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The United States of America as represented by the Department of Health and Human Services Patents
Assignee:
The United States of America as represented by the Department of Health and Human Services
Address:
Washington, DC
No. of patents:
974
Patents:


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Patent Number Title Of Patent Date Issued
RE41949 System and method for tomographic imaging of dynamic properties of a scattering medium November 23, 2010
A system and method for the detection and three dimensional imaging of absorption and scattering properties of a medium such as human tissue is described. According to one embodiment of the invention, the system directs optical energy toward a turbid medium from at least one source a
RE40862 Gossypolone for the treatment of cancer July 21, 2009
A method for treating cancer in a human, which comprises administering to the human subject an anti-cancer effective amount of a compound selected from gossypol, gossypol acetic acid, gossypolone, metabolites thereof, or physiologically acceptable salts thereof. Also included is a method
RE40839 Taxol treatment of cancer July 7, 2009
The present invention is a method of treatment for a patient with cancer. In particular, it is a method of treating patients having .[.lymphomas and .]. breast cancer using the microtubule agent, Taxol. The present method of administration, serves to prevent or retard the adverse side
RE39788 Gene therapy August 21, 2007
Primary human cells which are genetically engineered with DNA (RNA) encoding a marker or therapeutic which is expressed to be expressed in vivo. Such engineered cells may be used in gene therapy.
RE38424 Method for treating taxol side-effects with G-CSF February 10, 2004
A method of treating a host using taxol comprising administering granulocyte colony-stimulating factor to the host being treated with taxol. The present inventive method allows for increased levels of taxol to be administered to the host in the treatment of various conditions, partic
RE37381 Vaccine against hepatitis A virus September 18, 2001
The present invention provides an attenuated hepatitis A virus useful as a vaccine.
H2056 Model for von Hippel-Lindau disease December 3, 2002
Disclosed herein are nucleic acid molecules that can be used to effect a loss of function of the von Hippel-Lindau (VHL) allele in somatic and/or germ cells of a mammal and methods for using these molecules to create conditional VHL gene targeted and conditional VHL knockout animals.
8288530 Method of preparing macromolecular contrast agents and uses thereof October 16, 2012
Disclosed are methods of preparing a macromolecular conjugated ligand and a metal complex thereof. The metal complex is targeted for use as a contrast agent, for example, in MRI. The method of preparing a macromolecular conjugated ligand comprises: (a) providing a compound of formula
8258106 Immunostimulatory nucleic acid molecules September 4, 2012
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are
8217222 Methods for identifying markers for early-stage human cancer, cancer progression and recurrence July 10, 2012
A method is described to identify secreted proteins identified with stages of malignancy of cancer. The proteins are initially identified by trapping them with a fluorescent protein containing vector that can insert in any gene. The secreted proteins are initially identified by their
8211445 PSM peptides as vaccine targets against methicillin-resistant Staphylococcus July 3, 2012
This disclosure concerns compositions and methods for the treatment and inhibition of infectious disease, particularly methicillin-resistant Staphylococcus. In certain embodiments, the disclosure concerns immunogenic peptides, for instance PSM peptides, which can be used to induce pr
8206933 Boris isoforms and methods of detecting and treating disease June 26, 2012
A method of detecting a proliferative disease, such as a disease associated with the abnormal expression of BORIS, in a mammal comprising testing for the expression of a BORIS isoform in the tissue of a mammal that does not express BORIS in the absence of disease, as well as a method
8198048 Mammalian sweet taste receptors June 12, 2012
The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting su
8175688 Multispectral/hyperspectral medical instrument May 8, 2012
A medical instrument that comprises: a first-stage optic responsive to a tissue surface of a patient; a spectral separator optically responsive to the first stage optic and having a control input; an imaging sensor optically responsive to the spectral separator and having an image data
8168195 Vaccines against Escherichia coli O157 infection May 1, 2012
This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including responses which
8158592 Immunostimulatory nucleic acid molecules April 17, 2012
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are
8148340 Immunomodulatory oligonucleotides April 3, 2012
Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylat
8148302 In situ assembling of protein microarrays April 3, 2012
The invention provides a microarray and methods for producing a protein microarray. The array comprises multiple nucleic acid molecules immobilized on a substrate, each comprising (i) a protein-binding domain and (ii) a nucleic acid sequence encoding a fusion protein comprising a pol
8137960 Bovine adeno-associated viral (BAAV) vector and uses thereof March 20, 2012
The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
8133859 SCGB3A2 as a growth factor and anti-apoptotic agent March 13, 2012
The present disclosure is generally related to methods of using the secretory protein SCGB3A2 for promoting lung development and treating lung disease. Some embodiments are, for example, methods for treating and inhibiting the development of neonatal respiratory distress. Other embod
8132911 Fundus photo-stimulation system and method March 13, 2012
An eye examination device has a fundus observation system and an optical stimulation system. The optical stimulation system has an optical targeting subsystem and an optical stimulation subsystem, wherein the optical stimulation system is structured to be used to provide light stimul
8124753 Compositions and methods for inhibiting translation of a Mect1-MAML2 chimeric gene February 28, 2012
Composition for the inhibition of the translation of a Mect1-MAML2 chimeric gene consisting essentially of: (a) a fragment of the nucleic acid encoding the chimeric gene, and (b) a nucleic acid complementary to the fragment, and a method of inhibiting the translation of a Mect1-MAML2
8124592 Development of a preventive vaccine for filovirus infection in primates February 28, 2012
The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
8124105 Compositions, methods and kits relating to poxvirus subunit vaccines February 28, 2012
The invention is directed to a poxvirus vaccine comprising a soluble truncated poxvirus envelope protein. The invention is also directed to a vaccine comprising a nucleic acid encoding such proteins. Also included is an antibody which specifically binds to the proteins and nucleic acid
8114848 Immunomodulatory oligonucleotides February 14, 2012
Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylat
8106027 Development of a preventive vaccine for filovirus infection in primates January 31, 2012
The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
8101739 Recombinant expression vectors comprising a human codon-optimized marburg virus (MARV) angola gl January 24, 2012
The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity wh
8088379 Modified T cell receptors and related materials and methods January 3, 2012
The invention is directed to a modified T cell receptor (TCR) comprising an amino acid sequence of a wild-type (WT) TCR with no more than three amino acid substitutions, wherein the modified TCR, as compared to the WT TCR, (i) has an enhanced ability to recognize target cells when expres
8076100 Molecular clones with mutated HIV gag/pol, SIV gag and SIV env genes December 13, 2011
Nucleic acid constructs containing HIV-1 gag/pol and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host cells containing these constructs and/or viral particles are also disclosed. The exemplified
8075903 Dengue tetravalent vaccine containing a common 30 nucleotide deletion in the 3'-UTR of dengue ty December 13, 2011
The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (.DELTA.30) in the 3'-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.
8071113 Live, oral vaccine for protection against Shigella dysenteriae serotype 1 December 6, 2011
The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and
8071084 Vaccine for protection against Shigella sonnei disease December 6, 2011
Compositions and methods for protecting a susceptible host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.
8067530 Scytovirin domain 1 related polypeptides November 29, 2011
A scytovirin domain 1 (SD1) polypeptide, a nucleic acid encoding the polypeptide, and related fusion proteins, conjugates, isolated cells, vectors, and antibodies, as well as a method of inhibiting a viral infection using the same.
8067159 Methods of detecting amplified product November 29, 2011
A microfluidic device comprising a first surface portion and a first sample retaining element, which have differing affinities to a fluid, and a method comprising supplying a sample to such a device. In some embodiments, the differing affinity is a result of plasma, ion embedding, su
8065092 Methods for analyzing high dimensional data for classifying, diagnosing, prognosticating, and/or November 22, 2011
A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised
8063209 Phosphonyl ester conjugates as prodrugs November 22, 2011
Cidofovir or foscarnet based compounds having an amino acid or dipeptide esters are provided as prodrugs.
8058395 Chimeric protein comprising a green fluorescent ptotein fused to a transcription factor November 15, 2011
The present invention provides a method of screening for a compound that binds to a selected nucleic acid comprising contacting compound fluorescently labeled by a fluorescent protein with a cell having a plurality of copies of the nucleic acid in an array such that the nucleic acid
8053443 N-substituted indenoisoquinolines and syntheses thereof November 8, 2011
N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are processes for preparing N-substituted indenoisoquinoline compounds. Also described are methods for treating cancer in mammals us
8053422 Anti-cancer oligodeoxynucleotides November 8, 2011
It is disclosed herein that suppressive ODNs are of use for preventing or delaying the formation of a tumor, reducing the risk of developing a tumor, treating a tumor, preventing conversion of a benign to a malignant lesion, or preventing metastasis. In some embodiments, methods are
8044189 Bacillus anthracis protective antigen nucleic acid sequences October 25, 2011
The invention relates to improved methods of producing and recovering B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, in
8039585 Therapeutic administration of the scrambled anti-angiogenic peptide C16Y October 18, 2011
Unregulated angiogenesis is associated with a variety of pathological conditions. Tumor growth and metastasis is dependent on the development of new blood vessels. The development of new blood vessels in the eye, or ocular neovascularization, has been implicated in a variety of serious
8030285 Oligodeoxynucleotide and its use to induce an immune response October 4, 2011
The present invention provides a substantially pure or isolated oligodeoxynucleotide of at least about 10 nucleotides comprising a sequence represented by either the formula: 5'N.sub.1N.sub.2N.sub.3T-CpG-WN.sub.4N.sub.5N.sub.63' wherein the central CpG motif is unmethylated, W is A o
8026350 Tumor suppressor gene, p28ING5 September 27, 2011
This disclosure provides a novel tumor suppressor, referred to as p28ING5, nucleic acid molecules encoding this protein, and methods of making and using these molecules. Also provided are methods of ameliorating, treating, detecting, prognosing, and diagnosing diseases and conditions
8017938 Apparatus for microarray binding sensors having biological probe materials using carbon nanotube September 13, 2011
A microarray apparatus is provided which contains at least one chip having source and drain electrodes positioned on an array of carbon nanotube transistors which allows for electronic detection of nucleic acid hybridizations, thereby affording both increased sensitivity and the capa
8017130 Method of accelerated vaccination against Ebola viruses September 13, 2011
The present invention relates to genetic vaccines for stimulating cellular and humoral immune responses in humans and other hosts, and, in particular, relates to recombinant viruses that express heterologous antigens of pathogenic viruses, in single dose form.
8008266 Methods of treating cancer using immunostimulatory oligonucleotides August 30, 2011
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adj
7998736 Adoptive immunotherapy with enhanced T lymphocyte survival August 16, 2011
The invention provides for compositions, e.g., pharmaceutical compositions, comprising a T lymphocyte, or a population thereof, expressing at least one recombinant polynucleotide encoding a cytokine that enhances T lymphocyte survival during the contraction phase of an immune respons
7993921 Cell cycle regulation and differentiation August 9, 2011
The present invention provides compositions and methods for regulating neural cell proliferation or differentiation. The present invention also provides methods for selecting for bioactive agents effective in regulating proliferation or differentiation.
7993919 Method of inducing memory B cell development and terminal differentiation August 9, 2011
A method is disclosed herein for inducing differentiation of a B cell progenitor into a memory B cells and/or a plasma cell. The method includes contacting a population of cells including a mature B cell or a B cell progenitor with an effective amount of IL-21, and isolating memory B
7993857 Determination of AM-binding proteins and the association of adrenomedullin (AM) therewith August 9, 2011
The present invention provides methods for the isolation, identification, and purification of adrenomedullin (AM)-binding proteins. Also, provided are methods for utilizing the purified AM-binding proteins, or functional portions thereof, to diagnose, treat, and monitor AM-related diseas
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