| Patent Number |
Title Of Patent |
Date Issued |
| 7371729 |
Boronic acid salts useful in parenteral formulations |
May 13, 2008 |
| Salts of a peptide boronic acid drug, for example of Cbz-(R)-Phe-(S)-Pro-(R)-Mpg-B(OH).sub.2. The counter-ion to the boronate may be an alkali metal or derived from a strongly basic organic nitrogen-containing compound. |
| 7112572 |
Multivalent metal salts of boronic acids |
September 26, 2006 |
| Salts of a pharmaceutically acceptable divalent metal and an organoboronic acid drug. Examples of such metals are calcium, magnesium and zinc. The organoboronic acid drug may be a boropeptide protease inhibitor. The salts may be formulated in oral dosage form. |
| 6451976 |
Bi-or multifunctional molecules based on a dendroaspin scaffold |
September 17, 2002 |
| Dendroaspin, a polypeptide neurotoxin analogue is modified by recombinant DNA techniques, particularly "loop grafting" to provide a modified polypeptide. The modified polypeptide is constructed so as to retain dendroaspin activity, for example, platelet adhesion to fibrinogen, in add |
| 6350731 |
Platelet-derived growth factor analogues |
February 26, 2002 |
| Novel peptide analogues of platelet-derived growth factor, for use in inhibiting or stimulating growth and/or chemotaxis of cells, for example, smooth muscle cells, are provided. Also provided are compositions of matter comprising those peptide analogues. |
| 6313096 |
Inhibitors of trypsin-like enzymes |
November 6, 2001 |
| Pharmaceutical compositions comprising compounds of the formula: ##STR1##in which X=H or is an N-protecting group; Y is 1-10 a-amino acids; Q1 and Q2 taken together represent the residue of a diol; R is C.sub.1-4 alkyl; and the asymmetric carbon atom marked * may have the D- or L-con |
| 6127340 |
Serine protease inhibitors |
October 3, 2000 |
| This invention is directed to peptide inhibitors of serine proteases, espcecially thrombin, in which the P1-P2 natural amide linkage is replaced by another bond. Exemplary thrombin inhibitors have the formula: X-(aa.sup.3)-(aa.sup.2)-.psi.-(aa.sup.1)-Z wherein X is H or a substituent |
| 6114308 |
Inhibitors of trypsin-like enzymes |
September 5, 2000 |
| Pharmaceutical compositions comprising compounds of the formula: ##STR1## in which X.dbd.H or is an N-protecting group; Y is 1-10 .alpha.-amino acids; Q1 and Q2 taken together represent the residue of a diol; R is C.sub.1-4, alkyl; and the asymmetric carbon atom marked * may have the |
| 6001802 |
Platelet-derived growth factor analogues |
December 14, 1999 |
| This invention relates to cyclic platelet-derived growth factor (PDGF) analogues and pharmaceutical compositions thereof. |
| 5952304 |
Platelet-derived growth factor analogues |
September 14, 1999 |
| Novel peptide analogues of platelet-derived growth factor, for use in inhibiting or stimulating growth and/or chemotaxis of cells, e.g., smooth muscle cells, are provided. Also provided are compositions of matter comprising those peptide analogues. |
| 5856306 |
Inhibitors of trypsin-like enzymes |
January 5, 1999 |
| Pharmaceutical compositions comprising compounds of the formula: ##STR1## in which X.dbd.H or is an N-protecting group; Y is 1-10 .alpha.-amino acids; Q1 and Q2 taken together represent the residue or a diol; R is C.sub.1-4 alkyl; and the asymmetric carbon atom marked * may have the |
