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The United States of America as represented by the Department of Health Patents
Assignee:
The United States of America as represented by the Department of Health
Address:
Washington, DC
No. of patents:
1010
Patents:












Patent Number Title Of Patent Date Issued
RE36529 Spectroscopic imaging device employing imaging quality spectral filters January 25, 2000
Techniques for providing spectroscopic imaging integrates an acousto-optic tunable filter (AOTF), or an interferometer, and a focal plane array detector. In operation, wavelength selectivity is provided by the AOTF or the interferometer. A focal plane array detector is used as the imagin
D352788 Sawhorse bracket November 22, 1994
7375520 Method for spectrally selective B1 insensitive T2 preparation contrast enhancement for high fiel May 20, 2008
A T.sub.2 preparation sequence uses a segmented BIR-4 adiabatic pulse with two substantially equal delays and is insensitive to B.sub.1 field variations and can simultaneously suppress fat signals with low specific absorption rate (SAR). An adiabatic reverse half passage pulse is applied
6140339 Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof October 31, 2000
The present invention provides new monomeric derivatives of the C-8'-7 linked naphthylisoquinoline alkaloid dioncophylline D. The invention also provides new C-4 substituted monomeric arylisoquinoline alkaloid derivatives. The present invention furthermore provides novel dimeric aryl
6136992 2-alkoxy estradiols and derivatives thereof October 24, 2000
Compounds represented by the following structural formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification. The compounds are disclosed as useful in the treatment of various forms of cancer.
6136534 Methods for sensitive detection of reverse transcriptase October 24, 2000
The present invention provides a method for detecting the presence of a retrovirus in a biological sample comprising the steps of: a) contacting the biological sample with an RNA template and a complementary DNA primer under conditions whereby the RNA template and the DNA primer will ann
6132980 Antibodies specific for TRP-2 a human tumor antigen recognized by cytotoxic T lymphocytes October 17, 2000
The infusion of TIL586 along with interleukin-2 (IL-2) into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by TIL586 was previously isolated and shown to encode gp75 or TRP-1. The present invention
6132954 Methods of screening for agents that delay a cell cycle and compositions comprising era and an a October 17, 2000
The present invention provides for methods of screening for agents which delay the cell cycle and methods of delaying the cell cycle. Analogues of Era having arginine, histidine, or lysine at amino acid codon 17 are embodied by the present invention. Human and other homologs of bacterial
6132732 Parvovirus capsids October 17, 2000
The present invention relates to a method of producing non-infections parvovirus capsids and to diagnostic assays and vaccines utilizing same. The invention further relates to recombinant baculoviruses encoding parvovirus structural proteins and host cells infected therewith. The inv
6130042 Compositions and methods for diagnosing periodontal disease October 10, 2000
Compositions and methods are described for diagnosing periodontal disease, and in particular, early-onset periodontal disease. Nucleic acid-based testing is described which permits the detection of a high risk haplotype.
6126944 Baculovirus expression vectors and recombinant antigens for detecting type-specific antibodies t October 3, 2000
Novel baculovirus expression vectors and recombinant antigens for detecting, type-specific herpes simplex virus (HSV) infection have been made. Diagnostic kits and assays for detecting type-specific HSV infection have been described. High level production of foreign proteins in subst
6117991 Biologically active synthetic thyrotropin and cloned gene producing same September 12, 2000
Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH are described.
6114397 Gossypol for the treatment of cancer September 5, 2000
A method for treating cancer in a human, which comprises administering to the human subject an anti-cancer effective amount of a compound selected from gossypol, gossypol acetic acid, gossypolone, metabolites thereof, or physiologically acceptable salts thereof. Also included is a method
6113912 Hepatitis A virus vaccines September 5, 2000
A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of va
6110490 Liposomal delivery system for biologically active agents August 29, 2000
The present invention is directed to a liposomal preparation which is based on specific lipid components. The liposomal compounds are also combined with a biologically active agent, forming liposomal compounds. These compounds are useful in drug delivery, where specific therapeutic c
6110465 Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of August 29, 2000
The nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of 49 isolates of hepatitis C are disclosed. The invention relates to the use of these sequences to design proteins and nucleic acid sequences useful in diagnostic methods and vaccines.
6110453 Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorpor August 29, 2000
A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in wh
6107050 Diagnostic test for alzheimers disease August 22, 2000
The present invention provides methods for the diagnosis of Alzheimer's disease using human cells. Specifically, one method detects differences between potassium channels in cells from Alzheimer's patient and normal donors, and differences in intracellular calcium concentrations between
6103694 Method of decreasing radiation of radio-mimetic chemotherapy for hematopoietic pluripotent cell August 15, 2000
The present invention provides a method of engrafting donor mammalian hematopoietic pluripotent cells in a mammalian recipient using a decreased amount of radiation, comprising: (a) administering to the recipient at least one dosage of a hematopoietic growth factor; (b) subjecting the
6103235 Methods of inducing immune tolerance using immunotoxins August 15, 2000
Provided is a method of treating an immune system disorder not involving T cell proliferation, comprising administering to the animal an immunotoxin comprising a mutant diphtheria toxin moiety linked to an antibody moiety which routes by the anti-CD3 pathway, or derivatives thereof under
6100051 Method utilizing convex geometry for laser capture microdissection August 8, 2000
A process of microdissection where a tissue sample is conventionally visualized in a microscope. A selectively activatable convex surface is provided, preferably on the periphery at the distal end of a rod. This selectively activatable convex surface when locally activated, typically
6099847 Chimeric Gag pseudovirions August 8, 2000
The present invention provides, inter alia, recombinant chimeric nucleic acids encoding a Gag-fs-fusion partner fusion protein; a pseudovirion comprising a retroviral Gag protein and a fusion partner, wherein the fusion partner is present in a Gag-fs-fusion partner fusion protein; an
6099842 Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin August 8, 2000
Single chain immunotoxins directed at the human transferrin receptor using PCR based methods are described. Anti-TFR(Fv)-PE40 contains DNA for the antigen binding portion (Fv) of a monoclonal antibody directed at the human transferrin receptor fused to the DNA for a 40,000 molecular weig
6096534 Retrovirus vectors derived from avian sarcoma leukosis viruses permitting transfer of genes into August 1, 2000
Recombinant avian sarcoma leukosis virus (ASLV)-derived retrovirus vectors having an expanded host range are described. The host range is expanded by the replacement of the ASLV envelope gene by an envelope gene from a virus capable of infecting both mammalian and avian cells. The result
6094780 Ergonomic handle for terminal insertion tool August 1, 2000
An ergonomic tool handle (21) which is useful for a terminal insertion hand tool, gardening hand tools, knives, box cutters, screwdrivers and other pushing or pulling type hand tools. The tool handle (21) of the present invention is contoured to promote neutral posture between the hand a
6093702 Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread July 25, 2000
A method and composition for inhibiting the spread of a retrovirus such as HIV in a human cell population in which a retrovirus such as HIV is present has been found. The spread of the retrovirus is inhibited by treatment of the cells with a synergistic combination mixture of a dideo
6090795 Human derived monocyte attracting purified peptide products useful in a method of treating infec July 18, 2000
Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM.
6089094 Acoustical method and system for measuring barrier membrane thickness and the correspondent area July 18, 2000
The invention relates a method and a system for membrane thickness and the correspondent area distribution measurement based on the dependency of the acoustic intensity transmission coefficient upon the thickness of the insertion membrane and the proportion of the power of the transmitte
6087117 Production and use of human nm23 protein and antibodies therefor July 11, 2000
Human nm23 DNA and protein is disclosed as well as antibodies which recognize human nm23 protein. The DNA and antibodies may be used to detect nm23 in human tumors to predict the malignancy potential of such tumors.
6087110 Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded the July 11, 2000
The present invention discloses that the normal melanogenic gene, gp75 gene, encodes a gene product, a 24 amino acid peptide of ORF3, which is processed to an antigenic cancer peptide recognized by T lymphocytes. The cancer peptide of the invention derived from ORF3 is recognized by canc
6084090 Human papilloma virus anti-sense oligonucleotides July 4, 2000
Antisense oligonucleotides having phosphorothioate backbone structure and sequences complementary to nucleotides contained with residues 415 to 445 of human papilloma virus 16 (HPV-16) are disclosed. Methods of treatment using antisense oligonucleotides having phosphorothioate backbone
6084069 Autotaxin: motility stimulating protein useful in cancer diagnosis and therapy July 4, 2000
The present invention relates, in general, to autotaxin. In particular, the present invention relates to a DNA segment encoding autotaxin; recombinant DNA molecules containing the DNA segment; cells containing the recombinant DNA molecule; a method of producing autotaxin; antibodies to a
6084063 Signal transduction inhibitors of allergic reactions July 4, 2000
The present invention provides an isolated polypeptide consisting of amino acids 1-66 of the human tyrosine kinase, Lyn A, in a pharmaceutically acceptable carrier and an isolated polypeptide consisting of amino acids 1-45 of the human tyrosine kinase, Lyn B, in a pharmaceutically accept
6083703 Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes July 4, 2000
The infusion of TIL586 along with interleukin-2 (IL-2) into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by TIL586 was previously isolated and shown to encode gp75 or TRP-1. The present invention
6083503 Interleukin-2 stimulated T lymphocyte cell death for the treatment of autoimmune diseases, aller July 4, 2000
A method for the treatment or prevention of autoimmune diseases, allergic or atopic disorders, and graft rejection is provided, comprising inducing the death by apoptosis of a subpopulation of T lymphocytes that is capable of causing such diseases, while leaving substantially unaffected
6083502 Mesothelium antigen and methods and kits for targeting it July 4, 2000
This invention relates to the discovery of a differentiation antigen termed mesothelin which is associated with mesotheliomas and ovarian cancers. Mesothelin is about 69 kD in its full-length form. The invention includes uses for the amino acid and nucleic acid sequences for mesothelin,
6080582 Cell tests for Alzheimer's disease June 27, 2000
The present invention provides methods for the diagnosis of Alzheimer's disease using human cells. Specifically, one method detects differences between potassium channels in cells from Alzheimer's patient and normal donors, and differences in intracellular calcium concentrations between
6077935 Acquired immune deficiency syndrome (AIDS) viral envelope protein and method of testing for AIDS June 20, 2000
An envelope protein of the etiologic agent of acquired immune deficiency syndrome (AIDS) and a method for its preparation are disclosed. Proviral DNA is transferred into a host cell after engineering into an expression vector which produces the envelope protein. A method of testing human
6077694 Method for over-expression and rapid purification of biosynthetic proteins June 20, 2000
The subject invention relates to a method of producing and purifying large quantities of a biosynthetic protein.The gene which codes for the protease is placed between the binding domain of a gene which codes for a binding protein and a gene coding for the target protein of interest. The
6074864 Cloned DNA for synthesizing unique glucocerebrosidase June 13, 2000
Glucocerebrosidase produced by recombinant methods and having use for treatment of Gaucher's disease is disclosed. A cDNA for encoding the specific protein is taught along with the method of preparing the construct used to produce the protein.
6074644 Nucleic acids encoding immunotoxins containing a disulfide-stabilized antibody fragment replacin June 13, 2000
This invention provides for nucleic acids encoding immunotoxins comprising a Pseudomonas exotoxin (PE) that does not require proteolytic activation for cytotoxic activity attached to an Fv antibody fragment having a variable heavy chain region bound through at least one disulfide bond to
6073039 Device and method for real-time monitoring of an electrocardiogram during magnetic resonance ima June 6, 2000
An electrode assembly for monitoring bioelectric signals includes a first electrode member and a second electrode member disposed around the first electrode member. When the electrode assembly is placed on a body of a person, a bioelectric signal is monitored by measuring the electrical
6072031 Cellular apoptosis susceptibility protein (CSP) June 6, 2000
The cDNA and amino acid sequences for a cellular apoptosis susceptibility (CAS) protein are used to detect expression and amplification of the CAS gene in normal and cancer cells. An antisense CAS gene sequence introduced into living cells inhibits CAS protein activity and thus prevents
6071949 Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents June 6, 2000
The present method provides a method for treating an epithelial cell-derived cancer in a subject in need of such treatment which comprises administering to the subject an amount of a 5-lipoxygenase inhibitor or derivative thereof effective to treat the epithelial cell-derived cancer.
6071709 Nerve growth factor/receptor complex June 6, 2000
The present invention relates to a complex comprising nerve growth factor (NGF) and trk proto-oncogene protein and a complex comprising neurotrophic factors, NT-3 or BDNF, and trkB proto-oncogene protein. The present invention also relates to methods for detecting the presence of NGF, NT
6068844 Increased resistance to stroke by developing immunologic tolerance to myelin or components there May 30, 2000
The present invention relates to a method of inducing oral tolerance to ischemic injury which has the objective of minimizing the severity and size of injured regions in the brain that arise as a result of ischemia. The method responds rapidly to the onset of infarction, with treatment
6066656 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and May 23, 2000
The present invention provides 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane (DAD) isosteres comprising benzamide, sulfonamide and anthranilamide subunits, a pharmaceutical composition comprising such compounds, a method of using such compounds to treat retroviral, specifically HI
6066642 Dihydropyridine-, pyridine-, benzopyran-4-one- and triazoloquinazoline derivative, their prepara May 23, 2000
The present invention provides certain novel compounds, compositions, and a method of treating a mammal by blocking its adenosine receptors comprising administering at least one compound of the present invention. Examples of the present inventive compounds include certain flavonoids of f
6063905 Recombinant human IGA-J. chain dimer May 16, 2000
Disclosed are compositions and methods of use that comprise engineered IgA antibodies that, when administered to a host are secreted across the epithelium into the mucosal barriers of the body providing external passive immunotherapy against agents such as viral, bacterial and eukary
6060505 Method of treating cancer using C-26 modified bryostatin May 9, 2000
Disclosed are modified bryostatins and their use as anticancer drugs.

 
 
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