoded into two separate two level sequences S1 and S2 such that the first occurrence of a logic "1" is encoded into the same level in both sequences and each subsequen
4771036 Method and ophthalmic composition for the prevention and reversal of cataracts September 13, 1988
The subject invention concerns a process for the prevention and reversal of cataracts. Specifically, the invention comprises the treatment of the eye lens with an effective cataract inhibiting amount of thioredoxin or thioredoxin-derived, or thioredoxin-like, dithiol peptide, alone, or i

 
 
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