| Patent Number |
Title Of Patent |
Date Issued |
| 7432236 |
Vasostatin as marrow protectant |
October 7, 2008 |
| Specific fragments of vasostatin are disclosed. Also disclosed is a method of stimulating the proliferation or survival of a hematopoietic cell exposed to a chemotherapeutic agent or irradiation using these fragments. A method of stimulating the proliferation or survival of a hematopoiet |
| 7431926 |
Tumor supressor gene p33ING2 |
October 7, 2008 |
| The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and |
| 7427590 |
Neurothrophic components of the ADNF I complex |
September 23, 2008 |
| This invention relates to Activity Dependent Neurotrophic Factor I complex (ADNF I complex) and polypeptides of this complex, which produce their neurotrophic effects through multiple proteases intrinsic to the ADNF I complex. The invention also relates to pharmaceutical compositions |
| 7425537 |
SH2 domain binding inhibitors |
September 16, 2008 |
| Disclosed are compounds for SH2 domain binding inhibition, for example, a compound of formula (I), wherein R.sub.1 is a lipophile; R.sub.2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R.sub.3 is hydrogen, azido, amino, |
| 7419957 |
Peptides of melanoma antigen and their use in diagnostic, prophylactic and therapeutic methods |
September 2, 2008 |
| Immunogenic peptides of a melanoma antigen recognized by T cells, designated gp100, bioassays using the peptides to diagnose, assess or prognose a mammal afflicted with cancer, more specifically melanoma or metastatic melanoma, and use of the proteins and peptides as immunogens to in |
| 7407658 |
Vaccines for blocking transmission of plasmodium vivax |
August 5, 2008 |
| The present invention relates novel methods and compositions for blocking transmission of Plasmodium vivax which cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including deglycosylated forms, and fusion proteins thereof, are disclosed which, when administered to a |
| 7371225 |
Method for convection enhanced delivery of therapeutic agents |
May 13, 2008 |
| A method for monitoring and controlling convection enhanced delivery of a therapeutic agent to a target tissue is disclosed. A tracer that is detectable, for example, by magnetic resonance imaging (MRI) and/or by X-ray computed tomography (CT) is co-infused with the therapeutic agent |
| 7365160 |
Mutated constitutively active nuclear orphan receptor |
April 29, 2008 |
| Disclosed are constitutively active nuclear orphan receptors (CAR), which include one or more mutations which decrease the constitutive nature of CAR in vitro. The resulting non-constitutively active nuclear orphan receptors can be used to screen for agents that metabolize xenochemicals |
| 7332167 |
Nucleic acid and amino acid sequences of hemoglobin-response genes in Candida albicans and the u |
February 19, 2008 |
| Three hemoglobin-response genes in the pathogenic yeast Candida albicans are disclosed. The expression of these genes is specifically induced when the organism is exposed to hemoglobin during disseminated infections. The invention relates to the nucleic acid and amino acid sequences of t |
| 7314725 |
Phenylthiocarbamide (PTC) taste receptor |
January 1, 2008 |
| The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of scree |
| 7314712 |
Systems for in vivo site-directed mutagenesis using oligonucleotides |
January 1, 2008 |
| This disclosure provides several methods to generate nucleic acid mutations in vivo, for instance in such a way that no heterologous sequence is retained after the mutagenesis is complete. The methods employ integrative recombinant oligonucleotides (IROs). Specific examples of the de |
| 7314632 |
Pseudomonas exotoxin A-like chimeric immunogens |
January 1, 2008 |
| This invention provides Pseudomonas exotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain of Pseudomonas exotoxin. Methods of eliciting an immune response using these immunogens also are provided. |
| 7312228 |
Cytotoxic indeno and isoindoloisoquinolones |
December 25, 2007 |
| The synthesis and biological activity of benzoisoindoloisoquinolone compounds are described. The synthesis and biological activity of C-11-substituted indenoisoquinolones are also described. Indenoisoquinolones substituted at C-11 are prepared by McMurry reactions of 11-ketoindenoiso |
| 7312032 |
Methods for screening ligands that activate the translocation of a steroid receptor to the nucle |
December 25, 2007 |
| The present invention provides a method of screening for a compound that binds to a selected nucleic acid comprising contacting compound fluorescently labeled by a fluorescent protein with a cell having a plurality of copies of the nucleic acid in an array such that the nucleic acid |
| 7300940 |
Integrin .alpha.-v .beta.-3 antagonists for use in imaging and therapy |
November 27, 2007 |
| Integrin receptor antagonists whose molecular structure includes a tetrahydropyridimidinylaminoethyloxybenzoyl group on a sulfonylamino-.beta.-alanine nucleus exhibit increased binding affinity for the .alpha.v.beta.3 receptor when further substituted on the sulfonyl moiety with an N |
| 7297492 |
LMNA gene and its involvement in Hutchinson-Gilford Progeria Syndrome (HGPS) and arteriosclerosi |
November 20, 2007 |
| Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal pro |
| 7285954 |
Imaging and reconstruction of partial field of view in phase contrast MRI |
October 23, 2007 |
| Phase contrast magnetic resonance images are produced using interleaved spiral k-space scanning with a bipolar phase contrast gradient. Spiral scanning is configured so that acquisition impulse response defines a central alias free portion in a partial field of view, and signal acqui |
| 7282205 |
Anti-hepatitis A virus antibodies |
October 16, 2007 |
| Chimpanzee monoclonal antibodies and antigen binding fragments including a .gamma.1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also disclosed are methods for using these antibodies and antigen binding fragments in the |
| 7276367 |
Method of etching islands of cells in a grid pattern |
October 2, 2007 |
| An apparatus and process for monitoring migratory cell proliferation with restricted migration on a substrate includes providing a substrate, coating the substrate with extracellular matrix, plating cells suspended in cell culture media on extracellular matrix, and placing intersecting |
| 7273699 |
Methods for detecting nucleic acid sequence variation |
September 25, 2007 |
| Sequence variations, such as polymorphisms, are detected by detecting differences between or among melting profiles of plural nucleic acids. Melting profiles are produced by observing the nucleic acids during a temperature change over a period of time. If the nucleic acids are dilute |
| 7271781 |
Multiplex hybridization system for identification of pathogenic mycobacterium and method of use |
September 18, 2007 |
| A method for species-specific identification of a Mycobacterium species is provided. Also disclosed is a method for identifying the species of Mycobacterium present in a sample. A device is disclosed for the detection of Mycobacterium. Mycobacterium-specific oligonucleotides are also |
| 7261900 |
Recombinant modified Bacillus anthracis protective antigen for use in vaccines |
August 28, 2007 |
| The invention relates to improved methods of producing and recovering sporulation-deficient B. anthracis mutant stains, and for producing and recovering recombinant B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these |
| 7260250 |
Computer-aided classification of anomalies in anatomical structures |
August 21, 2007 |
| Candidate anomalies in an anatomical structure are processed for classification. For example, false positives can be reduced by techniques related to the anomaly's neck, wall thickness associated with the anomaly, template matching performed for the anomaly, or some combination there |
| 7258859 |
Method for the treatment of multiple sclerosis |
August 21, 2007 |
| A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple sclerosis that includes administering to the subject a therapeutically effective amount of an IL-21 receptor antagonist, wherein t |
| 7255993 |
Detection of mutational frequency and related methods |
August 14, 2007 |
| Methods are provided herein for measuring the mutational frequency of a DNA molecule in cells, for example stem cells or hematopoietic cells such as CD34.sup.+ cells or granulocytes. The method includes sequencing corresponding regions of mtDNA from a set of hematopoietic cells, or a |
| 7247307 |
Vaccines against Escherichia coli O157 infection |
July 24, 2007 |
| This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including responses which provide |
| 7244584 |
T2R, a novel family of taste receptors |
July 17, 2007 |
| The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein |
| 7238473 |
TTP-related zinc finger domains and methods of use |
July 3, 2007 |
| The present invention provides methods of regulating the destruction of mRNA molecules containing an AU-rich element (ARE), for example, methods of stimulating the degradation of an mRNA molecule encoding TNF-.alpha., and methods of inhibiting the degradation of an mRNA molecule encoding |
| 7232654 |
DNA sequence of the LTR region of human immunodeficiency virus type 1 (HIV-1) |
June 19, 2007 |
| This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1) to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphade |
| 7226731 |
PB 39, a gene dysregulated in prostate cancer, and uses thereof |
June 5, 2007 |
| A novel gene, PB39, that is up-regulated, or over-expressed, in prostate cancer has been identified. The gene has been identified by means of its cDNA obtained by reverse transcription of the corresponding mRNA. Microdissection of prostate glands that had been surgically removed from |
| 7223853 |
Secreted frizzled related protein fragments |
May 29, 2007 |
| The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt |
| 7214477 |
Layered device with capture regions for cellular analysis |
May 8, 2007 |
| The present invention involves methods, systems, and devices for analyzing a biological material, such as a cellular or other specimen. The method includes placing the specimen on a substrate having different capture regions, such as contiguous layers, wherein the different capture regio |
| 7211445 |
Conjugation of biomolecules using diels-alder cycloaddition |
May 1, 2007 |
| A method is provided for covalently linking carbohydrates, proteins, nucleic acids, and other biomolecules under neutral conditions, using a Diels-Alder cycloaddition reaction. In an example, activated carbon-carbon double bonds were attached to free amino sites of a carrier protein, |
| 7205102 |
Cloned DNA sequences related to the genomic RNA of lymphadenopathy-associated virus (LAV) and pr |
April 17, 2007 |
| This invention is in the field of lymphadenopathy virus which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the |
| 7154268 |
Method and apparatus to improve an MRI image using regularization |
December 26, 2006 |
| An MRI imaging system includes at least one processor and a plurality of coils to acquire a plurality of k-space samples of a target to image. The system includes a machine-readable media comprising instructions which, when executed by the processor, result in determining a plurality of |
| 7109245 |
Vasoconstrictor cannabinoid analogs |
September 19, 2006 |
| Methods and compounds for reversing pathological vasodilation of blood vessels, for example vasodilation caused by activation of CB1-like receptors, by administering to a subject a therapeutically effective amount of a compound sufficient to induce vasoconstriction, the compound comp |
| 7101547 |
Method for the prevention and treatment of diseases caused by an inflammatory response mediated |
September 5, 2006 |
| The present invention provides methods for preventing or treating a disease in a subject which is caused by an inflammatory response to a disease or syndrome which is mediated by endogenous substance P. These methods comprise the administration to the subject of a pharmaceutically-ef |
| 7101541 |
Utilization of non-viral sequences for minus-strand DNA transfer and gene reconstitution |
September 5, 2006 |
| A retroviral vector for gene reconstitution is provided that includes a 3' portion of a heterologous nucleic acid sequence 5' of a first att site and a 5' portion of the heterologous nucleic acid sequence 3' of a second att site. A sub-portion of the 3' portion of the heterologous nuclei |
| 7094405 |
Peptides which elicit a high neutralizing antibody titer, cytotoxic T lymphocyte response and T |
August 22, 2006 |
| Peptide constructs comprised of multideterminant T helper peptides from the envelope glycoprotein of HIV previously identified to induce proliferative responses in four different haplotypes of mice and IL-2 responses in 52-73% of HIV positive, flu positive patients (cluster peptides) |
| 7067635 |
Nucleotide and deduced amino acid sequences of tumor gene Int6 |
June 27, 2006 |
| The present invention discloses the isolation of the human and murine wild-type Int6 gene and the cDNAs sorresponding to these genes. The invention further describes the use of reagents derived from the nucleic acid and amino acid sequences of the Int6 gene in diagnostic methods, imm |
| 7052904 |
Hybrid adeno-retroviral vector for the transfection of cells |
May 30, 2006 |
| An adenovirus, including adenoviral capsid proteins, and a replication-defective adenoviral vector that includes a 5' retroviral LTR nucleic acid sequence, a 3' retroviral LTR nucleic acid sequence, a nucleic acid sequence encoding a portion of a retroviral envelope protein adjacent |
| 7052703 |
T-cell receptor.gamma. alternate reading frame protein, (TARP) and uses thereof |
May 30, 2006 |
| This invention provides nucleic acids containing sequences from a TCR.gamma. transcript from prostate epithelial cells and many breast cancer cells and a T-cell receptor gamma Alternate Reading frame Protein ("TARP") expressed from the translation of those sequences. Vaccines made fr |
| 7001720 |
Cloning of a gene mutation for parkinson's disease |
February 21, 2006 |
| Parkinson's disease (PD) is a common neurodegenrative disorder with a lifetime incidence of approximately 2 percent. It was recently reported that a PD susceptibility gene is located on the long arm of human chromosome four. The present invention reports the subsequent identification |
| 6995018 |
Complex formed by N-linked glycoproteins (SIBLINGS)and Factor H |
February 7, 2006 |
| The invention provides methods and compositions for exploiting the discovery that members of the small integrin-binding ligand, n-linked glycoproteins family termed SIBLINGS bind to complement Factor H, and moreover that SIBLINGS proteins, such as BSP, exist in relatively acidic form |
| 6989263 |
Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attac |
January 24, 2006 |
| The present invention provides several classes of compounds which can be used to inactivate retroviruses, such as HIV-1, by attacking the CCHC zinc fingers of the viral nucleocapsid protein and ejecting the zinc therefrom. In addition, kits for identifying compounds that can react wi |
| 6479286 |
Methods and compositions for making dendritic cells from expanded populations of monocytes and f |
November 12, 2002 |
| Methods of generating IL-3 expanded populations of monocytes and differentiating the cells into dendritic cells are provided. The methods include use of the dendritic cells to activate T-cells, in vitro and in vivo, and for ex vivo and other therapeutic methods. |
| 6479255 |
Polynucleotides encoding human FRP and fragments thereof |
November 12, 2002 |
| The invention provides a novel, secreted protein that contains a region homologous to ligand binding domain of a cytokine receptor. This protein, called Frizzled-related protein (FRP), antagonizes the signaling of the Wnt family of cytokines. Extracellular signaling molecules such as the |
| 6406887 |
Compositions for diagnosing Rochalimaea henselae and Rochalmaea quintana infection |
June 18, 2002 |
| Fusion protein compositions containing the sequence of a 17 kilodalton antigenic polypeptide of Rochalimaea (SEQ ID NO:12) are disclosed for diagnosis of cat scratch disease and bacillary angiomatosis by detection of antibodies specifically binding to the polypeptide. |
| 6403635 |
Method of treating atherosclerosis or restenosis using microtubule stabilizing agent |
June 11, 2002 |
| The present invention is a method of preventing or reducing atherosclerosis or restenosis, and a pharmaceutical preparation used therefor. In particular, it is a method of preventing or reducing atherosclerosis or restenosis after arterial injury by treatment with a low dose of a mic |
| 6395495 |
Methods and kits for detecting antibodies against an HIV variant |
May 28, 2002 |
| The invention concerns a retrovirus extract containing a p25 protein which recognizes immunologically sera of patients afflicted with lymphadenopathy syndrom (LAS) or acquired immune deficiency syndrom (AIDS). It relates to a method and kit for in vivo assay of LAS or AIDS involving cont |
