| Patent Number |
Title Of Patent |
Date Issued |
| RE39240 |
Conotoxins I |
August 15, 2006 |
| Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetyl-choline receptor, and ion channels. The peptides are |
| RE30548 |
Peptides which effect release of hormones |
March 17, 1981 |
| The present invention relates to peptides which possess biological activity in respect to the inhibition of growth hormone, insulin .[.secretion.]. and glucagon secretion .[.are provided.].. The peptides have fewer amino acid components than somatostatin and some of the peptides have |
| RE30059 |
Assay for myasthenia gravis |
July 31, 1979 |
| A serum assay system for diagnosis of myasthenia gravis. The assay system includes a complex of acetylcholine receptor protein and a toxin labeled with a radioactive isotope. The complex is incubated with a serum sample from a patient. During incubation, antibodies engendered by myasthen |
| 7413853 |
Modulation of metabolism of steroids and xenobiotics |
August 19, 2008 |
| In accordance with the present invention, there are provided methods for modulating Phase II conjugating enzymes such as, for example, UGTs. Phase II conjugating enzymes such as UGTs function in concert with Phase I monooxygenase enzymes such as cytochrome P450 enzymes (CYPs) to eliminat |
| 7384759 |
Methods and compositions for determinig enzymatic activity and specificity of chalcone O-methylt |
June 10, 2008 |
| The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyltransferases, methods of identifying |
| 7371577 |
FLP-mediated gene modification in mammalian cells, and compositions and cells useful therefor |
May 13, 2008 |
| A gene activation/inactivation and site-specific integration system has been developed for mammalian cells. The invention system is based on the recombination of transfected sequences by FLP, a recombinase derived from Saccharomyces. In several cell lines, FLP has been shown to rapidly a |
| 7361483 |
Aromatic prenyltransferases, nucleic acids encoding same and uses therefor |
April 22, 2008 |
| In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation of a C--C bond between a |
| 7358225 |
Cloning and recombinant production of CRF receptor(s) |
April 15, 2008 |
| In accordance with the present invention, there are provided novel G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of .English Pound. 10 nM of CRF occupy .sup.350% of the |
| 7314747 |
SMRT co-repressors, transcriptional co-repressors that interact with nuclear hormone receptors |
January 1, 2008 |
| The present invention relates to isolated polynucleotides encoding a family of silencing mediators of retinoic acid and thyroid hormone receptor (SMRT) isoforms, including vertebrate and invertebrate isoforms thereof. The invention also relates to polypeptide SMRT co-repressors encod |
| 7312031 |
Alpha-complementation viral fusion assay |
December 25, 2007 |
| The present invention relates to the use of an alpha complementation assay as a quick, effective, and safe method for the detection of cell fusion mediated by viral proteins. Additionally, the method disclosed herein permits the identification of inhibitors of cell fusion using an alpha |
| 7288385 |
Increasing life span by modulation of Smek |
October 30, 2007 |
| The Smek (Suppressor of mek null) gene is described and characterized. Smek acts in the stress response pathway of animals by binding to and enhancing the transcription of FOXO, thereby providing the link between the stress response pathway and the insulin/IGF-1 pathway. Given the link |
| 7286973 |
Method of screening inhibitors of mevalonate-independent isoprenoid biosynthetic pathway |
October 23, 2007 |
| The present invention provides the structure of the enzyme 4-diphosphocytidyl-2-C-methylerythritol (CDP-ME) synthase, a member of the cytidyltransferase family of enzymes from Escherichia coli. CDP-ME is a critical intermediate in the mevalonate-independent pathway for isoprenoid bio |
| 7286712 |
Method and apparatus for efficiently encoding chromatic images using non-orthogonal basis functi |
October 23, 2007 |
| A method and apparatus for efficiently encoding images using a set of non-orthogonal basis functions, thereby allowing reduction of file size, shorter transmission time, and improved accuracy. The non-orthogonal basis functions include homogenous color basis functions, luminance-enco |
| 7285380 |
Methods of producing polyketide synthase mutants and compositions and uses thereof |
October 23, 2007 |
| The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acids encoding such non-native polyketide synthases. Also disclosed are methods of producing |
| 7270955 |
Transcriptional co-repressor that interacts with nuclear hormone receptors and uses therefor |
September 18, 2007 |
| In accordance with the present invention, there are provide novel receptor interacting factors, referred to herein as "SMRT", i.e., a silencing mediator (co-repressor) for retinoic acid receptor (RAR) and thyroid hormone receptor (TR). SMRT is a novel protein whose association with RAR |
| 7254500 |
Monitoring and representing complex signals |
August 7, 2007 |
| A method of displaying signals containing a spatial and a temporal aspect, where multiple signals are received by multiple sensors. The received signals are decomposed into separate signal components within one or more distinct frequency bands. Signal components are isolated within each |
| 7238775 |
Receptor(SSTR4)-selective somatostatin analogs |
July 3, 2007 |
| Analogs of SRIF which are selective for SSTR4 in contrast to the other cloned SRIF receptors are useful in determining tissue and cellular expression of the receptor SSTR4 and its biological role in regulating tumor growth. SRIF analog peptides, such as des-AA.sup.1,2,4,5,12,13[Ala.s |
| 7220587 |
Ethylene insensitive plants |
May 22, 2007 |
| Nucleic acid and polypeptide sequences are described which relate to an EIN6 gene, a gene involved in the plant ethylene response. Plant transformation vectors and transgenic plants are described which display an altered ethylene-dependent phenotype due to altered expression of EIN6 |
| 7220539 |
Protein kinase B/Akt modulators and methods for the use thereof |
May 22, 2007 |
| The present invention describes modulator of protein kinase B (PKB)/Akt proteins, exemplified by the Tribbles (TRB) family. An exemplary member of the TRB family, TRB-3, binds to Akt and inhibits its catalytic activity, in turn causing altered regulation of glucose metabolism pathway |
| 7217557 |
Three-dimensional structure of polyketide synthases |
May 15, 2007 |
| The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acids encoding such non-native polyketide synthases. Also disclosed are methods of predicting |
| 7214511 |
Hormone receptor compositions and methods |
May 8, 2007 |
| In accordance with the present invention, there are provided expression systems for the production of function glucocorticoid receptor proteins, methods for the recombinant production of glucocorticoid receptor proteins as well as sequences encoding novel members of the steroid/thyro |
| 7214482 |
Steroid-activated nuclear receptors and uses therefor |
May 8, 2007 |
| A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcription from response e |
| 7205103 |
Method of regulating transcription in a cell |
April 17, 2007 |
| The present invention provides methods and compounds for altering remodeling of chromatin in a cell. |
| 7189510 |
Response element compositions and assays employing same |
March 13, 2007 |
| DNA segments have been discovered, and characterized by sequence, which are response elements operative to confer responsiveness to ligands for several members of the steroid/thyroid superfamily of receptors, for the transcriptional activation and/or repression of promoters in cells. By |
| 7169972 |
Methods and compositions to modulate ethylene sensitivity |
January 30, 2007 |
| The field of the invention relates to plants and plant genes, including both plant mutants and transgenic plants containing a gene that confers an ethylene insensitive phenotype. Also encompassed by the invention are methods of using the disclosed plant gene to confer an ethylene ins |
| 7169964 |
Genetic control of organ abscission |
January 30, 2007 |
| A method for decreasing the rate of organ or floral abscission is described. The method includes modifying the ARF GAP domain of a gene. In one instance the gene is the NEVERSHED gene. |
| 7148003 |
NIMA interacting proteins |
December 12, 2006 |
| A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting |
| 7135608 |
Site-specific recombination in eukaryotes and constructs useful therefor |
November 14, 2006 |
| Site-specific recombinases provide a means of efficiently manipulating chromosomal sequences in mammalian cells in culture and in animals. Embryonic stem cells containing recombinase nucleic acid constructs that were expressed in the male germline simplify current protocols for produ |
| 7127357 |
Crystal structure of WW domains and methods of use thereof |
October 24, 2006 |
| A WW domain crystal structure of Pin1 is provided. In addition, methods of using the crystal structure and atomic coordinates for the development of WW domain binding agents is also provided. Also provided are computer programs on computer readable medium for use in developing WW domain |
| 7125955 |
NIMA interacting proteins |
October 24, 2006 |
| A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting |
| 7125677 |
NIMA interacting proteins |
October 24, 2006 |
| A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting |
| 7119077 |
Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspirac |
October 10, 2006 |
| In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the st |
| 7101540 |
Targeted retrograde gene delivery to motor neurons |
September 5, 2006 |
| Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting a muscle tissue innervated by the neuron with a viral vector comprising a heterologous gene, wherein the viral vector enters said neuron and is retrogradely moved to the cell body. Addit |
| 7090837 |
Compositions and methods for tissue specific targeting of lentivirus vectors |
August 15, 2006 |
| This disclosure provides lentiviral vectors containing an attachment incompetent fusogenic polypeptide and a heterologous targeting polypeptide. Also provided are lentiviral packaging constructs, lentiviral packaging systems, and lentiviral gene delivery systems. Finally, methods of |
| 7057015 |
Hormone receptor functional dimers and methods of their use |
June 6, 2006 |
| The invention provides chimeric proteins having at least two functional protein units, each containing the dimerization domain of a member of the steroid/thyroid hormone nuclear receptor superfamily. The chimeric proteins can fold under crystallization conditions to form functional e |
| 7056954 |
Means for the modulation of processes mediated by retinoid receptors and compounds useful theref |
June 6, 2006 |
| In accordance with the present invention, there are provided methods to modulate processes mediated by retinoid receptors, employing high affinity, high specificity ligands for such receptors. In one aspect of the present invention, there are provided ligands which are more selective |
| 7053116 |
Methods for protecting cells from amyloid toxicity and for inhibiting amyloid protein production |
May 30, 2006 |
| In accordance with the present invention, there are provided novel methods of blocking amyloid protein toxicity in cells using polycylic compounds. Also provided are novel methods of decreasing amyloid protein production in cells and methods of inhibiting cell death. Invention methods ca |
| 7045315 |
Methods for modulating expression of exogenous genes in mammalian systems |
May 16, 2006 |
| In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in an isolated cell and in a mammalian subject employing modified ecdysone receptors. Also provided are modified ecdysone receptors, as well as homomeric and |
| 7041498 |
Method for modulating processes mediated by farnesoid activated receptors |
May 9, 2006 |
| Farnesyl pyrophosphate, the metabolically active form of farnesol, is a key precursor in the synthesis of cholesterol, carotenoids, steroid hormones, bile acids and other molecules involved in cellular growth and metabolism. A nuclear receptor has been identified that is transcriptio |
| 7038022 |
Multimeric forms of members of the steroid/thyroid superfamily of receptors |
May 2, 2006 |
| In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact to form multimeric species comprising a complex of more than one receptor. Accordingly, the interaction of a first receptor species with a |
| 7034205 |
Genetically modified plants having modulated brassinosteroid signaling |
April 25, 2006 |
| Disclosed are plants and methods of making plants that have a dwarf stature in comparison to wildtype plants. By transforming a wildtype plant with a "bas1" gene, or functional homolog thereof, the plant grows to have a dwarf stature. |
| 7033828 |
Nucleic acid encoding gamma retinoic acid receptor fusion protein |
April 25, 2006 |
| A novel gamma retinoic acid receptor is disclosed. The novel receptor is encoded for by cDNA carried on plasmid pGEM-hRAR.gamma., which has been deposited with the American Type Culture Collection for patent purposes. Chimeric receptor proteins are also disclosed. The chimera contain at |
| 6998118 |
Targeted retrograde gene delivery for neuronal protection |
February 14, 2006 |
| Methods are disclosed for transducing neurons with heterologous genes using retrograde viral transport. The methods disclosed employ substantially non-toxic vectors, such as adeno-associated virus vectors, that are capable of retrograde axonal transport to introduce and express genes |
| 6992108 |
Means for the modulation of processes mediated by retinoid receptors and compounds useful theref |
January 31, 2006 |
| A method for modulating lipid metabolism in a subject by administering 9-cis retinoic acid is presented. The 9-cis retinoic acid is more specific for the retinoid X receptor than is retinoic acid. |
| 6984773 |
Transgenic mice expressing a human SXR receptor polypeptide |
January 10, 2006 |
| A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcription from response e |
| 6967244 |
Neuronal nicotinic acetylcholine receptor compositions |
November 22, 2005 |
| The present invention relates to a family of neuronal nicotinic acetylcholine receptors comprised of neuronal agonist and non-agonist binding subunits, and DNA sequences encoding such subunits. These novel neuronal nicotinic acetylcholine receptor subunits include the agonist binding |
| 6956146 |
FLP-mediated gene modification in mammalian cells, and compositions and cells useful therefor |
October 18, 2005 |
| A gene activation/inactivation and site-specific integration system has been developed for mammalian cells. The invention system is based on the recombination of transfected sequences by FLP, a recombinase derived from Saccharomyces. In several cell lines, FLP has been shown to rapidly a |
| 6946259 |
Compositions and methods for treating cells having double minute DNA |
September 20, 2005 |
| This invention provides methods by which test substances can be screened for their ability to inhibit, enhance or eliminate double minute (DM) or extrachromosomal DNA by micronucleation in cells. This invention also provides a method for inducing maturation or death of a cell having the |
| 6921848 |
Genes involved in brassinosteroid hormone action in plants |
July 26, 2005 |
| The present invention provides a BZR1 gene and an altered gene, bzr1-D, involved in the brassinosteroid response pathway. The expression of BZR1 genes in transgenic plants causes such plants to become significantly larger and more robust than their wild-type counterparts, thus increasing |
| 6911537 |
Xenobiotic compound modulated expression systems and uses therefor |
June 28, 2005 |
| A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcription from response eleme |
