| Patent Number |
Title Of Patent |
Date Issued |
| 7435390 |
Nucleic acid synthesizers |
October 14, 2008 |
| The present invention relates to nucleic acid synthesizers and methods of using and modifying nucleic acid synthesizers. For example, the present invention provides highly efficient, reliable, and safe synthesizers that find use, for example, in high throughput and automated nucleic acid |
| 7432048 |
Reactions on a solid surface |
October 7, 2008 |
| The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on a solid support and cleaving |
| 7429455 |
Methods for genotyping hepatitis C virus |
September 30, 2008 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 7407782 |
Nucleic acid detection compositions |
August 5, 2008 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 7384746 |
Charge tags and the separation of nucleic acid molecules |
June 10, 2008 |
| The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net ch |
| 7381530 |
Kits for detection of nucleic acids by invasive cleavage |
June 3, 2008 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 7354708 |
Invasion assays |
April 8, 2008 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 7312033 |
CFTR allele detection assays |
December 25, 2007 |
| The present invention provides compositions and methods for the detection and characterization of mutations associated with cystic fibrosis. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER |
| 7306917 |
Cleavage of nucleic acids |
December 11, 2007 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 7273696 |
Kits for the detection of target sequences |
September 25, 2007 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the de |
| 7256020 |
Methods and compositions for detecting target sequences |
August 14, 2007 |
| The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleavin |
| 7195871 |
Methods and compositions for detecting target sequences |
March 27, 2007 |
| The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleavin |
| 7150982 |
RNA detection assays |
December 19, 2006 |
| The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In |
| 7122364 |
FEN endonucleases |
October 17, 2006 |
| The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In |
| 7101672 |
Target-dependent reactions using structure-bridging oligonucleotides |
September 5, 2006 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acids and sequence changes. The methods of the present invention permit the |
| 7087381 |
Detection of target sequences by cleavage of non-target nucleic acids |
August 8, 2006 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, we used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the det |
| 7067643 |
Systems for the detection of target sequences |
June 27, 2006 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the de |
| 7060436 |
Nucleic acid accessible hybridization sites |
June 13, 2006 |
| The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes. The present invention also provides methods and compositions for identifyi |
| 7045289 |
Detection of RNA Sequences |
May 16, 2006 |
| The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In |
| 7011944 |
Invasive cleavage of nucleic acids |
March 14, 2006 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 6913881 |
Methods and compositions for detecting target sequences |
July 5, 2005 |
| The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving th |
| 6875572 |
Nucleic acid detection assays |
April 5, 2005 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 6872816 |
Nucleic acid detection kits |
March 29, 2005 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 6780982 |
Charge tags and the separation of nucleic acid molecules |
August 24, 2004 |
| The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge |
| 6780585 |
Polymorphism analysis by nucleic and acid structure probing |
August 24, 2004 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 6759226 |
Enzymes for the detection of specific nucleic acid sequences |
July 6, 2004 |
| The present invention relates to novel enzymes designed for direct detection, characterization and quantitation of nucleic acids, particularly RNA. The present invention provides enzymes that recognize specific nucleic acid cleavage structures formed on a target RNA sequence and that |
| 6709819 |
Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides |
March 23, 2004 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 6709815 |
Target-dependent reactions using structure-bridging oligonucleotides |
March 23, 2004 |
| The present invention relates to methods and compns. for treating nucleic acids, and in particular, methods and compns. for the detection and characterization of nucleic acid sequences and sequence changes. The invention provides methods for examg. the conformations assumed by single |
| 6706471 |
Detection of nucleic acid sequences by invader-directed cleavage |
March 16, 2004 |
| The present invention relates to methods for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving th |
| 6692917 |
Systems and methods for invasive cleavage reaction on dendrimers |
February 17, 2004 |
| The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on dendrimers and cleaving the nucle |
| 6673616 |
Methods and compositions for characterizing nucleic acids |
January 6, 2004 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detect |
| 6635463 |
Enzymes for the detection of nucleic acid sequences |
October 21, 2003 |
| The present invention relates to novel enzymes designed for direct detection, characterization and quantitation of nucleic acids, particularly RNA. The present invention provides enzymes that recognize specific nucleic acid cleavage structures formed on a target RNA sequence and that |
| 6555357 |
FEN-1 endonuclease, mixtures and cleavage methods |
April 29, 2003 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to improved cleavage means for the detection and characterization of nucleic acid sequences. St |
| 6458535 |
Detection of nucleic acids by multiple sequential invasive cleavages 02 |
October 1, 2002 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 6372424 |
Rapid detection and identification of pathogens |
April 16, 2002 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detect |
| 6358691 |
Target-dependent reactions using structure-bridging oligonucleotides |
March 19, 2002 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 6355437 |
Target-dependent reactions using structure-bridging oligonucleotides |
March 12, 2002 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 6348314 |
Invasive cleavage of nucleic acids |
February 19, 2002 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 6214545 |
Polymorphism analysis by nucleic acid structure probing |
April 10, 2001 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 6210880 |
Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides |
April 3, 2001 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 6194149 |
Target-dependent reactions using structure-bridging oligonucleotides |
February 27, 2001 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 6090606 |
Cleavage agents |
July 18, 2000 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to improved cleavage means for the detection and characterization of nucleic acid sequences. St |
| 6090543 |
Cleavage of nucleic acids |
July 18, 2000 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucl |
| 5994069 |
Detection of nucleic acids by multiple sequential invasive cleavages |
November 30, 1999 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 5888780 |
Rapid detection and identification of nucleic acid variants |
March 30, 1999 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to screen for known and unknown mutations, including single base changes, in nucleic acids. Methods are provided |
| 5846717 |
Detection of nucleic acid sequences by invader-directed cleavage |
December 8, 1998 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 5843669 |
Cleavage of nucleic acid acid using thermostable methoanococcus jannaschii FEN-1 endonucleases |
December 1, 1998 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Structure-specific nucleases, including 5' nucleases, thermostable FEN-1 endonucleases and 3' exonucleases, are used to detect and identify target nucleic acids. Methods a |
| 5843654 |
Rapid detection of mutations in the p53 gene |
December 1, 1998 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to screen for known and unknown mutations, including single base changes, in the human p53 gene. Methods are prov |
| 5837450 |
Detection of target nucleic acid molecules using thermostable 5' nuclease |
November 17, 1998 |
| A means for cleaving a nucleic acid cleavage structure in a site-specific manner is disclosed. A cleaving enzyme having 5' nuclease activity without interfering nucleic acid synthetic ability is employed as the basis of a novel method of detection of specific nucleic acid sequences. |
| 5795763 |
Synthesis-deficient thermostable DNA polymerase |
August 18, 1998 |
| A means for cleaving a nucleic acid cleavage structure in a site-specific manner is disclosed. A cleaving enzyme having 5' nuclease activity without interfering nucleic acid synthetic ability is employed as the basis of a novel method of detection of specific nucleic acid sequences. |
