| Patent Number |
Title Of Patent |
Date Issued |
| 5843642 |
Methods for detection of acute promyelocytic leukemia (APL) |
December 1, 1998 |
| The present invention provides a method of diagnosing APL in a subject which comprises detecting in a sample from the subject either nucleic acid encoding an abnormal RAR-.alpha. receptor or an expressed protein encoded thereby. The present invention also provides methods of identifying |
| 5840960 |
Potent inducers of terminal differentiation and method of use thereof |
November 24, 1998 |
| The invention provides compounds, several of which belong to a class having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound. The invention also concents a method of selectively inducing termini differentiation of neoplasti |
| 5840566 |
Isolation of a gene encoding human thyrotropin beta subunit |
November 24, 1998 |
| The gene expressing the beta subunit of human thyroid stimulating hormone has been isolated. The gene has been incorporated into plasmid pBR322. Vectors can be used to transform cells which in turn produce pure beta subunits. The beta subunits can then be combined with the alpha subunit |
| 5834298 |
Gene encoding the human homolog of MAD2 |
November 10, 1998 |
| This invention provides isolated nucleic acid encoding human MAD2, isolated human MAD2 protein. This invention further provides a method of detecting the presence of MAD2 in a tissue sample, a method of determining whether a tumor is susceptible to treatment with a mitotic spindle inhibi |
| 5824487 |
Method for screening for targets for anti-inflammatory or anti-allergic agents |
October 20, 1998 |
| This invention provides a method for identifying a cellular protein capable of specifically binding to an activated antibody receptor, whose cytoplasmic domain comprising an ARH1 motif, comprising (a) obtaining cells comprising receptors having the ARH1 motif; (b) lysing the cells un |
| 5824330 |
Highly purified interleukin-2 and method |
October 20, 1998 |
| This invention provides a composition comprising a therapeutically effective amount of purified human interleukin-2 and a pharmaceutically acceptable carrier. |
| 5821072 |
Combinations of PKC inhibitors and therapaeutic agents for treating cancers |
October 13, 1998 |
| This invention provides methods for screening protein kinase C inhibitors capable of potentiating apoptosis in tumor cells. This invention also provides methods for screening antitumor therapeutic agents suitable for combination therapy with a protein kinase C inhibitors capable of p |
| 5817773 |
Stimulation, production, culturing and transplantation of stem cells by fibroblast growth factor |
October 6, 1998 |
| Fibroblast growth factors are used in vivo, in situ and in vitro to stimulate stem cells, hemopoiesis, the immune system, transplant donor cells, culture and/or engraftment, wherein the use of fibroblast growth factors is disclosed for the stimulation of stem cells or hemopoietic cel |
| 5814612 |
Retinol derivatives and uses thereof |
September 29, 1998 |
| The present invention provides a purified retinoid compound characterized by a molecular mass of about 320 daltons and an atomic composition of C.sub.20 H.sub.32 O.sub.3. The present invention also provides a purified retinoid compound having the structure: ##STR1## wherein the c |
| 5807705 |
Antigen recognized by patients with antibody associated paraneoplastic sensory neuronopathy, DNA |
September 15, 1998 |
| An isolated nucleic acid sequence encoding Hu paraneoplastic antigenic polypeptide is provided by this invention. This invention also provides a purified Hu antigenic polypeptide and compositions containing the purified Hu antigenic polypeptide. Further provided by this invention is a |
| 5792455 |
Anti-idiotypic antibody vaccines |
August 11, 1998 |
| A vaccine for stimulating and enhancing in a subject to which the vaccine is administered, production of antibodies which recognize GD3 ganglioside, comprising an effective amount of anti-idiotypic monoclonal antibody, designated BEC2, an effective amount of the appropriate adjuvant and |
| 5773291 |
Non-melanotytic mammalian cell constitutively expressing biologically active human tyrosinase an |
June 30, 1998 |
| This invention provides a non-melanocytic eucaryotic cell constitutively expressing biologically active human tyrosinase. The present invention also provides methods of producing biologically active human tyrosinase. Additionally, the invention provides a non-melanocytic eucaryotic cell |
| 5767074 |
Compositions of soluble C-kit ligand and hematopoietic factors |
June 16, 1998 |
| A pharmaceutical composition which comprises the c-kit ligand (KL) purified by applicants or produced by applicants' recombinant methods in combination with other hematopoietic factors and a pharmaceutically acceptable carrier is provided as well as methods of treating patients which |
| 5766891 |
Method for molecular cloning and polynucleotide synthesis using vaccinia DNA topoisomerase |
June 16, 1998 |
| This invention provides a modified vaccinia topoisomerase enzyme containing an affinity tag which is capable of facilitating purification of protein-DNA complexes away from unbound DNA. This invention further provides a modified sequence specific topoisomerase enzyme. This invention |
| 5753459 |
Nucleotide sequences of T. pallidum rare outer membrane protein |
May 19, 1998 |
| Antigenic rare outer membrane proteins of Spirochaetaceae are obtained from organisms extracted from infected tissue by a novel process of isolation utilizing a discontinuous Ficoll gradient separation, release of outer membrane in a low isotonic and low pH buffer and identification of o |
| 5750675 |
2'-"up" fluorinated 2'-deoxy-arabinofuranosylpurines |
May 12, 1998 |
| The present invention provides a compound having the structure: ##STR1## wherein R.sup.1 is hydrogen, benzyl or a substituted benzyl group;X is hydrogen, a flouro, an amino or a substituted amino group;Y is hydrogen, a methoxy, a methylthio, a benzylthio, a methylethyl, a chloro, an amin |
| 5747279 |
Nucleic acid molecules encoding kappa.sub.3 opioid receptors, receptors encoded thereby, and use |
May 5, 1998 |
| The subject invention provides recombinant nucleic acid molecule which encodes a kappa.sub.3 opioid receptor, and the receptor encoded thereby. The subject invention further provides related anti-sense oligonucleotide molecules. The subject invention further provides a related host vecto |
| 5730982 |
Therapeutic use of hypervariable region of monoclonal antibody M195 and constructs thereof |
March 24, 1998 |
| Therapeutic agents and methods for treating and diagnosing acute or chronic leukemia are provided. Such agents comprises monoclonal antibody M195, or a chimeric antibody containing the hypervariable region of M195, conjugated to a cytotoxic agent, e.g. a radioisotope. |
| 5728377 |
Methods and compositions incorporating IP-10 |
March 17, 1998 |
| The present invention discloses the correct processing of IP-10, a myelosuppressive protein produced by certain cells such as keratinocytes, monocytes and human endothelial cells upon stimulation by .gamma.-interferon. Also disclosed is a method of treating human cancer patients by a |
| 5720981 |
Epidermal cell extracts and method to enhance wound healing and regenerate epidermis |
February 24, 1998 |
| This invention provides a composition capable of stimulating growth and regeneration of epidermal cells. The composition comprises an aqueous, cell-free extract derived from epidermal cells. |
| 5703056 |
Non-invasive imaging of gene transfer |
December 30, 1997 |
| The subject invention provides a method of detecting gene transfer to and expression in a target tissue of a host subject comprising: (a) administering to the host subject a transfer vector containing a marker gene not naturally present in the host and nontoxic to the host, wherein t |
| 5700811 |
Potent inducers of terminal differentiation and method of use thereof |
December 23, 1997 |
| This invention is directed to compounds having the structure: ##STR1## wherein R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, |
| 5700786 |
Analogues of adenosine 5'diphosphate and pharmaceutical compositions thereof |
December 23, 1997 |
| This invention provides a compound having the structure: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are same or different, and are hydrogen, hydroxyl, or fluorine; Z is O, CH.sub.2 or CF.sub.2 ; R is chlorine, bromine, iodine, carbonitrile, carboxylic ester, or carboxamide; a |
| 5691338 |
1,2-dithiole-3 thiones for the treatment of reverse transcriptase-dependent viral infections |
November 25, 1997 |
| This invention provides a method of inhibiting the replication of a reverse transcriptase-dependent virus in cells which comprises contacting infected cells with an effective amount of a 1,2-dithiole-3-thione. A composition for inhibiting reverse transcriptase-dependent viral replication |
| 5688665 |
Isolated nucleic acid molecules encoding the p27 KIP-1 protein |
November 18, 1997 |
| The subject invention provides an isolated protein having an apparent molecular weight of about 27 kD and capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. The subject invention further provides a recombinant nucleic acid molecule which encodes the p27 prote |
| 5684889 |
Parametric image representation of imaging agent kinetics |
November 4, 1997 |
| A method of imaging a characteristic of image intensity of an imaging agent in a subject consists of introducing the imaging agent into the subject and repetitively scanning the subject at each of a plurality of time intervals, so as to produce a plurality of time-sequenced images th |
| 5682893 |
Dome-shaped resonator for nuclear magnetic resonance imaging and spectroscopy |
November 4, 1997 |
| A radiofrequency resonator for nuclear magnetic resonance imaging and spectroscopy of the human head in which the geometry of the resonator comprises a single end ring connected to a plurality of legs which extend along a cylinder and which are joined in pairs on a hemispherical dome. |
| 5679769 |
Synthesis of asparagine-linked glycopeptides on a polymeric solid support |
October 21, 1997 |
| The present invention provides a process for synthesizing a glycopeptide having the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are each independently H, OH, OR.sup.1, NH.sub.2, NHCOR.sup.i, F, CH.sub.2 OH, CH.sub.2 OR.sup |
| 5670317 |
Diagnostic test for the desmoplastic small round cell tumor |
September 23, 1997 |
| The present invention provides an isolated nucleic acid molecule encoding a chimeric EWS-WT1 protein. This invention also provides an isolated protein which is a chimeric EWS-WT1 protein. This invention further provides a method of diagnosing a desmoplastic small round cell tumor in a su |
| 5668179 |
Potent inducers of terminal differentiation and method of use thereof |
September 16, 1997 |
| The invention also concerns a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable condition with an amount of the compound effect to selectively induce termi |
| 5668013 |
Antigen recognized by patients with antibody associated paraneoplastic cerebellar degeneration, |
September 16, 1997 |
| An isolated nucleic acid sequence encoding major Yo paraneoplastic antigenic polypeptide is provided by this invention. This invention also provides a purified major Yo antigenic polypeptide and compositions containing the purified major Yo antigenic polypeptide. Further provided by |
| 5658890 |
C-nucleoside isostere of nicotinamide adenine dinucleotide, analogs thereof and use as anti-canc |
August 19, 1997 |
| This invention provides a compound having the structure: ##STR1## wherein each R.sub.1, R.sub.2, R.sub.3, and R.sub.4 is independently fluorine, OH or H; Z is O, CH.sub.2 or CF.sub.2 ; each Y is independently OH or F; X.sub.7 is N or CH, X.sub.8 is NH, S or Se; and W is C or N, w |
| 5658775 |
Double copy retroviral vector |
August 19, 1997 |
| The present invention concerns a retroviral vector for introducing into a eucaryotic cell DNA encoding a transcription unit which comprises a first DNA sequence which is the reverse transcript of at least a portion of a retrovirus, said portion including both the 5' LTR sequence and the |
| 5652350 |
Complementary DNA and toxins |
July 29, 1997 |
| This invention relates to new derivatized solid supports and compounds having the formula: ##STR1## wherein S may be a solid support; L may be a chemical bond or a suitable inorganic or organic linker; Z may be --SO.sub.2 -- or --S--S--; R may be --OH, an H-phosphonate, an alkane |
| 5648563 |
Retro-alpha-retinol derivative and uses of retro-alpha-retinol |
July 15, 1997 |
| This invention provides a homogeneous retro-retinoid compound, a method of enhancing the growth of a cell in a vitamin A reduced environment, a method for enhancing transcription of a gene regulated by retinoid in a cell, and a method for enhancing an immune response in a subject, wherei |
| 5645852 |
Butyric ester cyto-differtiating agents |
July 8, 1997 |
| This invention provides a method of inducing cell differentiation in a subject and methods of treating leukemia, thalassemia, or sickle cell anemia by administration to the subject of one or more oral bolus doses of a pharmaceutical composition comprising an effective amount of one or mo |
| 5643550 |
Method of treating colorectal carcinoma lesion and composition for use therein |
July 1, 1997 |
| This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the colorectal carcinoma lesion and which is labeled with an im |
| 5641672 |
Cloning and uses of the genetic locus bcl-6 |
June 24, 1997 |
| This invention provides an isolated vertebrate nucleic acid molecule the bcl-6 locus. This invention also provides an isolated human nucleic acid molecule of bcl-6 locus. This invention further provides a nucleic acid molecule comprising a nucleic acid molecule of at least 15 nucleotides |
| 5641624 |
Method for measuring anti-HIV-1 p24 antibody and use thereof |
June 24, 1997 |
| The present invention provides a method for determining the amount of HIV-1 p24 antigen or anti-HIV-1 p24 antibody present in a suitable bodily fluid sample from an HIV-1-infected subject. This invention also provides a kit for determining the amount of HIV-1 p24 antigen or anti-HIV-1 p2 |
| 5622958 |
Enediyne quinone imines and methods of preparation and use thereof |
April 22, 1997 |
| A quinone imine enediyne possessing cytotoxic activity towards cancer cells having the general structure: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are independently the same or different and are H, Br, Cl, F, NH.sub.2, CO.sub.2 H, or OH or a linear or branched alkyl, etc.; w |
| 5614371 |
Ri fusion antigen recognized by antibodies associated with paraneoplastic opsoclonus and methods |
March 25, 1997 |
| An isolated nucleic acid sequence encoding Ri paraneoplastic antigenic polypeptide is provided by this invention. This invention also provides a purified Ri antigenic polypeptide and compositions containing the purified Ri antigenic polypeptide. Further provided by this invention is a an |
| 5612211 |
Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth fac |
March 18, 1997 |
| Fibroblast growth factors are used in vivo, in situ and in vitro to stimulate stem cells, hemopoiesis, the immune system, transplant donor cells, culture and/or engraftment, wherein the use of fibroblast growth factors is disclosed for the stimulation of stem cells or hemopoietic cel |
| 5610200 |
Anhydroretinol and derivatives thereof as antagonists of immune responses and inhibitors of canc |
March 11, 1997 |
| This invention provides methods of inhibiting the growth of cells, of treating a subject having a disease characterized by an uncontrolled growth of cells and of blocking an immune response as well as related inflammatory responses in a subject which comprises administering a compoun |
| 5608108 |
Potent inducers of terminal differentiation and method of use thereof |
March 4, 1997 |
| The invention provides compounds, several of which belong to a class having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound.The invention also concents a method of selectively inducing termini differentiation of neoplastic |
| 5603934 |
Antigen recognized by patients with antibody associated paraneoplastic sensory neuronopathy |
February 18, 1997 |
| An isolated nucleic acid sequence encoding Hu paraneoplastic antigenic polypeptide is provided by this invention. This invention also provides a purified Hu antigenic polypeptide and compositions containing the purified Hu antigenic polypeptide. Further provided by this invention is a |
| 5597931 |
Total synthesis of taxol and analogues thereof |
January 28, 1997 |
| The present invention provides three basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol an |
| 5571937 |
Complementary DNA and toxins |
November 5, 1996 |
| This invention relates to new derivatized solid supports and compounds having the formula: ##STR1## wherein S may be a solid support; L may be a chemical bond or a suitable inorganic or organic linker; Z may be --SO.sub.2 -- or --S--S--; R may be --OH, an H-phosphonate, an alkane |
| 5569650 |
C-nucleoside isosters of analogs thereof and pharmaceutical compositions |
October 29, 1996 |
| This invention provides a compound having the structure: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are same or different, and are hydrogen, hydroxyl, or fluorine; Z is O, CH.sub.2 or CF.sub.2 ; R is chlorine, bromine, iodine, carbonitrile, carboxylic ester, or carboxamide; a |
| 5543505 |
Synthetic compounds which bind to H. pylori, and uses thereof |
August 6, 1996 |
| The present invention provides a compound having the structure: ##STR1## wherein A is selected from the group consisting of (i) an amino acid bearing an .omega.-amino group or an .omega.--(C.dbd.O)-- group, (ii) an amino acid residue of a peptide, which residue bears an .omega.-amino |
| 5541327 |
Preparation of camptothecin analogs |
July 30, 1996 |
| Substituted analogues of camptothecin possessing cytotoxic activity towards cancer cells, of the general structure: ##STR1## wherein E is H, CO.sub.2 R, CONH.sub.2, CONHR, CONR.sub.2, acyl, or CN; X is H, OH, or OR; R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently the sam |
