| Patent Number |
Title Of Patent |
Date Issued |
| RE37919 |
Recombinant DNA method for production of parathyroid hormone |
December 3, 2002 |
| A recombinant DNA molecule coding for human parathyroid hormone operably linked to an inducible bacterial promoter, a leader growth hormone sequence, and a selective enzymatic cleavage site, expression of the molecule in bacteria, and methods for producing large quantities of human p |
| RE35152 |
Method for the diagnosis and treatment of inflammation |
February 6, 1996 |
| The invention relates to a method of detecting an inflammation site in an individual by administering to the individual a diagnostically effective amount of detectably labeled immunoglobulin or fragment thereof, wherein the immunoglobulin substantially accumulates at the site when the si |
| 7432706 |
Magnetic resonance imaging using blood flow navigation |
October 7, 2008 |
| An fMRI study is conducted using a 2D EPI pulse sequence. A separate blood flow navigator pulse sequence is interleaved with the fMRI data acquisition to monitor blood flow in arteries that feed the brain tissue. Information in the blood flow navigator data is used to reduce errors in |
| 7429383 |
Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion |
September 30, 2008 |
| The invention relates to methods for manipulating hematopoietic progenitor cells and related products. In one aspect the invention relates to the use of agents that activate a PTH/PTHrP receptor to enhance the growth and maintenance of hematopoietic progenitor cells in vivo and in vitro, |
| 7427486 |
Mullerian inhibiting substance levels and ovarian response |
September 23, 2008 |
| Methods and kits are provided for assessing the ovarian reserve and predicting the ovarian response to fertility treatments in a female subject. The serum levels of MIS are shown to be positively correlated with the production and retrieval of mature oocytes and serve as prognostic i |
| 7418169 |
Apparatus for controlling at least one of at least two sections of at least one fiber |
August 26, 2008 |
| An apparatus for controlling at least one of at least two sections of at least one fiber can be provided. The apparatus can include an arrangement which may be provided between the first and second sections of a particular continuous fiber of the fibers. A particular one of the first |
| 7414169 |
Therapeutic and diagnostic tools for impaired glucose tolerance conditions |
August 19, 2008 |
| Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for identifying or treating such conditions. |
| 7408039 |
Kits for treatment of hematologic disorders |
August 5, 2008 |
| The inventors have discovered that hematologic disorders, e.g., both neoplastic (hematologic cancers) and non-neoplastic conditions, can be treated by the induction of mixed chimerism using myeloreductive, but not myeloablative, conditioning. Methods of the invention reduce GVHD, esp |
| 7407756 |
Methods for detecting mutations associated with familial dysautonomia |
August 5, 2008 |
| This invention relates to methods and compositions useful for detecting mutations which cause Familial Dysautonomia. Familial dysautonomia (FD; Riley-Day syndrome), an Ashkenazi Jewish disorder, is the best known and most frequent of a group of congenital sensory neuropathies and is |
| 7399847 |
Nucleic acids encoding artificial P-selectin ligands |
July 15, 2008 |
| Disclosed herein are organic molecules to which are covalently bonded a sialyl-Le.sup.x determinant and a sulfated determinant, at least one of these determinants being positioned at a non-naturally occurring site on the molecule. Also disclosed are particular P-selectin ligands and |
| 7396658 |
Methods for screening HIF like ouabain-resistant Na.sup.+--K.sup.+-ATPase agents |
July 8, 2008 |
| The present invention relates to rapid, quantitative, specific, high through-put methods for screening test substances for their ability to inhibit activity of an ouabain-resistant Na.sup.+--K.sup.+-ATPase involved in a variety of biological processes such as regulation of osmotic ba |
| 7395120 |
Telescoping, dual-site pacing lead |
July 1, 2008 |
| A lead with a proximal electrode and a telescoping distal electrode enables dual-site electrical pacing or stimulation of a heart or another organ. The lead includes an outer tube with a proximal electrode and an inner tube connected to a distal electrode. The inner tube is concentric |
| 7394252 |
Regularized GRAPPA reconstruction |
July 1, 2008 |
| The invention relates to a method for reconstructing a fully sampled k-space data set. An undersampled GRAPPA scan of a subject is performed in a parallel MRI system using a set of receiver coil elements and corresponding receiver channels to obtain a reduced k-space data set. Autoca |
| 7390634 |
.beta.-netrin and uses thereof |
June 24, 2008 |
| .beta.-netrin nucleic acid molecules and polypeptides are provided. Methods of using the .beta.-netrin nucleic acid molecules and polypeptides are also provided. |
| 7388093 |
Gene for identifying individuals with familial dysautonomia |
June 17, 2008 |
| This invention relates to methods and compositions useful for detecting mutations which cause Familial Dysautonomia. Familial dysautonomia (FD; Riley-Day syndrome), an Ashkenazi Jewish disorder, is the best known and most frequent of a group of congenital sensory neuropathies and is |
| 7383076 |
Fluorescence-mediated molecular tomography |
June 3, 2008 |
| This invention relates to a fluorescence-mediated molecular tomographic imaging system, designed to detect near-infrared fluorescence activation in deep tissues. The system can use targeted fluorescent molecular probes or highly sensitive activatable fluorescence molecular probes. Such |
| 7382949 |
Fiber-optic rotational device, optical system and method for imaging a sample |
June 3, 2008 |
| A device, system and method for transmitting electro-magnetic radiation between at least two separate fibers (as well as for imaging a sample) are provided. For example, a first optical fiber and a second optical fiber may be provided, such that the first and/or second fibers is/are |
| 7381822 |
Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process |
June 3, 2008 |
| Piperidine or piperazine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The compounds are characterized by the formulae: ##STR00001## ##STR00002## ##STR00003## ##STR000 |
| 7381752 |
Selective, controlled manipulation of polymers |
June 3, 2008 |
| The present invention provides partial and complete shielding approaches to alter the cross-linking characteristics of irradiated polymers, such as polyethylene. Irradiated polymers and fabricated articles, such as medical prosteses, comprising irradiated polymers also are provided. |
| 7375094 |
Methods for decreasing or preventing pain using spicamycin derivatives |
May 20, 2008 |
| Methods of providing pain relief by administering a water-soluble derivative of spicamycin. Methods of using pain mediation agents are also provided. |
| 7371844 |
Nucleic acids encoding parathyroid hormone (PTH) derivatives |
May 13, 2008 |
| Parathyroid hormone(PTH) polypeptide derivatives are disclosed, as are pharmaceutical compositions containing said polypeptides, and synthetic and recombinant methods for producing said polypeptides. Also disclosed are methods for treating mammalian conditions characterized by decreases |
| 7371400 |
Multilayer device for tissue engineering |
May 13, 2008 |
| The invention provides for translating two-dimensional microfabrication technology into the third dimension. Two-dimensional templates are fabricated using high-resolution molding processes. These templates are then bonded to form three-dimensional scaffold structures with closed lum |
| 7368551 |
De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof |
May 6, 2008 |
| De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine methyltransferase polynucleotides and polypeptides in diagnostic assays, in vitro DNA methy |
| 7367341 |
Methods and devices for selective disruption of fatty tissue by controlled cooling |
May 6, 2008 |
| The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling. |
| 7366376 |
System and method for optical coherence imaging |
April 29, 2008 |
| Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in |
| 7365859 |
System and method for optical coherence imaging |
April 29, 2008 |
| A system and method for imaging of a sample, e.g., biological sample, are provided. In particular, at least one source electro-magnetic radiation forwarded to the sample and a reference may be generated. A plurality of detectors may be used, at least one of the detectors capable of detec |
| 7358732 |
System, method, software arrangement and computer-accessible medium for providing real-time moti |
April 15, 2008 |
| A system, method, software arrangement and computer-accessible medium for correcting for a motion of an object are provided. In this system, method, software arrangement and computer-accessible medium, the navigator data and map data can be obtained for the object. Then, the navigato |
| 7355716 |
Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and opt |
April 8, 2008 |
| Apparatus, method, logic arrangement and storage medium are provided for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry ("LCI") signals by detecting a parallel set of spectral bands, each band being a unique combination of |
| 7348412 |
Ouabain-specific monoclonal antibodies |
March 25, 2008 |
| The invention relates to a monoclonal antibody or antigen binding fragment thereof having binding specificity for ouabain, wherein the antibody or antigen binding fragment does not crossreact with digoxin. Preferably the anti-ouabain monoclonal antibody can bind ouabain with an affinity |
| 7344892 |
Screening for gestational disorders |
March 18, 2008 |
| The invention relates to methods and compositions for identifying subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of |
| 7344587 |
Magnetic ink tissue markings |
March 18, 2008 |
| The invention provides tissue markings (such as tattoos) comprising magnetic particles, e.g., magnetite, and methods for making and altering, e.g., removing them. |
| 7342108 |
De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof |
March 11, 2008 |
| De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine methyltransferase polynucleotides and polypeptides in diagnostic assays, for an in vitro DN |
| 7338461 |
Modified organ support devices |
March 4, 2008 |
| Methods and devices are provided that improve the function of organ support devices, and also provided are improved methods of treating conditions associated with hemodynamic instability. |
| 7333647 |
Systems and method for generating an image |
February 19, 2008 |
| A system for obtaining a resultant image and a method to utilize the same are provided. In particular, first and second images of a subject or a portion of the subject are obtained. The first image includes a first portion of the subject and a second portion of the subject, and each of |
| 7333213 |
Confocal microscopy |
February 19, 2008 |
| An improved confocal microscope system is provided which images sections of tissue utilizing heterodyne detection. The system has a synthesized light source for producing a single beam of light of multiple, different wavelengths using multiple laser sources. The beam from the synthesized |
| 7332200 |
Permeabilizing biofilms |
February 19, 2008 |
| Methods for permeabilizing biofilms using stress waves are described. The methods involve applying one or more stress waves to a biofilm, e.g., on a surface of a device or food item, or on a tissue surface in a patient, and then inducing stress waves to create transient increases in the |
| 7332157 |
Methods for human allografting |
February 19, 2008 |
| A method of preparing a human recipient for a graft from a human which includes: inducing mixed chimerism in the recipient (e.g., by administering to the recipient irradiation or chemotherapy), administering thymic irradiation, administering an antibody that depletes T cells, adminis |
| 7331993 |
Involuted endovascular valve and method of construction |
February 19, 2008 |
| A prosthetic tri-leaflet valve formed by involuting a portion of a tubular structure inside itself. The valve can be made by a method comprising providing a tubular segment in which three equidistant longitudinal incisions are made in one end of the tube creating three flaps which are |
| 7331350 |
Photochemical tissue bonding |
February 19, 2008 |
| Photochemical tissue bonding methods include the application of a photosensitizer to a tissue, e.g., cornea, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for wound repair, or other tissue repair. |
| 7326540 |
Methods for identifying compounds that modulate stabilization of secretase-associated proteins |
February 5, 2008 |
| The invention relates to methods and products for inhibiting caspase activation-induced A.beta. accumulation. The invention is useful for diagnosing, preventing, and treating A.beta.-accumulation-associated disorders, such as Alzheimer's disease. |
| 7323552 |
Variant integrin polypeptides and uses thereof |
January 29, 2008 |
| Polypeptides comprising all or part of a variant integrin .alpha. subunit A domain and its flanking region are described. In solution or in membrane-associated form, the A domain polypeptides of the invention exists predominantly in a high affinity conformation. In the polypeptides o |
| 7323346 |
Screening for gestational disorders |
January 29, 2008 |
| The invention relates to methods and compositions for identifying pregnant subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third tri |
| 7320787 |
Redirection of cellular immunity by protein tyrosine kinase chimeras |
January 22, 2008 |
| Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an auto |
| 7319138 |
Human DRG11-Responsive Axonal Guidance and Outgrowth of Neurite (DRAGON) proteins and variants t |
January 15, 2008 |
| This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family m |
| 7310150 |
Apparatus and method for low coherence ranging |
December 18, 2007 |
| A system, apparatus and method for performing low coherence ranging of a sample with high transverse resolution and large depth of focus can be provided. For example, an optical ranging system including a light source can be used. Certain exemplary arrangement can be provided, e.g., a fi |
| 7304034 |
Use of HMGB fragments as anti-inflammatory agents |
December 4, 2007 |
| Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation that specifically b |
| 7300652 |
Molecules and methods for inhibiting shedding of KIM-1 |
November 27, 2007 |
| Disclosed are antibodies that inhibit proteolytic release of a soluble KIM-1 polypeptide from KIM-1 expressing cells. Also disclosed are methods of using the antibodies to inhibit shedding of the KIM-1 polypeptide. |
| 7298816 |
Tomography system |
November 20, 2007 |
| A measurement system is presented. The measurement system includes a source and a detector located a selected distance from the source with the source and the detector movable about a point, an axis or about a plane located proximate the detector. |
| 7297326 |
Ocular diagnosis of Alzheimer's disease |
November 20, 2007 |
| The invention features a method of diagnosing or providing a prognosis regarding the state of Alzheimer's Disease in a mammal by contacting an ocular tissue with a detectably-labeled compound, which binds to an amyloid protein. An increase in binding of the compound to the ocular tis |
| 7294468 |
Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treat |
November 13, 2007 |
| The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyros |
