| Patent Number |
Title Of Patent |
Date Issued |
| 6800122 |
Permanent, removable tissue markings |
October 5, 2004 |
| The present invention provides microparticles that create permanent tissue markings, such as tattoos, designed in advance for change and/or removal on demand, as well as methods for implanting the microparticles in tissue and changing and/or removing the resulting markings. Colored m |
| 6794133 |
Broad range PCR amplification techniques |
September 21, 2004 |
| Disclosed herein are methods and kits for determining whether a nucleic acid sequence includes a particular allele of a polymorphic sequence. These methods and kits focus on two sets of primers that are specific for an allele and are contacted with a nucleic acid sequence. One primer in |
| 6786933 |
Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices |
September 7, 2004 |
| A medical prosthesis for use within a body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radial. Preferred prosthesis exhibits reduced production of particles from the prosthesis during wear of the prosthesis, and ar |
| 6780973 |
Eotaxin: an eosinophil chemoattractant |
August 24, 2004 |
| Disclosed is substantially pure eotaxin DNA sequence and eotaxin polypeptide, and methods of using such DNA and polypeptide to direct chemotaxis of eosinophils. Methods are provided for the treatment diseases and disorders such as inflammation and tumorigenesis. |
| 6773881 |
Methods of modulating hair growth |
August 10, 2004 |
| A method of modulating hair growth and/or hair thickness. The method includes modulating VEGF activity, e.g., modulating VEGF gene expression and/or modulating VEGF protein production and/or activity, to modulate hair growth and/or thickness. The methods can be used to either promote or |
| 6773673 |
Radiation handling system and set |
August 10, 2004 |
| A radioactive material such as an unstable isotopic gas is provided to a receiving chamber (1) directly from a source to form a purified or enriched bubble. The bubble is passed to a fluid handling set for preparation of the reagent or other delivery system. In an exemplary embodimen |
| 6770632 |
Folypolyglutamyl synthetase gene transfer to enhance antifolate |
August 3, 2004 |
| Methods of killing neoplastic cells are provided. The invention relates to the use of folylpolyglutamyl synthetase (FPGS) gene transfer to enhance the sensitivity of several types of tumor cells to polyglutamylatable antifolate drugs, such as methotrexate (MTX) and edatrexate (EDX). |
| 6770274 |
Viral mutant HSV mediated destruction of neoplastic cells |
August 3, 2004 |
| The present invention is drawn to compositions and methods for selectively killing neoplastic cells. Altered viruses are utilized which are capable of replication in neoplastic cells while sparing surrounding normal tissue. |
| 6759245 |
Cell culture systems and methods for organ assist devices |
July 6, 2004 |
| The invention features modular cell culturing devices including one or more flat-plate modules, and is based on the discovery that if the flows of liquid medium and oxygenated fluid are separated by a gas-permeable, liquid-impermeable membrane, and the cells are grown attached to the |
| 6759201 |
Method of identifying a neural progenitor cell by evaluating expression of daedalos |
July 6, 2004 |
| The invention provides Daedalos polypeptides, nucleic acids encoding Daedalos polypeptides, and methods of using Daedalos polypeptides and nucleic acids. Also included in the invention are methods of diagnosis, methods of treatment, methods of detection, and methods of controlling ne |
| 6753162 |
Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
June 22, 2004 |
| Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion |
| 6750235 |
Pramipexole as a treatment for cocaine craving |
June 15, 2004 |
| Disclosed herein are methods foe reducing stimulant dependency or craving, involving administration of a therapeutically-effective amount of a dopamine agonist, such as pramipexole. |
| 6749850 |
Methods, compositions and kits for promoting recovery from damage to the central nervous system |
June 15, 2004 |
| The present application relates to methods, kits and compositions for improving a subject's recovery from CNS injury. In certain aspects, methods of the invention comprise administering to a subject cells and a neural stimulant. Recovery may be manifest by improvements in sensorimotor |
| 6747795 |
Fiber-coupled multiplexed confocal microscope |
June 8, 2004 |
| A confocal microscope system that is inherently fiberoptic compatible is described which has line scanning aided image formation. An incoherent fiberoptic bundle maps a line illumination pattern into a dispersible group of separate sources, and then remaps this confocally selected re |
| 6743226 |
Adjustable trans-urethral radio-frequency ablation |
June 1, 2004 |
| A device for enlarging a urethral passage includes an elongate member having a distal portion configured for intraurethral placement in the urethral passage, and an electrode at the distal portion. The electrode is configured to be energized with high frequency energy to necrose tissue o |
| 6737247 |
Imaging of enzymatic activity |
May 18, 2004 |
| The invention features methods of detecting enzymatic activity (e.g., in a magnetic resonance image). In general, the methods include: (1) providing a monomeric substrate (e.g., a substrate that is polymerizable in the presence of an enzyme or as a result of an enzyme-catalyzed reaction) |
| 6728560 |
Non-invasive tissue glucose level monitoring |
April 27, 2004 |
| Instruments and methods for performing non-invasive measurements of analyte concentrations and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels. |
| 6720547 |
System and method for enhancing confocal reflectance images of tissue specimens |
April 13, 2004 |
| A confocal scanning microscope system (10) using cross polarization effects and an enhancement agent (acetic acid) to enhance confocal microscope reflectance images of the nuclei of BCCs (basal cell carcinomas) and SCCs (squamous call carcinomas) in the confocal reflectance images of exc |
| 6720309 |
Method of inducing vasodilation and treating pulmonary hypertension using adenoviral-mediated tr |
April 13, 2004 |
| This invention relates to a gene therapy method for inducing pulmonary vasodilation. More specifically, this invention involves introducing the nitric oxide synthase gene into lungs resulting in pulmonary vasodilation. This results in a hypotensive effect in the pulmonary circulation whi |
| 6719977 |
Methods to potentiate cancer therapies |
April 13, 2004 |
| Disclosed are methods for potentiating the anti-cancer properties of an anti-cancer therapy in a mammal by administering with the therapy a compound (such as relaxin or .gamma.-IFN) that has a tissue tensile modulus-reducing property, an ability to reduce the interstitial viscosity o |
| 6718986 |
Mixed chimerism and tolerance |
April 13, 2004 |
| A method of inducing tolerance without whole body irradiation. |
| 6712617 |
Methods of preventing UVB-induced skin damage |
March 30, 2004 |
| The invention features a method preventing or treating long-term UVB-induced wrinkles in a subject. The method includes inhibiting angiogenesis in the skin of the subject. |
| 6706764 |
Use of creatine or creatine analogs for the treatment of diseases of the nervous system |
March 16, 2004 |
| The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents against a variety of di |
| 6706032 |
Localized molecular and ionic transport to and from tissues |
March 16, 2004 |
| The present invention relates to methods and devices used for the formation of microconduits in a tissue. The term "microconduit" refers to a small opening, channel, or hole into, or through, a tissue, that allows transfer of materials by liquid flow, and by electrophoresis, the microcon |
| 6699663 |
Molecular sequence of swine retrovirus |
March 2, 2004 |
| Purified nucleic acid which can specifically hybridize with the sequence of swine retroviruses. |
| 6693169 |
Laminin 5, 13 and 14 and uses thereof |
February 17, 2004 |
| The present invention features two members of laminin family, i.e., laminin 13 and laminin 14, the methods of making these molecules, and the methods of using these molecules in treating neural disorders, e.g., retinal disorders. The present invention also features using a preparation of |
| 6692738 |
Delivery of therapeutic biologicals from implantable tissue matrices |
February 17, 2004 |
| Normal cells, such as fibroblasts or other tissue or organ cell types, are genetically engineered to express biologically active, therapeutic agents, such as proteins that are normally produced in small amounts, for example, MIS, or other members of the TGF-beta family Herceptin.TM., int |
| 6692493 |
Method for performing intraurethral radio-frequency urethral enlargement |
February 17, 2004 |
| Relief of urethral obstruction is achieved by heat ablation of prostatic tissue by an ablation electrode passed within the urethra to a position in the prostate near the point of urethral obstruction. The electrode is coupled to a high frequency power supply to ablatively heat the urethr |
| 6689094 |
Compound delivery using impulse transients |
February 10, 2004 |
| A method for delivering compounds through epithelial cell layers using impulse transients is described. The method involves applying a compound to, e.g., the stratum corneum, of a patient and then inducing impulse transients to create transient increases in the permeability of epithelial |
| 6682911 |
Laminins and uses thereof |
January 27, 2004 |
| The present invention is based on the discovery of a novel member of the laminin family, laminin 12. Accordingly, the present invention features a purified or isolated preparation or a recombinant preparation of laminin 12 which includes an .alpha.2 subunit, .beta.1 subunit and a .gamma. |
| 6680068 |
Drug delivery formulations and targeting |
January 20, 2004 |
| The invention is based on the discovery that angiogenic vessels have heterogeneous surface charge and that cationic liposomes actually target human tumor blood vessels only in irregularly shaped patches. The invention thus features methods for delivering therapeutic compounds to angi |
| 6677155 |
Triple hybrid amplicon vector systems to generate retroviral packaging lines |
January 13, 2004 |
| The present invention relates to a triple hybrid vector amplicon system comprising genetic elements derived from Herpes Simplex Virus (HSV), Epstein-Barr Virus (EBV) or Adeno-Associated Virus (AAV), and a retrovirus. The vector was developed to stably transform cells, both in culture |
| 6673909 |
Oligonucleotides for dysferlin, a gene mutated in distal myopathy and limb girdle muscular dystr |
January 6, 2004 |
| A novel gene and the protein encoded therein, i.e., dysferlin, are disclosed. This gene and its expression products are associated with muscular dystrophy, e.g., Miyoshi myopathy and limb girdle musclular dystrophy 2B. |
| 6673602 |
Herpes simplex virus amplicon vector targeting system and method of using same |
January 6, 2004 |
| The present invention relates to herpes simplex virus (HSV) amplicon vectors, and in particular, HSV-1 amplicon vectors, which have been genetically modified and used alone or with consequent genetically modified HSV virus, to target a selected cell type, such as neoplastic cells. Th |
| 6673352 |
Use of Mullerian inhibiting substance for treating excess androgen states |
January 6, 2004 |
| The present invention provides a method of treating a condition or disease characterized by an excess of one or more androgens, the method comprising administering an effective amount of MIS protein or nucleic acid encoding MIS to a patient. The present invention also provides a method o |
| 6667297 |
Methods for treating neuropsychiatric disorders |
December 23, 2003 |
| The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer's Disease, autism, depression, benign forgetfulness, childhood learning disorders, close head injury, and attention deficit disorder. The methods entail administering to a patient |
| 6663658 |
Phototherapy method for treatment of acne |
December 16, 2003 |
| The present invention is directed to methods for treating acne. The methods include exposing the subject afflicted with acne to ultraviolet light having a wavelength between about 320 to about 350 nm, such that the acne is treated, e.g., inhibited, diminished, eradicated or prevented. In |
| 6660487 |
Treatment of autoimmune disease |
December 9, 2003 |
| The present invention features a novel combination therapy useful in the treatment of autoimmune disease that increases or maintains the number of functional cells of a predetermined type in a mammal by killing or inactivating autoimmune cells and re-educating the host immune system. |
| 6656705 |
Sciellin and uses thereof |
December 2, 2003 |
| The present invention relates to novel epidermal protein, sciellin. Sciellin polypeptides comprise an N-terminal domain, a central domain containing sixteen repeats and a C-terminal LIM domain. Sciellin polypeptides may function as precursors of the cornified envelope of keratinizing |
| 6656452 |
Use of inhaled NO as anti-inflammatory agent |
December 2, 2003 |
| A method for lessening or preventing non-pulmonary ischemia-reperfusion injury or inflammation in a mammal by identifying a mammal which has ischemia-reperfusion or is at risk for developing ischemia-reperfusion in a non-pulmonary tissue; and causing the mammal to inhale a therapeuticall |
| 6652456 |
Medical screening |
November 25, 2003 |
| Mass medical, e.g., cervical cancer, screening is provided to areas of the world where a lack of sufficient laboratory infrastructure and technical skills presently compromises the effectiveness of screening or even makes mass screening impossible. These methods are cost-effective and pr |
| 6642368 |
Programmed cell death and caspase-12 |
November 4, 2003 |
| This invention relates to nucleic acids encoding caspase-12, proteins encoded by casp-12 nucleic acids, vectors, and hosts transformed with vectors. Caspase-12 is a member of the caspase family, which also includes mammalian interleukin-1.beta.-converting enzyme (ICE). Caspases are t |
| 6639130 |
Plant sterol reductases and uses thereof |
October 28, 2003 |
| Disclosed are plant DNA molecules encoding C-14 sterol reductase polypeptides, as well as plant DNA molecules encoding polypeptides having at least 50% identity to the Arabidopsis C-14 sterol reductase; and vectors, cells and plants expressing such DNA. Also provided are methods for |
| 6638711 |
Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation acti |
October 28, 2003 |
| The invention relates to methods for identifying candidate pharmacological agents to be used in the treatment and/or prevention of Alzheimer's disease and/or related pathological conditions. |
| 6635616 |
Laminin 15 |
October 21, 2003 |
| The present invention features a novel member of the laminin family, i.e., laminin 15, the methods of making these molecules, and the methods of using these molecules in treating neural disorders, e.g., retinal disorders. |
| 6633161 |
RF coil for imaging system |
October 14, 2003 |
| An RF coil suitable for use in imaging systems is provided which coil has a dielectric filled cavity formed by a surrounding conducting enclosure, the conducting enclosure preferably being patterned to form continuous electrical paths around the cavity, each of which paths may be tuned t |
| 6632924 |
Method of measuring plasma membrane targeting of GLUT4 |
October 14, 2003 |
| A method of measuring translocation of a protein in cells from an intracellular location to a plasma membrane or from the plasma membrane to an intracellular location, with particular reference to GLUT4 and modified GLUT4 useful in the method. |
| 6632602 |
Plant sugar sensors and uses thereof |
October 14, 2003 |
| Disclosed are methods and genes for manipulating the sugar-sensing capabilities of a plant, involving reducing or increasing the level of a hexokinase protein in a transgenic plant. |
| 6632223 |
Pulmonary vein ablation stent and method |
October 14, 2003 |
| A system for treating atrial fibrillation includes a stent and a delivery catheter for carrying the stent to a treatment site. The stent is self-expanding, for example, being formed of a shape memory alloy, and is configured to lodge against the interior wall of a pulmonary vein. The |
| 6630347 |
Endothelial NOS transgenic animals and methods of use |
October 7, 2003 |
| This invention relates to transgenic non-human animals comprising a disrupted endothelial nitric oxide synthase gene. These animals exhibit abnormal wound-healing properties and hypertension. This invention also relates to methods of using the transgenic animals to screen for compounds |
