| Patent Number |
Title Of Patent |
Date Issued |
| RE39057 |
Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of |
April 4, 2006 |
| The invention relates to an anti-immunodeficiency virus antibody which binds to a cellular protein and diagnostic and therapuetic methods of using the same. |
| PP8901 |
Enkianthus perulatus cv. `J. L. Pennock` |
September 20, 1994 |
| A new and distinct variety of Enkianthus perulatus plant named `J. L. Pennock,` which is particularly characterized by its distinctive, bright red fall coloration, and which can be readily distinguished from other Enkianthus plants by its onset of fall color development about two weeks |
| PP16890 |
Hybrid tea rose plant named `Meitravia` |
July 25, 2006 |
| A new and distinct Hybrid Tea rose plant is provided which forms attractive blossoms that are hot pink in coloration. The new variety is a spontaneous mutation of unknown causation of the `Meilavio` variety (U.S. Plant Pat. No. 10,845) that forms vivid red blossoms. The blossoms are |
| 7625751 |
WNV core protein/capsid interacting protein and uses of the same |
December 1, 2009 |
| Substantially pure WIP-1 and its use in assays to identify PAP-1/WIP-1 interaction inhibitors or WIP-I/WNV Cp interaction inhibitors are disclosed. Compositions comprising antisense sequences to prevent expression of WIP-1 and methods of treating cancer using the same are disclosed. |
| 7625558 |
Compositions and methods of treating tumors |
December 1, 2009 |
| Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise adminstering to the individual a nucleic acid molecule that encodes a protein that dimerizes |
| 7621948 |
Percutaneous heart valve |
November 24, 2009 |
| A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body member having a plurality of legs, each leg connecting at one end to the annular ring, c |
| 7608416 |
Targeting mPGES-1 as a treatment for inflammation which avoids cardiovascular risk |
October 27, 2009 |
| The present invention relates to methods for the treatment of inflammation and pain without increasing cardiovascular risk by administration of an inhibitor of mPGES-1. The invention further is related to identifying inhibitors of mPGES-1 that do not increase cardiovascular risk when |
| 7608038 |
Luminal coupling system |
October 27, 2009 |
| A luminal coupling tube system for providing access to a lumen of a subject is disclosed. The system includes an internal magnet assembly, a snare assembly, an external magnet, a pull wire system and a feeding tube assembly. The internal magnet assembly includes an internal magnet having |
| 7598041 |
HIV-1 VPR interactions with mitochondrial apoptosis inducing factor and methods of using the sam |
October 6, 2009 |
| Assays to identify Vpr/AIF interaction and translocation inhibitors are disclosed. |
| 7592012 |
Chimeric proteins for cell targeting and apoptosis induction and methods of using the same |
September 22, 2009 |
| Fusion proteins which comprise an apoptosis inducing protein portion and a cell targeting portion are disclosed. Fusion proteins which comprise a protease portion and a cell targeting portion are disclosed. Compositions for and methods of targeting and inducing the death of cells are |
| 7590517 |
Methods, systems, and computer program products for computational analysis and design of amphiph |
September 15, 2009 |
| Methods, systems, and computer program products for computational polymer processing including, without limitation, computational amphiphilic polymer design, conformational energy minimization, generation and refinement of torsional parameters for sub-units of potential polymers, gen |
| 7588930 |
Compositions and methods for enhancing the immunogenicity of antigens |
September 15, 2009 |
| The present invention includes compositions, methods and kits for enhancing the immunogenicity of an antigen via fusion to a Listerial protein. The present invention further encompasses Listeria vaccine strains for enhancing the immunogenicity of an antigen. |
| 7586166 |
Electronic and optoelectronic devices having nanoparticles configured by patterned ferroelectric |
September 8, 2009 |
| Disclosed are electronic, plasmonic and opto-electronic components that are prepared using patterned photodeposited nanoparticles on a substrate surface. Also disclosed are ferroelectric nanolithography methods for preparing components, circuits and devices. |
| 7582857 |
Sensor and polarimetric filters for real-time extraction of polarimetric information at the foca |
September 1, 2009 |
| A polarimetric imaging system employs a pixel pitch matched filter for use within, for example, a 2 by 2 pixel neighborhood, in which one pixel samples the scene via a 0 degree polarization filter and a second pixel samples the scene via a 45 degree polarization filter. The remaining two |
| 7576060 |
Inhibition of adhesion and migration of an endothelial cell to fibronectin by neutrophil alpha-d |
August 18, 2009 |
| The present invention relates to the inhibition of angiogenesis by neutrophil alpha-defensins. Further, the present invention relates to methods involving the inhibition of endothelial cell adhesion to the extracellular matrix, endothelial cell apoptosis, and endothelial cell angioge |
| 7569543 |
Compositions of Angiopoietin, fragments, mutants and analogs thereof and uses of the same |
August 4, 2009 |
| The present invention relates to Ang-1, Ang-2, and Ang-3, and to methods and uses of the same. The present invention also relates to ECM-binding fragments, non-ECM-binding fragments, proteolytic resistant fragments and C-terminal fragments of Ang-1, and to methods and uses of the same. |
| 7569218 |
Compositions for and methods of using herpes simplex virus glycoprotein D to suppress immune res |
August 4, 2009 |
| Methods of delivering a desired polypeptide to an individual are disclosed. The methods comprise administering to the individual an immunogenic vector comprising a nucleic acid encoding the desired polypeptide operably linked to regulatory elements in combination with one or more of |
| 7566741 |
Methods of inhibiting osteoclast activity |
July 28, 2009 |
| Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the methods, an amount of a TRANCE/RANK inhibitor effective to inhibit osteoclastogenesis is admi |
| 7560116 |
Compositions, methods and kits relating to poxvirus subunit vaccines |
July 14, 2009 |
| The invention is directed to a poxvirus vaccine comprising a soluble truncated poxvirus envelope protein. The invention is also directed to a vaccine comprising a nucleic acid encoding such proteins. Also included is an antibody which specifically binds to the proteins and nucleic acid |
| 7557350 |
Timing calibration using radioactive source |
July 7, 2009 |
| A cylinder (10) of radiation detectors (12) in a diagnostic imaging apparatus detects radiation pairs with corresponding electronic detector channels (22) which have non-uniform time-varying temporal delays. A plurality of calibration radiation sources (20) that concurrently emit rad |
| 7553955 |
Molecular beacons, methods and kits for detecting DNA damage response |
June 30, 2009 |
| This invention relates to embodiment to a molecular beacon, methods and kits for the detection of expression of p21(Waf1/Cip1), in response to chemotherapy. Specifically, the introduction of a phosphorothioate-modified p21-beacon by transfection in human tumor cells yields increased |
| 7524927 |
Compositions, method and kits relating to deletion mutations of immunodeficiency virus gp120 hyp |
April 28, 2009 |
| The present invention relates to replication competent variants of mammalian immunodeficiency virus comprising mutations and/or deletions of the V3 hypervariable loop and compensatory mutations, as well as methods for producing such variants. The invention also relates to V3-loop del |
| 7524628 |
Method for detecting molecules expressing a selected epitope via fluorescent dyes |
April 28, 2009 |
| Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR, CDR mimetic or engineered CDR structure attached to |
| 7522765 |
System and method for localizing imaging devices |
April 21, 2009 |
| A system and method for localizing imaging devices in a network using images taken by the imaging devices. The relative position and orientation of a network of camera-equipped communications devices are obtained by having each device examine images taken by its camera. The devices a |
| 7521431 |
Compositions and methods for siRNA inhibition of HIF-1 alpha |
April 21, 2009 |
| RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HI |
| 7491508 |
Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
February 17, 2009 |
| A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing the left and right termini of the adenovirus with the corresponding termini from an adeno |
| 7489391 |
Polarization and reflection based non-contact latent fingerprint imaging and lifting |
February 10, 2009 |
| An optical fingerprinting method extracts high quality latent fingerprints from a surface without any invasive chemical or physical contact with the examined object, and requires no cooperation of the subject. Rather than employing extraneous material, the optical properties of the laten |
| 7488817 |
Metal complex protein kinase inhibitors |
February 10, 2009 |
| This inventive subject matter relates to novel metal complex protein kinases inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by kinase activity. |
| 7488487 |
Methods of inducing immune responses through the administration of auxtrophic attenuated dal/dat |
February 10, 2009 |
| The present invention includes a method of eliciting a T-cell immune response to an antigen in mammal. The method of eliciting a T-cell immune response includes administering mammal an auxotrophic attenuated strain of listeria which expresses the antigen. The auxotrophic attenuated s |
| 7488484 |
Nucleic acid expression cassette encoding an HIV polyprotein comprising the ancillary gene produ |
February 10, 2009 |
| Improved vaccines and methods of using the same are disclosed. Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are disclosed. |
| 7485631 |
Phorboxazole compounds and methods of their preparation |
February 3, 2009 |
| Novel macrolactone compounds, their methods of preparation, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the macrolactone compounds may be useful, inter alia, for treating various cancers, indu |
| 7477770 |
Virtual bone biopsy |
January 13, 2009 |
| The present indention comprises a system and method for analyzing trabecular bone structure. A means for scanning the trabecular bone using a magnetic resonance image (MRI) scanner generates bone image data, which is then processed including correcting, deshadi4 and reducing noise in |
| 7468264 |
Method and device for treating osteoarthritis, cartilage disease, defects and injuries in the hu |
December 23, 2008 |
| A method of determining the voltage and current output required for the application of specific and selective electric and electromagnetic signals to diseased articular cartilage in the treatment of osteoarthritis, cartilage defects due to trauma or sports injury, or used as an adjun |
| 7465566 |
Regulation of genes via application of specific and selective electrical and electromagnetic sig |
December 16, 2008 |
| Methods and devices for the regulation of gene expression by cells via the application of fields generated by specific and selective electric and electromagnetic signals so as to target diseased or injured tissue for treatment. By gene expression is meant the up regulation or down re |
| 7465546 |
Regulation of transforming growth factor-beta (TGF-.beta.) gene expression in living cells via t |
December 16, 2008 |
| Methods and devices are described for the regulation of Transforming Growth actor (TGF)-.beta.1, .beta.2, and/or .beta.3 protein gene expression in bone cells and other tissues via the capacitive coupling or inductive coupling of specific and selective electric fields to the bone cel |
| 7459309 |
Isolated polypeptide deletion mutants of survival of motor neuron-interacting protein 1 |
December 2, 2008 |
| The invention relates to an isolated nucleic acid encoding a eukaryotic Survival of Motor Neuron-Interacting Protein 1 (SIP1), compositions comprising SIP1 and SIP1 and the spinal muscular atrophy (SMA) disease gene product Survival of Motor Neuron protein (SMN), and diagnostic and t |
| 7459197 |
Reversibly adaptive rough micro- and nano-structures |
December 2, 2008 |
| Reversibly adaptive rough structures, comprising: a substrate; a plurality of raised elements on the substrate, the raised elements mutually spaced apart by channel regions on the substrate, each of the raised elements having a lateral surface and a distal end; the lateral surface, the |
| 7455841 |
Genetic constructs and compositions comprising RRE and CTE and uses thereof |
November 25, 2008 |
| Genetic constructs that comprise a coding sequence for HIV-1 Rev, and a coding sequence for a desired protein are disclosed. Compositions that comprise at least two nucleic acid molecules in which at least one nucleic acid molecule comprises a coding sequence for HIV-1 Rev, and at le |
| 7447595 |
Heterologous protein production using the twin arginine translocation pathway |
November 4, 2008 |
| Provided are means for evaluating and identifying putative substrates of the twin arginine translocation (Tat) secretory pathway in Streptomyces and other bacterial species. Also provided, therefore, are simple ways to express, secrete and purify correctly folded heterologous proteins on |
| 7446189 |
Nucleic acids encoding mutant human CD80 and compositions comprising the same |
November 4, 2008 |
| Improved vaccines and methods of using the same are disclosed Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are disclosed. |
| 7445845 |
Synthesis, spectroscopy, photophysics of multi-chromophoric ZN(II) group 8 metal complexes |
November 4, 2008 |
| Novel multichromophoric complexes comprising the formula R.sub.1--R.sub.A-[MC]-([R.sub.M].sub.z-[MC]).sub.m-RA--R.sub.2 are provided. Polymeric compositions and devices comprising the same are also discussed. The complexes are characterized by a central bridging moiety comprising one |
| 7442386 |
Synthesis and use of reagents for improved DNA lipofection and/or slow release prodrug and drug |
October 28, 2008 |
| The invention relates to compositions and methods for a one-step synthetic technique for making cationic steroid or cationic drug molecules for use as delivery vehicles. The invention further relates to methods for using cationic steroid molecules in lipofection or transfection, delivery |
| 7439031 |
Method of identifying compounds that induce cell death by necrosis |
October 21, 2008 |
| The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in |
| 7436175 |
Practical pulse synthesis via the discrete inverse scattering transform |
October 14, 2008 |
| The discrete inverse scattering (DIST) approach is used to design selective RF pulses. As in SLR, a hard pulse approximation is used to actually design the pulse. Unlike SLR, the pulse is designed using the full inverse scattering data (the reflection coefficient and the bound states |
| 7432295 |
Preparation of compounds useful for the detection of hypoxia |
October 7, 2008 |
| Novel .sup.18F-fluorine compounds useful for non-invasive imaging techniques such as PET, for detecting tissue hypoxia and methods for preparing them are disclosed. Novel intermediate compounds and methods for preparing them are also disclosed. Diagnostic kits useful in practicing th |
| 7429471 |
Regulation of matrix metalloproteinase gene expression using specific and selective electrical a |
September 30, 2008 |
| Methods and devices for the regulation of matrix metalloproteinase gene expression in cartilage cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression |
| 7429267 |
Device and method using integrated neuronal cells and an electronic device |
September 30, 2008 |
| The present invention provides a device of integrated neuronal cells interfaced with an electronic device and a method of producing the same. |
| 7427594 |
Methods and pharmaceuticals compositions for treating coronary artery disease, ischemia,and vasc |
September 23, 2008 |
| Pharmaceutical compositions that comprise a pharmaceutically acceptable carrier and either a therapeutically effective amount of an ECM-binding fragment of Ang-1 protein that comprises SEQ ID NO:1 and/or SEQ ID NO:2 or a homologous peptide thereof and pharmaceutical compositions that |
| 7425534 |
Compositions and methods for modulating muscle cell and tissue contractility |
September 16, 2008 |
| The present invention relates to compositions and methods comprising one or more domains of urokinase-type plasminogen activator (uPA) in an amount effective to modulate one or more of the contractility and angiogenic activity of a mammalian muscle or endothelial cell or tissue for u |
| 7425318 |
Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
September 16, 2008 |
| This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid pro |
