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The Regents of the University of Michigan Patents
Assignee:
The Regents of the University of Michigan
Address:
Ann Arbor, MI
No. of patents:
761
Patents:


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Patent Number Title Of Patent Date Issued
RE37585 Method for controlling configuration of laser induced breakdown and ablation March 19, 2002
In one aspect the invention provides a method for laser induced breakdown of a material with a pulsed laser beam where the material is characterized by a relationship of fluence breakdown threshold (F.sub.th) versus laser beam pulse width (T) that exhibits an abrupt, rapid, and distinct
RE36187 Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents April 6, 1999
This invention relates to the use of acyclic substituted pyrrolo[2,3-d]pyrimidine nucleoside analogs in the treatment of viral infections. Such substituted compounds retain antiviral properties present in their parent compounds, yet exhibit significantly decreased levels of cytotoxic
RE35823 Proteins useful in the regulation of .kappa.B-containing genes June 9, 1998
Proteins, and corresponding DNA and RNA sequences, useful for the regulation of expression of .kappa.B-containing genes are disclosed. These proteins are useful to either stimulate or inhibit the expression of .kappa.B-containing genes. Proteins stimulating the expression of .kappa.B
D268220 Military helmet with visor March 15, 1983
D267287 Pneumatic liner for protective headgear December 21, 1982
D266711 Police helmet November 2, 1982
D266627 Protective helmet for athletes October 26, 1982
D266626 Police helmet October 26, 1982
7622977 Ramped clock digital storage control November 24, 2009
Disclosed herein are digital systems and methods for use with a ramped clock signal. The digital system includes an input element having a data input to receive a data signal, a control input to receive a control signal, and a dynamic node to be driven by the ramped clock signal. The
7622075 Films for detecting fluoride November 24, 2009
A film for detecting fluoride concentrations is disclosed. The film includes an organic matrix having a lipophilic aluminum compound incorporated therein. The lipophilic aluminum compound is adapted to selectively bind with fluoride ions via a binding interaction. The fluoride is det
7618510 Imprinting polymer film on patterned substrate November 17, 2009
A method of applying a pattern on a topography includes first applying a polymer film to an elastomer member, such as PDMS, to form a pad. The pad is then applied to a substrate having a varying topography under pressure. The polymer film is transferred to the substrate due to the pl
7615573 Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors November 10, 2009
Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
7615369 Reconfigurable protein patterning using electrowetting microelectrodes November 10, 2009
A protein patterning electrode device consisting of capacitor microelectrode arrays coated with a protein non-adherent layer is provided. Operation of the electrode is based on a phenomenon called "electrowetting," where surface wettability can dynamically be controlled by varying th
7614032 Method for correcting a mask design layout November 3, 2009
A method for performing a mask design layout resolution enhancement includes determining a level of correction for the design layout for a predetermined parametric yield with a minimum total correction cost. The design layout is corrected at the determined level of correction based on
7604939 Methods of identifying active BRM expression-promoting HDAC inhibitors October 20, 2009
The present invention provides screening methods for identifying BRM expression-promoting histone deacetylase (HDAC) inhibitors, diagnostic methods for determining the suitability of treatment of a candidate subject with a BRM expression-promoting HDAC inhibitor, and therapeutic meth
7598381 Near-infrared emitting organic compounds and organic devices using the same October 6, 2009
Certain iridium compounds which may comprise an iridium(III)-ligand complex having the general formula: (C^N).sub.2--Ir--(N^N). (C^N) and (N^N) may each represent a ligand coordinated to an iridium atom. The iridium compounds may have a primary phosphorescent photoluminescence peak w
7598052 Expression profile of thyroid cancer October 6, 2009
The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with thyroid cancers. Genes identified as cancer markers using the methods of
7598028 Compositions and methods for detecting and treating prostate disorders October 6, 2009
The present invention relates to compositions and methods for the detecting, treating, and empirically investigating cellular proliferation disorders and cellular motility disorders. In particular, the present invention provides compositions and methods for using CXCL chemokines (e.g
7597890 Methods and compositions for diagnosing lung cancer October 6, 2009
The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ubiquilin 1 markers for cancer.
7588907 Ubiquitin mediated fluorescence complementation assay September 15, 2009
The present invention relates to methods and compositions for identifying covalent joining or modification of proteins. In particular, the present invention relates to covalent fluorescence complementation assays for the detection of modified (e.g., ubiquitinated) proteins. The present
7587105 High frequency ultrasound detection using polymer optical-ring resonator September 8, 2009
A polymer waveguide resonator device for high-frequency ultrasound detection having a optical resonator coupled to a straight optical waveguide which serves as input and output ports. Acoustic waves irradiating the waveguide induce strain modifying the waveguide cross-section or othe
7582798 Covalently linked organic frameworks and polyhedra September 1, 2009
A covalently linked organic network includes a plurality of boron-containing clusters linked together by a plurality of linking groups. The covalently linked organic networks are characterized by having each linking group bonded to at least two distinct boron-containing clusters.
7582442 Methods and compositions for using aleveolar macrophage phospholipase A2 September 1, 2009
The present invention is directed to methods and compositions for improving pulmonary surfactant catabolism. More specifically, the specification describes methods and compositions for making and using a lysosomal phospholipase A2 in methods for the diagnosis, and treatment of disord
7582425 Atlastin September 1, 2009
The present invention relates to methods and compositions of a novel gene and the peptide encoded by the gene. Mutations in the gene, named atlastin, are factors in the disease Hereditary Spastic Paraplegia and related disorders. The present invention will be used for the in the rese
7579757 Method and micro power generator for generating electrical power from low frequency vibrational August 25, 2009
A method and a micro power generator for generating electrical power from low frequency, vibrational energy includes a frequency up-conversion process. The generator is preferably an electromagnetic, vibration-to-electrical power generator which can efficiently scavenge energy from l
7576334 Photoacoustic indicators August 18, 2009
A method of measuring fluorophore excited state lifetimes comprising initiating an excitation laser pulse at a dye to excite dye molecules of the dye from a ground state to an excited state and initiating a probing pulse at the dye molecules thereby generating a first set of photoaco
7576169 Facile synthesis of polyhedral silsesquioxane anions and use thereof August 18, 2009
Polyhedral silsesquioxane anions are economically prepared by reaction of a silica source derived from combusted organic material with a quaternary ammonium hydroxide compound. Reaction of the resulting anions with chlorosilanes may be effected in near stoichiometric fashion in organic
7575797 Blast reducing structures August 18, 2009
A blast reducing structure having a first web and a second web. Each of the webs having a first section defining a first plane, a second section defining a second plane, the second plane being generally parallel to the first plane, an interconnecting section interconnecting the first sec
7575759 Tissue engineering scaffolds August 18, 2009
The present invention relates to methods and compositions for the production of scaffolds, such scaffolds to be used for a variety of purposes, including tissue engineering. More specifically, the present invention relates to the use of fused crystals, such as fused salt crystals to
7572788 Compositions and methods relating to novel compounds and targets thereof August 11, 2009
The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of condi
7572501 Engineered self healing cementitious composites August 11, 2009
Cementitious composites engineered for self-healing, combining self-controlled tight crack width and extreme tensile ductility. Self-healing takes place automatically at cracked locations without external intervention. In the exemplary embodiment, fiber-reinforced cementitious compos
7563097 Stabilizing hand grip system July 21, 2009
In a self-contained actively-controlled stabilization system within a hand-grip, all components are contained within the handgrip, and one generic handgrip can be attached to a variety of devices for a wide range of applications, thereby increasing portability, reducing weight and bu
7560658 Method for forming nanoscale features July 14, 2009
Here is presented a versatile technique for machining of nanometer-scale features using tightly-focused ultrashort laser pulses. By the invention, the size of features can be reduced far below the wavelength of light, thus enabling nanomachining of a wide range of materials. The features
7557251 Production of gossypol co-crystals July 7, 2009
This invention relates to relates to methods for producing gossypol acetic acid co-crystals and (-)-gossypol acetic acid co-crystals. The invention also relates to pharmaceutical compositions comprising gossypol acetic acid co-crystals and (-)-gossypol acetic acid co-crystals and the use
7553958 Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on June 30, 2009
A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surfac
7551043 Micromechanical structures having a capacitive transducer gap filled with a dielectric and metho June 23, 2009
Micromechanical structures having at least one lateral capacitive transducer gap filled with a dielectric and method of making same are provided. VHF and UHF MEMS-based vibrating micromechanical resonators filled with new solid dielectric capacitive transducer gaps to replace previou
7549985 Method and system to create and acoustically manipulate a microbubble June 23, 2009
A method and system to create and acoustically manipulate without destroying a microbubble which, in biological applications, can manipulate structures such as cells and subcellular structures at a nanoscopic scale.
7548775 Intracranial neural interface system June 16, 2009
In some preferred embodiments, without limitation, the present invention comprises an implantable, intracranial neural interface node which is an integrated and minimally invasive platform system and supports cross-modal neural interfaces to the cerebrum and other associated structur
7544638 Device for chemical and biochemical reactions using photo-generated reagents June 9, 2009
This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the present invention provides methods and devices for generating a photogenerated reaction in soluti
7544481 Nucleic acids encoding CD40 binding protein June 9, 2009
This invention provides a novel purified mammalian protein having the ability to bind the cytoplasmic region or domain of a CD40 receptor and the nucleic acid molecules coding for this protein. Also provided by this invention are antibodies which specifically bind CD40bp. Methods of usin
7542544 Ultrasound gating of cardiac CT scans June 2, 2009
An ultrasonic imaging system acquires echo signals from an object being imaged such as a moving coronary artery and the cross-correlation between echo signals is employed as an objective measure of relative object location. The method is used in a prescan procedure to determine an op
7540963 Ultrafiltration membrane, device, bioartificial organ, and methods June 2, 2009
The present invention relates to ultrafiltration. In particular, the present invention provides a compact ultrafiltration device and methods for generating an ultrafiltrate, both of which can be used for a variety of applications, including, but not limited to filtering blood, diagno
7537890 Methods of performing biochemical reactions in a convective flow field May 26, 2009
The present invention provides methods and systems for running reactions, in particular, biological reactions and assays, in a Rayleigh-Benard convection cell. The utilization of Rayleigh-Benard convection principles for conducting biological or biochemical reactions is a novel appli
7534418 Imaging agents May 19, 2009
The present invention provides novel compounds that find use as imaging agents within nuclear medicine applications (e.g., PET imaging and SPECT imaging). The present invention also provides imaging compositions for use within nuclear medicine applications. Additionally, the present
7524444 Shaped bodies containing metal-organic frameworks April 28, 2009
The present invention relates to shaped bodies containing a metal-organic framework material (MOF) as well as a process for the preparation thereof and their use especially as catalyst or storage medium.
7521188 Optical monitoring of cleaving enzyme activity April 21, 2009
A marker molecule for monitoring cleaving enzyme activity is disclosed. The marker molecule includes a protein, a peptide, or an oligonucleotide. A co-factor is conjugated to the protein, the peptide, or the oligonucleotide, thereby forming a co-factor labeled protein, a co-factor la
7518120 Long-distance quantum communication and scalable quantum computation April 14, 2009
Methods and apparatus for long-distance quantum communication and scalable quantum computation are disclosed. The methods and apparatus are based on probabilistic ion-photon mapping. Scalable quantum computation is achieved by forming deterministic quantum gates between remotely located
7517648 NPHP nucleic acids and proteins April 14, 2009
The present invention relates to Nephronophthisis, in particular to the NPHP5 protein (nephrocystin-5) and nucleic acids encoding the NPHP5 protein. The present invention also provides assays for the detection of NPHP5 polymorphisms and mutations associated with disease states.
7517522 ADAMTS13 genes and proteins and variants and therapeutic compositions and methods utilizing the April 14, 2009
The present invention relates to a disintegrin and metalloproteinase containing thrombospondin 1-like domains (ADAMTS) and in particular to a novel ADAMTS13 protease and to nucleic acids encoding ADAMTS13 proteases. The present invention encompasses both native and recombinant wild-type
7516610 Scalable flat-panel nano-particle MEMS/NEMS thruster April 14, 2009
A scalable flat-panel nano-particle MEMS/NEMS thruster includes a grid having a plurality of electrodes to establish electrical fields. A liquid is disposed in a liquid reservoir of the grid. The liquid is positioned within the electrical fields. A plurality of nano-particles are suspend
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