| Patent Number |
Title Of Patent |
Date Issued |
| T958011 |
Objective focusing method and apparatus for fundus photography |
May 3, 1977 |
| apparatus and method for objectively focusing an instrument used for photographing the fundus of the eye such that consistent high resolution fundus photographs can be attained.A narrow sharp oscillating needle 11 is focused onto the ocular fundus 22. The image 23 of the oscillating need |
| 7435562 |
Modular vector systems |
October 14, 2008 |
| The present invention provides improved techniques and reagents for producing nucleic acid molecules. In certain preferred embodiments, the nucleic acid molecules are modular vectors. In certain preferred embodiments, the nucleic acid molecules are produced in polymerase chain reacti |
| 7393384 |
Hydrogen separation using oxygen ion-electron mixed conduction membranes |
July 1, 2008 |
| A process for purification of hydrogen from a stream of synthesis gas or other reformate gases is described. The process, generally conducted at temperatures of approximately 800-1000.degree. C., involves the use of a cell in which a mixture of reformate gas and steam are flowed on one s |
| 7339045 |
Bioreactive agents |
March 4, 2008 |
| This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bou |
| 7336187 |
Patient activity monitor |
February 26, 2008 |
| A patient activity monitoring system that allows caregivers of multiple patients to work more efficiently and with reduced cost, while increasing the quality and level of patient care. The system includes a plurality of remote monitoring subsystems, a plurality of user notification units |
| 7319003 |
Arrays of probes for positional sequencing by hybridization |
January 15, 2008 |
| This invention is directed to methods and reagents useful for sequencing nucleic acid targets utilizing sequencing by hybridization technology comprising probes, arrays of probes and methods whereby sequence information is obtained rapidly and efficiently in discrete packages. That i |
| 7312038 |
Photocleavable bioreactive agents |
December 25, 2007 |
| This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bou |
| 7309606 |
Methods and compositions for treating hypercholesterolemia |
December 18, 2007 |
| The present invention provides methods and compositions for treating hypercholesterolemia using therapeutic apoE proteins. A therapeutic apoE protein is a naturally-occurring apoE protein (e.g., apoE1, apoE2, apoE2*, apoE2**, apoE3, and apoE4) that has one or more amino acid substitu |
| 7251609 |
Method for conducting clinical trials over the internet |
July 31, 2007 |
| The invention encompasses a method of conducting a clinical trial of a test substance from a primary site, via the internet. The internet is used in various phases of a clinical trial, including: recruiting and screening for candidates who are eligible to participate in a clinical tr |
| 7235819 |
Semiconductor device having group III nitride buffer layer and growth layers |
June 26, 2007 |
| An epitaxial growth system comprises a housing around an epitaxial growth chamber. A substrate support is located within the growth chamber. A gallium source introduces gallium into the growth chamber and directs the gallium towards the substrate. An activated nitrogen source introduces |
| 7230415 |
Quantum junction device as switch and detector |
June 12, 2007 |
| A quantum junction device having three or more wires connected to a loop surrounding a magnetic flux is used to act as a switch responsive to magnetic flux and therefore useable for mass storage devices or as a flux detector by sensing current direction, conductance tensor, in response t |
| 7211394 |
Detection of markers in nascent proteins |
May 1, 2007 |
| The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino ac |
| 7208120 |
Cellular diagnostic arrays, methods of using and processing for producing same |
April 24, 2007 |
| A cellular diagnostic array has been developed that provides accurate and reproducible measurements of the physical parameters of individual cells en masse, including cell membrane surface area, cell volume, and excess membrane. Three differing patterns are employed. In the first design, |
| 7202949 |
Binocular spectrometer |
April 10, 2007 |
| A direct-view handheld binocular spectrometer for use in a variety of educational settings. The device comprises a holographic transmission diffraction grating and a uniquely curved quantitative wavelength scale for viewing visible-wavelength spectra with both eyes simultaneously. A |
| 7195874 |
Detecting targets in heterologous mixtures |
March 27, 2007 |
| This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bou |
| 7169558 |
Detection of disease related genes |
January 30, 2007 |
| The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino ac |
| 7098718 |
Tunable current-mode integrator for low-frequency filters |
August 29, 2006 |
| A tunable current mode integrator for low-frequency continuous-time filters that requires a reduced amount of area when implemented in an integrated circuit (IC). The integrator includes input and output transistors, and cross-coupled current mirrors, integration capacitors, and oper |
| 7038041 |
Selective nuclear receptor-targeted systems for delivery of cytotoxins to cancer cells for targe |
May 2, 2006 |
| An estrogen/antiestrogen-porphyrin conjugate, their composition and methods for their use are claimed. The active compounds of the invention are conjugates consisting of an estrogen or anti estrogen portion, tether or linker portion and a porphyrin portion. The method of invention ex |
| 6991903 |
Solid phase sequencing of double-stranded nucleic acids |
January 31, 2006 |
| Methods for detecting and sequencing of target double-stranded nucleic acid molecules, nucleic acid probes and arrays of probes useful in these methods, and kits and systems that contain these probes are provided. The methods involve hybridizing the nucleic acids or nucleic acids which |
| 6953703 |
Method of making a semiconductor device with exposure of sapphire substrate to activated nitroge |
October 11, 2005 |
| An epitaxial growth system comprises a housing around an epitaxial growth chamber. A substrate support is located within the growth chamber. A gallium source introduces gallium into the growth chamber and directs the gallium towards the substrate. An activated nitrogen source introduces |
| 6949341 |
Diagnosing genetic disorders |
September 27, 2005 |
| This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bou |
| 6929721 |
Ion beam modification of residual stress gradients in thin film polycrystalline silicon membrane |
August 16, 2005 |
| Method and apparatus for reducing the curvature of a micromachined structure having lamella (12). Surface treatment by an ion beam (30) of the lamella (12) such as by sputtering removes regions of stress allowing the lamella (12) to return to a planar condition. The resulting outer s |
| 6919179 |
Detection of markers in nascent proteins |
July 19, 2005 |
| The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino ac |
| 6907881 |
Variable peak pressure ventilation method and system |
June 21, 2005 |
| A system and method for ventilating a lung in a living being by varying the peak inspiratory pressure. The peak inspiratory pressure may deviate about a mean that is chosen to correspond with a knee in a pressure-volume curve of the lung. |
| 6887853 |
Use of geldanamycin and related compounds for treatment of fibrogenic disorders |
May 3, 2005 |
| A method for prophylaxis or treatment of a mammal, particularly human, at risk for a fibrogenic disorder is disclosed. The compositions and methods of the invention are directed both to treatments for existing fibrogenic disorders and prevention thereof. Such disorders include, but are n |
| 6840117 |
Patient monitoring system employing array of force sensors on a bedsheet or similar substrate |
January 11, 2005 |
| A patient monitoring system includes a replaceable laminar sensor to be placed on a bed, the sensor including distributed force sensing elements providing output signals to processing apparatus including a near-bed processor and a central processor coupled to the near-bed processor by a |
| 6705345 |
Micro valve arrays for fluid flow control |
March 16, 2004 |
| An array of micro valves, and the process for its formation, used for control of a fluid flow and having a substrate with a plurality of apertures for directing the fluid to flow from one side to another. A micromechanically formed fluid seal surrounds each aperture along with a valv |
| 6687058 |
Numerical aperature increasing lens (nail) techniques for high-resolution sub-surface imaging |
February 3, 2004 |
| A viewing enhancement lens (18-NAIL) which functions to increase the numerical aperture or light gathering or focusing power of viewing optics such as a microscope (26) used to view structure within a substrate such as a semiconductor wafer or chip or of imaging optics such as media |
| 6677302 |
Compositions and methods for the treatment of viral disorders |
January 13, 2004 |
| This invention relates to compositions and methods for the treatment of virus infections and other viral-associated disorders. Compositions comprise an inducing agent and an anti-viral agent. The inducing agent induces the expression of a cellular or viral product, such as viral thym |
| 6673538 |
Methods and compositions for designing vaccines |
January 6, 2004 |
| Methods and compositions are described for determining a statistically significant number of different strains within a species of bacteria indicative of the species population structure as a whole in order to permit the evaluation of a vaccine target. |
| 6660229 |
Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed |
December 9, 2003 |
| Methods and kits that use nucleotide analogs to confer increased accuracy and improved resolution in the analysis and sequencing of oligonucleotide mixtures are provided. |
| 6657764 |
Very large angle integrated optical scanner made with an array of piezoelectric monomorphs |
December 2, 2003 |
| A micromachined mirror scanning system having plural benders of morphs and support arms between a mirror surface of silicon and a surrounding frame. Electrical energization of the morphs with a DC voltage under the control of a computer provides a large range of mirror orientations and p |
| 6630302 |
Methods and compositions for determining species of bacteria and fungi |
October 7, 2003 |
| Methods and compositions are described for methods and compositions for determining the species for an unknown bacterium (or fungus) in a sample. The approach, which utilizes Ribosomal operon sequences, permits one to identify important bacteria (or fungi) pathogens in a clinical setting |
| 6589736 |
Photocleavable agents and conjugates for the detection and isolation of biomolecules |
July 8, 2003 |
| This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bou |
| 6566070 |
Detection of disease related genes |
May 20, 2003 |
| The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino ac |
| 6546813 |
Patient monitoring system employing array of force sensors on a bedsheet or similar substrate |
April 15, 2003 |
| A patient monitoring system includes a replaceable laminar sensor to be placed on a bed, the sensor including distributed force sensing elements providing output signals to processing apparatus including a near-bed processor and a central processor coupled to the near-bed processor by a |
| 6529311 |
MEMS-based spatial-light modulator with integrated electronics |
March 4, 2003 |
| Method and apparatus for forming an array of reflective elements for spatial light modulation. The array includes a substrate supporting electronically addressable actuators, each associated with a corresponding reflective element, a coupling attaching each actuator to the correspond |
| 6402986 |
Compositions and methods for luminescence lifetime comparison |
June 11, 2002 |
| This patent disclosure describes novel compositions and methods used in the verification of products or documents based on the reading of emitted light from luminescent compositions that can be incorporated or applied to a wide variety of materials. Specifically, the compositions are uni |
| 6368813 |
Multiflavor streptavidin |
April 9, 2002 |
| Compounds and methods are described for producing streptavidin mutants with changed affinities. In particular, modifications to the sequence of the natural streptavidin gene is described to create amino acid substitutions resulting in greater affinity for biotin substitutes than for biot |
| 6360597 |
In-shoe remote telemetry gait analysis system |
March 26, 2002 |
| A gait analysis system includes a shoe insert for use in a shoe worn by a subject while walking as part of a process of collecting gait data. The insert has force-sensing sensors distributed to define a sensing aperture, and each sensor provides an electrical output signal. Processing ap |
| 6344320 |
Electrophoresis of nascent proteins |
February 5, 2002 |
| The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino ac |
| 6335163 |
Polyclonal antibody libraries |
January 1, 2002 |
| The invention is directed to methods for the creation and use of libraries of proteins which comprise polyclonal antibodies to a common antigen or group of antigens, receptor proteins with related variable regions, or other immune related proteins with variable regions. These polyclonal |
| 6304678 |
Image artifact reduction using maximum likelihood parameter estimation |
October 16, 2001 |
| A technique for post-processing decoded compressed images to reduce decoding-related artifacts employs a maximum likelihood estimation of an original image f. The decoded image is modeled as a montage of "flat surfaces" of different intensities, where the number of flat surfaces and |
| 6287844 |
Compositions and methods for controlling genetically engineered organisms |
September 11, 2001 |
| Compositions and methods for the control of genetically engineered organisms are described. A more effective cell suicide approach is contemplated based on the conditional expression of the lethal Streptomyces avidinii streptavidin gene. Toxicity of streptavidin is derived from its e |
| 6210941 |
Methods for the detection and isolation of proteins |
April 3, 2001 |
| The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino ac |
| 6207390 |
Methods for the use of reduced affinity streptavidin |
March 27, 2001 |
| The present invention relates to methods for contacting biological targets using a mutated streptavidin protein having a reduced affinity for biotin. |
| 6197743 |
Compositions and methods for the treatment of viral disorders |
March 6, 2001 |
| This invention relates to compositions and methods for the treatment of virus infections and other viral-associated disorders. Compositions comprise an inducing agent and an anti-viral agent. The inducing agent induces the expression of a cellular or viral product, such as viral thym |
| 6123768 |
Method for the preparation and doping of highly insulating monocrystalline gallium nitride thin |
September 26, 2000 |
| This invention relates to a method of preparing highly insulating GaN single crystal films in a molecular beam epitaxial growth chamber. A single crystal substrate is provided with the appropriate lattice match for the desired crystal structure of GaN. A molecular beam source of Ga a |
| 6057096 |
Photocleavable agents and conjugates for the detection and isolation of biomolecules |
May 2, 2000 |
| This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bou |
| 6007987 |
Positional sequencing by hybridization |
December 28, 1999 |
| This invention is directed to methods and reagents useful for sequencing nucleic acid targets utilizing sequencing by hybridization technology comprising probes, arrays of probes and methods whereby sequence information is obtained rapidly and efficiently in discrete packages. That i |
