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The Curators of the University of Missouri Patents
Assignee:
The Curators of the University of Missouri
Address:
Columbia, MO
No. of patents:
332
Patents:


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Patent Number Title Of Patent Date Issued
7547816 .alpha.(1,3)-galactosyltransferase knockout swine, tissues and organs June 16, 2009
The invention relates to the genetic manipulation of non-human animals. More particularly, the invention relates to genetic manipulation of non-human animals to be used for xenotransplantation. The invention provides viable gene knockout swine including swine in which the .alpha.(1,3
7544857 Brachytic2 (Br2) promoter from maize and methods of use June 9, 2009
The invention relates to the regulation of gene expression, particularly to methods and compositions for regulating gene expression in plants. Expression cassettes comprising a polynucleotide molecule of interest operably linked to the Brachytic2 (Br2) promoter, or a functional fragm
7517695 Local flow and shear stress sensor based on molecular rotors April 14, 2009
A method for detecting local shear stress values using molecular rotors that allows for an extremely sensitive determination of a shear stress field or a flow field, even at very low flow rates. In one embodiment, molecular rotors may be adhered to a fiber optic probe or other solid
7485430 Methods and compositions for evaluation of fertility February 3, 2009
The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In various embodiments of the invention, an Sptrx-3 enzyme is used as a fertility marker.
7464005 Electromagnetic emissions stimulation and detection system December 9, 2008
A system and method for detecting and identifying electronic devices based on their unintended electromagnetic emissions ("UEE") signals is presented. During device classification, UEE signals are measured from a plurality of test devices and characteristic data is obtained from the
7460234 Light scattering detector December 2, 2008
The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light bea
7439749 Non-destructive testing of physical characteristics of composite structures October 21, 2008
A method for detecting an anomaly in a composite material comprising directing two transmitted electromagnetic wave signals orthogonally polarized with respect to each other from a probe to the composite material, wherein the probe and composite material are positioned for near-field
7421910 Strain sensitive coax cable sensors for monitoring structures September 9, 2008
The invention provides increased structural monitoring systems that have sensitive continuous coaxial cable sensors. A preferred embodiment sensor cable of the invention includes an inner conductor, a dielectric jacket, and an outer conductor that is configured to passively deform re
7419507 Elbow arthroplasty system September 2, 2008
A prosthetic elbow for replacing an elbow of a dog or a human to restore normal, pain-free joint function. The elbow includes a humeral component for attachment to a humerus and a radioulnar component for attachment to an ulna. The humeral component includes a generally cylindric spool
7390984 High power liquid dielectric switch June 24, 2008
Method and apparatus for switching high power at high repetition rates. The apparatus is preferably a switch utilizing a pressurized flowing dielectric. The pressurized dielectric suppresses growth of dielectric breakdown byproducts, such as large bubbles and breakdown contamination,
7368249 Methods and compositions for evaluation and modulation of fertility May 6, 2008
The present invention concerns compositions and methods for regulating or determining fertility in humans and animals. In various embodiments of the invention, LOX and other related enzymes can be used as fertility markers, contraceptive agents, or means of treating infertility. LOX may
7361261 Method of preparing a chiral substrate surface by electrodeposition April 22, 2008
A solid substrate comprising a surface comprising an achiral array of atoms having thereupon a chiral metal oxide surface. The chiral metal oxide surface is prepared by electrodeposition of a chiral metal oxide array from a solution of a chiral salt of the metal. In one embodiment, c
7332938 Domino logic testing systems and methods February 19, 2008
A domino logic test circuit includes a dynamic node, a precharge device for charging the dynamic node, and an output inverter for inverting an output of the dynamic node. A logic network is coupled to the dynamic node for discharging the dynamic node in accordance with logic. A footer
7327860 Conjunctival scans for personal identification February 5, 2008
Conjunctival vascular images are obtained from individual's eye for purposes of creating a multi-dimension, non-iris based biometric. The biometric can be used for identification or authentication purposes. Multi-dimensional correlation processing can be used to evaluate pairs of bio
7312412 High power liquid dielectric switch December 25, 2007
Method and apparatus for switching high power at high repetition rates. The apparatus is preferably a switch utilizing a pressurized flowing dielectric. The pressurized dielectric suppresses growth of dielectric breakdown byproducts, such as large bubbles and breakdown contamination,
7294720 Opioid receptor active compounds November 13, 2007
The invention provides compounds of formula I: ##STR00001## wherein R.sup.1 to R.sup.4 and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I,
7268881 Light scattering detector September 11, 2007
The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light bea
7262844 Ultrasensitive spectrophotometer August 28, 2007
The invention concerns measurements in which light interacts with matter to generate light intensity changes, and spectrophotometer devices of the invention provide ultrasensitive measurements. Light source noise in these measurements can be reduced in accordance with the invention.
7244815 Attachment and elaboration strategies for inverse peptide synthesis July 17, 2007
The present invention provides a process for preparing a peptide of formula I): Sub-[L]-[N(R.sup.1)-A-C(O)].sub.p--[NH-A-C(O)].sub.n+m--OH (I) comprising: (a) reacting an immobilized compound of formula (II): Sub-(L)-[N(R.sup.1)-A-C(O)].sub.p--[NH-A-C(O)].sub.n--OH (II) with an a
7238669 Phage-display peptides as novel antimicrobial agents against Haemophilus influenzae July 3, 2007
Whole cell phage-display techniques were used to identify several peptides that bound preferentially to a non-typeable strain of Haemophilus influenzae. These peptides were able to inhibit growth of both H. influenzae and Staphylococcal aureus. Thus, methods for treating bacterial in
7233261 Microwave frequency electro-optical beam deflector and analog to digital conversion June 19, 2007
A microwave frequency deflection cell analog to digital converter is provided. The phase velocity of an optical wave is effectively reduced to that of a microwave frequency electro-magnetic signal in an optical deflector. The electro-optic effect is used for a controlled deflection o
7230168 Reversible male sterility in transgenic plants by expression of cytokinin oxidase June 12, 2007
Methods for the production of reversibly male-sterile plants by introduction of a polynucleotide encoding a cytokinin oxidase are disclosed along with nucleic acid constructs and transformed cells useful in the production of such plants. Also disclosed are the use of plants containin
7214769 Method for inverse solid phase synthesis of peptides May 8, 2007
The present invention provides a process for preparing a peptide of formula (I): Sub-[L]-[NH-A-C(O)].sub.n+m--OH (I) comprising: (a) reacting an immobilized compound of formula (II): Sub-(L)-[NH-A-C(O)].sub.n--OH (II) with an amino acid ester or peptide derivative of formula (II
7214664 Peptidyl prodrugs that resist P-glycoprotein mediated drug efflux May 8, 2007
Dipeptide, and tripeptide and tetrapeptide ester derivatives of bioactive agents are provided wherein the parent agents are substrates effluxed by the P-gp transporter. The derivatives are useful in treating the same condition as the bioactive agent. Also disclosed is a method for pr
7190177 Method and apparatus for nondestructive sample inspection March 13, 2007
An apparatus for inspecting a sample for defects includes a signal generator for generating a signal and a device for splitting the signal into two separate signals which have substantially equal phase and magnitude. A sensor radiates the two signals on the sample and receives the tw
7164021 Opiate analogs selective for the .delta.-opioid receptor January 16, 2007
Novel compounds which selectively bind to the .delta.-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the .delta.-opioid receptor have show
7160945 Water borne film-forming compositions January 9, 2007
The present invention provides a film-forming composition comprising a particulate polymer or emulsified liquid pre-polymer, water and a coalescent aid comprising an ester having the formula RCOOX wherein R and X are independently hydrocarbyl or substituted hydrocarbyl, and at least
7152675 Subterranean hydrogen storage process December 26, 2006
A method for the storage of hydrogen within a subterranean solid carbonaceous formation such as a coal seam. At least one well extends from the surface of the earth into the formation and a pressure gradient extends from the formation to the well to desorb methane within the formatio
7148401 Brachytic2 (BR2) promoter from maize and methods of use December 12, 2006
The invention relates to the regulation of gene expression, particularly to methods and compositions for regulating gene expression in plants. Expression cassettes comprising a polynucleotide molecule of interest operably linked to the Brachytic2 (Br2) promoter, or a functional fragm
7144701 High-throughput methods for detecting DNA methylation December 5, 2006
The present invention provides a method of hybridization, differential methylation hybridization (DMH) for high throughput methylation analysis of multiple CpG island loci. DMH utilizes nucleic acid probes prepared from a cell sample to screen numerous CpG dinucleotide rich fragments
7135615 Chromosome doubling method November 14, 2006
The invention provides methods for chromosome doubling in plants. The technique overcomes the low yields of doubled progeny associated with the use of prior techniques for doubling chromosomes in plants such as grasses. The technique can be used in large scale applications and has be
7132571 Self-assembled calixarene-based guest-host assemblies for guest storage by van der Waals confine November 7, 2006
A guest-host assembly having a generally spheroidal host assembly formed of trimers of calixarene molecules in a hexagonal close-packed assembly and its preparation. The calixarene trimers are associated together predominantly by van der Waals forces to provide dilated channels having
7122322 Endometriosis-specific secretory protein October 17, 2006
A method and kit of diagnosing endometriosis in a female patient suspected of having endometriosis. The method includes obtaining a sample from the patient. The sample is analyzed to detect the presence of a purified and isolated endometriotic haptoglobin designated ENDO-I and functional
7117754 Torque ripple sensor and mitigation mechanism October 10, 2006
A torque ripple sensor and method for torque ripple sensing and/or mitigation. A piezoelectric sensor is positioned relative to a motor so that torque fluctuations due to torque ripple of the motor are transmitted to the sensor, resulting in strain of a piezoelectric element. A resul
7114468 Internal small volume storage water heater October 3, 2006
The invention concerns devices for water storage, heating and delivery. A storage water heater of the invention provides an amount of unmixed recently heated water from an internal small volume during a draw along with water from a main volume. When water is drawn from the storage water
7074605 .alpha.-N-acetylgalactosaminidase from Clostridium perfringens July 11, 2006
An isolated and purified .alpha.-N-acetyl-D-galactosaminidase from Clostridium perfringens and homologs thereof are disclosed. A method for purifying and isolating the .alpha.-N-acetylgalactosaminidase from Clostridium perfringens by removing neuramidases is disclosed. A process for
7060247 Gastrin receptor-avid peptide conjugates June 13, 2006
A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease
7048807 Cerium-based spontaneous coating process for corrosion protection of aluminum alloys May 23, 2006
A cerium-based coating for corrosion resistance is applied by exposing a cleaned aluminum-based component to a corrosion-inhibiting cerium solution containing cerium ions in the presence of an oxidizing agent. The coating deposits spontaneously without an external source of electrons
7045520 Opioid receptor active compounds May 16, 2006
The invention provides compounds of formula I: ##STR00001## wherein R.sup.1 to R.sup.4 and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I,
7041874 Isolated nucleic acid molecules encoding the Br2 P-glycoprotein of maize and methods of modifyin May 9, 2006
The invention relates to the genetic modification of plants, particularly to the expression of P-glycoprotein genes in transformed plants. Nucleotide sequences for the Br2 gene encoding a P-glycoprotein of maize and methods for their use are provided. The sequences find use in modify
7033435 Process for preparing p-n junctions having a p-type ZnO film April 25, 2006
A process for preparing p-n or n-p junctions having a p-type oxide film is disclosed. In one embodiment, a p-type zinc oxide film has a net acceptor concentration of at least about 10.sup.15 acceptors/cm.sup.3.
7025943 Method for preparation of nanometer cerium-based oxide particles April 11, 2006
The invention comprises novel undoped and doped nanometer-scale CeO.sub.2 particles as well as a novel semi-batch reactor method for directly synthesizing the novel particles at room temperature. The powders exhibited a surface area of approximately 170 m.sup.2/g with a particle size
6989158 Gold-containing chemotherapeutic agents January 24, 2006
There is provided a complex for use as a therapeutic pharmaceutical, the complex has a ligand containing at least one hydroxyalkyl phosphine donor group bound to a gold atom to form a stable gold-ligand complex. Also provided is a method of treating cancer by administering an effective
6930167 DNA encoding bovine immunoglobulin a inducing protein and uses therefor August 16, 2005
The invention provides an isolated and purified nucleic acid molecule encoding mammalian immunoglobulin A inducing protein (IGIP), and methods of using the IGIP nucleic acid molecule and IGIP.
6905060 Method and sealant for weld joints June 14, 2005
A sealant for a weld joint and an associated weld joint and method are provided. The sealant includes aluminum and germanium and is characterized by a melting temperature that is lower than the melting temperature of the structural member that is joined. The sealant, which is disposed be
6891024 Monoclonal antibodies to Sarcocystis neurona and uses therefor May 10, 2005
The present invention is directed to particular monoclonal antibodies that find use in the identification and purification of Sarcocystis neurona and related antigens. In particular, these antibodies permit the diagnosis of Sarcocystis related diseases such as equine protozoal myeloencep
6869770 Compositions and methods for early pregnancy diagnosis March 22, 2005
Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the outer epithelial cell layer (chorion/trophectoderm) of the placenta. By cloning expressed
6867034 Methods of screening novel agents for use in cancer therapy and prevention March 15, 2005
The present invention provides for methods of screening agents for cancer therapeutic and prophylactic activity. In particular embodiments, cells of the cellular slime mold Dictyostelium discoideum are contacted with candidate agents and the expression of genes in the Nucleotide Excision
6818806 Maize lls1 promoter November 16, 2004
The present invention is drawn to a maize lls1 promoter that can be used in DNA constructs to express polynucleotides in plants, plant cells, tissues and seeds.
6818116 Additive-assisted cerium-based electrolytic coating process for corrosion protection of aluminum November 16, 2004
The corrosion resistance of an aluminum or aluminum alloy component is enhanced by immersing an aluminum alloy to act as a cathode and an oxygen-evolving anode in an electrolyte comprising water, cerium ions, and an additive selected from among animal gelatin, derivatives of animal g
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