| Patent Number |
Title Of Patent |
Date Issued |
| RE36529 |
Spectroscopic imaging device employing imaging quality spectral filters |
January 25, 2000 |
| Techniques for providing spectroscopic imaging integrates an acousto-optic tunable filter (AOTF), or an interferometer, and a focal plane array detector. In operation, wavelength selectivity is provided by the AOTF or the interferometer. A focal plane array detector is used as the imagin |
| D352788 |
Sawhorse bracket |
November 22, 1994 |
|
| 7375520 |
Method for spectrally selective B1 insensitive T2 preparation contrast enhancement for high fiel |
May 20, 2008 |
| A T.sub.2 preparation sequence uses a segmented BIR-4 adiabatic pulse with two substantially equal delays and is insensitive to B.sub.1 field variations and can simultaneously suppress fat signals with low specific absorption rate (SAR). An adiabatic reverse half passage pulse is applied |
| 6140339 |
Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof |
October 31, 2000 |
| The present invention provides new monomeric derivatives of the C-8'-7 linked naphthylisoquinoline alkaloid dioncophylline D. The invention also provides new C-4 substituted monomeric arylisoquinoline alkaloid derivatives. The present invention furthermore provides novel dimeric aryl |
| 6136992 |
2-alkoxy estradiols and derivatives thereof |
October 24, 2000 |
| Compounds represented by the following structural formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification. The compounds are disclosed as useful in the treatment of various forms of cancer. |
| 6136534 |
Methods for sensitive detection of reverse transcriptase |
October 24, 2000 |
| The present invention provides a method for detecting the presence of a retrovirus in a biological sample comprising the steps of: a) contacting the biological sample with an RNA template and a complementary DNA primer under conditions whereby the RNA template and the DNA primer will ann |
| 6132980 |
Antibodies specific for TRP-2 a human tumor antigen recognized by cytotoxic T lymphocytes |
October 17, 2000 |
| The infusion of TIL586 along with interleukin-2 (IL-2) into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by TIL586 was previously isolated and shown to encode gp75 or TRP-1. The present invention |
| 6132954 |
Methods of screening for agents that delay a cell cycle and compositions comprising era and an a |
October 17, 2000 |
| The present invention provides for methods of screening for agents which delay the cell cycle and methods of delaying the cell cycle. Analogues of Era having arginine, histidine, or lysine at amino acid codon 17 are embodied by the present invention. Human and other homologs of bacterial |
| 6132732 |
Parvovirus capsids |
October 17, 2000 |
| The present invention relates to a method of producing non-infections parvovirus capsids and to diagnostic assays and vaccines utilizing same. The invention further relates to recombinant baculoviruses encoding parvovirus structural proteins and host cells infected therewith. The inv |
| 6130042 |
Compositions and methods for diagnosing periodontal disease |
October 10, 2000 |
| Compositions and methods are described for diagnosing periodontal disease, and in particular, early-onset periodontal disease. Nucleic acid-based testing is described which permits the detection of a high risk haplotype. |
| 6126944 |
Baculovirus expression vectors and recombinant antigens for detecting type-specific antibodies t |
October 3, 2000 |
| Novel baculovirus expression vectors and recombinant antigens for detecting, type-specific herpes simplex virus (HSV) infection have been made. Diagnostic kits and assays for detecting type-specific HSV infection have been described. High level production of foreign proteins in subst |
| 6117991 |
Biologically active synthetic thyrotropin and cloned gene producing same |
September 12, 2000 |
| Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH are described. |
| 6114397 |
Gossypol for the treatment of cancer |
September 5, 2000 |
| A method for treating cancer in a human, which comprises administering to the human subject an anti-cancer effective amount of a compound selected from gossypol, gossypol acetic acid, gossypolone, metabolites thereof, or physiologically acceptable salts thereof. Also included is a method |
| 6113912 |
Hepatitis A virus vaccines |
September 5, 2000 |
| A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of va |
| 6110490 |
Liposomal delivery system for biologically active agents |
August 29, 2000 |
| The present invention is directed to a liposomal preparation which is based on specific lipid components. The liposomal compounds are also combined with a biologically active agent, forming liposomal compounds. These compounds are useful in drug delivery, where specific therapeutic c |
| 6110465 |
Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of |
August 29, 2000 |
| The nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of 49 isolates of hepatitis C are disclosed. The invention relates to the use of these sequences to design proteins and nucleic acid sequences useful in diagnostic methods and vaccines. |
| 6110453 |
Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorpor |
August 29, 2000 |
| A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in wh |
| 6107050 |
Diagnostic test for alzheimers disease |
August 22, 2000 |
| The present invention provides methods for the diagnosis of Alzheimer's disease using human cells. Specifically, one method detects differences between potassium channels in cells from Alzheimer's patient and normal donors, and differences in intracellular calcium concentrations between |
| 6103694 |
Method of decreasing radiation of radio-mimetic chemotherapy for hematopoietic pluripotent cell |
August 15, 2000 |
| The present invention provides a method of engrafting donor mammalian hematopoietic pluripotent cells in a mammalian recipient using a decreased amount of radiation, comprising: (a) administering to the recipient at least one dosage of a hematopoietic growth factor; (b) subjecting the |
| 6103235 |
Methods of inducing immune tolerance using immunotoxins |
August 15, 2000 |
| Provided is a method of treating an immune system disorder not involving T cell proliferation, comprising administering to the animal an immunotoxin comprising a mutant diphtheria toxin moiety linked to an antibody moiety which routes by the anti-CD3 pathway, or derivatives thereof under |
| 6100051 |
Method utilizing convex geometry for laser capture microdissection |
August 8, 2000 |
| A process of microdissection where a tissue sample is conventionally visualized in a microscope. A selectively activatable convex surface is provided, preferably on the periphery at the distal end of a rod. This selectively activatable convex surface when locally activated, typically |
| 6099847 |
Chimeric Gag pseudovirions |
August 8, 2000 |
| The present invention provides, inter alia, recombinant chimeric nucleic acids encoding a Gag-fs-fusion partner fusion protein; a pseudovirion comprising a retroviral Gag protein and a fusion partner, wherein the fusion partner is present in a Gag-fs-fusion partner fusion protein; an |
| 6099842 |
Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin |
August 8, 2000 |
| Single chain immunotoxins directed at the human transferrin receptor using PCR based methods are described. Anti-TFR(Fv)-PE40 contains DNA for the antigen binding portion (Fv) of a monoclonal antibody directed at the human transferrin receptor fused to the DNA for a 40,000 molecular weig |
| 6096534 |
Retrovirus vectors derived from avian sarcoma leukosis viruses permitting transfer of genes into |
August 1, 2000 |
| Recombinant avian sarcoma leukosis virus (ASLV)-derived retrovirus vectors having an expanded host range are described. The host range is expanded by the replacement of the ASLV envelope gene by an envelope gene from a virus capable of infecting both mammalian and avian cells. The result |
| 6094780 |
Ergonomic handle for terminal insertion tool |
August 1, 2000 |
| An ergonomic tool handle (21) which is useful for a terminal insertion hand tool, gardening hand tools, knives, box cutters, screwdrivers and other pushing or pulling type hand tools. The tool handle (21) of the present invention is contoured to promote neutral posture between the hand a |
| 6093702 |
Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread |
July 25, 2000 |
| A method and composition for inhibiting the spread of a retrovirus such as HIV in a human cell population in which a retrovirus such as HIV is present has been found. The spread of the retrovirus is inhibited by treatment of the cells with a synergistic combination mixture of a dideo |
| 6090795 |
Human derived monocyte attracting purified peptide products useful in a method of treating infec |
July 18, 2000 |
| Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. |
| 6089094 |
Acoustical method and system for measuring barrier membrane thickness and the correspondent area |
July 18, 2000 |
| The invention relates a method and a system for membrane thickness and the correspondent area distribution measurement based on the dependency of the acoustic intensity transmission coefficient upon the thickness of the insertion membrane and the proportion of the power of the transmitte |
| 6087117 |
Production and use of human nm23 protein and antibodies therefor |
July 11, 2000 |
| Human nm23 DNA and protein is disclosed as well as antibodies which recognize human nm23 protein. The DNA and antibodies may be used to detect nm23 in human tumors to predict the malignancy potential of such tumors. |
| 6087110 |
Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded the |
July 11, 2000 |
| The present invention discloses that the normal melanogenic gene, gp75 gene, encodes a gene product, a 24 amino acid peptide of ORF3, which is processed to an antigenic cancer peptide recognized by T lymphocytes. The cancer peptide of the invention derived from ORF3 is recognized by canc |
| 6084090 |
Human papilloma virus anti-sense oligonucleotides |
July 4, 2000 |
| Antisense oligonucleotides having phosphorothioate backbone structure and sequences complementary to nucleotides contained with residues 415 to 445 of human papilloma virus 16 (HPV-16) are disclosed. Methods of treatment using antisense oligonucleotides having phosphorothioate backbone |
| 6084069 |
Autotaxin: motility stimulating protein useful in cancer diagnosis and therapy |
July 4, 2000 |
| The present invention relates, in general, to autotaxin. In particular, the present invention relates to a DNA segment encoding autotaxin; recombinant DNA molecules containing the DNA segment; cells containing the recombinant DNA molecule; a method of producing autotaxin; antibodies to a |
| 6084063 |
Signal transduction inhibitors of allergic reactions |
July 4, 2000 |
| The present invention provides an isolated polypeptide consisting of amino acids 1-66 of the human tyrosine kinase, Lyn A, in a pharmaceutically acceptable carrier and an isolated polypeptide consisting of amino acids 1-45 of the human tyrosine kinase, Lyn B, in a pharmaceutically accept |
| 6083703 |
Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes |
July 4, 2000 |
| The infusion of TIL586 along with interleukin-2 (IL-2) into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by TIL586 was previously isolated and shown to encode gp75 or TRP-1. The present invention |
| 6083503 |
Interleukin-2 stimulated T lymphocyte cell death for the treatment of autoimmune diseases, aller |
July 4, 2000 |
| A method for the treatment or prevention of autoimmune diseases, allergic or atopic disorders, and graft rejection is provided, comprising inducing the death by apoptosis of a subpopulation of T lymphocytes that is capable of causing such diseases, while leaving substantially unaffected |
| 6083502 |
Mesothelium antigen and methods and kits for targeting it |
July 4, 2000 |
| This invention relates to the discovery of a differentiation antigen termed mesothelin which is associated with mesotheliomas and ovarian cancers. Mesothelin is about 69 kD in its full-length form. The invention includes uses for the amino acid and nucleic acid sequences for mesothelin, |
| 6080582 |
Cell tests for Alzheimer's disease |
June 27, 2000 |
| The present invention provides methods for the diagnosis of Alzheimer's disease using human cells. Specifically, one method detects differences between potassium channels in cells from Alzheimer's patient and normal donors, and differences in intracellular calcium concentrations between |
| 6077935 |
Acquired immune deficiency syndrome (AIDS) viral envelope protein and method of testing for AIDS |
June 20, 2000 |
| An envelope protein of the etiologic agent of acquired immune deficiency syndrome (AIDS) and a method for its preparation are disclosed. Proviral DNA is transferred into a host cell after engineering into an expression vector which produces the envelope protein. A method of testing human |
| 6077694 |
Method for over-expression and rapid purification of biosynthetic proteins |
June 20, 2000 |
| The subject invention relates to a method of producing and purifying large quantities of a biosynthetic protein.The gene which codes for the protease is placed between the binding domain of a gene which codes for a binding protein and a gene coding for the target protein of interest. The |
| 6074864 |
Cloned DNA for synthesizing unique glucocerebrosidase |
June 13, 2000 |
| Glucocerebrosidase produced by recombinant methods and having use for treatment of Gaucher's disease is disclosed. A cDNA for encoding the specific protein is taught along with the method of preparing the construct used to produce the protein. |
| 6074644 |
Nucleic acids encoding immunotoxins containing a disulfide-stabilized antibody fragment replacin |
June 13, 2000 |
| This invention provides for nucleic acids encoding immunotoxins comprising a Pseudomonas exotoxin (PE) that does not require proteolytic activation for cytotoxic activity attached to an Fv antibody fragment having a variable heavy chain region bound through at least one disulfide bond to |
| 6073039 |
Device and method for real-time monitoring of an electrocardiogram during magnetic resonance ima |
June 6, 2000 |
| An electrode assembly for monitoring bioelectric signals includes a first electrode member and a second electrode member disposed around the first electrode member. When the electrode assembly is placed on a body of a person, a bioelectric signal is monitored by measuring the electrical |
| 6072031 |
Cellular apoptosis susceptibility protein (CSP) |
June 6, 2000 |
| The cDNA and amino acid sequences for a cellular apoptosis susceptibility (CAS) protein are used to detect expression and amplification of the CAS gene in normal and cancer cells. An antisense CAS gene sequence introduced into living cells inhibits CAS protein activity and thus prevents |
| 6071949 |
Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents |
June 6, 2000 |
| The present method provides a method for treating an epithelial cell-derived cancer in a subject in need of such treatment which comprises administering to the subject an amount of a 5-lipoxygenase inhibitor or derivative thereof effective to treat the epithelial cell-derived cancer. |
| 6071709 |
Nerve growth factor/receptor complex |
June 6, 2000 |
| The present invention relates to a complex comprising nerve growth factor (NGF) and trk proto-oncogene protein and a complex comprising neurotrophic factors, NT-3 or BDNF, and trkB proto-oncogene protein. The present invention also relates to methods for detecting the presence of NGF, NT |
| 6068844 |
Increased resistance to stroke by developing immunologic tolerance to myelin or components there |
May 30, 2000 |
| The present invention relates to a method of inducing oral tolerance to ischemic injury which has the objective of minimizing the severity and size of injured regions in the brain that arise as a result of ischemia. The method responds rapidly to the onset of infarction, with treatment |
| 6066656 |
2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and |
May 23, 2000 |
| The present invention provides 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane (DAD) isosteres comprising benzamide, sulfonamide and anthranilamide subunits, a pharmaceutical composition comprising such compounds, a method of using such compounds to treat retroviral, specifically HI |
| 6066642 |
Dihydropyridine-, pyridine-, benzopyran-4-one- and triazoloquinazoline derivative, their prepara |
May 23, 2000 |
| The present invention provides certain novel compounds, compositions, and a method of treating a mammal by blocking its adenosine receptors comprising administering at least one compound of the present invention. Examples of the present inventive compounds include certain flavonoids of f |
| 6063905 |
Recombinant human IGA-J. chain dimer |
May 16, 2000 |
| Disclosed are compositions and methods of use that comprise engineered IgA antibodies that, when administered to a host are secreted across the epithelium into the mucosal barriers of the body providing external passive immunotherapy against agents such as viral, bacterial and eukary |
| 6060505 |
Method of treating cancer using C-26 modified bryostatin |
May 9, 2000 |
| Disclosed are modified bryostatins and their use as anticancer drugs. |
