| Patent Number |
Title Of Patent |
Date Issued |
| D306347 |
Delayed action dosage unit for releasing medicaments or the like in ruminants |
February 27, 1990 |
|
| D283931 |
Pharmaceutical tablet |
May 20, 1986 |
|
| D277459 |
Bottle cap |
February 5, 1985 |
|
| 5498529 |
Protein protease inhibitors from streptomyces |
March 12, 1996 |
| This invention relates to a process for producing a heterologous polypeptide in Streptomyces which involves transforming a Streptomyces organism with a recombinant DNA molecule comprising an LEP-10 of LTl sequence selected from the group consisting of a sequence encoding a gene expre |
| 5422274 |
Internal deletion mutants of soluble T4(CD4) |
June 6, 1995 |
| This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in |
| 5356877 |
Methods for promoting growth using porcine growth hormone analogs |
October 18, 1994 |
| An analog of porcine growth hormone, is disclosed which retains the diabetogenic, insulin-sparing and lipolytic properties of porcine growth hormone while being capable of improving growth in mammals. |
| 5110906 |
Derivatives of soluble T-4 |
May 5, 1992 |
| This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence sh |
| 5037812 |
Tumor cell growth-inhibiting pharmaceutical compositions containing phosphino-hydrocarbon-gold, |
August 6, 1991 |
| Pharmaceutical compositions and a method for inhibiting the growth of tumor cells by administering a tumor cell growth-inhibiting amount of a bis[bis (diphenylphosphino)hydrocarbon]-, bis[bis(diethylphsophino) hydrocarbon]-, bis[bis(diphenylphosphine-deithylphosphino) hydrocarbon]gold(I) |
| 5008390 |
Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines |
April 16, 1991 |
| 6-Aryl-2,3-dihydroimidazo[2,1-b]thiazoles and corresponding thiazines act as nucleophiles, either directly or in the form of Grignard reagents, with N-acylpyridinium salts to produce new 6-aryl-5-(N-acyl-1,4-dihydro-4-pyridyl)-2,3-dihydroimidazo-[2,1-b]thiazole s and corresponding thi |
| 4937237 |
Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase |
June 26, 1990 |
| Invented are phosphinic acid substituted analogues of steroidal synthetic compounds, pharamaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size. |
| 4935438 |
Dopamine-.beta.-hydroxylase inhibitors |
June 19, 1990 |
| Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in |
| 4912226 |
Intermediate to dopamine-.beta.-hydroxylase inhibitors |
March 27, 1990 |
| Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in |
| 4910226 |
Steroid 5-alpha-reductase inhibitors |
March 20, 1990 |
| Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates used in preparing these compounds. |
| 4908475 |
Intermediates for preparing 1,6-dicarba-vasopressin compounds |
March 13, 1990 |
| New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pa |
| 4902675 |
"2-pyridyl and 4-pyridyl phosphine gold (I) anti tumor complexes" |
February 20, 1990 |
| 2-pyridyl and 4-pyridyl phosphine gold compounds of the formula: ##STR1## and 2-pyridyl phosphine gold compounds of the formula: ##STR2## and pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound. |
| 4888336 |
Steroid 5-alpha-reductase inhibitors |
December 19, 1989 |
| Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase. |
| 4882348 |
2-(aminoalkylthio)imidazoles as dopamine-.beta.-hydroxylase inhibitors |
November 21, 1989 |
| Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in |
| 4882319 |
Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-.alpha.-reductase |
November 21, 1989 |
| Invented are phosphonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size. A |
| 4882313 |
Carboxamide derivatives of glycopeptides |
November 21, 1989 |
| Carboxamide derivatives of glcopeptide antibiotics and their salts are useful for treating or preventing infection in an animal by gram-positive bacteria and also increase feed-utilization efficiency, promote growth in domestic animals and increase propionate production in lactating |
| 4876266 |
1-aralkyl-2-mercaptoimidazolines as DBH inhibitors |
October 24, 1989 |
| Disclosed are novel substituted 3-aralkylimidazolines of the structure. ##STR1## processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy in particular as dopamine-.beta.-hydroxylase inhibitors. |
| 4876243 |
Vasopressin compounds |
October 24, 1989 |
| Vasopressin-like peptide whose structures have been modified by an alpha-methyl amino acid at the 4 or 7 position are set forth. These compounds have potent vasopressin antagonist activities. |
| 4874792 |
Thiophenyl Alkanoic acids useful as leukotriene antagonists |
October 17, 1989 |
| This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to treating diseases in which leukotrienes are a factor by administ |
| 4873357 |
Trifluoro acetyl-cyano-aniline intermediates for dopamine-.beta.hydroxylase inhibitors |
October 10, 1989 |
| Potent dopamine-.beta.-hydroxylase inhibitors having the Formula: ##STR1## which are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity i |
| 4871771 |
Leukotriene antagonists |
October 3, 1989 |
| A method for inhibiting the effects of LTB.sub.4 comprises administration of an effective amount of a compound represented by the following structural formula (I) ##STR1## wherein m is 1 or 2; n is 1, 2 or 3; p is 0, 1, or 2; R' is hydrogen or methyl; R is phenyl substituted with |
| 4865982 |
Cloned streptomycete gene |
September 12, 1989 |
| A DNA fragment from Streptomyces sp. which contains the XP55 gene expression unit. |
| 4863944 |
Dopamine-.beta.-hydroxylase inhibitors |
September 5, 1989 |
| Potent DBH Inhibitors having the formula: ##STR1## wherein R is --CO.sub.2 H or --CH.sub.2 NHR.sup.1 can be used to inhibit DBH activity in mammals. |
| 4861771 |
Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benz azepin |
August 29, 1989 |
| Prodrug carbamate derivatives of fenoldopam which provide fenoldopam plasma levels of similar magnitude and over a much longer period of time than the parent compound. An absence of a high initial peak effect associated with the parent compound is noted. A lead compound of the series is |
| 4859779 |
Dopamine-.beta.-hydroxylase inhibitors |
August 22, 1989 |
| Potent dopamine-.beta.-hydroxylase inhibitors having the formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in |
| 4859601 |
Streptomyces Bgl protein gene promoter |
August 22, 1989 |
| A DNA fragment from Streptomyces sp. which contains the Bgl protein (P49) promoter, the P1 promoter, for expressing heterologous genes. |
| 4859584 |
Cell growth rate determination by measurement of changes in cyanine dye levels in plasma membran |
August 22, 1989 |
| Methods for determining growth rate of cells growing in vivo and in vitro. Cells are labelled with cyanine dyes and changes in plasma membrane cyanine dye levels are used to determine growth rate. Cell growth rate determinations are utilized to monitor transplanted bone marrow cell e |
| 4857549 |
Antitumor compounds |
August 15, 1989 |
| Compounds, pharmaceutical compositions and a method for treating tumors by administering an effective tumor cell growth-inhibiting amount of a .alpha.,.omega.-bis(disubstitutedphosphino)hydrocarbon compound or a [.alpha.,.omega.-bis(disubstitutedphosphino)hydrocarbon] digold(I), digo |
| 4857540 |
Dopamine-.beta.-hydroxylase inhibitors |
August 15, 1989 |
| 1-substituted-2-mercapto(or aminomethyl)benzimidazole compounds which inhibit dopamine-.beta.-hydroxylase activity. |
| 4849362 |
Fluorescent intracellular calcium indicators |
July 18, 1989 |
| Invented are new tetracarboxylate compounds which are chelators for calcium ions. Also invented is a useful method of measuring intracellular calcium concentrations using these novel compounds as an optical indicator. |
| 4847270 |
Inhibition of the 5-lipoxygenase pathway utilizing certain 2,2'-alkyldiyl bis(thio)bis-imidazole |
July 11, 1989 |
| Novel compounds, pharmaceutical compositions and a method of inhibiting the 5-lipoxygenase products in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a 2,2'-[1,2-ethanediylbis-(thio)]-bis-1H-imidazole or 2,2'-[1,3-pro |
| 4843163 |
Certain 3-(2-phenethyl)-1-carbamoyloxypyridinium halide intermediates |
June 27, 1989 |
| 3-(2-Phenethyl)-1-carbamoyloxypyridinium halide is an intermediate for the preparation of the antihistamine azatadine. |
| 4840892 |
Polynucleotide hybridization probes |
June 20, 1989 |
| Polynucleotide hybridization probes are labeled in non-probe regions but not in probe regions by selectively protecting probe regions prior to modification of the polynucleotide. |
| 4839371 |
3-aralkyl-2-mercaptoyridines as dopamine-.beta.-hydroxylase inhibitors |
June 13, 1989 |
| Disclosed are novel substituted 3-aralkyl-2-mercaptopyridines of the structure: ##STR1## processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy in particular as dopamine-.beta.-hydroxylase i |
| 4837353 |
Dopamine-.beta.-hydroxylase inhibitors |
June 6, 1989 |
| 2-(N-Phenylakyl-N-formyl)amino-3-hydroxy-2-propenoic acids are intermediates for mercaptoimidazolecarboxylic acids which are dopamine-.beta.-hydroxylase inhibitors. |
| 4835154 |
1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as d |
May 30, 1989 |
| Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in |
| 4831018 |
Polyene antibiotic emulsion formulation |
May 16, 1989 |
| A polyene antibiotic emulsion formulation comprising a therapeutically effective amount of the antibiotic incorporated into an oil-in-water emulsion, and a method of treating an active infection in an animal caused by a microorganism with sterols in its cell membrane by parenterally |
| 4826813 |
4'-Methyl-.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid vasopressin antagonist |
May 2, 1989 |
| Vasopressin antagonists which have a 4'-methyl-.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid group have vasopressin antagonist activity without substantial agonist activity. A species of the invention is [1-(4'-methyl-.beta.-mercapto-.beta.,.beta.-cyclopentamethylen |
| 4824839 |
Sulfinyl and sulfonyl substituted 2,3,4,5 tetrahydro-1H-3-benzazepines and their use in treating |
April 25, 1989 |
| Sulfinyl and sulfonyl substituted 3-benzazepine compounds are useful in treating gastrointestinal motility disorders and emesis. A particular compound of this invention is 7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine. |
| 4820719 |
Leukotriene antagonists |
April 11, 1989 |
| This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor |
| 4818767 |
Quinate salts of antimalarial phenanthrenemethanol compounds |
April 4, 1989 |
| The compounds of formula (I) ##STR1## wherein R.sub.1 is hydrogen or an alkyl radical containing one to six carbon atoms and R.sub.2 is an alkyl radical containing one to six carbon atoms possess markedly increased activity against malaria-causing parasites. Pharmaceutical compos |
| 4810811 |
Dopamine-beta-hydroxylase inhibitors |
March 7, 1989 |
| The compounds of this invention are 1-phenylalkyl-2-mercaptotetrazole compounds which are dopamine-.beta.-hydroxylase inhibitors. |
| 4810778 |
Intermediates for preparing 1,6-dicarba-vasopressin compounds |
March 7, 1989 |
| New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by the Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure |
| 4803279 |
1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and the corresponding thiazines. |
February 7, 1989 |
| 6-Aryl-2,3-dihydroimidazo[2,1-b]thiazoles and corresponding thiazines act as nucleophiles, either directly or in the form of Grignard reagents, with N-acylpyridinium salts to produce new 6-aryl-5-(N-acyl-1,4-dihydro-4-pyridyl)-2,3-dihydroimidazo-[2,1-b]thiazole s and corresponding thi |
| 4803072 |
Immunomodulation |
February 7, 1989 |
| An immunomodulating pharmaceutical composition comprising an effective, leukocyte interferon production inducing amount of NS1 and a pharmaceutically acceptable carrier or diluent; and a method of modulating the immune response in a human or other animal in need thereof by inducing t |
| 4802323 |
Automated inspection of capsule seals |
February 7, 1989 |
| In a capsule-sealing machine comprising a slat conveyor for carrying capsules over liquid binder application wheels and a bucket conveyor for receiving the sealed capsules and carrying them through the air drying chamber, a set of photoelectric inspection heads is positioned adjacent to |
| 4798843 |
2-mercaproimidazole dopamine-.beta.-hydroxylase inhibitors |
January 17, 1989 |
| Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutial compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in |
