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The United States of America as represented by the Secretary, Department of Health and Human Service Patents
Assignee:
The United States of America as represented by the Secretary, Department of Health and Human Service
Address:
Washington, DC
No. of patents:
12
Patents:




Patent Number Title Of Patent Date Issued
7342099 cDNA encoding a gene BOG (B5T over-expressed gene) and its protein product March 11, 2008
Nucleic acids that encode novel polypeptides, designated in the present application as "BOG" (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-.beta
7341726 Modified HCV peptide immunogens March 11, 2008
Provided are an isolated peptide having the amino acid sequence DLMGYIPAV (SEQ ID NO: 1), an isolated HCV core polypeptide comprising an L.fwdarw.A substitution at amino acid position 139, an isolated HCV core polypeptide having the amino acid sequence of SEQ ID NO: 2, and a fragment of
7319091 Human derived monocyte attracting purified protein product useful in a method of treating infect January 15, 2008
Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM.
7244558 Production of novel Newcastle disease virus strains from cDNAs and improved live attenuated Newc July 17, 2007
The present invention concerns cDNAs for making attentuated, infectious Newcastle disease virus (NDV). Another aspect of the invention relates to methods of making the cDNAs. Another aspect of the invention is a vector containing the cDNA optionally linked to an operable promoter. Within
7232671 Pertussis toxin gene: cloning and expression of protective antigen June 19, 2007
A cloned gene encoding the expression of an antigenic mutant pertussis toxin with substantially reduced enzymatic activity has been described.
7226602 Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses June 5, 2007
A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.
7220419 Self-assembling recombinant papillomavirus capsid proteins May 22, 2007
Recombinant papillomavirus capsid proteins that are capable of self assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression produ
7211432 Recombinant vector expressing multiple costimulatory molecules and uses thereof May 1, 2007
The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimul
7078507 Synthetic genes for malarial proteins and methods of use July 18, 2006
Synthetic gene sequences encoding erythrocyte binding protein of a malaria pathogen for the expression of the erythrocyte binding protein. The codon composition of the synthetic gene sequences approximates the mammalian codon composition. The synthetic gene sequences are useful for i
5879882 RNA probe for detecting c-fes MRNA March 9, 1999
A recombinant plasmid and an RNA sequence expressed by said plasmid are described. The RNA sequence hybridizes specifically with human c-fes mRNA.
5879299 Method and system for multidimensional localization and for rapid magnetic resonance spectroscop March 9, 1999
A method and system for providing prelocalization of a volume of interest and for rapidly acquiring a data set for generating spectroscopic images. Spatial prelocalization of a volume of interest is achieved by providing a presuppression sequence before a stimulated echo (STE) sequence a
5843648 P15 and tyrosinase melanoma antigens and their use in diagnostic and therapeutic methods December 1, 1998
The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated p15. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognoses a mammal

 
 
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