| Patent Number |
Title Of Patent |
Date Issued |
| 7141363 |
Purposeful movement of human migratory cells away from an agent source |
November 28, 2006 |
| This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of cells of hematopoietic, neural, epithelial, or mesenchymal origin, in a |
| 7138486 |
Insulinotropic hormone derivatives and uses thereof |
November 21, 2006 |
| Derivatives of glucagon-like peptide I (GLP-1) and especially GLP-1 (7-37) have been found to have insulinotropic activity. The invention pertains to a composition comprising an acid addition salt of GLP-I (7-37) and to a composition comprising a carboxylate salt of GLP-I (7-37). The |
| 7138380 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention |
November 21, 2006 |
| Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential |
| 7138253 |
Streptavidin-binding peptides and uses thereof |
November 21, 2006 |
| The invention provides peptides with high affinity for streptavidin. These peptides may be expressed as part of fusion proteins to facilitate the detection, quantitation, and purification of proteins of interest. |
| 7132260 |
DNA encoding parathyroid hormone receptor |
November 7, 2006 |
| DNA encoding a parathyroid hormone receptor; production and isolation of recombinant and synthetic parathyroid hormone receptor polypeptides and fragments; antibodies to parathyroid hormone receptors and receptor fragments; methods for screening candidate compounds for antagonistic or |
| 7125666 |
Collagen XXII, a novel human collagen and uses thereof |
October 24, 2006 |
| The invention provides isolated nucleic acids molecules, designated collagen XXII nucleic acid molecules, which encode a novel collagen. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing collagen XXII nucleic acid molecules, host |
| 7119183 |
Rapid immunoselection cloning method |
October 10, 2006 |
| A simple and highly efficient method for cloning cDNAs including CD27 (SEQ ID NO:28) from mammalian expression libraries based on transient expression in mammalian host cells has been discovered. Novel expression vectors allowing highly efficient construction of mammalian cDNA librar |
| 7115711 |
Retinoid X receptor-interacting polypeptides and related molecules and methods |
October 3, 2006 |
| Disclosed is a method for determining whether a test protein is capable of interacting with a retinoid X receptor protein. The method involves: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses |
| 7115120 |
Selective photocoagulation |
October 3, 2006 |
| Selective photocoagulation of particular cells, tissue or portion of tissue can be aided by monitoring microcavitation within the material exposed to electromagnetic radiation (12). The information gained by the detection of microcavitation events can be used to modulate the intensity |
| 7112716 |
Methods for screening and identifying host pathogen defense genes |
September 26, 2006 |
| Disclosed are methods for identifying nematodes having enhanced susceptibility to a pathogen; for identifying pathogen defense response genes; and for identifying compounds that enhances a host's defense response to a pathogen. |
| 7110114 |
System and method for enhancing confocal reflectance images of tissue specimens |
September 19, 2006 |
| A confocal scanning microscope system (10) using cross polarization effects and an enhancement agent (acetic acid) to enhance confocal microscope reflectance images of the nuclei of BCCs (basal cell carcinomas) and SCCs (squamous call carcinomas) in the confocal reflectance images of |
| 7107092 |
Methods for diagnosing a neurodegenerative condition |
September 12, 2006 |
| A method of diagnosing, prognosing, staging, and/or monitoring a mammalian amyloidogenic disorder or a predisposition thereto by detecting a protein or polypeptide aggregate in the cortical and/or supranuclear regions of an ocular lens of the mammal. |
| 7105678 |
Boat tropanes |
September 12, 2006 |
| Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin |
| 7104965 |
Interactive system and method for peripheral nerve mapping and blocking |
September 12, 2006 |
| A system for providing nerve mapping in human patients, which includes a processor coupled to a pulse generator and to a multi-position switch. The system further includes a conductive needle having a first end adapted for insertion into tissue and a second end coupled to a negative |
| 7094889 |
AGE-1 polypeptides and related molecules and methods |
August 22, 2006 |
| Disclosed are substantially pure AGE-1 polypeptides and purified DNAs, vectors, and cells encoding those polypeptides. Also disclosed are methods for determining longevity and isolating antagonists using the AGE-1 sequence. |
| 7094601 |
Microinjection of cryoprotectants for preservation of cells |
August 22, 2006 |
| A preservation method for biological material having cell membranes includes microinjecting the cells with sugar; preparing the cells for storage; storing the biological material; and recovering the stored biological material from storage. The invention also features a method of cult |
| 7094599 |
Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
August 22, 2006 |
| Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion |
| 7087717 |
Sp110, a polypeptide component of the nuclear body |
August 8, 2006 |
| Cloning and characterization of a full length cDNA encoding Sp110 (speckled 110), a novel 110 kDa polypeptide, is disclosed. It is disclosed that Sp110 is a component of the nuclear body, is expressed in leukocytes, and is also expressed in other types of cells, including endothelial |
| 7084323 |
Stress-protected transgenic plants |
August 1, 2006 |
| Disclosed are methods for increasing a plant's tolerance to environmental stress. |
| 7081349 |
High-affinity melatonin receptor and uses thereof |
July 25, 2006 |
| Disclosed are cDNAs and DNAs encoding high-affinity melatonin 1a and 1b receptors and the recombinant polypeptides expressed from such cDNAs. The recombinant receptor polypeptides, receptor fragments and analogs expressed on the surface of cells are used in methods of screening candi |
| 7081238 |
Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level |
July 25, 2006 |
| A method of diagnosing attention deficient-hyperactivity disorder (ADHD) in a human patient by assessing the level of dopamine transporter in at least one region of the patient's central nervous system, where an elevated level of dopamine transporter in the patient is indicative of A |
| 7078584 |
Salmonella typhimurium-infected Caenorhabditis elegans for identifying inhibitors of infection |
July 18, 2006 |
| Disclosed are screening methods for identifying the interplay between environmental and host signals (e.g., host-dependent or host-independent signals) and physiological pathogenic pathways that control or regulate genes responsible for establishing a persistent infection, as in the |
| 7078500 |
Genetic immunization with nonstructural proteins of hepatitis C virus |
July 18, 2006 |
| Nucleic acid molecule that comprise a hepatitis C nonstructural protein including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising a hepatitis C nonstructural protein including a nucleotide sequence encodin |
| 7078487 |
PTH1R receptors |
July 18, 2006 |
| The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid |
| 7078032 |
Delivery of therapeutic biologicals from implantable tissue matrices |
July 18, 2006 |
| Normal cells, such as fibroblasts or other tissue or organ cell types, are genetically engineered to express biologically active, therapeutic agents, such as proteins that are normally produced in small amounts, for example, MIS, or other members of the TGF-beta family Herceptin.TM., |
| 7077840 |
Heads for dermatology treatment |
July 18, 2006 |
| Methods and apparatus for dermatology treatment are provided which involve the use of continuous wave (CW) radiation, preheating of the treatment volume, precooling, cooling during treatment and post-treatment cooling of the epidermis above the treatment volume, various beam focusing |
| 7073510 |
Photochemical tissue bonding |
July 11, 2006 |
| Photochemical tissue bonding methods include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin |
| 7070772 |
Salicylic acid biosynthetic genes and uses thereof |
July 4, 2006 |
| The invention provides methods for inducing or increasing disease resistance in a plant. The invention also features methods of using a plant having a mutation in an inducible isochorismate synthase to determine if the success of a pathogen in infecting a plant is affected by a plant |
| 7064180 |
High affinity integrin polypeptides and uses thereof |
June 20, 2006 |
| Polypeptides comprising all or part of a variant integrin .alpha. subunit A domain or a variant integrin .beta. subunit A-like domain are described. In solution or in membrane-associated form, the A domain or the A-like domain of the polypeptides of the invention exists predominantly |
| 7060251 |
Imaging agents for early detection and monitoring of cardiovascular plaque |
June 13, 2006 |
| The invention provides imaging agents comprising a label in association with a plaque specific targeting molecule. Methods for using the imaging agents to diagnose or monitor plaque formation and growth and kits containing the cardiovascular agents or components suitable for producti |
| 7060061 |
Method and apparatus for the selective targeting of lipid-rich tissues |
June 13, 2006 |
| A method and apparatus are provided for targeting lipid-rich tissue to effect a desired, the method/apparatus involving irradiating the lipid-rich tissue with energy at a wavelength preferentially absorbed by lipid cells, such wavelength being preferably in a band between 880 nm and |
| 7057012 |
PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor |
June 6, 2006 |
| Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1 34) fragment are disclosed that combine the N-terminal signaling domain (residues 1 9) and the C-terminal binding domain (residues 15 31) via a linker. Nucleic acid molecules and peptides for PTH(1 9)-(Gly)5-PTH(15 |
| 7049423 |
Use of the RTX secretion system to achieve heterologous polypeptide secretion by Vibrio cholerae |
May 23, 2006 |
| Compositions and methods for secreting large heterologous polypeptides are described. |
| 7049136 |
Redirection of cellular immunity by receptor chimeras |
May 23, 2006 |
| Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an auto |
| 7047055 |
Fetal pulse oximetry |
May 16, 2006 |
| A fetal blood pulse oximetry method and apparatus using a first wavelength of light at about 655 to 705 nm and a second wavelength of light at about 820 to 900 nm. Measurements are taken through a mother's abdomen. Processing is performed to extract absorption information related to |
| 7045616 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention |
May 16, 2006 |
| Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also disclosed is the use of such transgenic animals and transfected cell lines to screen potential |
| 7045531 |
Composition comprising a metal chelator and a method of treating amyloidosis by administering th |
May 16, 2006 |
| The invention relates to the identification of pharmacological agents to be used in the treatment of Alzheimer's disease and related pathological conditions. Methods and compositions for treatment of conditions caused by amyloidosis, A.beta.-mediated ROS formation, or both, such as A |
| 7045306 |
Method for identifying compounds in vitro that modulate the dysregulation of transcription of tr |
May 16, 2006 |
| The invention relates to methods and products for deregulating gene transcription in neurodegenerative disease associated with an expanded polyglutamine tract in mutant proteins. The invention is useful for preventing and treating diseases associated with expanded polyglutamine tract |
| 7044959 |
Method and apparatus for hair growth management |
May 16, 2006 |
| A method and apparatus are provided for hair growth management by applying low energy optical radiation to a treatment area of a patient's skin, which radiation is sufficient to at least traumatize a matrix portion of each follicle being treated, but not to cause either necrosis of most |
| 7041448 |
Gene encoding a new TRP channel is mutated in mucolipidosis IV |
May 9, 2006 |
| The present invention relates to identification of a gene that is inactivated in a mucolipidosis condition. In particular, the invention concerns mutations that disrupt a mucolipin, preferably MCOLN1, in mucolipidosis IV. Recombinant nucleic acids encoding mutant forms of MCOLN1, oli |
| 7041437 |
Therapeutic and diagnostic tools for impaired glucose tolerance conditions |
May 9, 2006 |
| Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions. |
| 7041290 |
Molecules and methods for inhibiting shedding of KIM-1 |
May 9, 2006 |
| Disclosed are antibodies that inhibit proteolytic release of a soluble KIM-1 polypeptide from KIM-1 expressing cells. Also disclosed are methods of using the antibodies to inhibit shedding of the KIM-1 polypeptide. |
| 7034531 |
Diffusion MRI using spherical shell sampling |
April 25, 2006 |
| A diffusion MRI technique that employs a sampling/reconstruction scheme that samples the diffusion signal directly on the sphere and reconstructs the diffusion function directly on the sphere is presented. |
| 7033773 |
Screening assays for G protein coupled receptor agonists and antagonists |
April 25, 2006 |
| Parathyroid hormone (PTH) and its closely related peptide, PTHrP, share the same receptor, PTHR. LLC-PK1 cells are porcine renal epithelial cells which do not normally express PTHR. The present-invention provides stably transfected LLC-PK1 cells which express human PTHR. Also provided ar |
| 7033768 |
Reverse two-hybrid systems |
April 25, 2006 |
| Disclosed are methods for identifying molecular interactions (e.g., protein/protein, protein/DNA, protein/RNA, or RNA/RNA interactions). All of the methods within the invention employ counterselection and at least two hybrid molecules. Molecules which interact reconstitute a transcri |
| 7026466 |
Serotonin-gated anion channel |
April 11, 2006 |
| Disclosed is a novel serotonin-gated anion channel that is permeable to chloride ions. Also disclosed are methods for the screening of therapeutics useful for treating serotonin-mediated cellular responses and conditions, as well as diagnostic methods for identifying such conditions. |
| 7022815 |
Polypeptide derivatives of parathyroid hormone (PTH) |
April 4, 2006 |
| Novel parathyroid hormone(PTH) polypeptide derivatives are disclosed, as are pharmaceutical compositions containing said polypeptides, and synthetic and recombinant methods for producing said polypeptides. Also disclosed are methods for treating mammalian conditions characterized by |
| 7020578 |
Method for evaluating novel, stroke treatments using a tissue risk map |
March 28, 2006 |
| A method of evaluating novel stroke treatments includes generating a risk map indicative of the probability of tissue infarction on voxel-by-voxel basis and selecting a probability range for evaluating the therapeutic effect of the novel treatment. In one particular embodiment, tissue |
| 6997923 |
Method and apparatus for EMR treatment |
February 14, 2006 |
| A method and apparatus are provided for performing a therapeutic treatment on a patient's skin by concentrating applied radiation of at least one selected wavelength at a plurality of selected, three-dimensionally located, treatment portions, which treatment portions are within non-t |
| 6991936 |
Gridlock nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods |
January 31, 2006 |
| The invention provides a novel gene, gridlock, and its encoded protein. gridlock plays a role in vascular development and modeling, and a mutation in gridlock has been associated with an aortic arch disease, coarctation. Thus, gridlock nucleic acid molecules and polypeptides can be u |
