| Patent Number |
Title Of Patent |
Date Issued |
| 7456203 |
Muscarinic receptor antagonists |
November 25, 2008 |
| Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an |
| 7456199 |
Biphenyl compounds useful as muscarinic receptor antagonists |
November 25, 2008 |
| This invention provides compounds of formula I: ##STR00001## wherein a, b, c, m, p, s, t, W, Ar.sup.1, X.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.6, and R.sup.7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention |
| 7452995 |
Aryl aniline .beta..sub.2 adrenergic receptor agonists |
November 18, 2008 |
| The invention provides novel .beta..sub.2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with .beta..sub.2 adrenergic receptor activity, and process |
| 7452861 |
Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent |
November 18, 2008 |
| This invention is directed to methods of administering an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent having a substituent comprising at least about 8 carbon atoms. The invention is also directed to methods of using an echinocandin antifungal |
| 7446114 |
Quinolinone compounds as 5-HT.sub.4 receptor agonists |
November 4, 2008 |
| The invention provides novel quinolinone-carboxamide 5-HT.sub.4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT.sub.4 receptor activity, and processes |
| 7427639 |
.beta.2-adrenergic receptor agonists |
September 23, 2008 |
| Disclosed are multibinding compounds which are .beta.2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor. |
| 7419989 |
Indazole-carboxamide compounds |
September 2, 2008 |
| The invention provides novel indazole-carboxamide 5-HT.sub.4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT.sub.4 receptor activity, and processes an |
| 7405199 |
Cross-linked glycopeptide-cephalosporin antibiotics |
July 29, 2008 |
| This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a |
| 7402673 |
Diamine .beta..sub.2 adrenergic receptor agonists |
July 22, 2008 |
| The invention provides novel .beta..sub.2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with .beta..sub.2 adrenergic receptor activity, and process |
| 7399863 |
Amino-substituted ethylamino .beta..sub.2 adrenergic receptor agonists |
July 15, 2008 |
| The invention provides novel .beta..sub.2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with .beta..sub.2 adrenergic receptor activity, and process |
| 7399862 |
5-HT.sub.4 receptor agonist compounds |
July 15, 2008 |
| The invention provides novel quinolinone-carboxamide 5-HT.sub.4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT.sub.4 receptor activity, and processes |
| 7396933 |
Quinolinone-carboxamide compounds |
July 8, 2008 |
| The invention provides novel quinolinone-carboxamide 5-HT.sub.4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT.sub.4 receptor activity, and processes |
| 7375181 |
Process for purifying glycopeptide phosphonate derivatives |
May 20, 2008 |
| Disclosed are methods of purifying glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups that are useful as antibacterial agents. The methods include contacting a solution of the glycopeptide derivatives with a polystyrene-containin |
| 7375114 |
Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
May 20, 2008 |
| The invention provides novel quinolinone-carboxamide 5-HT.sub.4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT.sub.4 receptor activity, and processes |
| 7368463 |
Substituted 4-amino-1-benzylpiperidine compounds |
May 6, 2008 |
| This invention provides 4-amino-1-benzylpiperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates |
| 7358244 |
Azabicycloalkane compounds |
April 15, 2008 |
| This invention provides compounds of formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess |
| 7355046 |
Biphenyl derivatives |
April 8, 2008 |
| This invention provides biphenyl derivatives of formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl der |
| 7351791 |
Intermediate for preparing glycopeptide derivatives |
April 1, 2008 |
| This invention provides 9-fluorenylmethoxycarbonyl compounds that are useful as intermediates for preparing glycopeptide antibiotics. |
| 7351718 |
Substituted pyrrolidine and related compounds |
April 1, 2008 |
| This invention is directed to compounds of formula I: ##STR00001## wherein R.sup.1-R.sup.5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof. The invention also directed to pharmaceutical compositions containing such c |
| 7351717 |
Substituted pyrrolidine and related compounds |
April 1, 2008 |
| This invention is directed to compounds of formula I: ##STR00001## wherein R.sup.1-R.sup.5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof. The invention also directed to pharmaceutical compositions containing such c |
| 7351704 |
Indazole-carboxamide compounds as 5-HT.sub.4 receptor agonists |
April 1, 2008 |
| The invention provides novel indazole-carboxamide 5-HT.sub.4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT.sub.4 receptor activity, and processes an |
| 7351691 |
Glycopeptide phosphonate derivatives |
April 1, 2008 |
| Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents. |
| 7345175 |
Biphenyl derivatives |
March 18, 2008 |
| This invention provides biphenyl derivatives of formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl der |
| 7345060 |
Compounds having .beta..sub.2 adrenergic receptor agonist and muscarinic receptor antagonist act |
March 18, 2008 |
| The invention is directed to compounds of formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7a, R.sup.7b, W, G.sup.1, G.sup.2, a, b, c, d and m are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoiso |
| 7341993 |
Cross-linked glycopeptide--cephalosporin antibiotics |
March 11, 2008 |
| This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a |
| 7332471 |
Cross-linked glycopeptide-cephalosporin antibiotics |
February 19, 2008 |
| This invention provides cross-linked glycopeptide--cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a |
| 7329752 |
Carbamate compounds as 5-HT.sub.4 receptor agonists |
February 12, 2008 |
| The invention provides novel benzoimidazolone-carboxamide-derived carbamate 5-HT.sub.4 receptor agonist compounds of formula (I): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, a, and b are defined in the disclosure. The invention also provides pharmaceutical compositions |
| 7320990 |
Crystalline form of a biphenyl compound |
January 22, 2008 |
| The invention provides a crystalline naphthalene-1,5-disulfonic acid salt of biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro-quinolin-5 -yl)ethylamino]nonyl}piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositio |
| 7317102 |
Diarylmethyl and related compounds |
January 8, 2008 |
| This invention provides compounds of formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, Ar.sup.1, Ar.sup.2, E, a, b, c and z are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The |
| 7317023 |
Diaryl ether .beta.2 adrenergic receptor agonists |
January 8, 2008 |
| The invention provides novel .beta..sub.2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with .beta..sub.2 adrenergic receptor activity, and process |
| 7317022 |
Benzoimidazolone-carboxamide compounds as 5-HT.sub.4 receptors agonists |
January 8, 2008 |
| The invention provides novel benzoimidazolone-carboxamide 5-HT.sub.4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT.sub.4 receptor activity, and proc |
| 7301004 |
Process for preparing glycopeptide phosphonate derivatives |
November 27, 2007 |
| Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the |
| 7288657 |
Biphenyl compounds useful as muscarinic receptor antagonists |
October 30, 2007 |
| This invention provides compounds of formula I: ##STR00001## wherein a, b, c, d, m, n, p, s, t, W, Ar.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.6, R.sup.7, and R.sup.8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The inventi |
| 7285564 |
Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds |
October 23, 2007 |
| This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and inter |
| 7279458 |
Cross-linked glycopeptide-cephalosporin antibiotics |
October 9, 2007 |
| This invention provides cross-linked glycopeptide--cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a |
| 7265133 |
Biphenyl compounds useful as muscarinic receptor antagonists |
September 4, 2007 |
| This invention provides compounds of formula I: ##STR00001## wherein a, b, c, m, p, s, t, W, Ar.sup.1, X.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.6, and R.sup.7 are as defined specification. The compounds of formula I are muscarinic receptor antagonists. The invention also p |
| 7265086 |
Glycopeptide carboxy-saccharide derivatives |
September 4, 2007 |
| Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivat |
| 7262205 |
Biphenyl compounds useful as muscarinic receptor antagonists |
August 28, 2007 |
| This invention provides compounds of formula I: ##STR00001## wherein a, b, c, d, m, n, p, r, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also p |
| 7256294 |
Crystalline form of a benzimidazole-carboxamide medicinal compound |
August 14, 2007 |
| The invention provides crystalline forms of the novel benzimidazole-carboxamide 5-HT.sub.4 receptor agonist compound, 4-(4-{[(2-isopropyl-1H-benzoimidazole-4-carbonyl)amino]methyl}-piperidin-- 1-ylmethyl)piperidine-1-carboxylic acid methyl ester. The invention also provides pharmaceut |
| 7250414 |
Diphenylmethyl compounds useful as muscarinic receptor antagonists |
July 31, 2007 |
| This invention provides compounds of formula I: ##STR00001## wherein a, b, c, e, m, n, Ar.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4a, R.sup.4b, R.sup.5 and R.sup.6 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also |
| 7244705 |
Polyacid glycopeptide derivatives |
July 17, 2007 |
| Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO.sub.2H) groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide deriva |
| 7238709 |
Therapeutic carbamates |
July 3, 2007 |
| This invention relates to hindered carbamate derivatives that are muscarinic receptor antagonists, pharmaceutical compositions comprising such compounds, and methods of preparing these compounds. |
| 7226950 |
Sodium channel modulators |
June 5, 2007 |
| The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, a |
| 7226946 |
Substituted phenol compounds useful for anesthesia and sedation |
June 5, 2007 |
| The invention provides substituted phenol compounds and pharmaceutical compositions containing substituted phenol compounds which are useful for inducing or maintaining anesthesia or sedation in a mammal. This invention also provides methods for inducing or maintaining anesthesia or |
| 7223783 |
Indolinone derivatives |
May 29, 2007 |
| Compounds of formula (I) ##STR00001## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings given in the specification, are receptor tyrosine kinase inhibitors useful in the treatment of proliferative disorders, such as cancer. |
| 7217738 |
.beta.2-adrenergic receptor agonists |
May 15, 2007 |
| Disclosed are multibinding compounds which are .beta.2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor. |
| 7211695 |
.beta.2-adrenergic receptor agonists |
May 1, 2007 |
| Disclosed are multibinding compounds which are .beta.2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor. |
| 7208515 |
Diphenylmethyl compounds useful as muscarinic receptor antagonists |
April 24, 2007 |
| This invention provides compounds of formula I: ##STR00001## wherein a, b, c, e, m, R.sup.1, R.sup.2, R.sup.3, R.sup.4a, R.sup.4b, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention |
| 7208471 |
Glycopeptide phosphonate derivatives |
April 24, 2007 |
| Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents. |
| 7195876 |
Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic |
March 27, 2007 |
| Oncokinase fusion polypeptides associated with hyperproliferative disorders and the polynucleotides encoding for such fusion polypeptides are provided. The fusion polypeptides have a C-terminal tyrosine kinase domain fused to an N-terminal domain that is not normally fused to the C-t |
