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Trustees of Boston University Patents
Assignee:
Trustees of Boston University
Address:
Boston, MA
No. of patents:
273
Patents:


1 2 3 4 5 6










Patent Number Title Of Patent Date Issued
8580253 Immunomodulating compositions and methods of use November 12, 2013
This invention is directed to .beta.-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The .beta.-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid
8273052 Fully automated control system for type 1 diabetes September 25, 2012
An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject model is recursively
8257987 Planarization of GaN by photoresist technique using an inductively coupled plasma September 4, 2012
Films of III-nitride for semiconductor device growth are planarized using an etch-back method. The method includes coating a III-nitride surface having surface roughness features in the micron range with a sacrificial planarization material such as an appropriately chose photoresist. The
8242172 2,2-dimethylbutyric acid oral pharmaceutical compositions August 14, 2012
The invention is directed to novel pharmaceutical compositions comprising chemicals agents that are useful in the treatment and prevention of cystic fibrosis and the prevention of signs and symptoms of this disease. These pharmaceutical compositions are surprisingly successful in the
8198604 System and method for providing enhanced background rejection in thick tissue with differential- June 12, 2012
A system for providing enhanced background rejection in thick tissue contains an aberrating element for introducing controllable extraneous spatial aberrations in an excitation beam path; at least one mirror capable of directing received laser pulses to the aberrating element; an obj
8183222 Method to inhibit cell growth using oligonucleotides May 22, 2012
Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence ident
8182804 Engineered enzymatically active bacteriophages and methods of uses thereof May 22, 2012
The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also provides genetically engineered bacteriophages expressing the biofilm degrading enzymes and
8153377 Method for detecting and quantifying rare mutations/polymorphisms April 10, 2012
The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The rare mutation can be any type of functional or non-functional nucleic acid change or mutat
8153119 Engineered enzymatically active bacteriophage and methods for dispersing biofilms April 10, 2012
The present invention is directed to engineered enzymatically active bacteriophages that are both capable of killing the bacteria by lysis and dispersing the bacterial biofilm because they have been also engineered to express biofilm-degrading enzymes, particularly dispersin B (DspB), an
8137509 Asymmetric synthesis of rocaglamides via enantioselective photocycloaddition mediated by chiral March 20, 2012
The present invention provides a new strategies for the synthesis of compounds of the rocaglamide family and related natural products. The synthetic approach generally involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by an ena
8093417 Lipoxin analogs and methods for the treatment of periodontal disease January 10, 2012
This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides
8093288 Genipin derivatives and uses thereof January 10, 2012
Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.
8063535 Nanomechanical oscillator November 22, 2011
A mechanical oscillator has components with dimensions in a sub-micron range to produce resonance mode oscillations in a gigahertz range. A major element is coupled to a minor, sub-micron element to produce large amplitude gigahertz frequency oscillation that is detected with readily
8034567 Quantification of gene expression October 11, 2011
The present invention relates to a method for measuring the amount of a target nucleic acid in a sample using a standard which is designed to have one base difference compared with the gene of interest or a "target nucleic acid sequence." Use of such standard in combination with a method
7929195 MEMS based retroreflector April 19, 2011
A deformable reflective surface is disclosed that may be used with a retroreflector to provide a modulated retroreflector. The modulated retroreflector may be used in communication systems such as optical laser communication systems wherein an incident beam is reflected back to the s
7919093 Roles for dual endothelin-1/angiotensin II receptor (Dear) in hypertension and angiogenesis April 5, 2011
The present application is directed to the identification of mutations and/or polymorphisms in the Dual Endothelin-1/Angiotensin II Receptor (Dear) that indicate susceptibility to, or show current affliction with, hypertension. Additionally, the present invention discloses methods for
7914778 Methods of treatment using IL-16 antagonist peptides March 29, 2011
The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 a
7903246 Deterministic aperiodic patterned dielectric and plasmonic materials for localized electromagnet March 8, 2011
A method is shown for the extension in higher spatial dimensions of deterministic, aperiodic structures which exhibit strong aperiodic effects and have overall compatibility with the planar technology of integrated optical circuits. Disclosed devices are operative in response to inci
7888044 Melanoma biomarker and methods of uses February 15, 2011
The present invention relates to the use of TROY, also called tumor necrosis factor receptor superfamily, member 19 (TNFRSF 19) also called toxicity and JNK inducer (TAJ), in diagnosis and therapy of non-epithelial cancers, such as melanoma. Accordingly, the invention provides in vit
7883475 Manipulators employing multiple deformable elongate members February 8, 2011
A manipulator is configured with three or more substantially concentric, elongate members configured such that relative rotation and translation of the elongate members adjusts both the spatial position and orientation of the distal end of the manipulator and the spatial positioning of t
7867770 Nanostructured substrate for surface enhanced raman scattering January 11, 2011
The present invention provides a nanostructured substrate for SERS. A substrate of the invention comprises a surface featuring substantially monodisperse-sized metal nanoparticles disposed thereon. Preferably, the substrate surface provides for SERS and spectra therefrom. For example, a
7816544 Synthesis of rocaglamide natural products via photochemical generation of oxidopyrylium species October 19, 2010
The present invention provides new strategies for the synthesis of compounds of the rocaglamide family and related natural products. In particular, the new biomimetic synthetic approach involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative
7812054 Lipoxin analogs and methods for the treatment of periodontal disease October 12, 2010
This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides
7807375 Method for de novo detection of sequences in nucleic acids: target sequencing by fragmentation October 5, 2010
The present invention provides a method for determining nucleic acid sequences of a template nucleic acid that requires no prior knowledge of the nucleic acid sequence present in the template nucleic acid. The method is based on combining information about the mass of a fragment, the
7806854 Fully automated control system for type 1 diabetes October 5, 2010
An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject model is recursively
7799539 Apparatus for detecting and recording cellular responses September 21, 2010
Cellular physiology workstations for automated data acquisition and perfusion control are described. The cellular physiology workstation may be used for physiological and electrophysiological experiments. Methods for employing such cellular physiology workstations in physiological and
7798000 Non-destructive imaging, characterization or measurement of thin items using laser-generated lam September 21, 2010
A laser-based ultrasonic technique for the inspection of thin plates and membranes employs an amplitude-modulated laser source to excite narrow bandwidth Lamb waves. The dominant feature in the acoustic spectrum is a sharp resonance peak that occurs at the minimum frequency of the fi
7785798 Methods for prenatal diagnosis of chromosomal abnormalities August 31, 2010
Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal blood sample. The
7709451 Method and composition for treating immune complex associated disorders May 4, 2010
The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for developing ICAD. The i
7709262 Method for detecting and quantifying rare mutations/polymorphisms May 4, 2010
The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The rare mutation can be any type of functional or non-functional nucleic acid change or mutat
7700650 Lipoxin analogs and method for the treatment of periodontal disease April 20, 2010
This invention provides new lipoxin analogs, compositions containing these analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also pro
7700325 Haplotype analysis April 20, 2010
The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic acid markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dil
7655399 Methods for prenatal diagnosis of chromosomal abnormalities February 2, 2010
Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal blood sample. The
7652773 Enhanced detection of acousto-photonic emissions in optically turbid media using a photo-refract January 26, 2010
A system and method of detecting acousto-photonic emissions in optically turbid media that provide increased levels of detection sensitivity. The detection system includes an ultrasonic transducer, a laser, a photo-detector for detecting ultrasound-modulated laser light, and circuitr
7649014 Genipin derivatives and uses thereof January 19, 2010
Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.
7626007 Transcription factor regulating TNF-.alpha. December 1, 2009
Disclosed herein is an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1. The isolated polypeptide binds to the DNA binding domain located from -550 to -487 in the promoter of the human TNF-.alpha. gene. Additionally, the level of the mRNA transcript encod
7608691 Antibodies against IL-16 antagonist peptides October 27, 2009
The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 a
7595872 Analyzer for nanostructured substrate for surface enhanced Raman scattering September 29, 2009
A Raman scattering spectrographic analyzer wherein a microscope objective is adapted to view single bio-specimens on a substrate having monodispersed-sized metal particles. A defined wavelength of radiation is applied through the microscope and returning radiation resulting from Rama
7588626 Composite mixed oxide ionic and electronic conductors for hydrogen separation September 15, 2009
A mixed ionic and electronic conducting membrane includes a two-phase solid state ceramic composite, wherein the first phase comprises an oxygen ion conductor and the second phase comprises an n-type electronically conductive oxide, wherein the electronically conductive oxide is stab
7579146 Nucleic acid cloning August 25, 2009
The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be c
7569341 Nucleic acid directed immobilization arrays and methods of assembly August 4, 2009
The invention relates to supramolecular bioconjugates and to methods for assembling and utilizing supramolecular bioconjugates. Supramolecular bioconjugates comprise a plurality of first nucleic acids and a plurality of mediators wherein each mediator comprises a second nucleic acid
7495998 Biomimetic acoustic detection and localization system February 24, 2009
An acoustic detection and localization system includes a signal acquisition stage, a biomimetic processor, and an acoustic feature processor. The system uses multiple acoustic cues including spectral content, inter-aural time delay (ITD), inter-aural intensity difference (IID), and p
7479632 E-beam vision system for monitoring and control January 20, 2009
A method of characterizing an electron beam is described, comprising providing a system including an electron gun having a steering coil. A material having a surface is also provided. An electron beam from said electron gun is directed to said surface. The directing includes providin
7470517 Method for de novo detection of sequences in nucleic acids: target sequencing by fragmentation December 30, 2008
The present invention provides a method for determining nucleic acid sequences of a template nucleic acid that requires no prior knowledge of the nucleic acid sequence present in the template nucleic acid. The method is based on combining information about the mass of a fragment, the
7439021 Nucleic acid cloning October 21, 2008
The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be c
7396646 Alien sequences July 8, 2008
The present invention provides sequences and reagents for preparing microarrays with internal controls. Specifically, the present invention defines and provides sequences that are not present in the hybridizing mRNA or cDNA, and therefore can be used both as hybridization controls an
7385268 Method for linearizing deflection of a MEMS device using binary electrodes and voltage modulatio June 10, 2008
A micromechanical device comprising one or more electronically movable structure sets comprising for each set a first electrode supported on a substrate and a second electrode supported substantially parallel from said first electrode. Said second electrode is movable with respect to
7385023 Cancer immunotherapy and diagnosis using cytochrome P450 1B1 June 10, 2008
The invention provides methods for conducting cancer immunotherapy and diagnosis using cytochrome P450 1B1 and peptide fragments thereof.
7378243 Nucleic acid cloning May 27, 2008
The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be c
7361735 LITAF binding site peptides and methods of using the same April 22, 2008
The invention provides molecules containing nucleic acid sequences for fragments of LPS-induced TNF-.alpha. factor (LITAF) and vectors containing these sequences. Also provided are molecules that contain the peptide sequence SQTWREPGAAGSPFHL, or homologs thereof. Such molecules may b
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