| Patent Number |
Title Of Patent |
Date Issued |
| RE35465 |
Method and agents for removing advanced glycosylation endproducts |
February 25, 1997 |
| The present invention relates to a method and associated agents for the inhibition and treatment of protein aging in animals by stimulating the bodies of the animals to increase their recognition and affinity for advanced glycosylation end products. Specifically, the method contemplates |
| 7442377 |
Protective antigen of epstein barr virus |
October 28, 2008 |
| The present invention relates to the identification of a subunit vaccine to prevent or treat infection of Epstein Barr Virus. In particular, EBNA-1 was identified as a vaccine antigen. In a specific embodiment, a purified protein corresponding to EBNA-1 elicited a strong CD4.sup.+ T |
| 7427485 |
Method for classification of anti-psychotic drugs |
September 23, 2008 |
| The present invention provides a method for identifying an agent to be tested for an ability to treat a psychotic disorder in a patient in need of such treatment. The invention provides a method for screening candidate drugs for anti-psychotic drug activity, preferably atypical anti- |
| 7425327 |
Choline binding proteins for anti-pneumococcal vaccines |
September 16, 2008 |
| The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA se |
| 7419954 |
Staphylococcus peptides for bacterial interference |
September 2, 2008 |
| The present invention provides a cyclic peptide comprising the structure: ##STR00001## wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and |
| 7417120 |
Purified Stat proteins and methods of purifying thereof |
August 26, 2008 |
| The present invention describes methods of producing milligram quantities of three forms of purified Stat1 protein from recombinant DNA constructs. In addition, the Stat proteins may be isolated in their phosphorylated or nonphosphorylated forms (Tyr 701). The proteins can be produced in |
| 7416842 |
DNA virus microRNA |
August 26, 2008 |
| The invention relates to isolated nucleic acid molecules comprising the sequence of a DNA virus microRNA. In another embodiment, the invention relates to single stranded DNA virus microRNA molecules. In yet another embodiment, the invention relates to single stranded anti-DNA virus m |
| 7416733 |
Flavivirus fusion inhibitors |
August 26, 2008 |
| The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome into the cell cytoplasm. The invention provides for methods which employ peptides or peptide |
| 7416726 |
Enhancement of antibody-mediated immune responses |
August 26, 2008 |
| The present invention is related to enhancing the function of anti-tumor antibodies by regulating Fc.gamma.RIIB-mediated activity. In particular, disrupting SHIP activation by Fc.gamma.RIIB enhances cytotoxicity elicited by a therapeutic antibody in vivo in a human. The invention fur |
| 7405052 |
Voltage sensor domains of voltage-dependent ion channel proteins and uses thereof |
July 29, 2008 |
| A composition of matter suitable for use in identifying chemical compounds that bind to voltage-dependent ion channel proteins, the composition comprising a screening protein that comprises an ion channel voltage sensor domain of the ion channel protein immobilized on a solid support. |
| 7402309 |
Phage-associated lytic enzymes for treatment of Bacillus anthracis and related conditions |
July 22, 2008 |
| The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Bacillus anthracis and B. cereus bacteria and spores, and related conditions. The disclosure further relates to methods and compositions for the identification of a phage a |
| 7393927 |
Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding |
July 1, 2008 |
| A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells |
| 7368293 |
Liver enriched transcription factor |
May 6, 2008 |
| HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the transthyretin (TTR) and apolipoprotein CIII (apoCIII) genes (Costa et al., 1989; Costa et al., 1990; Leff et al., 1989). We have purified HNF-4 protei |
| 7365058 |
MicroRNA and methods for inhibiting same |
April 29, 2008 |
| The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a pancreatic islet microRNA. In another embodiment, the invention relates to isolated single stranded pancreatic islet microRNA molecules or anti-pancreatic islet microRNA |
| 7341874 |
Method for detecting post-translation modifications of peptides |
March 11, 2008 |
| This invention provides for novel methods of identifying covalent modifications of an amino acid residue in a polypeptide chain by detecting mass differences. |
| 7332173 |
Group A streptococcal polysaccharide immunogenic compositions and methods |
February 19, 2008 |
| This invention provides a novel immunogenic composition and vaccine, processes for producing them and methods for immunization against infections and disease caused by group A Streptococci. The compositions include group A streptococcal polysaccharide covalently linked to protein or |
| 7323683 |
Linear ion trap for mass spectrometry |
January 29, 2008 |
| A method for manipulating ions in an ion trap includes storing ions, spatially compressing, and ejecting selected ions according to mass-to-charge ratio. An ion trap includes an injection port, an arm having a first and a second end for confining and spatially compressing the ions, a |
| 7320878 |
Protease assay for therapeutic drug monitoring |
January 22, 2008 |
| The present invention concerns a further development and use of biological assays to determine the amount or concentration of an active ingredient present in a sample. The enzyme assay of the present invention determines the amount or concentration of protease inhibitors, including retro |
| 7320785 |
Compositions and methods for modulation of DARPP-32 phosphorylation |
January 22, 2008 |
| The present invention provides methods and compositions for modulating the phosphorylation of DARPP-32 in a serotonergic receptor intracellular signaling pathway. The invention provides methods and compositions for modulating the activities of DARPP-32, casein kinase 1 (CK1), cyclin- |
| 7285416 |
Regulated gene expression in plants |
October 23, 2007 |
| A method is provided of regulating transcription in a plant cell from a DNA sequence comprising a target DNA operably linked to a coding sequence, which method comprises introducing an engineered zinc finger polypeptide in said plant cell which polypeptide binds to the target DNA and |
| 7262055 |
Regulated gene expression in plants |
August 28, 2007 |
| A method is provided of regulating transcription in a plant cell from a DNA sequence comprising a target DNA operably linked to a coding sequence, which method comprises introducing an engineered zinc finger polypeptide in said plant cell which polypeptide binds to the target DNA and |
| 7230157 |
Chemical inducible promoter used to obtain transgenic plants with a silent marker and organisms |
June 12, 2007 |
| Disclosed is a chemically inducible promoter for transforming plants or plant cells with genes which are regulatable by adding the plants or cells to a medium containing an inducer or by removing them from such medium. The promoter is inducible by a glucocorticoid, estrogen or induce |
| 7211655 |
Methods for identifying modulators of transcriptional activator protein interactions |
May 1, 2007 |
| The present invention relates to methods for identifying interacting regions of transcription factors, and methods for identifying agents which modulate the interactions, useful for affecting gene regulation, for example, cellular transformation. A site within residues 130 154 and wi |
| 7198948 |
Methods and compositions for obtaining mature dendritic cells |
April 3, 2007 |
| We describe an improved method for generating sizable numbers of mature dendritic cells from nonproliferating progenitors in human blood. The first step or "priming" phase is a culture of T cell depleted mononuclear cells in medium supplemented with GM-CSF and IL-4 to produce immature |
| 7148004 |
Oligonucleotides of the OB-R isoforms and methods of diagnosing body weight |
December 12, 2006 |
| The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the |
| 7129073 |
Regulation of neuronal function through metabotropic glutamate receptor signaling pathways |
October 31, 2006 |
| The present invention provides methods and compositions for modulating the activities of metabotropic glutamate receptor intracellular signaling molecules. The present invention provides methods and compositions for modulating the activities of casein kinase I and/or cyclin-dependent |
| 7129037 |
Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or toleri |
October 31, 2006 |
| This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocy |
| 7115567 |
Purified STAT proteins and methods of purifying thereof |
October 3, 2006 |
| The present invention describes methods of producing milligram quantities of three forms of purified Stat1 protein from recombinant DNA constructs. In addition, the Stat proteins may be isolated in their phosphorylated or nonphosphorylated forms (Tyr 701). The proteins can be produced in |
| 7115268 |
Peptides useful for reducing symptoms of toxic shock syndrome and septic shock |
October 3, 2006 |
| This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates to peptides derived from homologous sequences of the family of staphylococcal and strept |
| 7109479 |
Method and system for mass spectroscopy |
September 19, 2006 |
| A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion gu |
| 7091396 |
Animals, cells and methods for production of detectably-labeled antibodies |
August 15, 2006 |
| Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encodin |
| 7084252 |
DB, the receptor for leptin |
August 1, 2006 |
| The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the |
| 7071315 |
Alleles of the human mu opioid receptor, diagnostic methods using said alleles, and methods of t |
July 4, 2006 |
| Provided herein are variant alleles of a gene encoding a mu opioid receptor, along with cloning vectors for replicating such variant alleles, expressing vectors for expressing the variant alleles to produce variant mu opioid receptors, and antibodies to such variant receptors. Also d |
| 7063960 |
Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding |
June 20, 2006 |
| A method of modulating immune response in an animal is disclosed. Such a method comprises: interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature |
| 7063958 |
Nucleic acids db, the receptor for leptin |
June 20, 2006 |
| The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the |
| 7060682 |
Receptor recognition factors, protein sequences and methods of use thereof |
June 13, 2006 |
| Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a |
| 7060265 |
Cloning and recombinant production of polistinae venom enzymes, such as phospholipase and hyalur |
June 13, 2006 |
| A unique clone of a Polistinae venom enzyme, recombinantly produced Polistinae venom enzymes, and methods of using the recombinant enzymes are provided. In a specific example, both phospholipase and hyaluronidase cDNA from Polistes annulares contain apparent "intronic" sequences. In |
| 7019119 |
Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding |
March 28, 2006 |
| A protein belonging to the TNF superfamily called TRANCE involved in signal transduction, along with nucleic acids comprising DNA sequences and degenerate variants thereof which encode TRANCE are disclosed. Modulators which are TRANCE agonists and TRANCE antagonists are also disclose |
| 7012249 |
High capacity and scanning speed system for sample handling and analysis |
March 14, 2006 |
| Disclosed is an apparatus for examining and inspecting at least one sample in order to determine characteristics of the sample having the a support for receiving a compact disc, the compact disc having deposited on a surface thereof at least one sample, inspection means for effecting a |
| 7005131 |
Protective antigen of Epstein Barr Virus |
February 28, 2006 |
| The present invention relates to the identification of a subunit vaccine to prevent or treat infection of Epstein Barr Virus. In particular, EBNA-1 was identified as a vaccine antigen. In a specific embodiment, a purified protein corresponding to EBNA-1 elicited a strong CD4.sup.+ T |
| 6989362 |
Methods of treating dopamine dysregulation using agents that regulate phosphorylation/dephosphor |
January 24, 2006 |
| The present invention discloses that DARPP-32 is substrate for the cyclin dependent kinase Cdk5. The phosphorylation takes place at a specific threonine residue of DARPP-32 (Threonine 75). The Cdk5 catalyzed phosphorylation of DARPP-32 converts this protein into an inhibitor of the c |
| 6960647 |
Stat3 protein fragments and mutants |
November 1, 2005 |
| The present invention relates to methods for identifying interacting regions of transcription factors, and methods for identifying agents which modulate the interactions, useful for affecting gene regulation, for example, cellular transformation. A site within residues 130-154 and wi |
| 6953861 |
Method of re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall deps |
October 11, 2005 |
| The present invention relates to pyrrolidine compounds of the general structure: ##STR1##where n is an integer 1-6 and R is hydrogen or a C.sub.1 to C.sub.6 straight chain or branched alkyl group, and wherein when n=1, R=CH.sub.3 or H, useful for re-sensitizing vancomycin resistant G |
| 6953833 |
Staphylococcus peptides for bacterial interference |
October 11, 2005 |
| The present invention provides a cyclic peptide comprising the structure: ##STR1##wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a bio |
| 6900050 |
DNA encoding TRIP |
May 31, 2005 |
| A novel component of the TRAF (TNF Receptor Associated Factor) signaling complex, designated TRIP (TRAF Interacting Protein) which associates with the TNFR2 or CD30 signaling complex through its interaction with the TRAF2 protein and influences signals responsible for cell activation, ce |
| 6875594 |
Methods of ligating expressed proteins |
April 5, 2005 |
| The present invention provides a method of cleaving a recombinantly expressed protein from an intein and ligating the protein to a peptide containing an N-terminal cysteine having an unoxidized sulfhydryl side chain which comprises contacting the protein with the peptide in a reactio |
| 6821945 |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeu |
November 23, 2004 |
| The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of body weight, and to diagnostic and therapeutic uses of such modulators. In its broadest aspect, the present |
| 6821759 |
Methods of performing homologous recombination based modification of nucleic acids in recombinat |
November 23, 2004 |
| A simple method for modifying genes in a recombination deficient host cell is disclosed. Such modifications include generating insertions, deletions, substitutions, and/or point mutations at any chosen site in the independent origin based cloning vector. The modified gene is contained in |
| 6812378 |
Esr1--a plant gene that can promote plant regeneration and transformation |
November 2, 2004 |
| A plant gene, Esr 1, has been found which when overexpressed in plant cells results in cells which have cytokinin-independent cell growth. This feature allows the encoded protein ESR1 to be used as a selectable marker of transformed cells by growing the transformed cells on cytokinin-fre |
| 6809318 |
Method of transmitting ions for mass spectroscopy |
October 26, 2004 |
| A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion gu |
