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The University of Chicago Patents
Assignee:
The University of Chicago
Address:
Chicago, IL
No. of patents:
253
Patents:


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Patent Number Title Of Patent Date Issued
RE37393 Mutant E. coli strain with increased succinic acid production September 25, 2001
A method for isolating succinic acid producing bacteria is provided comprising increasing the biomass of an organism which lacks the ability to catabolize pyruvate, and then subjecting the biomass to glucose-rich medium in an anaerobic environment to enable pyruvate-catabolizing mutants
D413678 Solid liquid extractor September 7, 1999
7394923 Imaging system for generating a substantially exact reconstruction of a region of interest July 1, 2008
A method and apparatus for reconstruction of a region of interest for an object is provided. The reconstruction of the object may be based on chords which may fill a part, all, or more than all of the region of interest. Using chords for reconstruction may allow for reducing data acq
7389653 Medical ice slurry production device June 24, 2008
The present invention relates to an apparatus for producing sterile ice slurries for medical cooling applications. The apparatus is capable of producing highly loaded slurries suitable for delivery to targeted internal organs of a patient, such as the brain, heart, lungs, stomach, ki
7381401 T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase June 3, 2008
T cell anergy has been correlated with defective Ras signaling. However, neither a causal relationship nor the mechanism of Ras hypoactivation have been established. Using adenoviral transduction of CAR Tg T cells to enable genetic manipulation in nonproliferating cells, we show that
7374760 Methods and compositions for nerve regeneration May 20, 2008
Methods and compositions for modulating growth of a neuron with a Wnt, a Wnt-like substance, and/or a chemical compound affecting a Wnt signaling pathway are disclosed. Also disclosed are methods for identifying a substance that modulates growth of a neuron by obtaining a candidate s
7326692 Induction of immunity using inhibitors of granzymes February 5, 2008
The present invention provides methods for enhancing host immunity to a virus and/or a cancer and methods for enhancing the cytotoxic T-cell (CTL) mediated immune responses by providing granzyme B inhibitors to a subject. One objective of the invention is to induce long-term protective
7303874 Discrimination of Bacillus anthracis from closely related microorganisms by analysis of 16S and December 4, 2007
The present invention relates to methods and compositions for using nucleotide sequence variations of 16S and 23S rRNA within the B. cereus group to discriminate a highly infectious bacterium B. anthracis from closely related microorganisms. Sequence variations in the 16S and 23S rRN
7288371 Discrimination of Bacillus anthracis from closely related microorganisms by analysis of 16S and October 30, 2007
The present invention is directed to a novel method of discriminating a highly infectious bacterium Bacillus anthracis from a group of closely related microorganisms. Sequence variations in the 16S and 23S rRNA of the B. cereus subgroup including B. anthracis are utilized to construct
7265356 Image-guided medical intervention apparatus and method September 4, 2007
In some embodiments, an image-guided radiotherapy apparatus and method is provided in which a radiotherapy radiation source and a gamma ray photon imaging device are positioned with respect to a patient area so that a patient can be treated by a beam emitted from the radiotherapy apparat
7250298 Monomeric red fluorescent proteins July 31, 2007
Disclosed are sequences encoding monomeric variants of DsRed fluorescent proteins and methods of use.
7247297 Use of DF3/MUC1 regulated expression in gene therapy July 24, 2007
The present invention provides for improved vectors for use in gene therapy. Utilizing the cancer specific DF3/MUC1 promoter to drive a replication essential gene, vectors are made conditionally replication-competent, permitting wider infection and expression of tumor cells. In addit
7235716 Plant centromere compositions June 26, 2007
The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve as vectors for the construction of transgenic plant and animal cells.
7230125 Methods of performing cycloadditions, reaction mixtures, and methods of performing asymmetric ca June 12, 2007
Methods of performing cycloadditions are described that include (a) combining a first reactant and a second reactant in a hydrogen bonding solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form a cycloadduct. Methods of performing asym
7227057 Plant centromere compositions June 5, 2007
The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve as vectors for the construction of transgenic plant and animal cells.
7226782 Plant centromere compositions June 5, 2007
The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve as vectors for the construction of transgenic plant and animal cells.
7214187 System and method for identification of false statements May 8, 2007
A method of detecting lie detection including the steps of first conditioning the subject to produce an involuntary physiological response triggered when the subject provides false statements; and secondly asking the subject to state whether each of series of statements presented to
7205072 Layered cathode materials for lithium ion rechargeable batteries April 17, 2007
A number of materials with the composition Li.sub.1+xNi.sub..alpha.Mn.sub..beta.Co.sub..gamma.M'.sub..delta.O.sub.2-- zF.sub.z (M'=Mg,Zn,Al,Ga,B,Zr,Ti) for use with rechargeable batteries, wherein x is between about 0 and 0.3, .alpha. is between about 0.2 and 0.6, .beta. is between ab
7202371 Catalytic asymmetric epoxidation April 10, 2007
The present invention relates to the synthesis of chiral epoxides via a catalytic asymmetric oxidation of olefins. Additionally, the methodology provides a method of asymmetrically oxidizing sulfides and phosphines. This asymmetric oxidation employs a catalyst system composed of a metal
7172905 Polypeptide immobilization February 6, 2007
A substrate comprises a surface, and a plurality of moieties, on at least a portion of the surface. The moieties are moieties of formula: Surf-L--Q--T, where --T comprises a reactant ligand, and Surf- designates where the moiety attaches to the surface. The substrate can be made into
7160864 Methods for production of growth-promoting proteins and peptides for kidney epithelial cells January 9, 2007
Novel growth peptides derived from protein factors having molecular weights of about 22 and 45 kDa stimulate mitogenic activity of epithelial, but not fibroblastic cells, in particular, kidney epithelial cells. A source of the factors is scrape-wounded kidney epithelial cells in cult
7135508 Coatings and films derived from clay/wax nanocomposites November 14, 2006
The invention provides methods for making clay/wax nanocomposites and coatings and films of same with improved chemical resistance and gas barrier properties. The invention further provides methods for making and using emulsions of such clay/wax nanocomposites. Typically, an organoph
7132240 Use of methylated nucleic acid segments for isolating centromere DNA November 7, 2006
The invention provides efficient methods for the isolation of centromeres from potentially any organism. Using the methods of the invention, methylated centromere DNA may be isolated from potentially any centromere in an organism. The technique is amenable to mass screenings employing
7119250 Plant centromere compositions October 10, 2006
The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve as vectors for the construction of transgenic plant and animal cells.
7118862 Induction of apoptosis by cellular stress October 10, 2006
The invention provides methods of screening to identify compounds that modulate the ability of a protein to translocate to the mitochondria when a cell is subjected to cellular stress. Such compounds can be useful to modulate the level of apoptosis in a cell. For example, compounds i
7118591 Heat transfer probe October 10, 2006
Apparatuses, systems, methods, and computer code for, among other things, monitoring the health of samples such as the brain while providing local cooling or heating. A representative device is a heat transfer probe, which includes an inner channel, a tip, a concentric outer channel, a
7114858 Laser based ignition system for natural gas reciprocating engines, laser based ignition system h October 3, 2006
A laser based ignition system for stationary natural gas engines, a distributor system for use with high-powered lasers, and a method of determining a successful ignition event in a laser-based ignition system are provided. The laser based ignition (LBI) system for stationary natural
7109149 Regulation of plant fertility by modulation of GABA levels in flowers September 19, 2006
The invention provides methods for the alteration of fertility in plants through modulation of floral GABA levels. The techniques of the invention may find use in plant breeding techniques. Also provided by the invention are assays for the screening of candidate modulators of GABA metabo
7087211 Hydrogen production by high temperature water splitting using electron conducting membranes August 8, 2006
A device and method for separating water into hydrogen and oxygen is disclosed. A first substantially gas impervious solid electron-conducting membrane for selectively passing protons or hydrogen is provided and spaced from a second substantially gas impervious solid electron-conduct
7085675 Subband domain signal validation August 1, 2006
A system, method and program product for predictive condition monitoring of a monitored system by means of sub-band decomposition of a complex monitored signal. Features of the decomposed signal are extracted for modeling estimation and detection of deviations in the features. Deviat
7081483 Polyfunctional dispersants for controlling viscosity of phyllosilicates July 25, 2006
This invention provides phyllosilicates and polyfunctional dispersants which can be manipulated to selectively control the viscosity of phyllosilicate slurries. The polyfunctional dispersants used in the present invention, which include at least three functional groups, increase the
7073513 Superconducting magnetic control system for manipulation of particulate matter and magnetic prob July 11, 2006
A system and method of controlling movement of magnetic material with at least first and second high temperature superconductors at spaced locations. A plurality of solenoids are associated with the superconductors to induce a persistent currents in preselected high temperature super
7049073 Double stranded nucleic acid biochips May 23, 2006
This invention describes a new method of constructing double-stranded DNA (dsDNA) microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The complementary oligonucleotide chains are bonded together by a novel connector that includes a linke
7049031 Protective coating on positive lithium-metal-oxide electrodes for lithium batteries May 23, 2006
A positive electrode for a non-aqueous lithium cell comprising a LiMn.sub.2-xM.sub.xO.sub.4 spinel structure in which M is one or more metal cations with an atomic number less than 52, such that the average oxidation state of the manganese ions is equal to or greater than 3.5, and in
7045290 Yeast screens for treatment of human disease May 16, 2006
Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective
7042036 Magnetic memory using single domain switching by direct current May 9, 2006
A method for implementing miniaturization of magnetic random access memory (MRAM) and a magnetic memory using single domain switching by direct current are provided. The magnetic memory preferably includes a half-circle or U-shaped architecture with an exchange biasing pad, such as a
7041653 Gene transcription and ionizing radiation: methods and compositions May 9, 2006
The present invention provides a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. An encoding region can comprise a single encoding sequence for a polypeptide or two or more encoding seque
7041414 Silver manganese oxide electrodes for lithium batteries May 9, 2006
This invention relates to electrodes for non-aqueous lithium cells and batteries with silver manganese oxide positive electrodes, denoted Ag.sub.xMnO.sub.y, in which x and y are such that the manganese ions in the charged or partially charged electrodes cells have an average oxidatio
7041150 Preparation of alloys by the Armstrong method May 9, 2006
A method and apparatus for making alloys or ceramics by the subsurface injection of an equilibrium vapor of a boiling liquid of the ceramic or alloys constituents is disclosed. Various powders and products are disclosed.
7038727 Method to smooth photometric variations across multi-projector displays May 2, 2006
A method is provided to smooth photometric variations across multi-projector displays. Photometric calibration is performed to generate a luminance attenuation map (LAM) for each projector. An image for each projector is modified using the luminance attenuation map (LAM) for each pro
7026074 Lithium ion battery with improved safety April 11, 2006
A lithium battery with improved safety that utilizes one or more additives in the battery electrolyte solution wherein a lithium salt is dissolved in an organic solvent, which may contain propylene, carbonate. For example, a blend of 2 wt % triphenyl phosphate (TPP), 1 wt % diphenyl
7023673 Superconducting shielded core reactor with reduced AC losses April 4, 2006
A superconducting shielded core reactor (SSCR) operates as a passive device for limiting excessive AC current in a circuit operating at a high power level under a fault condition such as shorting. The SSCR includes a ferromagnetic core which may be either closed or open (with an air gap)
7019713 Methods and measurement engine for aligning multi-projector display systems March 28, 2006
An image pattern description is stored and tiled display test pattern images are captured. The stored image pattern description and at least one captured tiled display test pattern image are used to identify a tile array placement and layout; a tile registration measurement; and a dot
7012386 Enhanced RF window for waveguide used with particle accelerator March 14, 2006
An RF window and a method of manufacture of the RF window are provided. The RF window of the invention has very low reflected RF power. The RF window includes a center sleeve assembly including a ceramic disc mounted within a copper sleeve. The ceramic disc has opposed surfaces, a cerami
7012275 Method for fabrication of high temperature superconductors March 14, 2006
A layered article of manufacture and a method of manufacturing same is disclosed. A substrate has a biaxially textured MgO crystalline layer having the c-axes thereof inclined with respect to the plane of the substrate deposited thereon. A layer of one or more of YSZ or Y.sub.2O.sub.
7001860 Construction material and method February 21, 2006
A structural material of a polystyrene base and the reaction product of the polystyrene base and a solid phosphate ceramic. The ceramic is applied as a slurry which includes one or more of a metal oxide or a metal hydroxide with a source of phosphate to produce a phosphate ceramic an
6995351 Multiple optical vortices for manipulating particles February 7, 2006
A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into
6987361 Field emission cathode gating for RF electron guns and planar focusing cathodes January 17, 2006
A novel method of gating electron emission from field-emitter cathodes for radio frequency (RF) electrode guns and a novel cathode that provides a focused electron beam without the need for magnetic fields or a curved cathode surface are provided. The phase and strength of a predefined
6984335 Redundantly constrained laminar structure as weak-link mechanisms January 10, 2006
Redundantly constrained laminar structures as weak-link mechanisms and a novel method for manufacturing the redundantly constrained laminar structures as weak-link mechanisms are provided. The method for producing the redundantly constrained laminar structures as weak-link mechanisms is
6977122 Proton conducting membrane for fuel cells December 20, 2005
An ion conducting membrane comprising dendrimeric polymers covalently linked into a network structure. The dendrimeric polymers have acid functional terminal groups and may be covalently linked via linking compounds, cross-coupling reactions, or copolymerization reactions. The ion co
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