| Patent Number |
Title Of Patent |
Date Issued |
| RE28939 |
3-Aminoindazole derivatives |
August 24, 1976 |
| .Iadd.Pharmaceutical compositions having muscle relaxant and analgesic activity containing 3-aminoindazoles..Iaddend. |
| RE28691 |
Methods and compositions for increasing feed intake of animals using tertiary alcohols |
January 20, 1976 |
| New methods and compositions for inducing polyphagia in growing or fattening meat producing animals such as sheep or cattle are described using as active ingredients tertiary alcohols or the corresponding carbamates, ureas, oxyureas or ureides. The active ingredients are used most us |
| 7247748 |
Amide compounds and methods of using the same |
July 24, 2007 |
| Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agon |
| 4353902 |
Livestock feed and method for improving food utilization |
October 12, 1982 |
| Supplemented livestock feedstuffs and methods of feeding using as active ingredient a chemical compound having histamine H.sub.2 antagonist activity improve the utilization of food by meat producing animals. A specific compound of use as the active ingredient is metiamide. |
| 4352809 |
Method of producing alpha.sub.2 antagonism |
October 5, 1982 |
| Method of producing alpha.sub.2 antagonism by administering thiadiazolo- and oxadiazolotetrahydroisoquinoline compounds. |
| 4352754 |
3-Thienylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1 H-3-benzazepines |
October 5, 1982 |
| 3-Furylmethyl- and thienylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaz epines have potent dopaminergic activity. As such they have utility an antihypertensive and anti-Parkinsonism agents. |
| 4350698 |
Antiallergic imidosulfamides |
September 21, 1982 |
| Imidosulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and chlorosulfonylisocyanate in the presence of a non-nucleophilic organic base. Pharmaceutical compositions and methods of inhibi |
| 4350685 |
Antiallergic imidodisulfamides |
September 21, 1982 |
| Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted phenylcycloalkylamine and bis(chlorosulfonyl)imide in the presence of a non-nucleophilic organic base. Pharmaceutical compositions and methods of inhib |
| 4342686 |
Intermediates for preparing 6-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaze |
August 3, 1982 |
| The preparation and use as intermediates is described for 7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures are characterized by having either an aralkyl or lower alkanoyl group at position 2 or an .alpha.-hydroxyalkyl or .alpha.-chloroalkyl group at positi |
| 4341786 |
Pharmaceutical compositions and method of producing central alpha.sub.1 agonist activity utilizi |
July 27, 1982 |
| Octahydrobenzo[f]quinoline compounds having 7- and 10-substituents are centrally acting alpha.sub.1 agonists. |
| 4340733 |
Process for preparing 3-chloro-6-(2-hydroxyphenyl)-pyridazines |
July 20, 1982 |
| A process for preparing 3-chloro-6-(2-hydroxyphenyl)pyridazines by the reaction of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones with phosphorus oxychloride and a disubstituted formamide. The chloropyridazine compounds are useful intermediates for preparing compounds which have .beta.-adre |
| 4340601 |
Dopaminergic isoquinolines |
July 20, 1982 |
| A new series of compounds having renal vasodilating activity described. The compounds are 2-allyl-8-halo-4-(p-hydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines. |
| 4340600 |
Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquino |
July 20, 1982 |
| 4-Phenyl-1,2,3,4-tetrahydroisoquinolines whose structures have two hydroxy groups substituted at the 3,4-position on the 4-phenyl ring have been found to have renal vasodilating activity upon internal administration. The active ingredients are prepared by cyclizing N-(2-substituted b |
| 4336255 |
Pharmaceutical compositions containing guanidinopyrimidines |
June 22, 1982 |
| Pharmaceutical compositions having as active diuretic ingredients certain 4-guanidinopyridines are described. Representative diuretic compounds are 5-amino-6-chloro-4-guanidinopyrimidine and 6-amino-5-nitro-4-guanidinopyrimidine. |
| 4336254 |
Guanidinopyrimidine compounds, compositions and method of using as a diuretic |
June 22, 1982 |
| 2,4-Amino, guanidinopyrimidines have diuretic activity. A representative species of these compounds is 2-guanidino-4-amino-6-chloroguanidine which is prepared by the stepwise replacement of first the 2-halo of a 2,4,6-trihalopyrimidine by guanidino and then the 4-halo by ammonia. |
| 4328153 |
Dopaminergic benzazepines |
May 4, 1982 |
| A new series of compounds having renal vasodilating activity is described. The compounds are 3-cycloalkylmethyl-7,8-dihydroxy-6-halo-1-(p-hydroxyphenyl)-2,3,4,5-tetrah ydro-1H-3-benzazepines. |
| 4327023 |
Intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
April 27, 1982 |
| A group of new chemical compounds are described which are intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines. The intermediates are distinguished in structure by a benzyloxy substituent at either the 7 or 8-position. |
| 4321399 |
Preparation of 2-thiophenecarbonyl chloride |
March 23, 1982 |
| Thiophenecarbonyl chloride is produced in good yields by the direct acylation of thiophene in the presence of aluminum chloride with control of temperature and concentration. |
| 4321393 |
Method for preparing 2-cyanamidobenzimidazoles or 2-cyanamidobenzoxazoles |
March 23, 1982 |
| A method of preparing 2-cyanamidobenzimidazoles or 2-cyanamidobenzoxazoles comprising reacting N-cyanodiphenoxyiminocarbonate with an o-amino or o-hydroxy aniline. |
| 4321254 |
Antiallergic imidodisulfamides |
March 23, 1982 |
| Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and bis(chlorosulfonyl)imide in the presence of a tertiary amine. Pharmaceutical compositions and methods of inhibiting the symp |
| 4321195 |
6 -Halo-7,8-dimethoxy-1-(methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine s |
March 23, 1982 |
| Certain 6-halo-7,8-dimethoxy-1-(methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine s and N-[2-(2-halo-3,4-dimethoxyphenyl)ethyl]-2-hydroxy-2-(methoxyphenyl)ethylam ines are intermediates for preparing 6-halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine s w |
| 4320148 |
2-Aminotetralin compounds, pharmaceutical compositions and method of producing central alpha.sub |
March 16, 1982 |
| 2-Aminotetralin compounds having 5- and 8- substituents are centrally acting alpha.sub.1 agonists. |
| 4317826 |
N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimides and antiallergic composition |
March 2, 1982 |
| Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and bis (chlorosulfonyl)imide in the presence of a tertiary amine. Pharmaceutical compositions and methods of inhibiting the sym |
| 4317812 |
Polynitroxin antibiotics produced by Nocardiopsis mutabilis Shearer sp. nov. ATCC 31520 |
March 2, 1982 |
| A novel antibiotic, polynitroxin, is produced by the cultivation of a fermentation broth containing Nocardiopsis mutabilis Shearer sp. nov. ATCC 31520 in an aqueous nutrient medium under submerged aerobic conditions. |
| 4315935 |
N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic composi |
February 16, 1982 |
| Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and bis(chlorosulfonyl)imide in the presence of a tertiary amine. |
| 4314944 |
4-Aminoalkyl-7-hydroxy-2(3H)-indolones |
February 9, 1982 |
| A new group of 2(3H)-indolones whose structures are characterized by having an aminoalkyl substituent at position 4 and a hydroxy group at position 7 of the indolone nucleus have beneficial activity on the cardiovascular system. A typical species of the group is 4-di-n-propylaminoeth |
| 4308267 |
7-[2-Alkoxyimino-2-(amino-thiazole)acetami do]-3-[1-(sulfaminoalkly)tetrazolthiomethyl]cephalospo |
December 29, 1981 |
| Novel cephalosporins with improved antibacterial and pharmacokinetic properties are disclosed. These compounds have a 2-alkoxyimino-2-(2-amino-4-thiazolyl)-acetamido group at position 7 and a sulfaminoalkyltetrazolythio group at position 3. |
| 4299969 |
Method for preparing lower alkyl .beta.-(S-benzylmercapto)-.beta.,.beta.-pentamethylenepropionat |
November 10, 1981 |
| Lower alkyl .beta.-(S-benzylmercapto)-.beta.,.beta.-pentamethylenepropionates are prepared in improved yields by reacting lower alkyl cyclohexylideneacetates with benzylmercaptan in the presence of an alkali metal mercaptide. |
| 4293546 |
Anthracycline antibiotics produced by Streptosporangium fragilis Shearer sp. nov. ATCC 31519 |
October 6, 1981 |
| A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragilis Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin compl |
| 4292305 |
Antiallergic imidodisulfamides |
September 29, 1981 |
| Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted primary amine and bis(chlorosulfonyl) imide in the presence of a tertiary amine. |
| 4286089 |
7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins |
August 25, 1981 |
| The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity. |
| 4285938 |
7,8-Dihydroxy-1-(sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives |
August 25, 1981 |
| New 7,8-dihydroxy-1-(sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines having pharmaceutical activity together with new intermediates and methods of synthesis for preparing them. The lead compound is 6-chloro-7,8-dihydroxy-1-(p-sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzaz epine w |
| 4285878 |
N-Phenyl-N'-cyano-O-phenylisoureas |
August 25, 1981 |
| N-Phenyl-N'-cyano-O-phenylisoureas are prepared from N-cyanodiphenoxyimidocarbonate and an optionally substituted o-phenylenediamine or o-aminophenol. The isoureas are new chemical intermediates especially useful for preparing 2-cyanamido and 2-carbomethoxyaminobenzimidazole and benz |
| 4284556 |
7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
August 18, 1981 |
| A group of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures have amino, hydroxy substituents at the 7,8-positions of the benzazepine nucleus is disclosed. Novel intermediates and routes of synthesis used for preparing them are also described. The end products have pharmacod |
| 4282227 |
Renal vasodilating 3,4-dihydroxyphenyltetrahydrothienopyridines |
August 4, 1981 |
| 3,4-Dihydroxyphenyltetrahydrothieno[2,3-c] or [3,2-c] pyridines are prepared by cyclization of a N-thienylmethyl-2-(3',4'-dimethoxyphenyl)-ethanolamine. These compounds have renal vasodilating activity. A species is 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydrothieno[2,3-c]pyridine and |
| 4278670 |
7-Alpha-oxyiminoacylcephalosporins |
July 14, 1981 |
| New semisynthetic cephalosporins having antibacterial activity are described. The structures of the new compounds are characterized by having an .alpha.-oxyimino group in the 7-acetamidomoiety plus a carboxyalkyltetrazolylthiomethyl group at position 3. |
| 4272531 |
3,3'-Bis-methylene-1,3-benzo-thiazine compounds |
June 9, 1981 |
| 3,3'-Bis-Methylene-1,3-benzothiazine compounds are inhibitors of phenylethanolamine N-methyl-transferase. |
| 4272440 |
Intermediates for preparing hydroxyphenylpyridazinones |
June 9, 1981 |
| 5-(5'-Halo-2'-methoxyphenyl)-3,4-dihalo-2(5H)-furanones are prepared by a Friedel-Crafts reaction using a p-haloanisole and a mucohalic acid in the presence of aluminum chloride. They are used as chemical intermediates for preparing hydroxyphenylpyridazinones. |
| 4265890 |
6-Phenyl thio- and 6-cyclohexyl thio-2,3,4,5-tetrahydro-1H-3-benzazepines |
May 5, 1981 |
| Mercapto substituted-2,3,4,5-tetrahydro-1H-3-benzazepines having dopamine receptor blocking activity are prepared from o-quinones or via standard preparative procedures. |
| 4265889 |
6-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
May 5, 1981 |
| A series of 6-lower alkyl-7,8-dihydroxyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having dopaminergic activity together with intermediates and processes for their preparation are disclosed. |
| 4263311 |
5,6-Phenyl-2,3-dihydroimidazo [2,1-b] thiazoles |
April 21, 1981 |
| The compounds are 5,6-phenyl-2,3-dihydroimidazo[2,1-b]thiazoles which have antiarthritic activity. A preferred compound is 5,6-bis(p-anisyl)-2,3-dihydroimidazo[2,1-b]thiazole. |
| 4258198 |
5-Cycloalkyl thio- and oxy-2-carbalkoxyaminobenzimidazoles |
March 24, 1981 |
| New anthelmintic compounds, compositions and methods of use are described utilizing 5-cycloalkylthio and oxy-2-carbalkoxyaminobenzimidazole. Methods of preparation involve the reaction of 4-cycloalkylthio- or oxy-o-phenylenediamine with methyl cyanocarbamate in aqueous miscible organ |
| 4258049 |
Inhibiting phenylethanolamine N-methyltransferase with thiadiazolo and oxadiazolotetrahydroisoqu |
March 24, 1981 |
| Thiadiazolo- and oxadiazolotetrahydroisoquinoline compounds are inhibitors of phenylethanolamine N-methyltransferase. |
| 4257947 |
3-Amino-2-hydroxy, halo or mercaptomethyl-4-oxoazetidines |
March 24, 1981 |
| The stereospecific cycloaddition of nitrogen containing acetic acid halides or anhydrides with Schiff bases having a carbalkoxy group substituted on the methine carbon atom offers new intermediates and methods for preparing synthetic cephalosporin congeners having antibacterial activity. |
| 4255445 |
8-Hydro xy-6,7-(2-methyl-2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaz epines |
March 10, 1981 |
| 8-Hydroxy-6,7-(2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin es are prepared by a reaction sequence whose key is a dual cyclization forming the 3-benzazepine ring and fused thereto a dihydrofuran. |
| 4255422 |
6-Halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
March 10, 1981 |
| 7,8-Dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having a halo substituent at the 6-position have potent dopaminergic activity. The 6-chloro congeners are most active. |
| 4255413 |
Gelatin capsule dosage unit containing triamterene |
March 10, 1981 |
| A gelatin capsule unit dosage form containing triamterene, 2,4,7-triamino-6-phenylpteridine, which results in rapid dissolution of the active ingredient. The dosage form comprises the addition of a combination of a surfactant and a carbonate or bicarbonate salt as diluents. |
| 4254140 |
4-(2-Aminoethyl)-7-hydroxy-2-methyl-2,3-dihydrobenzofurans |
March 3, 1981 |
| 4-(2-Aminoethyl)-7-hydroxy-2-methyl-2,3-dihydrobenzofuran derivatives having dopaminergic activity are prepared by cyclizing a 2-allyl-3,4-dimethoxyphenethylamine such as by reacting the phenethylamine with hydrogen bromide. |
| 4251660 |
Method for preparing tetrahydroisoquinolines |
February 17, 1981 |
| A method for preparing 1,2,3,4-tetrahydroisoquinolines comprising heating N-halo or hydroxyethyl-N-benzylamines in an aluminum chloride melt at 160.degree.-210.degree.. |
| 4251525 |
3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydr oxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives |
February 17, 1981 |
| 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-be nzazepine derivatives are prepared by N-allylation of 7,8-dimethoxy-6-halo-1-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepi ne using an allyl halide in acetonitrile in the presence of base followed by O-de |
