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Schering Corporation Patents
Assignee:
Schering Corporation
Address:
Kenilworth, NJ
No. of patents:
1807
Patents:












Patent Number Title Of Patent Date Issued
RE43298 Peptides as NS3-serine protease inhibitors of hepatitis C virus April 3, 2012
The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat
RE42461 Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents June 14, 2011
Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula ##STR00001## or a pharmaceutically acceptable salt thereof, wherein: Ar.sup.1 and Ar.sup.2 are aryl or R.sup.4-substituted aryl; Ar.sup.3 is aryl or R.sup.5-substituted aryl; X, Y and Z are --CH.sub.2--, --CH(low
RE39015 DNA encoding interleukin-B30 March 14, 2006
Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using the reagents and diagnostic kits are also provided.
RE37721 Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents May 28, 2002
Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula ##STR1##or a pharmaceutically acceptable salt thereof, wherein:Ar.sup.1 and Ar.sup.2 are aryl or R.sup.4 -substituted aryl;Ar.sup.3 is aryl or R.sup.5 -substituted aryl;X, Y and Z are --CH.sub.2 --, --CH(lower alkyl)-- or
RE32465 AZA penem compounds July 28, 1987
Described is a novel process for the preparation of penems and carbapenems useful as antibacterial agents which comprises the reaction of an appropriate 4-substituted-azetidine-2-one with an acid halide in the presence of a tertiary amine and an alkaline earth metal carbonate, follow
RE31422 Hydrophilic polymers and contact lenses of high water content October 18, 1983
Cross-linked hydrophilic interpolymers and contact lenses made therefrom comprising hydrophilic units of which the only or major proportion are derived from .Iadd.vinyl pyridine or .Iaddend.an N-vinyl heterocyclic monomer, hydrophobic units derived from the group consisting of styrene
D650065 Nozzle for nasal spray device December 6, 2011
D634641 Container with viewing window March 22, 2011
D624421 Container with side viewing window September 28, 2010
D607729 Container with side viewing window January 12, 2010
D607728 Container with viewing window January 12, 2010
D471831 Counting device March 18, 2003
D471830 Counting device March 18, 2003
D471120 Counting device March 4, 2003
D422782 Heel cushion with insert April 18, 2000
D387874 Syringe tray December 16, 1997
D383535 Tablet September 9, 1997
D355844 Bottle February 28, 1995
D350193 Combined inhaler and cover August 30, 1994
D349572 Aerosol inhaler August 9, 1994
D348928 Inhaler July 19, 1994
D345013 Combined inhaler and cover March 8, 1994
D344797 Combined inhaler and cover March 1, 1994
D344796 Combined inhaler and cover March 1, 1994
D308100 Nasal spray pump May 22, 1990
D307646 Cosmetic powder container May 1, 1990
D294063 Vaginal applicator February 2, 1988
D285375 Poultry vaccination unit August 26, 1986
D270283 Nasal nozzle August 23, 1983
D267587 Plunger rod/needle protector for a hypodermic syringe January 11, 1983
8293883 Engineered anti-IL-23P19 antibodies October 23, 2012
Engineered antibodies to human IL-23p19 are provided, as well as uses thereof, e.g., in treatment of inflammatory, autoimmune, and proliferative disorders.
8273790 Exo-selective synthesis of himbacine analogs September 25, 2012
This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. T
8263748 Lyophilized formulations of engineered anti-IL-23p19 antibodies September 11, 2012
The present invention provides lyophilized formulations of antibodies, such as antibodies that specifically bind to human interleukin-23 p19 (IL-23p19), or antigen binding fragments thereof.
8263080 Use of agonists and antagonists of IL-23 in the treatment of viral infection September 11, 2012
Provided are methods of modulating cytokine activity, e.g., for the purpose of treating viral infections. Also provided are reagents for use in screening for agonists or antagonists of IL-23.
8263070 Methods of modulating CD200 receptors September 11, 2012
Provided are methods for modulating activity of the immune system using agonists or antagonists of a CD200 receptor. Also provided are methods of treatment and diagnosis of immune disorders.
8258319 Exo- and diastereo- selective synthesis of himbacine analogs September 4, 2012
This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by th
8257921 NRIP1 regulation of apolipoprotein A1 September 4, 2012
The present invention provides, in part, methods for identifying inhibitors of NRIP1 and methods of using such inhibitors. Methods of treating NRIP1-mediated disorders using NRIP1 inhibitor are also provided.
8242112 Heterocyclic aspartyl protease inhibitors August 14, 2012
Disclosed are compounds of the formula I ##STR00001## or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, --C(.dbd.S)--, --S(O)--, --S(O).sub.2--, --C(.dbd.O)--, --O--, --C(R.sup.6)(R.sup.7)--, --N(R.sup.5)-- or --C(.dbd.N(R.s
8236309 Use of bispecific antibodies to regulate immune responses August 7, 2012
The invention relates generally to the field of immunology, in particular, to bispecific antibodies. Methods for designing a bispecific antibody for use in treating diseases relating to the immune system are disclosed. Specific examples relate to bispecific antibodies which recognize
8227605 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors July 24, 2012
The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder,
8226947 Interleukin-10 antibodies July 24, 2012
The methods and compositions provided herein relate generally to IL-10 specific antibodies and uses thereof. More specifically, compositions of humanized IL-10 specific antibodies and methods to use such antibodies in modulating the biological activity of IL-10, particularly in autoimmun
8222259 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidin-3-one co July 17, 2012
Compounds of the Formula I wherein R.sup.1 and R.sup.2 together with the carbon atoms to which they are bonded optionally form a further heteroaromatic ring of the formula (II) as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof are adenosine A2a recep
8216571 Fully human anti-VEGF antibodies and methods of using July 10, 2012
Disclosed herein are fully human antibodies and antigen-binding fragments thereof that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. The antibodies and antigen-binding fragments disclosed herein may be used, for exampl
8212016 NPC1L1 orthologues July 3, 2012
The present invention provides, in part, NPC1L1 from various species. Methods of using the NPC1L1 polypeptides and polynucleotide set forth herein, e.g., in screening assays, are also set forth.
8212008 Antibodies to CD200R July 3, 2012
The present invention relates to binding compounds specific for the human inhibitory CD200R and uses thereof. More specifically, the invention relates to antibodies that recognize the human inhibitory CD200R and modulates its activity in inflammatory and autoimmune disorders.
8211854 Methods for inhibiting protein kinases July 3, 2012
The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim kinases, and tyrosine kinase using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or ameliorat
8207221 Crystalline polymorphs of a CXC-chemokine receptor ligand June 26, 2012
The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure: ##STR00001## These four polymorphic forms, herein referred to as Forms I, II, III and IV are active as a CXC-chemokine receptor ligands. The
8207170 Heterocyclic substituted piperazines with CXCR3 antagonist activity June 26, 2012
The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in
8206943 Assay for PCSK9 inhibitors June 26, 2012
The present invention provides methods for identifying modulators of PCSK9, for example, using a variety of assay formats. Inhibitors of PCSK9 can be used for example, to treat diseases such as hyperlipidemia and related disorders.
8202854 Heterocyclic aspartyl protease inhibitors June 19, 2012
Disclosed are compounds of the formula I ##STR00001## or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein Ar, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification; and pharmaceutical compositions comprising the

 
 
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