| Patent Number |
Title Of Patent |
Date Issued |
| 7553830 |
Compositions for the delivery of negatively charged molecules |
June 30, 2009 |
| This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex |
| 7521184 |
Detection and quantitation of nucleic acid molecules in biological samples |
April 21, 2009 |
| The present invention concerns processes for the detection and quantitation of nucleic acid molecules, polynucleotides, and/or oligonucleotides in a sample using hybridizationdetection assays, antibody-mediated recognition assays, nucleic acid sensor molecules, chromatographic assays |
| 7517864 |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothel |
April 14, 2009 |
| This invention relates to compounds, compositions, and methods useful for modulating VEGF and/or VEGFR gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and a |
| 7514099 |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecu |
April 7, 2009 |
| The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and |
| 7491805 |
Conjugates and compositions for cellular delivery |
February 17, 2009 |
| This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including galactosamine and N-acetyl galactosamine derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, |
| 7404969 |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecu |
July 29, 2008 |
| The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that ef |
| 7205399 |
Methods and reagents for oligonucleotide synthesis |
April 17, 2007 |
| The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof. |
| 7109165 |
Conjugates and compositions for cellular delivery |
September 19, 2006 |
| This invention features conjugates, compositions, methods of synthesis, and applications thereof, including folate derived conjugates of nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids and antisense nucleic acid molecules. |
| 7071311 |
Antibodies having specificity for 2'-C-allyl nucleic acids |
July 4, 2006 |
| The present invention relates to antibodies, antibody conjugates, and compositions thereof, methods of antibody synthesis, and applications of antibodies useful for detecting the presence of nucleic acid molecules in vivo, such as in a clinical setting. The antibodies of the invention ar |
| 7041817 |
Synthesis, deprotection, analysis and purification of RNA and ribozymes |
May 9, 2006 |
| Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form. |
| 7034009 |
Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of |
April 25, 2006 |
| The present invention relates to nucleic acid molecules such as ribozymes, DNAzymes, and antisense which modulate the synthesis, expression and/or stability of an mRNA encoding one or more receptors of vascular endothelial growth factor, such as flt-1 and KDR. Nucleic acid molecules |
| 6995259 |
Method for the chemical synthesis of oligonucleotides |
February 7, 2006 |
| The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof. |
| 6989442 |
Deprotection and purification of oligonucleotides and their derivatives |
January 24, 2006 |
| Method for synthesis, one-pot deprotection, and purification of molecules comprising one or more ribonucleotides. |
| 6972330 |
Chemical synthesis of methoxy nucleosides |
December 6, 2005 |
| Process for chemical synthesis of methoxy nucleosides. |
| 6852535 |
Polymerase III-based expression of therapeutic RNAS |
February 8, 2005 |
| A transcribed non-naturally occurring RNA molecule comprising a desired RNA molecule, wherein the 3' region of the RNA is able to base-pair with at least 8 bases at the 5' terminus of the same RNA molecule. |
| 6849726 |
Non-nucleotide containing RNA |
February 1, 2005 |
| The present invention relates to RNA molecules containing one or more non-nucleotide mimetics. |
| 6831171 |
Nucleic acid catalysts with endonuclease activity |
December 14, 2004 |
| The present invention relates to novel Nucleic acid catalysts, methods of synthesis, and uses thereof. |
| 6818759 |
2'-O-alkylthioalkyl and 2'-C-alkylthioalkyl-containing nucleic acids |
November 16, 2004 |
| A compound having the formula: ##STR1##wherein, R1 represents 2'-O-alkylthioalkyl or 2'-C-alkylthioalkyl; X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group. |
| 6818447 |
Method and reagent for the treatment of diseases or conditions related to levels of vascular end |
November 16, 2004 |
| The present invention relates to nucleic acid molecules which modulate the synthesis, expression and/or stability of an mRNA encoding one or more receptors of vascular endothelial growth factor. |
| 6797815 |
Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides |
September 28, 2004 |
| Novel xylo nucleoside or xylo nucleotide analogs, polynucleotides comprising xylo nucleotide substitution, processes for their synthesis and incorporation into polynucleotides. |
| 6686463 |
Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives |
February 3, 2004 |
| The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2'-amino, 2'-N-phthaloyl, 2'-O-methyl, 2'-O-silyl, 2'-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside deri |
| 6673918 |
Deprotection of RNA |
January 6, 2004 |
| Method for one-pot deprotection of RNA molecules. |
| 6673611 |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression |
January 6, 2004 |
| This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using |
| 6649751 |
Synthesis, deprotection, analysis and purification of RNA and ribozymes |
November 18, 2003 |
| Provided is a method for purification and synthesis of RNA molecules that have at least one chemical modification. |
| 6623962 |
Enzymatic nucleic acid treatment of diseases of conditions related to levels of epidermal growth |
September 23, 2003 |
| Enzymatic nucleic acid molecules which cleave EGFR RNA. |
| 6620926 |
Purification of oligomers |
September 16, 2003 |
| Compositions and methods are disclosed which facilitate purification of oligomers and other compounds. The disclosed compositions are silyl compositions that can be directly coupled, or coupled through a linking group, to a compound of interest, preferably to an oligomer at the end of |
| 6620805 |
Delivery of nucleic acids by porphyrins |
September 16, 2003 |
| Efficient methods and compositions are provided for the targeted delivery of effective concentrations of compounds, including nucleic acid molecules and oligonucleotides such as EGSs, ribozymes and antisense, proteins, peptides, carbohydrate, and synthetic organic and inorganic molecules |
| 6617438 |
Oligoribonucleotides with enzymatic activity |
September 9, 2003 |
| Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to |
