| Patent Number |
Title Of Patent |
Date Issued |
| 7381729 |
4-(4-trans-hydroxycyclohexyl)amino-2-phenyl-7H-pyrrolo [2,3D] pyrimidine hydrogen mesylate, its |
June 3, 2008 |
| The present invention relates to the novel compound 4-(4-trans-hydroxycyclohexyl)amino-2-phenyl-7H-pyrrolo[2,3d]pyrimidine hydrogen mesylate, the polymorphic .alpha. and .beta. forms thereof, and a method for the production of said compounds. |
| 7371769 |
Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D.sub.2 receptors and |
May 13, 2008 |
| The present invention relates to a group of novel tetrahydropyridin-4-yl indoles with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine-D.sub.2 receptors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of |
| 7371737 |
2-substituted-6-trifluoromethyl purine derivatives with adenosine-A.sub.3 antagonistic activity |
May 13, 2008 |
| The present invention relates to 2-substituted-6-trifluoromethyl purine derivatives as selective adenosine antagonists, in particular adenosine-A.sub.3 receptor antagonists, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said |
| 7338964 |
2-substituted-1-deaza purine derivatives with adenosine receptor modulating activity |
March 4, 2008 |
| The present invention relates to 2-substituted-1-deaza purine derivatives as adenosine receptor modulating agents, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said purine derivatives.The compounds have the general formula (1) |
| 7319110 |
1H-1,2,4-triazole-3-carboxamide derivatives having cannabinoid-CB.sub.1 receptor agonistic, part |
January 15, 2008 |
| The present invention relates to a group of 1H-1,2,4-triazole-3-carboxamide derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing at least one of these compounds as an active ingredient.These 1H-1,2,4-triazole-3-carboxamide deri |
| 7312321 |
Antibody to human enzymes of the metalloprotease family |
December 25, 2007 |
| This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are us |
| 7307079 |
1,3,5-Triazine derivatives as ligands for human adenosine-A3 receptors |
December 11, 2007 |
| The invention relates to a group of novel triazine derivatives which are ligands for human adenosine-A.sub.3 receptors, as well as to pharmaceutical compositions containing a pharmacologically active amount of at least one of these compounds as an active ingredient. The invention rel |
| 7244734 |
Hexa- and octahydro-pyrido[1,2-a]pyrazine derivatives with NK.sub.1 antagonistic activity |
July 17, 2007 |
| The invention relates to hexahydro-pyrido[1,2-a]pyrazine derivatives having interesting neurokinin-NK.sub.1 receptor antagonistic activity. The invention also relates to methods for the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically acti |
| 7189525 |
Human enzymes of the metalloprotease family |
March 13, 2007 |
| This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are us |
| 7186741 |
Neurotensin active 2,3,diaryl-pyrazolidine derivatives |
March 6, 2007 |
| The invention relates to a group of novel 2,3 diaryl-pyparazolidine derivatives having formula (1). The symbols used in formula (1) have the meanings given in the specification. The compounds have inhibiting activity on enzymes which degrade the neuropeptide neurotensin and can be us |
| 7173044 |
Imidazoline derivatives having CB.sub.1-antagonistic activity |
February 6, 2007 |
| The present invention relates to 1,2,4-tri-substituted imidazoline derivatives, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazoline derivatives, to methods for the preparation of these intermediates, to pharmaceutical |
| 7094779 |
Piperazine oxime dervatives having NK-1 receptor antagonistic activity |
August 22, 2006 |
| The present invention relates to a group of novel piperazine oxime derivatives having interesting NK-1 antagonistic activity. The invention relates to compounds of the general formula (1) wherein: X represents phenyl or pyridyl substituted with 1 or 2 substituents from the group CH.s |
| 7083965 |
Human enzymes of the metalloprotease family |
August 1, 2006 |
| This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are us |
| 7067513 |
Phenylpiperazines |
June 27, 2006 |
| The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D.sub.2 receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/ |
| 7030241 |
Mesylates of piperazine derivatives and process for their preparation |
April 18, 2006 |
| The invention relates to the mesylates of a group of piperazine derivatives and to a process for the preparation of these mesylates in an economic way in the high yield and of high purity. According to the process of the invention the synthesis of the piperazine ring and the mesylate |
| 7015333 |
Process for preparation of imidazolyl compounds |
March 21, 2006 |
| A method for preparing an imidazolyl compound corresponding to the formula (I) ##STR00001## by reacting a compound corresponding to formula (II) ##STR00002## with a compound corresponding to formula (III) ##STR00003## and then reacting the product with a compound corresponding to |
| 6998398 |
Solid salts of benzazepine compounds and pharmaceutical compositions containing them |
February 14, 2006 |
| Pharmaceutically acceptable metal salts of compounds of formula (I): ##STR00001## in which R.sub.1 is selected from the group consisting of (C.sub.1 C.sub.6)alkoxy(C.sub.1 C.sub.6)alkyl which may be substituted with (C.sub.1 C.sub.6)alkoxy, phenyl-(C.sub.1 C.sub.6)-alkyl and/or phen |
| 6998255 |
Human G-protein coupled receptor |
February 14, 2006 |
| The present invention relates to novel identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to the G-protein c |
| 6974810 |
4,5-Dihydro-1H-pyrazole derivatives having potent CB1-antagonistic activity |
December 13, 2005 |
| The present invention relates to a group of novel 4,5-dihydro-1H-pyrazole derivatives which are potent cannabinoid (CB.sub.1) receptor antagonists with utility for the treatment of diseases connected with disorders of the cannabinoid system. The compounds have the general formula (Ia) or |
| 6958396 |
8-{4-[3-(5-fluoro-1H-indol-3-YL)-Propyl]-Piperazin-1-YL}-2-methyl-4H-Benzo[ 1,4]oxazin-3-one mesy |
October 25, 2005 |
| The invention relates to the novel mesylate of a phenylpiperazine derivative of the formula (I). This salt has favorable properties as compared with the free base of this compound. |
| 6911448 |
Piperazine and piperidine compounds |
June 28, 2005 |
| The invention relates to a group of novel piperazine and piperidine derivatives of the formula wherein Y is hydrogen, halogen, alkyl (1-3C), or CN, CF.sub.3, OCF.sub.3, SCF.sub.3, alkoxy(1-3C), amino or mono- or dialkyl(1-3C) substituted amino or hydroxy, X is O, S, SO or SO.sub.2, - |
| 6855532 |
Human enzymes of the metalloprotease family |
February 15, 2005 |
| This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are us |
| 6828325 |
Phenylpiperazines |
December 7, 2004 |
| The invention relates to novel phenylpiperazine derivatives of the formula wherein: --R represents the group (a) or (b) as indicated in the description. These compounds are (partial) D2 receptor agonists and are usefull for treating CNS disorders, in particular Parkinson's disease. # |
