| Patent Number |
Title Of Patent |
Date Issued |
| RE38689 |
Ceramidase gene |
January 25, 2005 |
| To provide a polypeptide having ceramidase activity, and a gene encoding thereof useful as an reagent for lipid engineering and as indices for diagnosis of atopic dermatitis, an easy method for detecting the polypeptide and method for detecting the gene as well as a method for detect |
| 7045322 |
Process for producing lysosphingolipids |
May 16, 2006 |
| A process for producing lysosphingolipids by using an enzyme capable of specifically hydrolyzing the acid amide bond between a sphingoid and a fatty acid in a sphingolipid, characterized in that the enzyme reaction is carried out in a two-phase system liquid reaction mixture containing |
| 6949634 |
Method for synthesizing cDNA |
September 27, 2005 |
| A method for synthesizing cDNA characterized by performing a reverse transcription reaction in the presence of an enzyme having a reverse transcriptional activity and another enzyme different from the former one which as a 3'-5' exonuclease activity. |
| 6924097 |
Plant promoter and method for gene expression using said promoter |
August 2, 2005 |
| A plant promoter capable of inducing the expression specifically at the site and stage wherein the reconstitution of plant cell wall xyloglucan is necessary, namely, a plant promoter originating in a gene which encodes an endo-xyloglucan transferase or a gene which encodes a substance ha |
| 6849441 |
Hyperthermostable protease gene |
February 1, 2005 |
| There are provided hyperthermostable proteases having an amino acid sequences represented by SEQ ID NOs: 1, 3 and 5 of the Sequence Listing or functional equivalents thereof and hyperthermostable protease genes encoding those hyperthermostable protease. There is also disclosed a proc |
| 6846630 |
Nucleic acid encoding receptor type protein kinase |
January 25, 2005 |
| To provide a nucleic acid encoding a receptor protein kinase, wherein the nucleic acid has tandem duplication in a nucleotide sequence of a juxtamembrane and is useful for diagnosis of leukemia; a polypeptide encoded by the nucleic acid; an antibody capable of specifically binding to |
| 6803367 |
Substance for inducing apoptosis |
October 12, 2004 |
| A substance for inducing apoptosis represented by specific formulae. A pharmaceutical composition which can be used for an anticancer agent containing said substance. |
| 6787359 |
Gene transfer methods |
September 7, 2004 |
| Improved methods for transferring a gene into target cells by using a retrovirus, wherein the gene transfer efficiency is improved and the target cells are efficiently transformed by binding the retrovirus to a functional substance which is immobilized on as carrier and having an act |
| 6770481 |
Gene isolation method |
August 3, 2004 |
| A plasmid vector characterized by comprising a promoter sequence that can be recognized by an RNA polymerase which is not inherent in a host and that controls the expression of desired genes and a replication origin that increases the number of copies under the induction by exogenous |
| 6720409 |
Anti-human influenza virus antibody |
April 13, 2004 |
| [Object] To provide an anti-human influenza virus antibody and an immunogenic artificial polypeptide.[Constitution] An anti-human influenza virus antibody which recognizes the stem regions of haemagglutinin molecules of the H1N1 and H2N2 subtypes and has a neutralization activity but doe |
| 6693174 |
Gene regulating aureobasidin sensitivity |
February 17, 2004 |
| The invention is directed to isolated DNAs having nucleic acid sequences which encode proteins which regulate aureobasidin sensitivity. Also disclosed are recombinant plasmids containing the DNAs, transformants containing the plasmids, and methods of producing the proteins. |
| 6686453 |
Antifucoidan antibody |
February 3, 2004 |
| ##STR1##An antifucoidan antibody recognizing the compound represented by formula (I) or (II). |
| 6673578 |
Method for synthesizing DNA |
January 6, 2004 |
| A DNA synthesis method with a shortened time period required for DNA synthesis by polymerase chain reaction (PCR), characterized in that a DNA polymerase is used in an amount effective for providing more than 10 ng of amplified DNA fragments of about 2 kb per 50 .mu.l of a reaction mixtu |
| 6670119 |
Cancer-associated genes |
December 30, 2003 |
| To provide a method for detecting a cancer cell in a resected specimen by determining a change in an expression level of at least one of cancer-associated genes selected from genes of which cDNA is a DNA comprising a nucleotide sequence as shown in any one of SEQ ID NOs: 1 to 16 and |
| 6608032 |
Medicinal compositions |
August 19, 2003 |
| ##STR1##Medicinal compositions for treating or preventing diabetes, rheumatoid, diseases wherein inflammation should be inhibited, diseases wherein .alpha.-glycosidase should be inhibited, diseases wherein the synthesis of prostaglandin should be inhibited, diseases wherein endotoxin sho |
| 6599729 |
.alpha.-agarase and process for producing the same |
July 29, 2003 |
| A polypeptide having an .alpha.-agarase activity, a gene encoding the polypeptide, a method for producing the polypeptide by genetic engineering and a method for producing an agarooligosaccharide using the polypeptide. |
| 6593311 |
Apoptosis inducers |
July 15, 2003 |
| Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof |
| 6590097 |
Sulfated fucogalactan |
July 8, 2003 |
| Sulfated fucogalactan or its salt useful as a reagent for sugar chain engineering or an HGF-production inducer; a degraded product or its salt obtained by treating the sulfated fucogalactan with a sulfated fucogalactan digesting enzyme; the sulfated fucogalactan digesting enzyme usef |
| 6573250 |
Food or beverage additive containing fucoidan and food and beverage containing fucoidan |
June 3, 2003 |
| Food or beverage where fucoidan which is derived from a fucoidan-containing substance is contained therein, added thereto and/or diluted therein. Food or beverage where fucoidan which is derived from a fucoidan-containing substance and where algins are reduced or eliminated, is contained |
| 6552001 |
Method breeding and feeds |
April 22, 2003 |
| ##STR1##A method of rearing useful organisms such as cultured animals which is effective in preventing the organisms from diseases, treating the organisms for diseases or maintaining the health of the organisms, characterized by administering to the organisms (1) a product of heat tr |
| 6548543 |
Remedies or preventives containing cyclopentenone compounds as the active ingredient |
April 15, 2003 |
| Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation o |
| 6531148 |
Therapeutic agents |
March 11, 2003 |
| ##STR1##Therapeutic or preventive agents for diseases requiring apoptosis induction, cancerous diseases, diseases requiring the inhibition of active oxygen production, those requiring the inhibition of nitrogen monoxide production, those requiring the inhibition of prostaglandin synthesi |
| 6528310 |
Cancer control |
March 4, 2003 |
| Clarification of the relationship between the functions of E1AF gene and the invasion and metastasis of cancers, and application thereof to cancer control, more specifically the control of cancer cell invasion by controlling the expression of E1AF gene and the products of expression, |
| 6525082 |
Apoptosis inducer |
February 25, 2003 |
| A substance for inducing apoptosis represented by specific formulae. A pharmaceutical composition which can be used for an anticancer agent containing said substance. |
| 6518317 |
Antiviral agents |
February 11, 2003 |
| An antiviral agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component. ##STR1## |
| 6518302 |
Remedies |
February 11, 2003 |
| ##STR1##Compounds represented by general formula (I) wherein X represents OH or OSO.sub.3 H; and R represents a substituent other than OH which allows, after leaving, the induction of unsaturated bonds into the 3- and 4-positions of 3,6-anhydrogalactose or its sulfated derivative, and/or |
| 6492338 |
Therapeutic agents |
December 10, 2002 |
| Therapeutic or preventive agents for diseases due to the action of aldose reductase; and aldose reductase inhibitors, characterized by containing at least one compound having an aldose reductase inhibiting activity which is selected from among 2,5-dihydroxytetra-hydro-2-furancarboxylic a |
| 6489155 |
Enzymes capable of degrading a sulfated-fucose-containing polysaccharide and their encoding gene |
December 3, 2002 |
| An isolated gene having a DNA sequence coding for the polypeptide having a degrading activity of the sulfated-fucose-containing polysaccharide or having the functionally identical activity as above. |
| 6489117 |
Ceramidase gene |
December 3, 2002 |
| To provide a polypeptide having ceramidase activity, and a gene encoding thereof useful as an reagent for lipid engineering and as indices for diagnosis of atopic dermatitis, an easy method for detecting the polypeptide and method for detecting the gene as well as a method for detect |
| 6485917 |
Method for synthesizing cDNA |
November 26, 2002 |
| A method for synthesizing cDNA characterized by performing a reverse transcription reaction in the presence of an enzyme having a reverse transcriptional activity and another enzyme different from the former one which as a 3'-5' exonuclease activity. |
| 6482806 |
Product of heat treatment of uronic acid, food, drink, or drug including the product |
November 19, 2002 |
| A product obtained by heating at least one substance selected from the following (a), (b) and (c). (a) uronic acid or uronic acid derivative; (b) a saccharide compound containing uronic acid or a saccharide compound containing uronic acid derivative; and (c) a substance containing a |
| 6479260 |
Cold-inducible expression vector |
November 12, 2002 |
| A vector which is characterized in containing each of the following elements: (1) a promoter which shows its action in the host to be used; (2) regulatory region for regulating the action of the promoter of (1); and (3) a region which codes for the 5'-untranslated region derived from |
| 6475990 |
Drugs, foods or drinks with the use of algae-derived physiologically active substances |
November 5, 2002 |
| Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): ##STR1##foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the abo |
| 6448048 |
Method for effecting site-directed mutagenesis |
September 10, 2002 |
| A method for performing site-directed mutagenesis characterized in that the method includes the step of carrying out PCR by the use of a double-stranded DNA vector having one or more amber codons, the vector resulting from insertion of a target DNA fragment for site-directed mutagene |
| 6432664 |
Processes of screening for an antimycotic agent |
August 13, 2002 |
| The invention provides an isolated gene coding for a protein regulating aureobasidin sensitivity; a process for cloning the gene with the use of the gene or a part of the same as a probe; a nucleic acid probe being hybridizable with the gene; an antisense DNA or RNA of the gene; a re |
| 6432407 |
Antigenic protein originating in malassezia |
August 13, 2002 |
| A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the |
| 6428999 |
Sphingolipid ceramide N-deacylase, methods for producing sphingolipids and sphingolipid derivati |
August 6, 2002 |
| The present invention relates to a novel sphingolipid ceramide N-deacylase (SCDase) having a wide substrate specificity; a method for enzymatically producing a lysosphingolipid or a sphingolipid derivative using the SCDase which is useful in the fields of medicine, carbohydrate engineeri |
| 6410277 |
DNA polymersases with enhanced length of primer extension |
June 25, 2002 |
| A formulation and kit of thermostable or other DNA polymerases comprising at least one thermostable or other DNA polymerase which lacks 3'-exonuclease activity, and at least one thermostable DNA polymerase exhibiting 3'-exonuclease activity. Also provided is an improved method for en |
| 6395526 |
DNA polymerase |
May 28, 2002 |
| The present invention relates to a DNA polymerase possesses the properties of 1) exhibiting higher polymerase activity when assayed by using as a substrate a complex resulting from primer annealing to a single stranded template DNA, as compared to the case where an activated DNA is used |
| 6380262 |
5-membered ring compounds |
April 30, 2002 |
| ##STR1##5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect. In said formula the bond shown by the dotted line in the 5-membered ring represents |
| 6380245 |
Antibiotics TKR1912-I and TKR1912-II and process for producing the same |
April 30, 2002 |
| The present invention relates to novel antibiotics TKR1912-I having the following formula I and TKR1912-II having the following formula II or pharmacologically acceptable salts thereof, which are useful as a remedy for fungal infections, as well as a process for producing them and a |
| 6379947 |
Biologically pure culture of Fucoidanobacter marinus SI-0098 (FERM BP-5403) |
April 30, 2002 |
| A novel endo-fucoidan-lyase and a novel microorganism, Fucoidanobacter marinus SI-0098 (FERM BP-5403) useful in the production of sugar compounds are disclosed Sugar compounds represented by the following general formula (1), wherein at least one of alcoholic hydroxyl group has been sulf |
| 6358726 |
Thermostable protease |
March 19, 2002 |
| A hyperthermostable protease having the amino acid sequence represented by the SEQ ID NO:1 of the Sequence Listing or a sequence derived therefrom by deletion, substitution, insertion or addition of one to several amino acid residues, a gene encoding the hyperthermostable protease, and a |
| 6350917 |
.alpha.-crystal of cyclopentenone |
February 26, 2002 |
| Crystals of trans-4,5-dihydroxy-2-cyclopenten-1-one of an .alpha.-type. |
| 6348577 |
Regulation of aureobasidin sensitivity in fungus |
February 19, 2002 |
| The present invention provides a protein regulating the sensitivity of fungus to an antimycotic aureobasidin, a gene coding for this protein, the use thereof, an antibody for the protein and the use thereof. The invention is useful in the diagnosis and treatment for diseases including |
| 6337410 |
Antibiotic TKR459, production method, and microorganism |
January 8, 2002 |
| The present invention has its object to provide a noble antifungal substance which is use of as clinical medicine in the therapy of fungal infectious diseases.The present invention is related to an antibiotic TKR459 having the following chemical formula (1) or its pharmacologically accep |
| 6337070 |
Polypeptides for use in generating anti-human influenza virus antibodies |
January 8, 2002 |
| The invention provides an anti-human influenza virus antibody which recognizes the stem regions of haemagglutinin molecules of the H1N1 and H2N2 subtypes and has a neutralization activity but does not recognize the stem region of the H3N2 subtype and has no neutralization activity. Also |
| 6333305 |
Antibiotic TKR2999, process for the preparation thereof and microbe |
December 25, 2001 |
| The antibiotic TKR2999 having the physicochemical properties described below and its pharmacologically acceptable salt:(1) FAB-MS m/z 971 [M+H)].sup.+, (2) the molecular formula: C.sub.44 H.sub.78 N.sub.10 O.sub.14, and high-resolution FAB-MS m/z 971.5776 [M+H].sup.+, (3) the ultraviolet |
| 6333164 |
Fungal antigens and process for producing the same |
December 25, 2001 |
| There can be provided a fungal antigen which is an insoluble fraction obtainable from fungal cells of which cell wall has been substantially removed or at least partially removed; a process for producing the same; a nucleic acid encoding the fungal antigen; a biologic product containing |
| 6333158 |
DNA polymerase-related factors |
December 25, 2001 |
| The present invention relates to a thermostable DNA polymerase-associated factor capable of enhancing DNA synthesizing-activity of a DNA polymerase; a thermostable DNA polymerase-associated factor possessing an activity of binding to a DNA polymerase and a method for producing the same; |
