| Patent Number |
Title Of Patent |
Date Issued |
| 6566116 |
Matrix metalloprotease |
May 20, 2003 |
| This invention relates to a novel metalloprotease having a proteolytic activity, its partial peptide or a salt either of them, a DNA coding for the protein, a recombinant vector comprising the DNA, a transformant carrying the recombinant vector, a process for producing the protein, a |
| 6562978 |
Cyclic amine compounds as CCR5 antagonists |
May 13, 2003 |
| A compound of formula (I) (wherein R.sup.1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R.sup.2 is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted |
| 6555565 |
Apoptosis inhibitor |
April 29, 2003 |
| An apoptosis inhibitor which comprises a compound of the formula: ##STR1##wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: --CO--, --CH(OH)-- or --NR.sup.3 -- where R.sup.3 represents an |
| 6552058 |
Oxazolidinedione derivatives and their use |
April 22, 2003 |
| Novel 2,4-oxazolidinedione compounds of the formula: ##STR1##wherein R is a hydrocarbon residue or a heterocyclic group each of which may be substituted; Y is --CO--, --CH(OH)-- or --NR.sup.3 -- (wherein R.sup.3 is an alkyl group which may be substituted); m is 0 or 1; n is 0, 1 or 2 |
| 6552054 |
Chromone derivatives, process for the preparation of the same and uses thereof |
April 22, 2003 |
| The invention provides chromone derivatives of the following general formula, a process for preparing such chromone derivatives and a prophylactic and therapeutic agent comprising such chromone derivatives for bone diseases and chondropathy: ##STR1##wherein the ring A is an optionall |
| 6545009 |
Retinoid-related receptor function regulating agent |
April 8, 2003 |
| 1,3-Azole derivatives, pharmaceutical compositions thereof and methods for regulating the function of retinoid-related receptors with 1,3-azole derivatives are disclosed. Such regulation may be useful for preventing or treating diabetes, preventing or treating hyperlipidemia, preventing |
| 6538107 |
G protein coupled receptor protein production, and use thereof |
March 25, 2003 |
| DNA primers effective in screening G protein coupled receptor protein-encoding DNA fragments are provided. The primers which are complementary to nucleotide sequences that are in community with (homologous to) the nucleotide sequences encoding amino acid sequences corresponding to or |
| 6531604 |
Benzothiepine derivatives, their production and use |
March 11, 2003 |
| The invention provides compounds of the formula: ##STR1##wherein the ring A is an optionally substituted benzene ring; R.sup.1 is an optionally substituted non-aromatic heterocyclic group; R.sup.2 and R.sup.3 are independently hydrogen atom or an optionally substituted hydrocarbon gr |
| 6528093 |
Sustained-release preparation |
March 4, 2003 |
| A sustained-release preparation which comprises a physiologically active peptide of general formula: ##STR1## wherein X represents an acyl group; R.sub.1, R.sub.2 and R.sub.4 each represents an aromatic cyclic group; R.sub.3 represents a D-amino acid residue or a group of the formul |
| 6521256 |
Stabilized pharmaceutical composition |
February 18, 2003 |
| The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1##wherein R.sup.1 is hydrogen, alkyl, halogen, cyanot carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl |
| 6518435 |
Process for the preparation of oxyiminoalkanoic acid derivatives |
February 11, 2003 |
| The present invention provides, as an industrially advantageous production method, a method of producing a compound represented by the formula (III) ##STR1## |
| 6518257 |
1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use there |
February 11, 2003 |
| To provide a composition having a steroid C.sub.17,20 -lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound represented by the formula: ##STR1##wherein R is a hydrogen atom or a protecting group, |
| 6514988 |
Condensed-ring thiophene derivatives, their production and use |
February 4, 2003 |
| A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the preven |
| 6514907 |
Bromine-impregnated activated carbon and process for preparing the same |
February 4, 2003 |
| A bromine-impregnated activated carbon wherein the contents of any alkali metal, any alkali earth metal and iron are not higher than 0.3 wt % and the content of bromine is not lower than 3 wt %, with respect to the weight of a material activated carbon. The bromine-impregnated activated |
| 6503918 |
D-mannitol and its preparation |
January 7, 2003 |
| D-mannitol having a specific surface area of not less than about 1 m.sup.2 /g is disclosed. The D-mannitol shows improved compressibility and is useful as an excipient. |
| 6500820 |
Pharmaceutical composition for neurotrophic action |
December 31, 2002 |
| The present invention provides a composition for neurotrophic action which comprises a compound of the formula: ##STR1##wherein Ar is an optionally condensed phenyl group which may be substituted; n is an integer of 1 to 10; R is a hydrogen atom or a hydrocarbon group which may be s |
| 6498179 |
Oxazole derivatives, their production and use |
December 24, 2002 |
| A novel compound of the formula: ##STR1##wherein R.sup.1 is a halogen atom, an optionally substituted heterocyclic, hydroxy, thiol or amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, or an o |
| 6498019 |
Lecithin-cholesterol acyltransferase protein |
December 24, 2002 |
| This invention relates to a novel protein having a lecithin-cholesterol acyltransferase-like activity, etc. or its salt, a precursor protein of the protein or its salt, a partial peptide of the protein or its salt; a DNA coding for the protein; a recombinant vector; a transformant; a met |
| 6495604 |
Cycloalkene derivatives, process for producing the same, and use |
December 17, 2002 |
| The present invention provides a compound represented by the formula: ##STR1##wherein R represents an aliphatic hydrocarbon group optionally having substituents, an aromatic hydrocarbon group optionally having substituents, a heterocyclic group optionally having substituents, a group |
| 6495581 |
Oxyiminoalkanoic acid derivatives |
December 17, 2002 |
| A compound represented by the formula: ##STR1##wherein R.sup.1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond, --CO--, --CH(OH)-- or a group represented by --NR.sup.6 -- wherein R.sup.6 is a hydrogen atom or an optionally s |
| 6492446 |
Alatex compound for dip molding and a dip-molded product |
December 10, 2002 |
| A latex compound for dip molding, which can be used for production of a high-quality dip-molded product that is excellent in oil resistance and mechanical strength, has uniform film thickness and soft feeling to the skin and is free of pinholes, as is required for gloves etc. especially |
| 6492324 |
APJ ligand polypeptides |
December 10, 2002 |
| This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety o |
| 6489351 |
Condensed 4,5,6,7-tetrahydrobenzo[C]thiophenes as enhancer for cell differentation induction fac |
December 3, 2002 |
| A compound represented by the formula: ##STR1##wherein X represents a sulfur atom or an oxygen atom; Y represents an optionally oxidized sulfur atom or an oxygen atom; Z represents a bond or a divalent hydrocarbon group; R.sup.1 represents an optionally substituted hydrocarbon group; |
| 6489315 |
Cyclic compounds, their production and use |
December 3, 2002 |
| Novel compounds of the following general formula or salts thereof. ##STR1##wherein Ring M is a heterocyclic ring having --N.dbd.C<, --CO--N< or --CS--N< as the partial structure --X-- -- -- -- -- -- -- -- -- Y<; R.sup.a and R.sup.b are bonded to each other to form Ring A, or |
| 6482864 |
Sustained-release preparation of physiologically active polypeptide and production thereof |
November 19, 2002 |
| A method for producing a sustained-release preparation, which comprises dispersing a physiologically active polypeptide into an organic solvent solution of a biodegradable polymer and removing the organic solvent, wherein the polypeptide is a powder obtained by lyophilizing an aqueous |
| 6479536 |
Benzofuran derivatives, process for the preparation of the same and uses thereof |
November 12, 2002 |
| Compounds represented by the formula: ##STR1##wherein R.sup.1 and R.sup.2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R.sup.1 and R.sup.2 may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates (i) a g |
| 6469037 |
Prophylactic or therapeutic drug for renal diseases |
October 22, 2002 |
| This invention relates to methods for lowering urinary total protein comprising, administering as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1##wherein R.sup.1 stands for H or alkyl; R.sup.2 stands for an optionally esterified carboxyl gr |
| 6462230 |
Method of and apparatus for decomposing wastes |
October 8, 2002 |
| A method of decomposing wastes containing target compounds having one or more of hydrolyzable bonds of ether bond, ester bond, amide bond and isocyanate bond wherein the method comprises continuously supplying the wastes in a molten state or liquid state to a reactor, continuously su |
| 6462058 |
Benzimidazole compound crystal |
October 8, 2002 |
| A novel crystal of (R)-2-[[[3-methyl-4-(2, 2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent. |
| 6440946 |
Multiple-agents-binding compound, production and use thereof |
August 27, 2002 |
| The present invention is to provide a multiple-agents-binding compound comprising a compound having anti-HIV activity and having no affinity for cell surface protein bound together with a same or different kind of at least one compound having anti-HIV activity and having no affinity for |
| 6437132 |
Thienopyridine derivatives, their intermediates and production thereof |
August 20, 2002 |
| The present invention provides an intermediate for producing a thienopyridine derivative useful as a GnRH antagonist as well as an efficient and safe method for producing the same in an industrial scale at a high yield. |
| 6432996 |
Pharmaceutical composition |
August 13, 2002 |
| To provide a pharmaceutical composition which performs a remarkable effect with a relatively decreased dosage, and, with less side effects, a pharmaceutical composition formulated by combination of an angiotensin II-mediated compound or a salt thereof with at least one species of a c |
| 6429296 |
Complex of human growth hormone and zinc and use |
August 6, 2002 |
| The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release preparation which comprises the complex of human growth hormone and zinc and a biodegradable polymer |
| 6428813 |
Gastrointestinal mucosa-adherent pharmaceutical composition |
August 6, 2002 |
| In order to provide a composition having a long gastroduodenal residence time and exhibiting an improved efficacy, is provided a gastrointestinal mucosa-adherent composition comprising an active ingredient and a material which swells a viscogenic agent capable of being viscous with water |
| 6420415 |
Thiol compounds, their production and use |
July 16, 2002 |
| Compounds represented by general formula (1) or salts thereof which have a matrix metalloprotease inhibitory activity and are useful as drugs, wherein the rings A and B represent each an optionally substituted homocycle or heterocycle, etc.; R.sub.1 s are the same or different and ea |
| 6420405 |
Pharmaceutical composition for angiotensin II-mediated diseases |
July 16, 2002 |
| This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula ##STR1##wherein R.sup.1 is H or an optionally substituted hydrocarbon residue; R.sup.2 is an optionally e |
| 6420375 |
Fused ring compounds, process for producing the same and use thereof |
July 16, 2002 |
| To provide a novel compound of the formula: ##STR1##[wherein A.sub.1 ix a 5 or 6-membered ring which may be substituted by a group not containing a cyclic group, A.sub.2 is an aromatic ring which may be substituted, X is a divalent group, Y is a nitrogen atom or a methine group, Z is |
| 6419961 |
Sustained release microcapsules of a bioactive substance and a biodegradable polymer |
July 16, 2002 |
| A method of production of sustained-release microcapsules that comprises obtaining microcapsules comprising a bioactive substance that are encapsulated with a biodegradable polymer, and thermally drying the obtained microcapsules at a temperature not lower than the glass transition t |
| 6417213 |
Tricyclic compound, their production and use |
July 9, 2002 |
| A compound of the formula ##STR1##wherein R.sup.1 is H or a substituent; m is 1-3; Ar is an aromatic group which may be substituted; X is a bond or a divalent straight-chain group having 1-6 atoms which may be substituted; Y is --S--, --O--, or --N(R.sup.2)-- (R.sup.2 is H or a subst |
| 6417175 |
Phosphonocephem derivatives, process for the preparation of the same, and use thereof |
July 9, 2002 |
| A novel cephem compound of the formula: ##STR1##wherein R.sup.1 is a phosphono group or a group convertible to a phosphono group; R.sup.2 is a hydrogen atom or a group having a linkage through a carbon atom; each of Q and X is a nitrogen atom or CH; Y is S, O or CH.sub.2 ; n is 0 or |
| 6414003 |
Oxazolone derivatives and their use as anti-helicobacter pylori agents |
July 2, 2002 |
| An anti-Helicobacter pylori agent comprising a compound represented by the formula: ##STR1##wherein A represents an aromatic ring group which may be substituted; R.sup.1 and R.sup.2, whether identical or not, each represent a hydrogen atom or a hydrocarbon group which may be substitu |
| 6413972 |
Nitrogen-containing heterocyclic compounds, their production and use |
July 2, 2002 |
| A compound of the formula: ##STR1##wherein one of A and D is N and the other is C, or both are N; B is N or C; m is 0-3; R.sup.1, R.sup.2 and R.sup.3 each is (i) H or (ii) a group bound via C, N, O or S; R.sup.4 is a group bound via C; R.sup.5 is H or a group bound via C or O; R.sup. |
| 6413947 |
Anilide derivative, production and use thereof |
July 2, 2002 |
| This invention is to provide a compound of the formula: ##STR1##wherein R.sup.1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: ##STR2##wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substit |
| 6407251 |
Process for preparing 2-chloro-5-chloromethylthiazole |
June 18, 2002 |
| A novel process for preparing 2-chloro-5-chloromethylthiazole is provided which is suitable for industrial application.The process for preparing 2-chloro-5-chloromethylthiazole involves allowing 2-halogenoallyl isothiocyanate to react with chlorinating agent in the presence of an aromati |
| 6407248 |
.alpha.-unsaturated amines, their production and use |
June 18, 2002 |
| .alpha.-Unsaturated amines of the formula: ##STR1##wherein X.sup.1 and X.sup.2 are such that one is an electron-attracting group with the other being a hydrogen atom or an electron-attracting group; R.sup.1 is a group attached through a nitrogen atom; R.sup.2 is a hydrogen atom or a |
| 6407129 |
Azole compounds, their production and their use |
June 18, 2002 |
| A quaternized nitrogen-containing imidazol-1-yl or 1,2,4-triazol-1-yl compound wherein one of the nitrogen atoms constituting an azole ring is quaternized with a substituent capable of being eliminated in vivo and the substituent can be eliminated in vivo to be converted into an antifung |
| 6403606 |
Thienopyridine derivatives and their use |
June 11, 2002 |
| There is disclosed a compound of the formula (A): ##STR1##wherein W is C--G or C--G' (G is optionally esterified carboxyl; and G' is halogen); X is oxygen, optionally oxidized sulfur or --(CH.sub.2).sub.q --, (q is 0 to 5); R is optionally substituted amino or heterocyclic group; the |
| 6403595 |
Sulfonamide derivatives, processes for producing the same and utilization thereof |
June 11, 2002 |
| The present invention is to provide a compound or a salt thereof represented by the formula: ##STR1##wherein R.sup.1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, the ring A is an optionally substituted divalent nitrogen-containing he |
| 6399639 |
Apoptosis inhibitor |
June 4, 2002 |
| An apoptosis inhibitor which comprises a compound of the formula: ##STR1##wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: --CO--, --CH(OH)-- or --NR.sup.3 -- where R.sup.3 represents an |
| 6399325 |
DNA encoding a galanin receptor |
June 4, 2002 |
| Galanin receptor proteins, production and use thereof including screening of galanin receptor agonists and antagonists are provided. Galanin receptor proteins, etc. or salts thereof, partial peptides thereof, DNAs coding for the above galanin receptor protein, processes for producing the |
