| Patent Number |
Title Of Patent |
Date Issued |
| 8252904 |
Glycodelin monoclonal antibodies and methods for their use in the detection of ovarian cancer |
August 28, 2012 |
| Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to gly |
| 8177084 |
Container assembly and pressure-responsive penetrable cap for the same |
May 15, 2012 |
| A pressure-responsive container assembly and elastically-deformable penetrable cap is provided. Embodiments of the penetrable cap of the present invention include, but are not limited to: an annular sealing portion for engaging an inner surface of a container, a substantially rigid p |
| 8135236 |
System and method for re-locating an object in a sample on a slide with a microscope imaging dev |
March 13, 2012 |
| A method of re-locating an object in a sample is provided for a previously-scanned slide having determined objects each with corresponding stored coordinates and a stored image, the objects being mapped relative to each other. The slide is positioned on a microscope stage, stored ima |
| 8076093 |
Monoclonal antibodies and methods for their use in the detection of cervical disease |
December 13, 2011 |
| Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an M |
| 8058404 |
MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disea |
November 15, 2011 |
| Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics |
| 7989209 |
Methods of chromogen separation-based image analysis |
August 2, 2011 |
| Methods for chromogen separation-based image analysis are provided, with such methods being directed to quantitative video-microscopy techniques in cellular biology and pathology applications. |
| 7940998 |
System and method for re-locating an object in a sample on a slide with a microscope imaging dev |
May 10, 2011 |
| A method of re-locating an object in a sample is provided for a previously-scanned slide having determined objects each with corresponding stored coordinates and a stored image, the objects being mapped relative to each other. The slide is positioned on a microscope stage, stored ima |
| 7899623 |
Methods and computer program products for analysis and optimization of marker candidates for can |
March 1, 2011 |
| Methods and computer program products for evaluating and optimizing one or more markers for use in establishing a prognosis for a patient suffering from a disease are provided. More particularly, the methods include steps for systematically evaluating a number of features that may be ext |
| 7846692 |
HE4 monoclonal antibodies and methods for their use |
December 7, 2010 |
| Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to HE4 |
| 7826650 |
Method for quantitative video-microscopy and associated system and computer software program pro |
November 2, 2010 |
| A method of determining an amount of at least one molecular species in a sample from an image of the sample captured by an image acquisition device is provided, each molecular species being indicated by a dye. A dye space representation of a plurality of dyes is formed by orthogonally |
| 7772535 |
Method of capturing a focused image via an objective of a microscopy device |
August 10, 2010 |
| A method of capturing a focused image of a continuously moving slide/objective arrangement is provided. A frame grabber device is triggered to capture an image of the slide through an objective at a first focus level as the slide continuously moves laterally relative to the objective |
| 7632498 |
MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disea |
December 15, 2009 |
| Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics |
| 7605356 |
Apparatus and method for rapid microscopic image focusing |
October 20, 2009 |
| A method of capturing a focused image of a continuously moving slide/objective arrangement is provided. A frame grabber device is triggered to capture an image of the slide through an objective at a first focus level as the slide continuously moves laterally relative to the objective |
| 7602954 |
Method for quantitative video-microscopy and associated system and computer software program pro |
October 13, 2009 |
| A method of determining an amount of at least one molecular species in a sample from an image of the sample captured by an image acquisition device is provided, each molecular species being indicated by a dye. A dye space representation of a plurality of dyes is formed by orthogonally |
| 7595380 |
Monoclonal antibodies and methods for their use in the detection of cervical disease |
September 29, 2009 |
| Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an M |
| 7510838 |
Methods and compositions for the detection of cervical disease |
March 31, 2009 |
| Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical |
| 7455973 |
Methods and compositions for the detection of cervical disease |
November 25, 2008 |
| Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical |
| 7417213 |
Apparatus and method for rapid microscopic image focusing having a movable objective |
August 26, 2008 |
| A method of capturing a focused image of a continuously moving slide/objective arrangement is provided. A frame grabber device is triggered to capture an image of the slide through an objective at a first focus level as the slide continuously moves laterally relative to the objective |
| 7157233 |
Methods and compositions for the detection of cervical disease |
January 2, 2007 |
| Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical |
| 7133547 |
Method for quantitative video-microscopy and associated system and computer software program pro |
November 7, 2006 |
| A method of determining an amount of at least one molecular species in a sample from an image of the sample captured by an image acquisition device is provided, each molecular species being indicated by a dye. A dye space representation of a plurality of dyes is formed by orthogonally |
| 7065236 |
Method for quantitative video-microscopy and associated system and computer software program pro |
June 20, 2006 |
| A method of determining an amount of at least one molecular specie comprising a sample is provided, each molecular specie being indicated by a dye. The amount of the molecular specie is determined from an image of the sample captured as image data by a color image acquisition device in |
| 6657003 |
Cell adhesion solution |
December 2, 2003 |
| A cell adhesion solution of a cross-linked polymer for substrates includes an amino acid polymer, a buffered cross-linking agent, and deionized water (DI H.sub.2 O). In one example, the amino acid polymer is selected from a neutral or basic amino acid, such as poly l-lysine or poly l-arg |
| 6453060 |
Method and apparatus for deriving separate images from multiple chromogens in a branched image a |
September 17, 2002 |
| A system for collecting images at multiple wavelengths for image analysis of biological specimens. The process separates contrasts for images of a biological specimen prepared with a chromogen. Light wavelengths matched with each chromogen optimize separation for each image. Computing |
| 6252979 |
Interactive method and apparatus for sorting biological specimens |
June 26, 2001 |
| An interactive process for sorting biological specimens includes the steps of processing a biological specimen to provide an analysis score, sorting the biological specimens according to the analysis score into categories including: clearly normal, interactive review, and microscopy revi |
| 6198839 |
Dynamic control and decision making method and apparatus |
March 6, 2001 |
| Dynamic control of the processing flow of an image analyzer such as a biological specimen analyzer as processing proceeds. Data collected and processed from a specimen under analysis, such as a biological specimen on a microscope slide, determines the fate of further processing. If there |
| 6137899 |
Apparatus for the identification of free-lying cells |
October 24, 2000 |
| A free-lying cell classifier. An automated microscope system comprising a computer and high speed processing field of view processors identifies free-lying cells. An image of a biological specimen is obtained and the image is segmented to create a set of binary masks. The binary masks ar |
| 6134354 |
Apparatus for the identification of free-lying cells |
October 17, 2000 |
| A free-lying cell classifier. An automated microscope system comprising a computer and high speed processing field of view processors identifies free-lying cells. An image of a biological specimen is obtained and the image is segmented to create a set of binary masks. The binary masks ar |
| 6130967 |
Method and apparatus for a reduced instruction set architecture for multidimensional image proce |
October 10, 2000 |
| A reduced instruction set architecture implements complicated image processing algorithms that are decomposed into combinations of simple operations. The simple operations are further decomposed into multiple operations of one dimensional data with an address controller to scan data |
| 6122397 |
Method and apparatus for maskless semiconductor and liquid crystal display inspection |
September 19, 2000 |
| Image primitive based maskless semiconductor wafer and liquid crystal display panel inspection by the characterization of wafer patterns. Potential defects are detected as exceptions to the rules of general semiconductor surface pattern structure. The wafer or liquid crystal display, |
| 6067370 |
Cytological system illumination integrity checking apparatus and method |
May 23, 2000 |
| A method for checking cytological system illumination including the steps of checking global illumination variation, static field uniformity, dynamic field uniformity, specimen thickness variation, strobe repeatability, calibration plate cleanliness, and strobe dropout. A calibration |
