| Patent Number |
Title Of Patent |
Date Issued |
| RE40948 |
APC antibodies |
October 27, 2009 |
| A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most |
| RE38916 |
APC Antibodies |
December 6, 2005 |
| A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most no |
| RE38168 |
Mono-allelic mutation analysis for identifying germline mutations |
July 1, 2003 |
| A diagnostic strategy for detection of inherited diseases caused by germline mutations is based on somatic cell hybridization. Each allele of a human gene involved in the inherited disease is isolated in a somatic cell hybrid. The products of the isolated human allele are then observed |
| RE37410 |
Controlled local delivery of chemotherapeutic agents for treating solid tumors |
October 16, 2001 |
| A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices consist of reservoirs which release d |
| RE36784 |
Chemoprotective isothiocyanates |
July 18, 2000 |
| Sulforaphane has been isolated and identified as a major and very potent phase II enzyme inducer in broccoli (Brassica oleracea italica). Sulforaphane is a monofunctional inducer, inducing phase II enzymes selectively without the induction of aryl hydrocarbon receptor-dependent cytoc |
| RE36713 |
APC gene and nucleic acid probes derived therefrom |
May 23, 2000 |
| A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in hum tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as wel as in sporadic colorectal cancer patents. APC is expressed in most normal |
| 7605003 |
Use of biomarkers for detecting ovarian cancer |
October 20, 2009 |
| The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying |
| 7601489 |
Manganese ion regulation of reverse transcriptase activity and methods of modulating same |
October 13, 2009 |
| Methods of identifying agents that modulate reverse transcriptase activity in a cell by affecting manganese ion transport across a membrane of the cell are provided, as are agents identified using such methods. Also provided are methods of modulating reverse transcriptase activity by |
| 7599729 |
Evaluating the urethra and the periurethral tissues |
October 6, 2009 |
| Systems and methods for the evaluation of the urethra and periurethral tissues may involve an MRI coil adapted for insertion into the male, female or pediatric urethra. The MRI coil may be in electrical communication with an interface circuit made up of a tuning-matching circuit, a d |
| 7596409 |
Cardiac shock electrode system and corresponding implantable defibrillator system |
September 29, 2009 |
| An implantable cardioverter defibrillator (ICD) system includes an internal electrode placed in the right ventricle of the heart, and a quasi-Faraday cage (which includes a single or multiple electrodes) placed over a significant portion of the heart. Defibrillation shocks are applie |
| 7593914 |
Method and system for the autonomous design of cybernetic systems |
September 22, 2009 |
| A system and method is provided for constructing optimal cybernetic based systems. The method is based on a process of formalized rational inquiry, measurement and planned action. More particularly, the method relies upon the precise determination of alternatives through inquiry, a forma |
| 7582290 |
Packaging cell line for diphtheria toxin expressing non-replicating adenovirus |
September 1, 2009 |
| The invention provides a packaging cell line for production of diphtheria toxin (DT) expressing, non-replicating adenovirus for use in suicide gene therapy of cancer cells, as well as production of immunotoxins. Also provided are methods for producing diphtheria toxin (DT) expressing, |
| 7570426 |
Apparatus and system for wide angle narrow-band optical detection in daylight |
August 4, 2009 |
| Techniques for filtering light include, along a central optical axis, an entrance window; a first polarizer, a narrowband polarization-changing material, a second polarizer, and an exit window. The optical paths through the filter are substantively unscattered and pass through unstre |
| 7570202 |
Polarimetric selectivity method for suppressing cross-track clutter in sounding radars |
August 4, 2009 |
| Methods for suppressing cross-track clutter in a sounding radar utilize polarimetric selectivity in two ways: (1) transmitting full-beam circular polarization and separating the desired signal of interest from the clutter based on the signal and clutter having different polarizations, |
| 7561802 |
Mobile communications via an optical signal during adverse atmospheric conditions |
July 14, 2009 |
| A communications system for wireless transceiving of information, comprising at least one multiple optical beam scanning array transceiver located in a satellite for wirelessly transceiving the information; and at least two terminals at diverse locations capable of wirelessly transce |
| 7560540 |
Nucleic acid encoding dendritic cell co-stimulatory molecules |
July 14, 2009 |
| A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells express |
| 7560482 |
Inhibitors of plasmepsins |
July 14, 2009 |
| Compounds and methods for the inhibition of anti-malarial target aspartyl protease plasmepsins (e.g. Plasmepsin I, Plasmepsin II, Plasmepsin IV and HAP) are provided. The compounds are based on allophenylnorstatine substituted at positions R1-R4, such that R1 is isoquinoline, carboxyl, |
| 7557144 |
Modulation of protein expression using carbocyclic aryl alkenoic acid derivatives |
July 7, 2009 |
| The present invention generally relates to diseases or conditions modulated by undesired protein expression. In one aspect, the methods provide for administration to a mammal, particularly a human, of a therapeutically effective amount of a carbocyclic aryl compound capable of modula |
| 7556855 |
Impact resistant flexible body device |
July 7, 2009 |
| An impact resistant device is provided comprising a support matrix and a plurality of energy absorbing elements operatively connected to the support matrix, each element comprising at least one ceramic material and at least one strain rate sensitive material. The impact resistant device |
| 7554294 |
Battery health monitor |
June 30, 2009 |
| A battery health monitor (BHM) that operates as a battery-mountable full-spectrum alternating current (ac) impedance meter that facilitates monitoring a state-of-charge and a state-of-health of a battery. The BHM is used for monitoring one or more electrical parameters, e.g., impedan |
| 7553487 |
Method and compositions for treating asthma |
June 30, 2009 |
| The present invention is directed to methods for treating asthma. |
| 7548897 |
Mission-centric network defense systems (MCNDS) |
June 16, 2009 |
| The Mission Centric Network Defense System (MCNDS) is a deployable network defense system that monitors network activities, generates and maintains situational awareness of operational activities, and uses this joint situational awareness of networked and operational activities to predic |
| 7547673 |
Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production |
June 16, 2009 |
| The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising such inhibitors and methods for administering them intraarterially directly to a tumor, as |
| 7544470 |
Method for finding mutations caused by the insertion of repeated DNAs |
June 9, 2009 |
| The present invention provides a method for identifying repeat insertion mutation, a method for identifying or classifying genetic diseases characterized by genome rearrangement, as well as a method for mapping complex traits controlled by repeat insertion mutations in a plant or mam |
| 7543664 |
Mono-track vehicle |
June 9, 2009 |
| A vehicle includes a motorized belt track directly or indirectly connected to a frame. The belt track frictionally contacts a drive surface on which the vehicle moves, such as any form of road or off-road surface. The belt track moves forward and backward in a direction parallel to a cen |
| 7536914 |
Sensor for detecting arcing faults |
May 26, 2009 |
| The present invention is directed to a sensor for detecting arcing faults, the sensor combining a photodetector, a pressure detector, and an accelerometer along with integrated circuitry. The circuitry controls each detector, operates the self-test circuitry, conditions the signals f |
| 7530218 |
Pulsed plasma thruster using vapor |
May 12, 2009 |
| A pulsed plasma thruster (PPT) and a method of making the PPT are disclosed. The PPT includes no moving parts and can be made in a small size. The PPT can achieve long operating duration by using vapor as a fuel. Liquid used to form the vapor can be easily stored and can provide an a |
| 7519714 |
Adaptive image format translation in an ad-hoc network |
April 14, 2009 |
| The invention presented hereby is an apparatus and method for developing a common protocol between a data source such as a scanner and a recipient in real time. It includes means for evaluating the protocol format of a data user, which may be any apparatus requiring input data, to ascert |
| 7517325 |
Automated chest compression apparatus with a bladder between the belt and the patient |
April 14, 2009 |
| A system applies cardiopulmonary resuscitation (CPR) to a recipient. An automated controller is provided together with a compression device which periodically applies a force to a recipient's thorax under control of the automated controller. A band is adapted to be placed around a portio |
| 7515953 |
Techniques for identifying molecular structures and treating cell types lining a body lumen usin |
April 7, 2009 |
| Techniques for detecting fluorescence emitted by molecular constituents in a wall of a body lumen include introducing an autonomous solid support into the body lumen. Cells in a lumen wall of the body lumen are illuminated by a light source mounted to the solid support with a wavelen |
| 7514216 |
Methods for generating hypermutable yeast |
April 7, 2009 |
| Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast cells with the defective mismatch repair system are hypermutable, but after selection of |
| 7507536 |
Methylation markers for diagnosis and treatment of ovarian cancer |
March 24, 2009 |
| Twenty-three markers are provided which are epigenetically silenced in ovarian cancers. The markers can be used diagnostically, prognostically, therapeutically, and for selecting treatments that are well tailored for an individual patient. Restoration of expression of silenced genes can |
| 7494981 |
Inhibition of interaction of PSD93 and PSD95 with nNOS and NMDA receptors |
February 24, 2009 |
| PSD-95/SAP90 antisense-treated animals not only experience a significant decrease in MAC for isoflurane, but also experience an attenuation in the NMDA-induced increase in isoflurane MAC. PSD-95/SAP90 appears to mediate the role of the NMDA receptor in determining the MAC of inhalational |
| 7494769 |
Method and apparatus for detection of bioaerosols |
February 24, 2009 |
| A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaero |
| 7491499 |
Method for diagnosing or predicting susceptibility to psychiatric disorders |
February 17, 2009 |
| The present invention provides a method for diagnosing or predicting susceptibility to a psychiatric disorder in an individual, which comprises confirming molecular diversity and/or subcellular distribution of DISC 1 in the cell from the individual. In addition, a novel risk haplotyp |
| 7488815 |
Gene imprinting and methylated CpG islands |
February 10, 2009 |
| Genomic imprinting is a parent of origin-dependent gene silencing that involves marking of alleles in the germline and differential expression in somatic cells of the offspring. Imprinted genes and abnormal imprinting have been implicated in development, human disease, and embryonic |
| 7485418 |
Aberrantly methylated genes in pancreatic cancer |
February 3, 2009 |
| The present invention provides a method for detecting pancreatic carcinoma in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory |
| 7477927 |
System and method for laser based computed tomography and magnetic resonance registration |
January 13, 2009 |
| A method and system for laser based instrument registration. The system includes an operating table coupled with a robot holding an instrument, and CT scanner. The CT scanner has first and second laser markers. The method includes moving the robot to align the instrument in a first p |
| 7475053 |
Method and system for the autonomous design of cybernetic systems |
January 6, 2009 |
| A system and method is provided for constructing optimal based systems. The method is based on a process of formalized rational inquiry, measurement and planned action. More particularly, the method relies upon the precise determination of alternatives through inquiry, a formal logic |
| 7471742 |
Method and construction for space-time codes for AM-PSK constellations |
December 30, 2008 |
| Space-time codes are developed for multi-radii AM-PSK constellations. Further, a "super-unified" space-time code construction is developed that incorporates multi-radii AM-PSK codes with the Lu-Kumar unified codes. The multi-radii space-time codes achieve the rate-diversity tradeoff- |
| 7468425 |
p40 protein acts as an oncogene |
December 23, 2008 |
| We have discovered p40, the shortest variant of a new human p53 homologue (p40/p51/p63/p73H). We have also found that it plays a role in cancer. Low level amplification of the p40 locus accompanied by RNA and protein overexpression was observed in primary lung cancers, and head and neck |
| 7468274 |
Single cell analysis of HIV replication capacity and drug resistance |
December 23, 2008 |
| A novel single-cell-level phenotypic assay is described, which can simultaneously analyze HIV-1 drug susceptibility and intrinsic replication capacity. This allows quantitative dissection of the functions of antiretroviral drugs into suppression of viral replication and selection of |
| 7465050 |
Method and apparatus for three-dimensional video-oculography |
December 16, 2008 |
| A device for measuring the three-dimensional movements of an eye includes: (a) a mark array that identifies prescribed positions on the eye whose movements are to be measured, (b) a digital camera for capturing the two-dimensional images of this marker array as the eye is moved, (c) a |
| 7458248 |
Method and apparatus to detect genuine or hoax contaminants |
December 2, 2008 |
| A system (100) and method for detecting contaminants in parcels or other mailings (110). The contaminants, either genuine or hoax, are detected using the system (100) that includes a jogger (140) that shakes the parcels or other mailings (110). The system (100) further comprises a pa |
| 7455408 |
Method and apparatus for reducing visual aberrations |
November 25, 2008 |
| A light source is situated on a headgear device and placed to direct light toward the pupil of the eye at an intensity that causes the iris to constrict, resulting in a smaller pupil. This prevents the light scattering due to ophthalmic surgery or eye injury from entering the eye, th |
| 7442513 |
Method of screening for agents that modulate a homer signaling pathway |
October 28, 2008 |
| The invention features a method of identifying, evaluating and screening for compounds or agents for the treatment of disorders involving the Homer signaling pathway in the modulation of immunosupression and neuroprotection. The method includes evaluating the ability of agents to mod |
| 7441444 |
AFM cantilevers and methods for making and using same |
October 28, 2008 |
| The invention provides high performance cantilevers with optimal combinations of high resonant frequency and low force constant. In one aspect, AFM cantilevers with spring constants in the range 1-10.sup.-6 N/m with (fundamental) resonant frequencies in aqueous solutions of 0.1-100 M |
| 7432246 |
Sir2 products and activities |
October 7, 2008 |
| A novel compound, 2'/3'-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2' and 3' regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2'-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated |
| 7429250 |
CPR chest compression monitor and method of use |
September 30, 2008 |
| Chest compressions are measured and prompted to facilitate the effective administration of CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of the CPR recipient's chest toward the recipient's spine. A signaling mechanism provides chest |
| 7422568 |
Device, systems and methods for localized heating of a vessel and/or in combination with MR/NMR |
September 9, 2008 |
| Featured are devices, systems and methods for localized heating of a vessel as well as devices, systems and methods for MR/NMR imaging of a vessel while locally heating a portion of the vessel. More particularly featured are such devices, systems and methods for use when administering |
