| Patent Number |
Title Of Patent |
Date Issued |
| RE39015 |
DNA encoding interleukin-B30 |
March 14, 2006 |
| Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using the reagents and diagnostic kits are also provided. |
| RE37721 |
Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
May 28, 2002 |
| Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula ##STR1##or a pharmaceutically acceptable salt thereof, wherein:Ar.sup.1 and Ar.sup.2 are aryl or R.sup.4 -substituted aryl;Ar.sup.3 is aryl or R.sup.5 -substituted aryl;X, Y and Z are --CH.sub.2 --, --CH(lower alkyl)-- or |
| RE32465 |
AZA penem compounds |
July 28, 1987 |
| Described is a novel process for the preparation of penems and carbapenems useful as antibacterial agents which comprises the reaction of an appropriate 4-substituted-azetidine-2-one with an acid halide in the presence of a tertiary amine and an alkaline earth metal carbonate, follow |
| RE31422 |
Hydrophilic polymers and contact lenses of high water content |
October 18, 1983 |
| Cross-linked hydrophilic interpolymers and contact lenses made therefrom comprising hydrophilic units of which the only or major proportion are derived from .Iadd.vinyl pyridine or .Iaddend.an N-vinyl heterocyclic monomer, hydrophobic units derived from the group consisting of styrene |
| D471831 |
Counting device |
March 18, 2003 |
|
| D471830 |
Counting device |
March 18, 2003 |
|
| D471120 |
Counting device |
March 4, 2003 |
|
| D422782 |
Heel cushion with insert |
April 18, 2000 |
|
| D387874 |
Syringe tray |
December 16, 1997 |
|
| D383535 |
Tablet |
September 9, 1997 |
|
| D355844 |
Bottle |
February 28, 1995 |
|
| D350193 |
Combined inhaler and cover |
August 30, 1994 |
|
| D349572 |
Aerosol inhaler |
August 9, 1994 |
|
| D348928 |
Inhaler |
July 19, 1994 |
|
| D345013 |
Combined inhaler and cover |
March 8, 1994 |
|
| D344797 |
Combined inhaler and cover |
March 1, 1994 |
|
| D344796 |
Combined inhaler and cover |
March 1, 1994 |
|
| D308100 |
Nasal spray pump |
May 22, 1990 |
|
| D307646 |
Cosmetic powder container |
May 1, 1990 |
|
| D294063 |
Vaginal applicator |
February 2, 1988 |
|
| D285375 |
Poultry vaccination unit |
August 26, 1986 |
|
| D270283 |
Nasal nozzle |
August 23, 1983 |
|
| D267587 |
Plunger rod/needle protector for a hypodermic syringe |
January 11, 1983 |
|
| 7619094 |
Ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus |
November 17, 2009 |
| The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat |
| 7618649 |
Extended release oral dosage composition |
November 17, 2009 |
| A bilayer solid composition comprising (a) an immediate release first layer comprising an anti-allergic effective amount of desloratadine and at least one pharmaceutically acceptable excipient and (b) a sustained release second layer comprising an effective amount of a nasal deconges |
| 7612058 |
Methods for inhibiting sterol absorption |
November 3, 2009 |
| The present invention provides compositions, therapeutic combinations and methods including: (a) at least one peroxisome proliferator-activated receptor activator; and (b) at least one substituted azetidinone or substituted .beta.-lactam sterol absorption inhibitor which can be useful |
| 7608690 |
IL-B30 antibodies |
October 27, 2009 |
| Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided. |
| 7608643 |
Compounds for inhibiting KSP kinesin activity |
October 27, 2009 |
| The present invention relates to compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: ##STR00001## The present invention provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated |
| 7605275 |
Exo- and diastereo- selective syntheses of himbacine analogs |
October 20, 2009 |
| This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by th |
| 7605155 |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
October 20, 2009 |
| In its many embodiments, the present invention provides a class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases (CDKs), methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharma |
| 7601833 |
Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines |
October 13, 2009 |
| A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent. |
| 7601815 |
Anti-CCL27 antibodies |
October 13, 2009 |
| Novel CC chemokines from human, reagents related thereto including purified proteins, specific antibodies and nucleic acids encoding these chemokines are provided. Also provided are methods of making and using said reagents and diagnostic kits. |
| 7601724 |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
October 13, 2009 |
| In its many embodiments, the present invention provides a class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases (CDKs), methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharma |
| 7598259 |
mGluR1 antagonists as therapeutic agents |
October 6, 2009 |
| In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J.sup.1-J.sup.4, X, and R.sup.1-R.sup.5 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 |
| 7598250 |
Cyclic amine BACE-1 inhibitors having a heterocyclic substituent |
October 6, 2009 |
| Disclosed are novel compounds of the formula ##STR00001## or a pharmaceutically acceptable salt or solvate thereof, wherein R.sup.1 is ##STR00002## X is --O--, --C(R.sup.14).sub.2-- or --N(R)--; Z is --C(R.sup.14).sub.2-- or --N(R)--; t is 0, 1, 2 or 3; each R and R.sup.2 is |
| 7598242 |
Compounds for the treatment of inflammatory disorders |
October 6, 2009 |
| This invention relates to compounds of the Formula (I): ##STR00001## or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-.alpha. or combinations thereof. |
| 7595419 |
Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propiona |
September 29, 2009 |
| In one embodiment, the present application relates to a process of making a compound of formula I: ##STR00001## and to certain intermediate compounds that are made within the process of making the compound of formula I. |
| 7595299 |
Peptides as NS3-serine protease inhibitors of hepatitis C virus |
September 29, 2009 |
| The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them t |
| 7592419 |
Macrocyclic inhibitors of hepatitis C virus NS3-serine protease |
September 22, 2009 |
| The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. The novel compounds typically include a 15-20 me |
| 7592348 |
Heterocyclic aspartyl protease inhibitors |
September 22, 2009 |
| Disclosed are compounds of the formula I ##STR00001## or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, --C(.dbd.S)--, --S(O)--, --S(O).sub.2--, --C(.dbd.O)--, --O--, --C(R.sup.6)(R.sup.7)--, --N(R.sup.5)-- or --C(.dbd.N(R.sup.5) |
| 7592316 |
Peptides as NS3-serine protease inhibitors of hepatitis C virus |
September 22, 2009 |
| The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat |
| 7592315 |
Peptide viral entry inhibitors |
September 22, 2009 |
| The present invention provides, inter alia, peptide compositions and methods for treating and preventing Flaviviridae virus (e.g., hepatitis C virus) infections. |
| 7585864 |
Farnesyl protein transferase inhibitors and their use to treat cancer |
September 8, 2009 |
| Disclosed are compounds of the formula: ##STR00001## wherein R.sup.8 represents a cyclic and acyclic moiety to which is bound an imidazolylalkyl group; R.sup.9 represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclo |
| 7585502 |
Mammalian CX.sub.3C chemokine antibodies |
September 8, 2009 |
| Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided. |
| 7582763 |
Enantioselective process |
September 1, 2009 |
| An enantioselective process for preparing intermediates useful in the preparation of the chiral tricyclic compound of formula I ##STR00001## is disclosed. |
| 7579440 |
Mammalian cytokines; related reagents |
August 25, 2009 |
| Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided. |
| 7576085 |
Imidazopyrazines as cyclin dependent kinase inhibitors |
August 18, 2009 |
| In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceut |
| 7575741 |
Methods of treating cutaneous ulcers and grafts using IL-23 |
August 18, 2009 |
| Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule. |
| 7572802 |
7-[2-[4-(6-fluoro-3-methyl-1,2-benzisoxazol-5-yl)-1-piperazinyl]ethyl]-2-(- 1-propynyl)-7H-pyrazo |
August 11, 2009 |
| The compound having the structural formula I ##STR00001## or a pharmaceutically acceptable salt thereof, is disclosed, as well as its use in the treatment of central nervous system diseases, in particular Parkinson's disease, Extra Pyramidal Syndrome, restless legs syndrome and atte |
| 7569705 |
Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexa |
August 4, 2009 |
| In one embodiment, the present application relates to a process of making a compound of formula I. ##STR00001## and to certain intermediate compounds that are made within the process of making the compound of formula I. |
