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The UAB Research Foundation Patents
Assignee:
The UAB Research Foundation
Address:
Birmingham, AL
No. of patents:
150
Patents:


1 2 3










Patent Number Title Of Patent Date Issued
8284805 Electrically pumped broadly tunable mid-infrared lasers based on quantum confined transition met October 9, 2012
Electrically pumped mid-IR semiconductor lasers that are operable at room temperature and possess a range of tunability up to 1100 nm, which constitutes a revolutionary (1-2 orders of magnitude) improvement in the range of tunability over existing semiconductor laser technology utili
8252546 Diagnosing pneumococcal pneumonia August 28, 2012
Compositions and methods for eliciting an immune response against Streptococcus pneumoniae are described. More particularly, the present disclosure relates to immunogenic PcpA polypeptides, including fragments of PcpA and variants thereof, and nucleic acids that encode the polypeptid
8233508 Mid-IR laser instrument for analyzing a gaseous sample and method for using the same July 31, 2012
An optical nose for detecting the presence of molecular contaminants in gaseous samples utilizes a tunable seed laser output in conjunction with a pulsed reference laser output to generate a mid-range IR laser output in the 2 to 20 micrometer range for use as a discriminating light sourc
8212018 Variable lymphocyte receptors, related polypeptides and nucleic acids, and uses thereof July 3, 2012
Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs).
8153443 Characterization of the CBir1 antigenic response for diagnosis and treatment of Crohn's disease April 10, 2012
This invention provides methods of diagnosing or predicting susceptibility to Crohn's Disease by determining the presence or absence of genetic variants. In one embodiment, the present invention provides methods to diagnose and/or predict susceptibility to Crohn's Disease in an indiv
8147698 Process for metabolic control and high solute clearance and solutions for use therein April 3, 2012
The present disclosure describes novel standardized citrate replacement fluid solutions and a standardized dialysate solution for use with CRRT methods. The standardized citrate replacement fluid solutions and standardized dialysate solutions do not require modification based on the
8129124 Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists March 6, 2012
Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing a
8119355 Biomarkers for cancer sensitivity and uses thereof February 21, 2012
Disclosed herein are biomarkers and uses thereof for evaluating anti-cancer efficacy and sensitivity.
8080421 Method for determining crystallization parameters and apparatus for use with the same December 20, 2011
The present disclosure provides a method to allow a user to pre-screen numerous crystallization conditions in the crystallization space to identify those conditions with the highest probability of yielding crystals and high quality diffracting crystals. In one embodiment, the dilute
8067001 Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and us November 29, 2011
An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vect
8048851 Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response November 1, 2011
This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, the peptides resemble a
8039588 Variable lymphocyte receptors October 18, 2011
Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs).
8008074 Compositions and methods for improving bone mass through modulation of receptors of PTH and frag August 30, 2011
The present invention relates to the discovery of novel receptors for the signaling of PTH and/or fragments of PTH, and the role of cPTH in bone development. The novel PTH receptors identified are selected from the group consisting of LRP5/6, TGF.beta.RII, BMPRII (long form and short
7994132 Peptides for treatment of scleroderma August 9, 2011
Peptides are provided that ameliorate one or more symptoms of scleroderma. In various embodiments, the peptides range in length from about 10 to about 30 amino acids, comprise a class A amphipathic helix, and bear at least one protecting group. The peptides are highly stable and read
7986992 Apparatus and method for treating atrial fibrillation and atrial tachycardia July 26, 2011
An apparatus for treating atrial fibrillation or atrial tachycardia comprises means for dynamically steering or selecting two or more current vector paths sequentially or simultaneously for defibrillation to change the transmembrane potential in the left and right atria sufficiently to
7981421 Combinations of antibodies selective for DR5 and other therapeutic agents July 19, 2011
An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therap
7934334 Aiming systems May 3, 2011
Provided herein are systems for aiming devices. For example, the aiming systems can be used to aim a firearm. The aiming systems can comprise a front sight portion having a cross-section with a truncated triangle shape when viewed by an operator aiming the device. The aiming systems
7920918 Apparatus and method for treating ventricular fibrillation and ventricular tachycardia April 5, 2011
An apparatus for treating ventricular fibrillation or ventricular tachycardia comprises means for dynamically steering or selecting two or more current vector paths sequentially or simultaneously for defibrillation so as to change the transmembrane potential in the left and right ven
7919262 14-3-3 proteins for diagnosis of Parkinson's disease April 5, 2011
The present disclosure is directed to methods for treatment and prevention of disease states characterized by a decreased 14-3-3 polypeptide expression or activity. In one embodiment, the present disclosure provides methods for the treatment and/or prevention of Parkinson's disease,
7884132 Process for metabolic control and high solute clearance and solutions for use therein February 8, 2011
The present disclosure describes novel standardized citrate replacement fluid solutions and a standardized dialysate solution for use with CRRT methods. The standardized citrate replacement fluid solutions and standardized dialysate solutions do not require modification based on the
7850974 Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and p December 14, 2010
A bioinformatic method for identifying and isolating proteins and peptides with MSCRAMM.RTM.-like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, and proteins and peptides obtained thereby are provided which can be u
7807640 Orally administered peptides synergize statin activity October 5, 2010
This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are class A amphipathic helical peptides. They are highly stable and readily administered via an oral route. The peptides are effective to stimulate the formation and cycling
7798646 Method and apparatus for the detection of impaired dark adaptation September 21, 2010
The present method describes a new method for the measurement of dark adaptation. The dark adaptation status of subjects may ten be used to identify those subjects who are at risk of developing and/or who are currently suffering from a variety of disease states having their clinical
7790165 Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and us September 7, 2010
An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors
7776916 Nitrated lipids and methods of making and using thereof August 17, 2010
Described herein are nitrated lipids and methods of making and using the nitrated lipids.
7727550 Biologically active native biomatrix composition June 1, 2010
The present disclosure relates to a biologically active biomatrix composition. In one embodiment, the biomatrix composition is derived from human amnions. The biomatrix is termed HuBiogel.TM.. The composition of HuBiogel.TM. closely mimics naturally occurring basement membrane compos
7723303 Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response May 25, 2010
This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, the peptides resemble a
7713525 Biomarkers for cancer sensitivity and uses thereof May 11, 2010
Disclosed herein are biomarkers and uses thereof for evaluating anti-cancer efficacy and sensitivity.
7704502 Combinations of antibodies selective for DR5 and other therapeutic agents April 27, 2010
An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therap
7655236 Lanthionine antibiotic compositions and methods February 2, 2010
According to the present invention, an isolated and purified DNA sequence which encodes a lantibiotic, mutacin I, is disclosed. The nucleic acid sequence is set forth in SEQ ID No: 1 and the amino acid sequence is set forth in SEQ ID No: 2.
7625885 Cytotoxin compound and method of isolation December 1, 2009
A compound or groups of compounds, present in an active principle, derived from tunicates of the species Synoicum adareanum, as well as to pharmaceutical compositions comprising these compounds. Extracts from tunicates show selective toxicity against several different cancer cell lin
7615616 Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and p November 10, 2009
A bioinformatic method is provided for identifying and isolating proteins with MSCRAMM.RTM.--like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, which can then be utilized in methods to prevent and treat infections
7606274 Mid-IR instrument for analyzing a gaseous sample and method for using the same October 20, 2009
An optical nose for detecting the presence of molecular contaminants in gaseous samples utilizes a tunable seed laser output in conjunction with a pulsed reference laser output to generate a mid-range IR laser output in the 2 to 20 micrometer range for use as a discriminating light sourc
7588770 Recombinant viruses of the paramyxoviridae family with heterologous envelope glycoproteins September 15, 2009
The invention provides recombinant viruses comprising heterologous envelope proteins capable of mediating entry of the recombinant viruses into host cells. In one embodiment, a recombinant virus of the invention is a member of the Paramyx-ovirzdae family (e.g., a respiratory syncytial
7548571 Mid-IR microchip laser: ZnS:Cr.sup.2+ laser with saturable absorber material June 16, 2009
A method of fabrication of laser gain material and utilization of such media includes the steps of introducing a transitional metal, preferably Cr.sup.2+ thin film of controllable thickness on the ZnS crystal facets after crystal growth by means of pulse laser deposition or plasma sp
7534603 Fusion protein delivery system and uses thereof May 19, 2009
The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter, comprising: DNA encoding a viral Vpr protein fused to DNA e
7531514 Orally administered peptides synergize statin activity May 12, 2009
This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. In certain embodiments, the peptides comprise an 18 amino acid class A amphipathic helix with protecting groups on the amino and the carboxyl terminus. The peptides are highly stable, read
7524510 Alkyl-glycoside enhanced vaccination April 28, 2009
Described herein are methods for the noninvasive immunization of a subject that involve alkyl glycosides. Also described herein are compositions, kits, and devices for the noninvasive immunization of a subject.
7504225 Reagents and methods for use in cancer diagnosis, classification and therapy March 17, 2009
Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predic
7494222 Method and apparatus for the detection of impaired dark adaptation February 24, 2009
The present method describes a new method for the measurement of dark adaptation. The dark adaptation status of subjects may then be used to identify those subjects who are at risk of developing and/or who are currently suffering from a variety of disease states having their clinical
7488598 Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof February 10, 2009
A host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside cleavage enzymes is provided. The transformed or transfected host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infec
7476383 Antibody selective for DR4 and uses thereof January 13, 2009
An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of DR5 and DR4 antibodies have been
7473527 Compounds promoting delivery of genes January 6, 2009
A process is provided for activating gene transfer in a cell by administering a gene transfer activating compound to the cell in conjunction with a gene transfer vector. A kit for activating gene transfer as well as process for identifying a compound that activates gene transfer are
7452420 Apparatus and method for diamond production November 18, 2008
An apparatus for producing diamond in a deposition chamber including a heat-sinking holder for holding a diamond and for making thermal contact with a side surface of the diamond adjacent to an edge of a growth surface of the diamond, a noncontact temperature measurement device posit
7439351 2' or 3' -deoxy and 2', 3'-dideoxy-.beta.-L-pentofuranonucleo-side compounds, method of preparat October 21, 2008
Method for the sterospecific preparation of 2' or 3' deoxy and 2',3'-dideoxy-.beta.-L-pentafuranonucleoside compounds. 2' or 3' deoxy and 2',3'-dideoxy-.beta.-L-pentofuranonucleoside compounds are also described. Finally, the invention concerns the use of these compounds, and particu
7364868 Kruppel-like transcriptional factor KLF4/GKLF and uses thereof April 29, 2008
The present invention proivdes methods of identifying new carcinoma oncogenes or analyzing functions of known carcinoma oncogenes by transformation of RK3E cells. Also provided are methods of using nuclear localization of Kruppel-like factor 4 (KLF4, or termed Gut-Enriched Kruppel-Li
7317087 Members of the FC receptor homolog gene family (FCRH1-3, 6), related reagents, and uses thereof January 8, 2008
The invention relates to members of the Fc receptor homolog (FcRH) subfamily, as well as fragments and variants thereof. Each FcRH is a Type I transmembrane receptor, preferably, comprises an extracellular region, a transmembrane region, and a cytoplasmic region. The cytoplasmic region
7311892 Multidrug multiligand conjugates for targeted drug delivery December 25, 2007
Described is a multi drug multiligand conjugate for targeted drug delivery. The MDML conjugate contains a plurality of tripartite molecules linked to a central scaffold moiety, with each tripartite molecule comprising a targeting molecule, a therapeutic agent and a scaffold binding e
7297542 Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob November 20, 2007
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention generates an adenovirus with modified fiber gene such that novel tropism is achieved. This recombin
7279160 Combinations of DR5 antibodies and other therapeutic agents October 9, 2007
An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therap
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